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  1. Book ; Online: Music: Its Theologies and Spiritualities : A Global Perspective

    Foley, Edward

    2020  

    Keywords Music ; Charismatic Prayer Meeting ; Praise and Worship ; Speaking/Singing in Tongues ; spirituality ; music ; wellbeing ; Korean migrants ; Theodor Adorno ; Dietrich Bonhoeffer ; Karl Barth ; Anton Webern ; Gustav Mahler ; demythologization ; secularization ; Confessing Church ; German modernism ; singing ; migration ; asylum-seeker ; refugee ; the sacred ; creativity ; sonority ; Ireland ; the Congo ; Passion ; liminality ; ritual ; postmodernism ; choral music ; 21st century music ; sacred music ; composition ; theology ; theoartistry ; annunciation ; Hebrew Bible ; James MacMillan ; Michael Symmons Roberts ; Jeremy Begbie ; keen ; wake ; funeral ; tradition ; custom ; culture ; history ; chant ; Georgian chant ; Orthodox theology ; exegesis of tradition ; aesthetics ; polyphony ; oral tradition ; Dionysios the Areopagite ; sacramentality ; gospel ; African American ; dance
    Size 1 electronic resource (182 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046768
    ISBN 9783039435944 ; 3039435949
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Vibrio cholerae arrests intestinal epithelial proliferation through T6SS-dependent activation of the bone morphogenetic protein pathway.

    Xu, Xinyue / Foley, Edan

    Cell reports

    2024  Volume 43, Issue 2, Page(s) 113750

    Abstract: To maintain an effective barrier, intestinal progenitor cells must divide at a rate that matches the loss of dead and dying cells. Otherwise, epithelial breaches expose the host to systemic infection by gut-resident microbes. Unlike most pathogens, ... ...

    Abstract To maintain an effective barrier, intestinal progenitor cells must divide at a rate that matches the loss of dead and dying cells. Otherwise, epithelial breaches expose the host to systemic infection by gut-resident microbes. Unlike most pathogens, Vibrio cholerae blocks tissue repair by arresting progenitor proliferation in the Drosophila model. At present, we do not understand how V. cholerae circumvents such a critical antibacterial defense. We find that V. cholerae blocks epithelial repair by activating the growth inhibitor bone morphogenetic protein (BMP) pathway in progenitors. Specifically, we show that interactions between V. cholerae and gut commensals initiate BMP signaling via host innate immune defenses. Notably, we find that V. cholerae also activates BMP and arrests proliferation in zebrafish intestines, indicating an evolutionarily conserved link between infection and failure in tissue repair. Our study highlights how enteric pathogens engage host immune and growth regulatory pathways to disrupt intestinal epithelial repair.
    MeSH term(s) Animals ; Zebrafish ; Anti-Bacterial Agents ; Bone Morphogenetic Proteins ; Drosophila ; Vibrio cholerae ; Cell Proliferation
    Chemical Substances Anti-Bacterial Agents ; Bone Morphogenetic Proteins
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Urban lake water quality responses to elevated road salt concentrations.

    Foley, Ellen / Steinman, Alan D

    The Science of the total environment

    2023  Volume 905, Page(s) 167139

    Abstract: Road salt runoff from de-icing applications is increasingly impacting water quality around the globe. Excess salt (especially chloride) concentrations can negatively impact the biological, chemical, and physical properties of freshwater ecosystems. ... ...

    Abstract Road salt runoff from de-icing applications is increasingly impacting water quality around the globe. Excess salt (especially chloride) concentrations can negatively impact the biological, chemical, and physical properties of freshwater ecosystems. Though road salt pollution is a prevalent issue affecting many northern temperate lakes, there are few studies on how freshwater salinization interacts with other ecological stressors such as eutrophication. We investigated how chloride from road deicers influences water quality in an urban lake. We sampled a tributary and lake receiving large amounts of road salt runoff from a nearby highway in Grand Rapids, Michigan over a 20-month period. Chloride concentrations in the deepest part of the lake consistently exceeded the US EPA chloride chronic toxicity threshold of 230 mg/L, at times reaching up to 331 mg/L. These high chloride concentrations appear to be responsible for preventing part of the lake from complete mixing, and causing hypoxia in the deepest regions of the lake. Total phosphorus concentrations near the surface averaged 35 μg/L but exceeded 7500 μg/L in the deepest part of the lake, which occupies 3-5 % of total lake volume. Phosphorus release rates from the sediments were low and unlikely to be a current source of the high phosphorus concentrations. Rather, both phosphorus and chloride likely have been accumulating in the hypolimnion over a relatively long period of time. Lake management actions will require control of both internal and external phosphorus and chloride sources in the future. We recommend that phosphorus be addressed first to avoid the extremely high phosphorus concentrations from reaching the photic zone and stimulating algal blooms, which would occur if salt was removed first and the halocline broke down. Our findings and recommendations are applicable to other lakes facing similar issues.
    Language English
    Publishing date 2023-09-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.167139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Mechanisms of epithelial growth and development in the zebrafish intestine.

