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  1. Artikel ; Online: Low-grade Serous Neoplasia of the Female Genital Tract.

    Folkins, Ann K / Longacre, Teri A

    Surgical pathology clinics

    2019  Band 12, Heft 2, Seite(n) 481–513

    Abstract: Low-grade serous neoplasia of the gynecologic tract includes benign (serous cystadenomas), borderline, and malignant lesions (low-grade serous carcinoma). Classification of these lesions relies on rigorous attention to several pathologic features that ... ...

    Abstract Low-grade serous neoplasia of the gynecologic tract includes benign (serous cystadenomas), borderline, and malignant lesions (low-grade serous carcinoma). Classification of these lesions relies on rigorous attention to several pathologic features that determine the prognosis and the need for adjuvant therapy. Risk stratification of serous borderline tumor behavior based on histologic findings and criteria for low-grade serous carcinoma are the primary focus of this article, including the redesignation of invasive implants of serous borderline tumor as low-grade serous carcinoma based on the similar survival rates. The molecular underpinnings of these tumors are also discussed, including their potential for prognostication.
    Mesh-Begriff(e) Carcinoma in Situ/diagnosis ; Carcinoma in Situ/pathology ; Cystadenocarcinoma, Serous/diagnosis ; Cystadenocarcinoma, Serous/pathology ; Cystadenoma, Serous/diagnosis ; Cystadenoma, Serous/pathology ; Diagnosis, Differential ; Female ; Humans ; Neoplasm Grading ; Neoplasm Invasiveness ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/pathology
    Sprache Englisch
    Erscheinungsdatum 2019-04-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2019.02.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.

    Han, Lucy M / Weiel, Julianna J / Longacre, Teri A / Folkins, Ann K

    Advances in anatomic pathology

    2022  Band 29, Heft 5, Seite(n) 297–308

    Abstract: DICER1 syndrome is a tumor predisposition syndrome in which patients are at an increased risk of developing a wide variety of benign and malignant neoplasms with a hallmark constellation of pediatric pleuropulmonary blastoma, cystic nephroma, and thyroid ...

    Abstract DICER1 syndrome is a tumor predisposition syndrome in which patients are at an increased risk of developing a wide variety of benign and malignant neoplasms with a hallmark constellation of pediatric pleuropulmonary blastoma, cystic nephroma, and thyroid lesions. DICER1 encodes an RNA endoribonuclease that is crucial to the processing of microRNA and may play a role in the maturation of Müllerian tissue. Within the gynecologic tract, germline mutations in DICER1 are associated with an array of rare tumors, including Sertoli-Leydig cell tumor, embryonal rhabdomyosarcoma of the cervix, gynandroblastoma, and juvenile granulosa cell tumor, which typically present in childhood, adolescence, or early adulthood. In addition, somatic DICER1 mutations have been described in rare gynecologic tumors such as adenosarcoma, Sertoli cell tumor, ovarian fibrosarcoma, cervical primitive neuroectodermal tumor, carcinosarcoma, and germ cell tumors. In light of the significant association with multiple neoplasms, genetic counseling should be considered for patients who present with a personal or family history of these rare DICER1-associated gynecologic tumors. This review highlights the most current understanding of DICER1 genetic alterations and describes the clinical, histopathologic, and immunohistochemical features and differential diagnoses for gynecologic tumors associated with DICER1 mutation.
    Mesh-Begriff(e) Adolescent ; Adult ; DEAD-box RNA Helicases/genetics ; Diagnosis, Differential ; Female ; Fibrosarcoma/genetics ; Genital Neoplasms, Female/genetics ; Genital Neoplasms, Female/pathology ; Genitalia, Female/pathology ; Germ-Line Mutation ; Humans ; Mutation ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Ribonuclease III/genetics
    Chemische Substanzen DICER1 protein, human (EC 3.1.26.3) ; Ribonuclease III (EC 3.1.26.3) ; DEAD-box RNA Helicases (EC 3.6.4.13)
    Sprache Englisch
    Erscheinungsdatum 2022-07-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1212493-x
    ISSN 1533-4031 ; 1072-4109
    ISSN (online) 1533-4031
    ISSN 1072-4109
    DOI 10.1097/PAP.0000000000000351
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Case of Metastatic Extramammary Paget Disease of the Vulva Treated Successfully With Trastuzumab Emtansine.

