LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 172

Search options

  1. Article ; Online: Präoperative Therapie des Rektumkarzinoms – Kritische Anmerkungen zur amerikanischen PROSPECT-Studie.

    Fokas, Emmanouil / Rödel, Claus

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2023  Volume 199, Issue 8, Page(s) 781–783

    Title translation Preoperative treatment of rectal cancer-Critical comments on the US-American PROSPECT trial.
    MeSH term(s) Humans ; United States ; Rectal Neoplasms/pathology ; Fluorouracil ; Preoperative Care ; Neoplasm Staging
    Chemical Substances Fluorouracil (U3P01618RT)
    Language German
    Publishing date 2023-07-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-023-02116-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Do We Have Enough Evidence to Propose a Preferred Total Neoadjuvant Therapy Sequence for Patients With Locally Advanced Rectal Cancer?-Reply.

    Fokas, Emmanouil / Rödel, Claus

    JAMA oncology

    2022  Volume 8, Issue 5, Page(s) 782–783

    MeSH term(s) Chemoradiotherapy ; Humans ; Neoadjuvant Therapy ; Neoplasm Staging ; Rectal Neoplasms/drug therapy ; Rectal Neoplasms/pathology ; Treatment Outcome
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2022.0235
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Eine Monotherapie mit Immuncheckpointblockade führt bei Patienten mit Rektumkarzinom und Mikrosatelliteninstabilität zur klinischen Komplettremission.

    Diefenhardt, Markus / Fokas, Emmanouil / Rödel, Claus

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2022  Volume 198, Issue 12, Page(s) 1116–1118

    Title translation Monotherapy with immune checkpoint blockade leads to clinical complete remission in patients with rectal cancer and microsatellite instability.
    MeSH term(s) Humans ; Microsatellite Instability ; Immune Checkpoint Inhibitors ; Rectal Neoplasms/genetics ; Rectal Neoplasms/therapy ; B7-H1 Antigen ; Colorectal Neoplasms
    Chemical Substances Immune Checkpoint Inhibitors ; B7-H1 Antigen
    Language German
    Publishing date 2022-08-11
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-022-01990-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Kein Vorteil für die lokale Kontrolle nach Dosiseskalation der Strahlentherapie bei Patienten mit Ösophaguskarzinom nach einer definitiven Radiochemotherapie: randomisierte Phase-III-Studie ARTDECO.

    Fokas, Emmanouil / Martin, Daniel / Rödel, Claus

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2022  Volume 198, Issue 4, Page(s) 397–399

    Title translation Radiotherapy dose escalation does not improve local control in patients with esophageal cancer after definitive radiochemotherapy: the ARTDECO randomized phase III trial.
    MeSH term(s) Chemoradiotherapy ; Esophageal Neoplasms/radiotherapy ; Humans
    Language German
    Publishing date 2022-02-15
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-022-01906-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Compliance to chemoradiation in squamous cell carcinoma of the anus.

    Mahmood, Asad / Bhuva, Neel / Fokas, Emmanouil / Glynne-Jones, Robert

    Cancer treatment reviews

    2022  Volume 106, Page(s) 102381

    Abstract: The randomized controlled trial (RCT) remains the preferred design to determine effectiveness of a novel intervention in patients with cancer. The accepted method of primary analysis of phase III trials of radical chemoradiotherapy is by intention to ... ...

    Abstract The randomized controlled trial (RCT) remains the preferred design to determine effectiveness of a novel intervention in patients with cancer. The accepted method of primary analysis of phase III trials of radical chemoradiotherapy is by intention to treat (ITT). Yet, investigators often resort to 'post hoc' analyses comparing only patients who received the treatment per protocol (PP). Analysis of treatment PP aims to maintain the comparable groups achieved by randomisation, whilst identifying a true or more accurate treatment effect if the planned chemoradiotherapy is optimally applied with full compliance. Poor compliance is recognised to be associated with inferior outcomes. Reasons for poor compliance if identified and understood, might influence the design of future trials. Yet this entire methodology risks substantial bias and is often disparaged. In localised squamous cell carcinoma of the anus (SCCA) chemoradiotherapy with concurrent 5-flurouracil (or capecitabine) and mitomycin C achieves high rates of local control, but results in substantial acute toxicities. Some novel radiotherapy techniques (intensity modulated radiotherapy (IMRT), meticulous organs-at-risk (OAR) contouring, and techniques such as sparing of PET-active bone marrow) appear to reduce acute toxicity. Good quality assurance in the design of trials, patient education, optimizing nutrition, proactive surveillance during treatment, and early interventions might also improve compliance. This review examines the recently published findings on compliance in the ACT II trial and data from other studies using chemoradiotherapy in SCCA to explore compliance.
    MeSH term(s) Anal Canal ; Anus Neoplasms/drug therapy ; Anus Neoplasms/radiotherapy ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/radiotherapy ; Chemoradiotherapy ; Humans ; Radiotherapy, Intensity-Modulated ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2022-03-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2022.102381
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1022: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 611: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Kurzzeitstrahlentherapie mit 5 × 5 Gy gefolgt von präoperativer Chemotherapie und Resektion bei Patienten mit lokal fortgeschrittenen Rektumkarzinomen führt zu einer Verbesserung des krankheitsfreien Überlebens.