    Willms, Reegan J / Foley, Edan

    Biochemical Society transactions

    2023  Volume 51, Issue 3, Page(s) 1213–1224

    Abstract: The intestinal epithelium is a complex tissue monolayer composed of regionally and functionally specialized intestinal epithelial cells. Given epithelial exposure to harsh and varied luminal conditions, epithelial cells continuously regenerate to sustain ...

    Abstract The intestinal epithelium is a complex tissue monolayer composed of regionally and functionally specialized intestinal epithelial cells. Given epithelial exposure to harsh and varied luminal conditions, epithelial cells continuously regenerate to sustain the barrier against environmental factors, including microbial invaders. Multipotent intestinal stem cells are essential to epithelial regenerative capacity, generating a programed mixture of absorptive and secretory cell types. Mechanisms of epithelial growth and differentiation in response to endogenous or external stressors remain under investigation. In this review, we highlight the zebrafish, Danio rerio, as a potent model of intestinal epithelial development and function. We describe epithelial composition and key regulators of epithelial renewal to promote the zebrafish as an investigative tool to study epithelial development and growth. We also highlight areas for discovery, particularly in the context of stress-dependent regulation of epithelial function.
    MeSH term(s) Animals ; Zebrafish/metabolism ; Intestines ; Intestinal Mucosa/metabolism ; Epithelial Cells/metabolism ; Cell Proliferation
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20221375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 944: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Genitourinary medicine consultant workforce in England 2023 - establishing the true numbers.

    Sherrard, Jackie / Shanks, Clare / Foley, Elzabeth

    International journal of STD & AIDS

    2023  , Page(s) 9564624231208238

    Abstract: Workforce planning of future requirements depends on accurate data and the GUM consultant and trainee workforce is reviewed annually by Health Education England (HEE) and the Royal College of Physicians (RCP) to make recommendations for specialty ... ...

    Abstract Workforce planning of future requirements depends on accurate data and the GUM consultant and trainee workforce is reviewed annually by Health Education England (HEE) and the Royal College of Physicians (RCP) to make recommendations for specialty training numbers. A deep dive exercise in 2017 undertaken with HEE revealed that the headcount was reasonably accurate but there was much less certainty around the whole-time equivalent (WTE). The aim of this study was to triangulate the multiple sources of data regarding Consultants in the specialty, to identify and complete the gaps in data.
    Language English
    Publishing date 2023-10-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018089-8
    ISSN 1758-1052 ; 0956-4624
    ISSN (online) 1758-1052
    ISSN 0956-4624
    DOI 10.1177/09564624231208238
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2829: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A glucose-supplemented diet enhances gut barrier integrity in

    Galenza, Anthony / Foley, Edan

    Biology open

    2021  Volume 10, Issue 3

    Abstract: Dietary intervention has received considerable attention as an approach to extend lifespan and improve aging. However, questions remain regarding optimal dietary regimes and underlying mechanisms of lifespan extension. Here, we asked how an increase of ... ...

    Abstract Dietary intervention has received considerable attention as an approach to extend lifespan and improve aging. However, questions remain regarding optimal dietary regimes and underlying mechanisms of lifespan extension. Here, we asked how an increase of glucose in a chemically defined diet extends the lifespan of adult
    MeSH term(s) Animal Feed ; Animals ; Drosophila/physiology ; Energy Intake ; Energy Metabolism ; Gastric Mucosa/metabolism ; Glucose/metabolism ; Intercellular Junctions/genetics ; Intercellular Junctions/metabolism ; Intestinal Mucosa/metabolism ; Longevity ; Male
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-03-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2632264-X
    ISSN 2046-6390 ; 2046-6390
    ISSN (online) 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.056515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Microbial recognition regulates intestinal epithelial growth in homeostasis and disease.

    Ferguson, Meghan / Foley, Edan

    The FEBS journal

    2021  Volume 289, Issue 13, Page(s) 3666–3691

    Abstract: The intestine is constantly exposed to a dynamic community of microbes. Intestinal epithelial cells respond to microbes through evolutionarily conserved recognition pathways, such as the immune deficiency (IMD) pathway of Drosophila, the Toll-like ... ...