    Hsieh, Gillian L / English, Diana P / Tu, Powen / Folkins, Ann K / Karam, Amer K

    JCO precision oncology

    2022  Band 2, Seite(n) 1–8

    Sprache Englisch
    Erscheinungsdatum 2022-01-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.17.00204
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  4. Artikel: Placental and Clinical Characteristics of Term Small-for-Gestational-Age Neonates: A Case-Control Study.

    Chisholm, Karen M / Folkins, Ann K

    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

    2016  Band 19, Heft 1, Seite(n) 37–46

    Abstract: Numerous conditions, including placental vascular compromise, can lead to small-for-gestational-age (SGA) infants. As few studies have investigated primarily term placentas from SGA infants, we compared placentas from 67 SGA infants to placentas from 67 ... ...

    Abstract Numerous conditions, including placental vascular compromise, can lead to small-for-gestational-age (SGA) infants. As few studies have investigated primarily term placentas from SGA infants, we compared placentas from 67 SGA infants to placentas from 67 infants with appropriate weights for gestational age (AGA) in this population, matched for gestational age and gender. Placental histology was reviewed and electronic records were queried for maternal and fetal birth data, infant morbidities, and infant follow-up weights. Comparison of these 2 cohorts showed that placentas from SGA infants were more likely to have smaller weights and thinner umbilical cords than those from AGA infants. SGA placentas had a significant increase in another uteroplacental malperfusion feature: single and multiple infarctions. Rates of preeclampsia, infant cardiac anomalies, and infant genetic abnormalities were not statistically different between groups. Fetal and maternal inflammatory responses, nongestational diabetes, and gestational hypertension were more common in the controls, but these are common indications for placental examination. No statistical differences were present for decidual vasculopathy, chronic villitis, intervillous thrombi, or meconium. More SGA neonates had hypoglycemia compared to their AGA counterparts. SGA infants tended to have decreased weights up to 7 months of age; however, the low number of infants with follow-up limited the statistical significance. This study confirms that small placental size and select features of uteroplacental malperfusion are more common in SGA versus AGA term placentas. The lack of other significant differences may be due to the inclusion of only term infants, with more severe pathology leading to preterm delivery.
    Mesh-Begriff(e) Adult ; Age Factors ; Biopsy ; Birth Weight ; Case-Control Studies ; Child Development ; Electronic Health Records ; Female ; Fetal Growth Retardation/immunology ; Fetal Growth Retardation/pathology ; Fetal Growth Retardation/physiopathology ; Humans ; Infant ; Infant, Newborn ; Infant, Small for Gestational Age/immunology ; Male ; Maternal Health ; Placenta/blood supply ; Placenta/immunology ; Placenta/pathology ; Placenta Diseases/immunology ; Placenta Diseases/pathology ; Placenta Diseases/physiopathology ; Placental Circulation ; Pregnancy ; Risk Factors ; Term Birth ; Weight Gain ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2016-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1463498-3
    ISSN 1615-5742 ; 1093-5266
    ISSN (online) 1615-5742
    ISSN 1093-5266
    DOI 10.2350/15-04-1621-OA.1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: The menstrual cycle phase impacts the detection of plasma cells and the diagnosis of chronic endometritis in endometrial biopsy specimens.