    Kirste, Simon / Fokas, Emmanouil / Rödel, Claus

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2021  Volume 197, Issue 6, Page(s) 567–569

    Title translation Short-term radiotherapy with 5 × 5 Gy followed by preoperative chemotherapy and resection in patients with locally advanced rectal carcinoma results in improved disease-free survival.
    Language German
    Publishing date 2021-03-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-021-01763-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Reply to A. Abdalla et al.

    Fokas, Emmanouil / Rödel, Claus

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2019  Volume 37, Issue 36, Page(s) 3562–3563

    MeSH term(s) Chemoradiotherapy ; Consolidation Chemotherapy ; Humans ; Neoadjuvant Therapy ; Rectal Neoplasms ; Rectum
    Language English
    Publishing date 2019-10-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.19.02179
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book ; Online ; Thesis: Charakterisierung des zellulären Mikromilieus in humanen Hirnmetastasen

    Roller, Bastian [Verfasser] / Harter, Patrick Nikolaus [Gutachter] / Fokas, Emmanouil [Gutachter]

    2022  

    Author's details Bastian Leon Roller ; Gutachter: Patrick Nikolaus Harter, Emmanouil Fokas
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Einfluss der Behandlungscompliance auf den Erfolg der Radiochemotherapie des Analkarzinoms.

    Martin, Daniel / Rödel, Claus / Fokas, Emmanouil

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2020  Volume 196, Issue 10, Page(s) 952–953

    Title translation Influence of treatment compliance on the success of chemoradiotherapy for anal carcinoma.
    MeSH term(s) Anus Neoplasms ; Carcinoma ; Chemoradiotherapy ; Humans ; Patient Compliance
    Language German
    Publishing date 2020-06-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-020-01648-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.40: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer-A Promising Signaling Network for Therapeutic Interventions.

    Güllülü, Ömer / Hehlgans, Stephanie / Rödel, Claus / Fokas, Emmanouil / Rödel, Franz

    Cancers

    2021  Volume 13, Issue 4

    Abstract: Despite recent advances in the treatment of colorectal cancer (CRC), patient's individual response and clinical follow-up vary considerably with tumor intrinsic factors to contribute to an enhanced malignancy and therapy resistance. Among these markers, ... ...

    Abstract Despite recent advances in the treatment of colorectal cancer (CRC), patient's individual response and clinical follow-up vary considerably with tumor intrinsic factors to contribute to an enhanced malignancy and therapy resistance. Among these markers, upregulation of members of the inhibitor of apoptosis protein (IAP) family effects on tumorigenesis and radiation- and chemo-resistance by multiple pathways, covering a hampered induction of apoptosis/autophagy, regulation of cell cycle progression and DNA damage response. These mechanisms are tightly controlled by the tumor suppressor p53 and thus transcriptional and post-translational regulation of IAPs by p53 is expected to occur in malignant cells. By this, cellular IAP1/2, X-linked IAP, Survivin, BRUCE and LIVIN expression/activity, as well as their intracellular localization is controlled by p53 in a direct or indirect manner via modulating a multitude of mechanisms. These cover, among others, transcriptional repression and the signal transducer and activator of transcription (STAT)3 pathway. In addition, p53 mutations contribute to deregulated IAP expression and resistance to therapy. This review aims at highlighting the mechanistic and clinical importance of IAP regulation by p53 in CRC and describing potential therapeutic strategies based on this interrelationship.
    Language English
    Publishing date 2021-02-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13040624
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top