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  1. Article ; Online: Flow Cytometry Analysis in Breast Implant-Associated Anaplastic Large Cell Lymphoma: Three Case Reports.

    Davanzo, Veronica / Falda, Alessandra / Fogar, Paola / Ludwig, Kathrin / Zuin, Jenny / Toffanin, Maria Cristina / Pizzi, Marco / Dei Tos, Angelo Paolo / Basso, Daniela

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Breast Implant-Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL) is a rare T-cell non-Hodgkin lymphoma associated with breast prosthetic implants and represents a diagnostic challenge. The National Comprehensive Cancer Network (NCCN) guidelines, ... ...

    Abstract Breast Implant-Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL) is a rare T-cell non-Hodgkin lymphoma associated with breast prosthetic implants and represents a diagnostic challenge. The National Comprehensive Cancer Network (NCCN) guidelines, updated in 2024, recommend for diagnosis an integrated work-up that should include cell morphology, CD30 immunohistochemistry (IHC), and flow cytometry (FCM). CD30 IHC, although the test of choice for BIA-ALCL diagnosis, is not pathognomonic, and this supports the recommendation to apply a multidisciplinary approach. A close collaboration between pathologists and laboratory professionals allowed the diagnosis of three BIA-ALCLs, presented as case reports, within a series of 35 patients subjected to periprosthetic effusions aspiration from 2018 to 2023. In one case, rare neoplastic cells were identified by FCM, and this result was essential in leading the anatomopathological picture as indicative of this neoplasm. In fact, the distinction between a lymphomatous infiltrate from reactive cells may be very complex in the cytopathology and IHC setting when neoplastic cells are rare. On the other hand, one limitation of FCM analysis is the need for fresh samples. In this study, we provide evidence that a dedicated fixative allows the maintenance of an unaltered CD30 expression on the cell surface for up to 72 h.
    MeSH term(s) Humans ; Female ; Breast Implants/adverse effects ; Lymphoma, Large-Cell, Anaplastic/diagnosis ; Lymphoma, Large-Cell, Anaplastic/etiology ; Lymphoma, Large-Cell, Anaplastic/pathology ; Flow Cytometry ; Breast Implantation/adverse effects ; Exudates and Transudates/metabolism ; Breast Neoplasms/complications
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063518
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  2. Article ; Online: Monocyte distribution width (MDW) parameter as a sepsis indicator in intensive care units.

    Piva, Elisa / Zuin, Jenny / Pelloso, Michela / Tosato, Francesca / Fogar, Paola / Plebani, Mario

    Clinical chemistry and laboratory medicine

    2021  Volume 59, Issue 7, Page(s) 1307–1314

    Abstract: Objectives: Patients in Intensive Care Units (ICU) are a high-risk population for sepsis, recognized as a major cause of admission and death. The aim of the current study was to evaluate the diagnostic accuracy and prognostication of monocyte ... ...

    Abstract Objectives: Patients in Intensive Care Units (ICU) are a high-risk population for sepsis, recognized as a major cause of admission and death. The aim of the current study was to evaluate the diagnostic accuracy and prognostication of monocyte distribution width (MDW) in sepsis for patients admitted to ICU.
    Methods: Between January and June 2020, we conducted a prospective observational study during the hospitalization of 506 adult patients admitted to the ICU. MDW was evaluated in 2,367 consecutive samples received for routine complete blood counts (CBC) performed once a day and every day during the study. Sepsis was diagnosed according to Sepsis-3 criteria and patients enrolled were classified in the following groups: no sepsis, sepsis and septic shock.
    Results: MDW values were significantly higher in patients with sepsis or septic shock in comparison to those within the no sepsis group [median 26.23 (IQR: 23.48-29.83); 28.97 (IQR: 21.27-37.21); 21.99 (IQR: 19.86-24.36) respectively]. ROC analysis demonstrated that AUC is 0.785 with a sensitivity of 66.88% and specificity of 77.79% at a cut-off point of 24.63. In patients that developed an ICU-acquired sepsis MDW showed an increase from 21.33 [median (IQR: 19.47-21.72)] to 29.19 [median (IQR: 27.46-31.47)]. MDW increase is not affected by the aetiology of sepsis, even in patients with COVID-19. In sepsis survivors a decrease of MDW values were found from the first time to the end of their stay [median from 29.14 (IQR: 26.22-32.52) to 25.67 (IQR: 22.93-30.28)].
    Conclusions: In ICU, MDW enhances the sepsis detection and is related to disease severity.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Area Under Curve ; Female ; Hematologic Tests/statistics & numerical data ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Monocytes/metabolism ; Prospective Studies ; ROC Curve ; Sensitivity and Specificity ; Sepsis/blood ; Sepsis/diagnosis ; Young Adult
    Language English
    Publishing date 2021-03-05
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2021-0192
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    Zs.A 121: Show issues Location:
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  3. Article ; Online: T Cell Senescence by Extensive Phenotyping: An Emerging Feature of COVID-19 Severity.

