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  1. Article ; Online: The glycocalyx affects the mechanotransductive perception of the topographical microenvironment.

    Chighizola, Matteo / Dini, Tania / Marcotti, Stefania / D'Urso, Mirko / Piazzoni, Claudio / Borghi, Francesca / Previdi, Anita / Ceriani, Laura / Folliero, Claudia / Stramer, Brian / Lenardi, Cristina / Milani, Paolo / Podestà, Alessandro / Schulte, Carsten

    Journal of nanobiotechnology

    2022  Volume 20, Issue 1, Page(s) 418

    Abstract: The cell/microenvironment interface is the starting point of integrin-mediated mechanotransduction, but many details of mechanotransductive signal integration remain elusive due to the complexity of the involved (extra)cellular structures, such as the ... ...

    Abstract The cell/microenvironment interface is the starting point of integrin-mediated mechanotransduction, but many details of mechanotransductive signal integration remain elusive due to the complexity of the involved (extra)cellular structures, such as the glycocalyx. We used nano-bio-interfaces reproducing the complex nanotopographical features of the extracellular matrix to analyse the glycocalyx impact on PC12 cell mechanosensing at the nanoscale (e.g., by force spectroscopy with functionalised probes). Our data demonstrates that the glycocalyx configuration affects spatio-temporal nanotopography-sensitive mechanotransductive events at the cell/microenvironment interface. Opposing effects of major glycocalyx removal were observed, when comparing flat and specific nanotopographical conditions. The excessive retrograde actin flow speed and force loading are strongly reduced on certain nanotopographies upon strong reduction of the native glycocalyx, while on the flat substrate we observe the opposite trend. Our results highlight the importance of the glycocalyx configuration in a molecular clutch force loading-dependent cellular mechanism for mechanosensing of microenvironmental nanotopographical features.
    MeSH term(s) Actins ; Glycocalyx/physiology ; Integrins ; Mechanotransduction, Cellular ; Perception
    Chemical Substances Actins ; Integrins
    Language English
    Publishing date 2022-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-022-01585-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Global attitudes in the management of acute appendicitis during COVID-19 pandemic