    Abstract The intestine is constantly exposed to a dynamic community of microbes. Intestinal epithelial cells respond to microbes through evolutionarily conserved recognition pathways, such as the immune deficiency (IMD) pathway of Drosophila, the Toll-like receptor (TLR) response of flies and vertebrates, and the vertebrate nucleotide-binding oligomerization domain (NOD) pathway. Microbial recognition pathways are tightly controlled to respond effectively to pathogens, tolerate the microbiome, and limit intestinal disease. In this review, we focus on contributions of different model organisms to our understanding of how epithelial microbe recognition impacts intestinal proliferation and differentiation in homeostasis and disease. In particular, we compare how microbes and subsequent recognition by the intestine influences barrier integrity, intestinal repair and tumorigenesis in Drosophila, zebrafish, mice, and organoids. In addition, we discuss the importance of microbial recognition in homeostatic intestinal growth and discuss how immune pathways directly impact stem cell and crypt dynamics.
    MeSH term(s) Animals ; Drosophila ; Homeostasis ; Intestinal Mucosa/metabolism ; Intestines ; Mice ; Toll-Like Receptors/metabolism ; Zebrafish
    Chemical Substances Toll-Like Receptors
    Language English
    Publishing date 2021-05-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.15910
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 260: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Sacral plexus catheter analgesia in a patient with traumatic sacral fractures and Tarlov cysts.

    Ireland, E / Womack, J / Foley, E

    Anaesthesia reports

    2019  Volume 7, Issue 2, Page(s) 76–78

    Abstract: We report the use of a sacral plexus catheter for continuous local anaesthetic infusion in a patient with a unilateral sacral ala fracture following a fall from a horse. Although sacral plexus blockade has been well described for lower limb surgery, an ... ...

    Abstract We report the use of a sacral plexus catheter for continuous local anaesthetic infusion in a patient with a unilateral sacral ala fracture following a fall from a horse. Although sacral plexus blockade has been well described for lower limb surgery, an ultrasound-guided continuous catheter technique for conservatively managed fractures has not been described. Despite appropriate oral analgesia, the patient reported severe pain, particularly in the right gluteal region, which meant she was unable to sit upright or take deep breaths. A sacral plexus catheter was inserted with ultrasound guidance and an initial bolus of 30 ml levobupivicaine 0.25% was delivered followed by infusion of 8 ml.h
    Language English
    Publishing date 2019-09-30
    Publishing country England
    Document type Case Reports
    ISSN 2637-3726
    ISSN (online) 2637-3726
    DOI 10.1002/anr3.12023
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  9. Article ; Online: Host-Microbe-Pathogen Interactions: A Review of

    Davoodi, Saeideh / Foley, Edan

    Frontiers in immunology

    2020  Volume 10, Page(s) 3128

    Abstract: Most animals maintain mutually beneficial symbiotic relationships with their intestinal microbiota. Resident microbes in the gastrointestinal tract breakdown indigestible food, provide essential nutrients, and, act as a barrier against invading microbes, ...

    Abstract Most animals maintain mutually beneficial symbiotic relationships with their intestinal microbiota. Resident microbes in the gastrointestinal tract breakdown indigestible food, provide essential nutrients, and, act as a barrier against invading microbes, such as the enteric pathogen
    MeSH term(s) Animals ; Cholera/microbiology ; Drosophila melanogaster/microbiology ; Drosophila melanogaster/physiology ; Gastrointestinal Microbiome/immunology ; Host Microbial Interactions ; Host-Pathogen Interactions ; Humans ; Immune System/metabolism ; Immunity ; Symbiosis ; Vibrio cholerae/physiology
    Language English
    Publishing date 2020-01-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.03128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A cell atlas of microbe-responsive processes in the zebrafish intestine.

    Willms, Reegan J / Jones, Lena O / Hocking, Jennifer C / Foley, Edan

    Cell reports

    2022  Volume 38, Issue 5, Page(s) 110311

    Abstract: Gut microbial products direct growth, differentiation, and development in animal hosts. However, we lack system-wide understanding of cell-specific responses to the microbiome. We profiled cell transcriptomes from the intestine, and associated tissue, of ...

    Abstract Gut microbial products direct growth, differentiation, and development in animal hosts. However, we lack system-wide understanding of cell-specific responses to the microbiome. We profiled cell transcriptomes from the intestine, and associated tissue, of zebrafish larvae raised in the presence or absence of a microbiome. We uncovered extensive cellular heterogeneity in the conventional zebrafish intestinal epithelium, including previously undescribed cell types with known mammalian homologs. By comparing conventional to germ-free profiles, we mapped microbial impacts on transcriptional activity in each cell population. We revealed intricate degrees of cellular specificity in host responses to the microbiome that included regulatory effects on patterning and on metabolic and immune activity. For example, we showed that the absence of microbes hindered pro-angiogenic signals in the developing vasculature, causing impaired intestinal vascularization. Our work provides a high-resolution atlas of intestinal cellular composition in the developing fish gut and details the effects of the microbiome on each cell type.
    MeSH term(s) Animals ; Gastrointestinal Microbiome/physiology ; Germ-Free Life/physiology ; Host Microbial Interactions/physiology ; Intestines/blood supply ; Microbiota/physiology ; RNA, Ribosomal, 16S/metabolism ; Zebrafish
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2022.110311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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