    Zuin, Jenny / Fogar, Paola / Musso, Giulia / Padoan, Andrea / Piva, Elisa / Pelloso, Michela / Tosato, Francesca / Cattelan, Annamaria / Basso, Daniela / Plebani, Mario

    Laboratory medicine

    2022  Volume 53, Issue 6, Page(s) 609–613

    Abstract: Objective: To identify the potential prognostic value of lymphocyte subsets in COVID-19 patients, where lymphopenia is a common finding.: Methods: In 353 COVID-19 inpatients and 40 controls T cell subsets with markers of senescence and exhaustion ... ...

    Abstract Objective: To identify the potential prognostic value of lymphocyte subsets in COVID-19 patients, where lymphopenia is a common finding.
    Methods: In 353 COVID-19 inpatients and 40 controls T cell subsets with markers of senescence and exhaustion were studied by flow cytometry.
    Results: In severe illness, total lymphocytes B, NK, and all T subsets were dampened. Senescent CD4+, but mainly CD8+ T cells, increased in patients with respect to controls. The most significant index predicting fatal outcome was neutrophils/CD3+ T ratio.
    Conclusion: In conclusion, an altered T cell pattern underlies COVID-19 severity and is involved in predicting the outcome.
    MeSH term(s) Humans ; COVID-19 ; Lymphocyte Subsets ; T-Lymphocyte Subsets ; CD8-Positive T-Lymphocytes ; Cellular Senescence
    Language English
    Publishing date 2022-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 391758-7
    ISSN 1943-7730 ; 0007-5027
    ISSN (online) 1943-7730
    ISSN 0007-5027
    DOI 10.1093/labmed/lmac048
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  4. Article ; Online: Circulating haematopoietic stem cells and long-term outcomes of COVID-19.

    Bonora, Benedetta Maria / Marassi, Marella / Fogar, Paola / Zuin, Jenny / Cappellari, Roberta / Marinello, Serena / Ferrari, Anna / Cattelan, Annamaria / Avogaro, Angelo / Basso, Daniela / Fadini, Gian Paolo

    European journal of clinical investigation

    2023  Volume 54, Issue 4, Page(s) e14150

    Abstract: Background and aims: An acute depletion of circulating haematopoietic stem/progenitor cells (HSPCs) occurs during COVID-19, especially among patients with a poorer disease course. We herein examined whether HSPCs levels at hospital admission for COVID- ... ...

