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  1. AU="Foerster, Bernd Uwe"
  2. AU="Wu, Hongzhuo"
  3. AU="Fleischer, Robert"
  4. AU="Di Carlo, S"
  5. AU="Rodrigue-Gervais, Ian Gaël"
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  1. Article: Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage.

    Mello, Tanira Giara / Rosado-de-Castro, Paulo Henrique / Vasques, Juliana Ferreira / Pinhão, Carolina / Santos, Tayná Monteiro / de Lima, Renata Rodrigues / Foerster, Bernd Uwe / Paiva, Fernando Fernandes / Mendez-Otero, Rosalia / Pimentel-Coelho, Pedro Moreno

    Future science OA

    2022  Volume 8, Issue 4, Page(s) FSO793

    Abstract: Aim: Intracerebral hemorrhage (ICH) has limited therapeutic options. We have shown that an intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) 24 h after an ICH in rats reduced the residual hematoma volume after a ... ...

    Abstract Aim: Intracerebral hemorrhage (ICH) has limited therapeutic options. We have shown that an intravenous injection of human umbilical cord-derived mesenchymal stromal cells (hUC-MSC) 24 h after an ICH in rats reduced the residual hematoma volume after a moderate hemorrhage but was inefficient in severe ICH. Here, we investigated whether a treatment in the hyperacute phase would be more effective in severe ICH.
    Materials & methods: Wistar rats were randomly selected to receive an intravenous injection of hUC-MSC or the vehicle 1 h after a severe ICH.
    Results: The hyperacute treatment with hUC-MSC did not affect the 22-day survival rate, the motor function or the residual hematoma volume.
    Conclusion: These results indicate the need for optimization of hUC-MSC-based therapies for severe ICH.
    Language English
    Publishing date 2022-03-24
    Publishing country England
    Document type Journal Article
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.2144/fsoa-2021-0121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Contrast optimization in arterial spin labeling with multiple post-labeling delays for cerebrovascular assessment.

    Paschoal, André Monteiro / Leoni, Renata Ferranti / Foerster, Bernd Uwe / Dos Santos, Antonio Carlos / Pontes-Neto, Octávio Marques / Paiva, Fernando Fernandes

    Magma (New York, N.Y.)

    2020  Volume 34, Issue 1, Page(s) 119–131

    Abstract: Objective: Improving the readout for arterial spin labeling with multiple post-labeling delays (multi-PLD ASL) through a flip angle (FA) sweep towards increasing contrast-to-noise ratio for long PLD images.: Methods: Images were acquired from 20 ... ...

    Abstract Objective: Improving the readout for arterial spin labeling with multiple post-labeling delays (multi-PLD ASL) through a flip angle (FA) sweep towards increasing contrast-to-noise ratio for long PLD images.
    Methods: Images were acquired from 20 healthy subjects and 14 patients with severe, asymptomatic carotid artery stenosis (ACAS) in a 3T MRI scanner. Multi-PLD ASL images with conventional and proposed (FA sweep) readouts were acquired. For patients, magnetic resonance angiography was used to validate the multi-PLD ASL results. Perfusion values were calculated for brain regions irrigated by the main cerebral arteries and compared by analysis of variance.
    Results: For healthy subjects, better contrast was obtained for long PLDs when using the proposed multi-PLD method compared to the conventional. For both methods, no hemispheric difference of perfusion was observed. For patients, the proposed method facilitated the observation of delayed tissue perfusion, which was not visible for long PLD using the conventional multi-PLD ASL.
    Conclusion: We successfully assessed brain perfusion of patients with asymptomatic CAS using multi-PLD ASL with FA sweep. We were able to show subtle individual differences. Moreover, prolonged arterial transit time in patients was observed, although they were considered asymptomatic, suggesting that it may not be an adequate term to characterize them.
    MeSH term(s) Brain ; Cerebrovascular Circulation ; Humans ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Perfusion Imaging ; Spin Labels
    Chemical Substances Spin Labels
    Language English
    Publishing date 2020-09-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1160826-2
    ISSN 1352-8661 ; 0968-5243
    ISSN (online) 1352-8661
    ISSN 0968-5243
    DOI 10.1007/s10334-020-00883-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3788: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Maternal childhood maltreatment: associations to offspring brain volume and white matter connectivity.

    Lugo-Candelas, Claudia / Chang, Le / Dworkin, Jordan D / Aw, Natalie / Fields, Andrea / Reed, Hannah / Spann, Marisa / Gilchrist, Michelle A / Hinds, Walter / Marsh, Rachel / Fifer, William P / Weissman, Myrna / Foerster, Bernd Uwe / Manin, Marina Giorgi / Silva, Ivaldo / Peterson, Bradley / Coelho Milani, Ana Carolina / Gingrich, Jay / Monk, Catherine /
    Duarte, Cristiane S / Jackowski, Andrea / Posner, Jonathan

    Journal of developmental origins of health and disease

    2023  Volume 14, Issue 5, Page(s) 591–601

    Abstract: The deleterious effects of adversity are likely intergenerational, such that one generation's adverse experiences can affect the next. Epidemiological studies link maternal adversity to offspring depression and anxiety, possibly via transmission ... ...