    Ryan, Emily / Tolani, Alisha T / Zhang, Jiaqi / Cruz, Giovanna I / Folkins, Ann K / Lathi, Ruth B

    Fertility and sterility

    2021  Band 118, Heft 4, Seite(n) 787–794

    Abstract: Objective: To assess the impact of menstrual cycle phase on the detection of plasma cells.: Design: A retrospective cohort study.: Setting: Fertility clinic.: Patient(s): Biopsies from 157 patients met criteria for inclusion, 91 in the ... ...

    Abstract Objective: To assess the impact of menstrual cycle phase on the detection of plasma cells.
    Design: A retrospective cohort study.
    Setting: Fertility clinic.
    Patient(s): Biopsies from 157 patients met criteria for inclusion, 91 in the follicular phase and 60 in the luteal phase. Patient groups were similar in body mass index and number of previous live births; however, differed in terms of age, infertility history, and biopsy indication.
    Interventions: Endometrial biopsies from patients at a fertility clinic from 2018-2020 were retrospectively reviewed. Biopsies were excluded if patients had a previous chronic endometritis diagnosis, abnormal uterine cavity or were on hormone therapy. Each case was reviewed by a gynecologic pathologist for plasma cells by hematoxylin and eosin and CD138 staining. Demographic and clinical data were collected. Continuous variables were compared using Welch t test and Wilcoxon's rank sum test, and categorical variables using Pearson's χ
    Main outcome measure(s): Presence and density of plasma cells.
    Result(s): We found a higher likelihood of finding plasma cells in the follicular than in luteal phase (59.3% vs. 19.7%). There was a higher likelihood of finding plasma cells in the early (cycle days 5-8, 29 cases or 76.3% of cases with plasma cells) than in the late follicular phase (cycle days 9-14, 25 cases or 47.2%). There was a higher density of plasma cells in the follicular phase group than in the luteal phase group (25.3% vs. 1.5% scattered and 13.2% vs. 0 clusters).
    Conclusion(s): Plasma cells are more likely to be present during the follicular phase compared with the luteal phase and in the early compared with the late follicular phase. Further studies are needed to identify the optimal timing of biopsy to standardize the diagnosis.
    Mesh-Begriff(e) Biopsy ; Chronic Disease ; Endometritis/diagnosis ; Endometritis/pathology ; Endometrium/pathology ; Eosine Yellowish-(YS) ; Female ; Hematoxylin ; Hormones ; Humans ; Luteal Phase ; Menstrual Cycle ; Plasma Cells/pathology ; Retrospective Studies
    Chemische Substanzen Hormones ; Eosine Yellowish-(YS) (TDQ283MPCW) ; Hematoxylin (YKM8PY2Z55)
    Sprache Englisch
    Erscheinungsdatum 2021-10-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2022.07.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Fumarate Hydratase Deficiency Should be Considered in the Differential Diagnosis of Uterine and Extrauterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMP).

    Pors, Jennifer / Weiel, Julianna J / Devereaux, Kelly A / Folkins, Ann K / Longacre, Teri A

    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

    2021  Band 41, Heft 3, Seite(n) 268–275

    Abstract: Fumarate hydratase-deficient leiomyomas (dFH leiomyomas) often display atypical pathologic features yet exhibit a benign clinical course. Recent data suggest that dFH leiomyomas may be misclassified as smooth muscle tumors of uncertain malignant ... ...