    Abstract Background and aims: An acute depletion of circulating haematopoietic stem/progenitor cells (HSPCs) occurs during COVID-19, especially among patients with a poorer disease course. We herein examined whether HSPCs levels at hospital admission for COVID-19 predict 1-year mortality and the long-COVID syndrome.
    Materials and methods: Patients hospitalized for COVID-19 in an infectious disease ward were consecutively enrolled. Circulating HSPC levels were assessed by flow cytometry as cells expressing CD34 and/or CD133. Follow-up was performed for 12 months after hospitalization through the review of electronic medical records and demographic local registers.
    Results: The study included 100 patients, 36 of whom reported symptoms of long-COVID and 20 died during follow-up. The reduction of 1-SD of HSPCs was associated with a 3- to 5-fold increase in the risk of 1-year mortality. Age, admission hyperglycaemia, C-reactive protein peak, liver enzymes, the need of high-flow oxygen and/or invasive ventilation were predictors of mortality at univariate analysis. Among pre-existing comorbidities, coronary heart disease and chronic kidney disease, but not diabetes, were associated with 1-year mortality. In multivariate analyses, HSPCs remained significantly associated with 1-year mortality independently of confounders. The development of pneumonia an in-hospital treatment with glucocorticoids and convalescent plasma were associated with long-COVID symptoms at follow-up. HSPCs, diabetes and other comorbidities were not predictors of long-COVID.
    Conclusions: In a cohort of patients hospitalized for COVID-19, lower HSPC levels at the time of admission were independent predictors of 1-year mortality. However, COVID-19 severity, but not HSPC level, was significantly associated with the development of long-COVID symptoms.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Post-Acute COVID-19 Syndrome ; COVID-19 Serotherapy ; Hospitalization ; Hematopoietic Stem Cells ; Diabetes Mellitus/epidemiology
    Language English
    Publishing date 2023-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14150
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    Zs.A 677: Show issues Location:
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  5. Article ; Online: Hyperglycemia, Reduced Hematopoietic Stem Cells, and Outcome of COVID-19.

    Bonora, Benedetta Maria / Fogar, Paola / Zuin, Jenny / Falaguasta, Daniele / Cappellari, Roberta / Cattelan, Annamaria / Marinello, Serena / Ferrari, Anna / Avogaro, Angelo / Plebani, Mario / Basso, Daniela / Fadini, Gian Paolo

    Diabetes

    2022  Volume 71, Issue 4, Page(s) 788–794

    Abstract: Admission hyperglycemia has emerged worldwide as a predictor of poor coronavirus disease 2019 (COVID-19) outcome. Hyperglycemia leads to a defect in circulating hematopoietic stem/progenitor cells (HSPCs), which, in turn, predicts diabetic complications. ...

    Abstract Admission hyperglycemia has emerged worldwide as a predictor of poor coronavirus disease 2019 (COVID-19) outcome. Hyperglycemia leads to a defect in circulating hematopoietic stem/progenitor cells (HSPCs), which, in turn, predicts diabetic complications. Here, we explored whether reduced HSPCs mediated at least part of the prognostic effect of hyperglycemia on COVID-19 outcome. We found that patients with COVID-19 (n = 100) hospitalized in a nonintensive setting displayed dramatically (50-60%) reduced levels of HSPCs measured by flow cytometry as CD34+, CD34+CD45dim, or CD34+CD133+ cells, compared with control subjects (n = 595). This finding was highly significant (all P < 10-10) after multivariable adjustment, or manual 1:1 patient match, or propensity score matching. Admission hyperglycemia (≥7.0 mmol/L) was present in 45% of patients, was associated with a significant further ∼30% HSPCs reduction, and predicted a 2.6-fold increased risk of the primary outcome of adverse COVID-19 course (admittance to the intensive care unit or death). Low HSPCs were also associated with advanced age, higher peak C-reactive protein, and neutrophil-to-lymphocyte ratio. Independently from confounders, 1 SD lower CD34+ HSPCs was associated with a more than threefold higher risk of adverse outcome. Upon formal analysis, reduction of HSPCs was a significant mediator of the admission hyperglycemia on COVID-19 outcome, being responsible for 28% of its prognostic effect.
    MeSH term(s) Antigens, CD34/metabolism ; COVID-19 ; Flow Cytometry ; Hematopoietic Stem Cells/metabolism ; Humans ; Hyperglycemia/metabolism
    Chemical Substances Antigens, CD34
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db21-0965
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  6. Article ; Online: Mucopolysaccharidosis type VII diagnosed from a peripheral blood smear.