    Ielpo, B. / Podda, M. / Pellino, G. / Pata, F. / Caruso, R. / Gravante, G. / Di Saverio, S. / Gallo, G. / Lui, R. / Orengia, A. / Chowdary, A. / Kulkarni, A. / Kuvvetli, A. / Navarro, A. / Pisanu, A. / Smith, A. / Ibiricu, A. C. / Nacion, A. J. D. / Alsaleh, A. /
    Alhazmi, A. / Elmabri, A. / Wani, A. / Rencuzogullari, A. / Lasarte, A. S. / Rubio, A. V. / Bavikatte, A. / Kumar, A. / Jamiri, A. -R. / Padilla, A. M. A. / Cacurri, A. / de San Ildefonso, A. / Porcu, A. / Sartori, A. / Rocca, A. / Yanez, A. P. / Becaria, A. / Solis-Pena, A. / Sretenovic, A. / Urbistondo, A. / Bandin, A. / Najar, A. / De Luca, A. / Boddy, A. / Charalabopoulos, A. / Tzivanakis, A. / Amendola, A. / de Velasco, A. R. -G. / Yildirim, A. C. / Frontali, A. / Toure, A. O. / Garcia-Granero, A. / Roldan, A. M. / Larrainzar, A. S. / Ratnayake, A. S. / Gonzalez-Ganso, A. M. / Minaya-Bravo, A. M. / Das, A. / Bondurri, A. / Costanzi, A. / Lucchi, A. / Mazzari, A. / Musig, A. / Peloso, A. / Piano, A. / Police, A. / Mihailescu, A. / Pouy, A. / Romano, A. / Iossa, A. / Leonetti, A. C. / Guariniello, A. / Isaac, A. / Bovi, A. P. D. / Chessa, A. / Tromba, A. / Martinez, A. A. / Brillantino, A. / Caira, A. / Castaldi, A. / Ferronetti, A. / Giuliani, A. / Prestera, A. / la Medina, A. R. -D. / Tarasconi, A. / Tornambe, A. / Picciariello, A. / Ioannidis, A. / Leppaniemi, A. / Khan, A. / Rashid, A. / Perez-Sanchez, A. L. E. / Mittal, A. / Mitul, A. R. / Mehraj, A. / Laharwal, A. / Dorisme, A. / Marinis, A. / Iqbal, A. / Moncada, A. / Braccio, B. / Alkhafaji, B. / de Andres Asenjo, B. / Martin-Perez, B. / Perez, B. S. / Creavin, B. / Cali, B. / Pascotto, B. / Stubbs, B. / Retes, B. Z. / Jovanovic, B. / Goh, B. K. P. / Sensi, B. / Biddau, C. / Gazia, C. / Vallicelli, C. / Fagundes, C. A. / Santacruz, C. C. / Chirico, C. / Diaz, C. J. G. / Petrola, C. / Rodriguez, C. S. / Benitez, C. Y. / Dammaro, C. / Faro, C. L. / Reinke, C. / Paez, C. D. / Oliva, C. / Paranjape, C. / Thomas, C. / Chia, C. F. / Kong, C. K. / De Lucia, C. / Chao, C. O. / Arcudi, C. / Guerci, C. / Chia, C. / Parise, C. / Folliero, C. / Varela, C. / Ferguson, D. M. / Camacho, D. / Popowich, D. / Lima, D. S. / Rega, D. / Delogu, D. / Zigiotto, D. / Vinci, D. / D'Antonio, D. / Parini, D. / Merlini, D. A. / Zimmerman, D. D. E. / Moro-Valdezate, D. / Pertile, D. / Giusti, D. M. / Keller, D. S. / Tarik, D. / Kalivaci, D. / Mazingi, D. / Maldonado-Pintado, D. G. / Sasia, D. / Linardoutsos, D. / Osilli, D. / Murrone, D. / Russello, D. / Rodas, E. / Roa, E. A. A. / Ricciardi, E. / Rosso, E. / Saladino, E. / Flores-Villalba, E. / Ajs, E. R. / Smith-Singares, E. / Baili, E. / Kouroumpas, E. / Bourmpouteli, E. / Douka, E. / Martin-Perez, E. / Guaitoli, E. / Samadov, E. / Francone, E. / Vaterlini, E. / Morales, E. / Pena, E. / Zhao, E. / Andres, E. D. P. / Benzoni, E. / Erdas, E. / Pinotti, E. / Colas-Ruiz, E. / Aytac, E. / Laterza, E. / Agastra, E. / Foianini, E. / Moscoso, E. / Laviano, E. / Marra, E. / Cardamone, E. / Licardie, E. / Mpaili, E. / Pinna, E. / Varo, E. / Navarro, F. M. / Marino, F. / Medas, F. / Romano, F. / Maraska, F. / Saliu, F. / Madrid, F. / Rosa, F. / Mastella, F. / Gheza, F. / Luvisetto, F. / Alconchel, F. / Vieira, F. M. / Pareja, F. / Agresta, F. / Luna, F. / Bonilla, F. / Cordera, F. / Burdio, F. / Mendoza-Moreno, F. / Flores, F. M. / Aranda, F. P. / Taylor, F. / Ramos, F. L. / Fernandes, F. / Tropeano, F. P. / Balestra, F. / Bianco, F. / Ceci, F. / Colombo, F. / Di