    Abstract Fumarate hydratase-deficient leiomyomas (dFH leiomyomas) often display atypical pathologic features yet exhibit a benign clinical course. Recent data suggest that dFH leiomyomas may be misclassified as smooth muscle tumors of uncertain malignant potential, a category that encompasses a heterogenous subgroup of uterine neoplasms with smooth muscle differentiation and atypical features that impart ambiguity regarding their expected clinical behavior. dFH leiomyomas can be seen in the context of hereditary leiomyomatosis and renal cell carcinoma syndrome or in the sporadic setting. In this retrospective study, we sought to examine the prevalence and clinicopathologic characteristics of dFH leiomyomas in 48 tumors previously diagnosed as smooth muscle tumors of uncertain malignant potential from 38 patients. Of these 48 tumors, 3 (6.3%) occurring in 2 patients were found to be deficient for FH by immunohistochemistry, including 1 uterine and 2 extrauterine (abdominopelvic) tumors. The 3 tumors showed histologic features typical of dFH leiomyomas, including hemangiopericytoma-like vessels, edema, macronucleoli, and atypia. Neither patient developed recurrent leiomyomas or renal cell carcinoma, and both were alive without disease at last follow-up. Our data suggest that dFH leiomyomas should be considered in the differential diagnosis of smooth muscle tumors of uncertain malignant potential, even in the context of extrauterine disease. Identification of FH deficiency in these tumors supports their classification as dFH leiomyomas despite their atypical morphologic features and/or clinical presentation. Importantly, detection of dFH in these cases may identify women at increased risk for hereditary leiomyomatosis and renal cell carcinoma who would benefit from genetic counseling and consideration for FH germline testing.
    Mesh-Begriff(e) Carcinoma, Renal Cell/diagnosis ; Diagnosis, Differential ; Female ; Fumarate Hydratase/deficiency ; Fumarate Hydratase/genetics ; Humans ; Kidney Neoplasms/diagnosis ; Leiomyomatosis/diagnosis ; Leiomyomatosis/genetics ; Leiomyomatosis/pathology ; Male ; Metabolism, Inborn Errors ; Muscle Hypotonia ; Psychomotor Disorders ; Retrospective Studies ; Skin Neoplasms/pathology ; Smooth Muscle Tumor/diagnosis ; Uterine Neoplasms/pathology
    Chemische Substanzen Fumarate Hydratase (EC 4.2.1.2)
    Sprache Englisch
    Erscheinungsdatum 2021-06-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 604859-6
    ISSN 1538-7151 ; 0277-1691
    ISSN (online) 1538-7151
    ISSN 0277-1691
    DOI 10.1097/PGP.0000000000000797
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  7. Artikel: Intra- and post-pandemic impact of the COVID-19 outbreak on Stanford Health Care.

    Phongpreecha, Thanaphong / Berson, Eloise / Xue, Lei / Shome, Sayane / Saarunya, Geetha / Fralick, Jennifer / Ruiz-Tagle, Bernardita Guridi / Foody, Andrew / Chin, Alexander L / Lim, Michael / Arthofer, Rudolph / Albini, Christopher / Montine, Kathleen / Folkins, Ann K / Kong, Christina S / Aghaeepour, Nima / Montine, Thomas / Kerr, Alison

    Academic pathology

    2024  Band 11, Heft 2, Seite(n) 100113

    Abstract: Stanford Health Care, which provides about 7% of overall healthcare to approximately 9 million people in the San Francisco Bay Area, has undergone significant changes due to the opening of a second hospital in late 2019 and, more importantly, the COVID- ... ...

    Abstract Stanford Health Care, which provides about 7% of overall healthcare to approximately 9 million people in the San Francisco Bay Area, has undergone significant changes due to the opening of a second hospital in late 2019 and, more importantly, the COVID-19 pandemic. We examine the impact of these events on anatomic pathology (AP) cases, aiming to enhance operational efficiency in response to evolving healthcare demands. We extracted historical census, admission, lab tests, operation, and AP data since 2015. An approximately 45% increase in the volume of laboratory tests (P < 0.0001) and a 17% increase in AP cases (P < 0.0001) occurred post-pandemic. These increases were associated with progressively increasing (P < 0.0001) hospital census. Census increase stemmed from higher admission through the emergency department (ED), and longer lengths of stay mostly for transfer patients, likely due to the greater capability of the new ED and changes in regional and local practice patterns post-pandemic. Higher census led to overcapacity, which has an inverted U relationship that peaked at 103% capacity for AP cases and 114% capacity for laboratory tests. Overcapacity led to a lower capability to perform clinical activities, particularly those related to surgical procedures. We conclude by suggesting parameters for optimal operations in the post-pandemic era.
    Sprache Englisch
    Erscheinungsdatum 2024-03-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2819382-9
    ISSN 2374-2895
    ISSN 2374-2895
    DOI 10.1016/j.acpath.2024.100113
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  8. Artikel ; Online: Hereditary gynaecological malignancies: advances in screening and treatment.