    Abstract The deleterious effects of adversity are likely intergenerational, such that one generation's adverse experiences can affect the next. Epidemiological studies link maternal adversity to offspring depression and anxiety, possibly via transmission mechanisms that influence offspring fronto-limbic connectivity. However, studies have not thoroughly disassociated postnatal exposure effects nor considered the role of offspring sex. We utilized infant neuroimaging to test the hypothesis that maternal childhood maltreatment (CM) would be associated with increased fronto-limbic connectivity in infancy and tested brain-behavior associations in childhood. Ninety-two dyads participated (32 mothers with CM, 60 without; 52 infant females, 40 infant males). Women reported on their experiences of CM and non-sedated sleeping infants underwent MRIs at 2.44 ± 2.74 weeks. Brain volumes were estimated via structural MRI and white matter structural connectivity (fiber counts) via diffusion MRI with probabilistic tractography. A subset of parents (
    MeSH term(s) Male ; Infant ; Child ; Humans ; Female ; Child, Preschool ; White Matter/diagnostic imaging ; Mothers ; Brain/diagnostic imaging ; Magnetic Resonance Imaging ; Anxiety
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2554780-X
    ISSN 2040-1752 ; 2040-1744
    ISSN (online) 2040-1752
    ISSN 2040-1744
    DOI 10.1017/S2040174423000247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Intravenous Human Umbilical Cord-Derived Mesenchymal Stromal Cell Administration in Models of Moderate and Severe Intracerebral Hemorrhage.

    Mello, Tanira Giara / Rosado-de-Castro, Paulo Henrique / Campos, Raquel Maria Pereira / Vasques, Juliana Ferreira / Rangel-Junior, William Simões / Mattos, Raphael Santos de Almeida Rezende de / Puig-Pijuan, Teresa / Foerster, Bernd Uwe / Gutfilen, Bianca / Souza, Sergio Augusto Lopes / Boltze, Johannes / Paiva, Fernando Fernandes / Mendez-Otero, Rosalia / Pimentel-Coelho, Pedro Moreno

    Stem cells and development

    2020  Volume 29, Issue 9, Page(s) 586–598

    Abstract: Intracerebral hemorrhage (ICH) is as a life-threatening condition that can occur in young adults, often causing long-term disability. Recent preclinical data suggest mesenchymal stromal cell (MSC)-based therapies as promising options to minimize brain ... ...

    Abstract Intracerebral hemorrhage (ICH) is as a life-threatening condition that can occur in young adults, often causing long-term disability. Recent preclinical data suggest mesenchymal stromal cell (MSC)-based therapies as promising options to minimize brain damage after ICH. However, therapeutic evidence and mechanistic insights are still limited, particularly when compared with other disorders such as ischemic stroke. Herein, we employed a model of collagenase-induced ICH in young adult rats to investigate the potential therapeutic effects of an intravenous injection of human umbilical cord Wharton's jelly-derived MSCs (hUC-MSCs). Two doses of collagenase were used to cause moderate or severe hemorrhages. Magnetic resonance imaging showed that animals treated with hUC-MSCs after moderate ICH had smaller residual hematoma volumes than vehicle-treated rats, whereas the cell therapy failed to decrease the hematoma volume in animals with a severe ICH. Functional assessments (rotarod and elevated body swing tests) were performed for up to 21 days after ICH. Enduring neurological impairments were seen only in animals subjected to severe ICH, but the cell therapy did not induce statistically significant improvements in the functional recovery. The biodistribution of Technetium-99m-labeled hUC-MSCs was also evaluated, showing that most cells were found in organs such as the spleen and lungs 24 h after transplantation. Nevertheless, it was possible to detect a weak signal in the brain, which was higher in the ipsilateral hemisphere of rats subjected to a severe ICH. These data indicate that hUC-MSCs have moderately beneficial effects in cases of less severe brain hemorrhages in rats by decreasing the residual hematoma volume, and that optimization of the therapy is still necessary.
    MeSH term(s) Animals ; Brain/cytology ; Cerebral Hemorrhage/therapy ; Humans ; Male ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/cytology ; Rats ; Recovery of Function/physiology ; Tissue Distribution/physiology ; Umbilical Cord/cytology ; Wharton Jelly/cytology
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2142214-X
    ISSN 1557-8534 ; 1547-3287
    ISSN (online) 1557-8534
    ISSN 1547-3287
    DOI 10.1089/scd.2019.0176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3616: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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