    Pelloso, Michela / Zuin, Silvia / Tosato, Francesca / Zuin, Jenny / Fogar, Paola / Piva, Elisa / Burlina, Alberto / Plebani, Mario

    American journal of hematology

    2020  Volume 96, Issue 5, Page(s) 638–639

    MeSH term(s) Abnormalities, Multiple/genetics ; Adolescent ; Basophils/ultrastructure ; Cytoplasmic Granules/chemistry ; Cytoplasmic Granules/ultrastructure ; Delayed Diagnosis ; Eosinophils/ultrastructure ; Female ; Flow Cytometry ; Glycosaminoglycans/urine ; Humans ; Mucopolysaccharidosis VII/blood ; Mucopolysaccharidosis VII/diagnosis ; Mucopolysaccharidosis VII/epidemiology ; Mucopolysaccharidosis VII/genetics ; Psychomotor Disorders/genetics ; Staining and Labeling
    Chemical Substances Glycosaminoglycans
    Language English
    Publishing date 2020-09-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.25984
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  7. Article ; Online: Computer-based-limited and personalised education management maximise appropriateness of vitamin D, vitamin B12 and folate retesting.

    Pelloso, Michela / Basso, Daniela / Padoan, Andrea / Fogar, Paola / Plebani, Mario

    Journal of clinical pathology

    2016  Volume 69, Issue 9, Page(s) 777–783

    Abstract: Aim: To identify the best management strategy for improving the appropriateness of vitamin D, vitamin B12 and folate retesting.: Methods: The study was conducted between 3 November 2012 and 8 June 2015, with inpatients and outpatients being ... ...

    Abstract Aim: To identify the best management strategy for improving the appropriateness of vitamin D, vitamin B12 and folate retesting.
    Methods: The study was conducted between 3 November 2012 and 8 June 2015, with inpatients and outpatients being considered separately. After an observational reference period (3 November 2012 to 14 September 2013), an information technology (IT)-based permissive strategy (16 September 2013 to 27 July 2014) followed by a limiting strategy was used to manage the demand for inpatient retesting. For outpatients, an educational strategy period (28 July 2014 to 16 December 2014) with direct contact between medical personnel and general practitioners (GPs) was followed by a post-educational period without any restriction. Data from a total of 66 496 patients for vitamin D, 14 618 for vitamin B12 and 14 445 for folate were retrieved from the laboratory IT system. The main outcomes measures were inappropriate vitamin D, vitamin B12 and folate retesting. The minimal retesting intervals were 90 (vitamin D) or 180 days (vitamin B12 and folate).
    Results: In the absence of a laboratory demand strategy, the frequency of inappropriate retesting for vitamin D, vitamin B12 and folate was 60%, 94% and 93%, respectively, for inpatients, and 27%, 87% and 87%, respectively, for outpatients. A limiting IT-based demand management strategy reduced inappropriate retesting for vitamin D (36%), but not for vitamin B12 and folate. The educational strategy was followed by a reduction in inappropriate retesting among outpatients (16% for vitamin D, 72% for vitamin B12 and folate).
    Conclusions: Laboratory demand management based on an IT-limiting management strategy or on education of the referring physicians appears helpful in maximising appropriate retesting.
    MeSH term(s) Adult ; Diagnostic Tests, Routine/economics ; Female ; Folic Acid/blood ; Health Care Costs ; Humans ; Male ; Middle Aged ; Vitamin B 12/blood ; Vitamin D/blood
    Chemical Substances Vitamin D (1406-16-2) ; Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2016-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2015-203447
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    Ud II Zs.139: Show issues Location:
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  8. Article ; Online: Neonatal lymphocyte subpopulations analysis and maternal preterm premature rupture of membranes: a pilot study.

    Amadi, Margherita / Visentin, Silvia / Tosato, Francesca / Fogar, Paola / Giacomini, Giulia / Res, Giulia / Bonadies, Luca / Zaramella, Patrizia / Plebani, Mario / Cosmi, Erich / Baraldi, Eugenio

    Clinical chemistry and laboratory medicine

    2021  Volume 59, Issue 10, Page(s) 1688–1698

    Abstract: Objectives: Preterm premature rupture of membranes (pPROM) causes preterm delivery, and increases maternal T-cell response against the fetus. Fetal inflammatory response prompts maturation of the newborn's immunocompetent cells, and could be associated ... ...