    Folkins, Ann K / Longacre, Teri A

    Histopathology

    2013  Band 62, Heft 1, Seite(n) 2–30

    Abstract: In the last two decades there have been significant advances in our understanding of female genital tract tumours. The discovery of BRCA1 and BRCA2 genes in ovarian cancer and the mismatch repair genes in endometrial carcinoma has revolutionized our ... ...

    Abstract In the last two decades there have been significant advances in our understanding of female genital tract tumours. The discovery of BRCA1 and BRCA2 genes in ovarian cancer and the mismatch repair genes in endometrial carcinoma has revolutionized our approach to the diagnosis and screening of women for ovarian and uterine cancers. This review discusses the pathogenesis of these two hereditary syndromes in depth and explains how the molecular genetics is tailoring the manner in which these diseases are diagnosed and potentially treated. Other, less common hereditary conditions associated with gynaecological tract manifestations, such as Cowden syndrome, Peutz-Jeghers syndrome, Gorlin syndrome and hereditary leiomyomatosis and renal cell carcinoma, are also summarized briefly.
    Mesh-Begriff(e) Combined Modality Therapy ; DNA Mismatch Repair/genetics ; Endometrial Neoplasms/diagnosis ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/therapy ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Humans ; Mass Screening/methods ; Mass Screening/trends ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/therapy
    Sprache Englisch
    Erscheinungsdatum 2013-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.12028
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  9. Artikel ; Online: Scattering-Based Light-Sheet Microscopy Imaging of Human Papillomavirus-Associated Squamous Lesions of the Anal Canal: A Proof-of-Principle Study.

    Liang, Brooke / Zhao, Jingwei / Kim, Yongjun / Barry-Holson, Keegan Q / Bingham, David B / Charville, Gregory W / Darragh, Teresa M / Folkins, Ann K / Howitt, Brooke E / Kong, Christina S / Longacre, Teri A / McHenry, Austin J / Toland, Angus M S / Zhang, Xiaoming / Lim, Koeun / Khan, Michelle J / Kang, Dongkyun / Yang, Eric J

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

    2024  Band 37, Heft 6, Seite(n) 100493

    Abstract: Demand for anal cancer screening is expected to rise following the recent publication of the Anal Cancer-HSIL Outcomes Research trial, which showed that treatment of high-grade squamous intraepithelial lesions significantly reduces the rate of ... ...

    Abstract Demand for anal cancer screening is expected to rise following the recent publication of the Anal Cancer-HSIL Outcomes Research trial, which showed that treatment of high-grade squamous intraepithelial lesions significantly reduces the rate of progression to anal cancer. While screening for human papillomavirus-associated squamous lesions in the cervix is well established and effective, this is less true for other sites in the lower anogenital tract. Current anal cancer screening and prevention rely on high-resolution anoscopy with biopsies. This procedure has a steep learning curve for providers and may cause patient discomfort. Scattering-based light-sheet microscopy (sLSM) is a novel imaging modality with the potential to mitigate these challenges through real-time, microscopic visualization of disease-susceptible tissue. Here, we report a proof-of-principle study that establishes feasibility of dysplasia detection using an sLSM device. We imaged 110 anal biopsy specimens collected prospectively at our institution's dysplasia clinic (including 30 nondysplastic, 40 low-grade squamous intraepithelial lesion, and 40 high-grade squamous intraepithelial lesion specimens) and found that these optical images are highly interpretable and accurately recapitulate histopathologic features traditionally used for the diagnosis of human papillomavirus-associated squamous dysplasia. A reader study to assess diagnostic accuracy suggests that sLSM images are noninferior to hematoxylin and eosin images for the detection of anal dysplasia (sLSM accuracy = 0.87; hematoxylin and eosin accuracy = 0.80; P = .066). Given these results, we believe that sLSM technology holds great potential to enhance the efficacy of anal cancer screening by allowing accurate sampling of diagnostic tissue at the time of anoscopy. While the current imaging study was performed on ex vivo biopsy specimens, we are currently developing a handheld device for in vivo imaging that will provide immediate microscopic guidance to high-resolution anoscopy providers.
    Sprache Englisch
    Erscheinungsdatum 2024-04-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 645073-8
    ISSN 1530-0285 ; 0893-3952
    ISSN (online) 1530-0285
    ISSN 0893-3952
    DOI 10.1016/j.modpat.2024.100493
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  10. Artikel ; Online: Utility of p16 Immunohistochemistry in Evaluating Negative Cervical Biopsies Following High-risk Pap Test Results.

    Shain, Alana F / Kwok, Shirley / Folkins, Ann K / Kong, Christina S

    The American journal of surgical pathology

    2017  

    Abstract: The Lower Anogenital Squamous Terminology (LAST) Standardization Project for human papilloma virus (HPV)-associated lesions specifically recommends the use of p16 immunohistochemistry (IHC) as an adjunct to morphologic assessment of cervical biopsies ... ...

    Abstract The Lower Anogenital Squamous Terminology (LAST) Standardization Project for human papilloma virus (HPV)-associated lesions specifically recommends the use of p16 immunohistochemistry (IHC) as an adjunct to morphologic assessment of cervical biopsies interpreted as negative or low-grade squamous intraepithelial lesion (LSIL) from patients with prior high-risk Pap test results (high-grade squamous intraepithelial lesion [HSIL], atypical squamous cells cannot exclude HSIL, atypical glandular cells [AGC], or HPV16 atypical squamous cells of undetermined significance [ASC-US]). The impetus for this recommendation is to increase detection of missed high-grade disease. However, the quality of evidence supporting this recommendation was lower than that for the other LAST recommendations addressing improved consistency in the diagnosis of HSIL with the use of p16. A database search spanning 10 years identified 341 cases (encompassing 736 discrete biopsy specimens) interpreted as negative for dysplasia from 330 patients with a prior high-risk Pap result (atypical squamous cells cannot exclude HSIL, HSIL, atypical glandular cells, not otherwise specified [AGC-NOS], atypical endocervical cells--NOS [AEC-NOS], and AEC-favor neoplastic). p16 IHC was performed and detected missed abnormalities in 11/341 (3.2%) cases. The abnormalities corresponded to missed foci of HSIL (cervical intraepithelial neoplasia [CIN] 2) (n=1), SIL-indeterminate grade (n=7), atypical squamous metaplasia (n=2), and LSIL [CIN1]) (n=1). Subsequent histologic follow-up identified HSIL or greater in 6/8 (75%) p16 cases versus 20/79 (25.3%) p16 cases (P=0.0079). p16 IHC performed on biopsies interpreted as negative from patients with prior high-risk Pap test results increased the detection rate of missed SIL. A p16 result also significantly increased the likelihood of HSIL on subsequent biopsy. Although further studies are required to determine what percentage of missed HSIL justifies the additional cost, improved detection of HSIL in high-risk patients may lead to fewer diagnostic procedures and fewer patients lost to follow-up.
    Sprache Englisch
    Erscheinungsdatum 2017-11-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 752964-8
    ISSN 1532-0979 ; 0147-5185
    ISSN (online) 1532-0979
    ISSN 0147-5185
    DOI 10.1097/PAS.0000000000000960
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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