    Abstract Objectives: Preterm premature rupture of membranes (pPROM) causes preterm delivery, and increases maternal T-cell response against the fetus. Fetal inflammatory response prompts maturation of the newborn's immunocompetent cells, and could be associated with unfavorable neonatal outcome. The aims were (1) to examine the effects of pPROM on the newborn's and mother's immune system and (2) to assess the predictive value of immune system changes in neonatal morbidity.
    Methods: Mother-newborn pairs (18 mothers and 23 newborns) who experienced pPROM and controls (11 mothers and 14 newborns), were enrolled. Maternal and neonatal whole blood samples underwent flow cytometry to measure lymphocyte subpopulations.
    Results: pPROM-newborns had fewer naïve CD4 T-cells, and more memory CD4 T-cells than control newborns. The effect was the same for increasing pPROM latency times before delivery. Gestational age and birth weight influenced maturation of the newborns' lymphocyte subpopulations and white blood cells, notably cytotoxic T-cells, regulatory T-cells, T-helper cells (absolute count), and CD4/CD8 ratio. Among morbidities, fewer naïve CD8 T-cells were found in bronchopulmonary dysplasia (BPD) (p=0.0009), and more T-helper cells in early onset sepsis (p=0.04).
    Conclusions: pPROM prompts maturation of the newborn's T-cell immune system secondary to antigenic stimulation, which correlates with pPROM latency. Maternal immunity to inflammatory conditions is associated with a decrease in non-major histocompatibility complex (MHC)-restricted cytotoxic cells.
    MeSH term(s) Birth Weight ; Female ; Fetal Membranes, Premature Rupture ; Gestational Age ; Humans ; Infant, Newborn ; Lymphocyte Subsets ; Pilot Projects ; Pregnancy ; Pregnancy Outcome
    Language English
    Publishing date 2021-06-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2021-0375
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  9. Article: The S100A8/A9 complex reduces CTLA4 expression by immature myeloid cells: Implications for pancreatic cancer-driven immunosuppression.

    Basso, Daniela / Fogar, Paola / Plebani, Mario

    Oncoimmunology

    2013  Volume 2, Issue 6, Page(s) e24441

    Abstract: An expansion of different myeloid derived suppressive cell (MDSC) subsets can be detected in the blood and secondary lymphoid organs of early and advanced pancreatic ductal adenocarcinoma (PDAC) patients. Double negative ( ... ...

    Abstract An expansion of different myeloid derived suppressive cell (MDSC) subsets can be detected in the blood and secondary lymphoid organs of early and advanced pancreatic ductal adenocarcinoma (PDAC) patients. Double negative (CD14
    Language English
    Publishing date 2013-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645309-5
    ISSN 2162-402X ; 2162-4011
    ISSN (online) 2162-402X
    ISSN 2162-4011
    DOI 10.4161/onci.24441
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  10. Article ; Online: Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects.

    Piarulli, Francesco / Sartore, Giovanni / Sechi, Annalisa / Basso, Daniela / Fogar, Paola / Greco, Eliana / Ragazzi, Eugenio / Lapolla, Annunziata

    Oxidative medicine and cellular longevity

    2017  Volume 2017, Page(s) 9185272

    Abstract: This study aims to assess the proinflammatory interleukin ... ...

    Abstract This study aims to assess the proinflammatory interleukin 1
    MeSH term(s) Aged ; Case-Control Studies ; Cells, Cultured ; Diabetes Mellitus, Type 2/immunology ; Diabetes Mellitus, Type 2/pathology ; Enzyme-Linked Immunosorbent Assay ; Glucose/pharmacology ; Healthy Volunteers ; Humans ; Interleukin-10/analysis ; Interleukin-10/metabolism ; Interleukin-1beta/analysis ; Interleukin-1beta/metabolism ; Lipopolysaccharides/pharmacology ; Middle Aged ; Monocytes/cytology ; Monocytes/drug effects ; Monocytes/metabolism ; Up-Regulation/drug effects
    Chemical Substances Interleukin-1beta ; Lipopolysaccharides ; Interleukin-10 (130068-27-8) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2017/9185272
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