Marzo, F. / Ferrara, F. / Lancellotti, F. / Lazzarin, F. / Litta, F. / Martini, F. / Pizza, F. / Roscio, F. / Virdis, F. / Antona, F. B. / Ramirez, F. C. / Fernandez, F. M. / Llinares, F. O. / Quezada, F. / Schlottmann, F. / Herrera-Almario, G. / Massaferro, G. / Bislenghi, G. / van Ramshorst, G. / Luglio, G. / Bointas, G. / Kampouroglou, G. / Papadopoulos, G. / Manrique, G. A. / Calini, G. / Nastri, G. / Formisano, G. / Galiffa, G. / Palini, G. M. / Colucci, G. / Pagano, G. / Vanni, G. / Pattacini, G. C. / De Paola, G. / Lisi, G. / Partida, G. / Bellanova, G. / De Nobili, G. / Necchi, G. S. / Sinibaldi, G. / Tebala, G. / Bagaglini, G. / Izzo, G. / Argenio, G. / Brisinda, G. / Candilio, G. / Di Grezia, G. / Esposito, G. / Faillace, G. / Frazzetta, G. / La Gumina, G. / Nigri, G. / Romeo, G. / Amatriain, G. C. / Ortega, G. / Martin-Martin, G. / Stavrou, G. A. / Gunadi, / Ugon, G. A. / Machain, G. / Marcucci, G. / Martinez-Mier, G. / Machain, G. M. / Nari, G. / Calvo, H. / Fathy, H. / Hamilto, / Ahmed, H. / Faraj, H. / Nava, H. / Macias, H. O. / Nikaj, H. / Solano, H. / Khan, H. A. / Alarcon, H. S. / Ebied, H. / Giani, I. / Ateca, I. V. / Neri, I. / Roman, I. A. S. / Fidoshev, I. / Rodriguez, I. M. / Negoi, I. / Ortega, I. / Bernescu, I. / Russo, I. S. / Rodriguez, I. V. / Palomares, I. / Baltazar, I. / Torrejimeno, I. J. / Jurado, I. M. C. / Reccia, I. / Hussain, I. / Toledo, I. B. / Mora-Guzman, I. / Dogaru, I. / Romic, I. / Balciscueta, I. / Kenington, J. C. / Sagolsem, J. / Jang, J. Y. / Olivier, J. / Lammel-Lindemann, J. / Dziakova, J. / Villavicencio, J. I. R. / Salinas, J. / Parreira, J. P. J. G. / Jovanovic, / Perez, J. R. / Reyes, J. A. S. / Luque, J. A. M. / Mak, J. / Rodriguez, J. S. / Kok, J. H. H. / Krook, J. / Diaz-Elizondo, J. A. / Castell, J. / Garcia-Flores, J. E. / Navalon, J. M. J. / Rodrigues, J. M. S. / Pereira, J. / Gomez, J. T. C. / Luque, J. B. / del Olmo, J. C. M. / Salamea, J. C. / Olivier, J. F. C. / Laina, J. L. B. / Ordonez, J. M. / Gutierrez, J. / Abba, J. / Sofi, J. A. / Sherafgan, K. / Sahnan, K. / Yanaga, K. / Beatson, K. / Asim, L. / Alvarez, L. / Siragusa, L. / Farber, L. / Ong, L. / Athanasios, L. / Garcia-Bruna, L. / De Martino, L. / Ferrario, L. / Giordano, L. / Gordini, L. / Pio, L. / Ponchietti, L. / Moletta, L. / Curella, L. / Poggi, L. / Taglietti, L. / Bonavina, L. / Conti, L. / Goffredi, L. / Ruiz, L. A. G. / Barrionuevo, L. / Fregoso, L. E. / Cabrera, L. F. / Rodriguez, L. G. / Grande, L. / Osoria, L. G. / Gonzalez, L. J. K. / Sanchez-Guillen, L. / Tallon-Aguilar, L. / Tresierra, L. / Giavarini, L. / Hasabelnabi, M. / Odovic, M. / Uemura, M. / Khan, M. / Artiles-Armas, M. / David, M. / Di Martino, M. / Spampinato, M. G. / Ribeiro, M. A. F. / Viola, M. / Angrisani, M. / Calussi, M. / Cannistra, M. / Catarci, M. / Cereda, M. / Conte, M. / Giordano, M. / Pellicciaro, M. / Marino, M. V. / Vaterlini, M. E. / Jimenez, M. F. / Lolli, M. G. / Bellini, M. I. / Lemma, M. / Chiarello, M. M. / Nicola, M. / Arrigo, M. / Mejia, M. C. / Manrique, M. M. / Rodriguez-Lopez, M. / Serradilla-Martin, M. / Lara, M. Z. / Martinez, M. / Bagnall, M. / Peter, M. / Lara, M. C. / Gomez, M. J. / Paniagua-Garcia-Senorans, M. / Gonzalez, M. P. / Rutegard, M. / Salo, M. / Franceschilli, M. / Silveri, M. / Veroux, M. / Pezzulo, M. / Nardi, M. / Rottoli, M. / Tolonen, M. / Ciro, M. P. / Zuluagua, M. / Cannavo, M. / Cervellera, M. / Iacobone, M. / Montuori, M. / Dominguez, M. G. / Bingol-Kologlu, M. / Tahir, M. / Lim, M. / Wilson, M. S. / Wilson, M. / Campanelli, M. / Bisaccia, M. / De Rosa, M. / Maruccia, M. / Paterno, M. / Pisano, M. / Torre, M. / Trevino, M. / Zuolo, M. / Hernandez Bartolome, M. A. / Farina, M. / Pera, M. / Calvo, M. P. / Sotelo, M. / Thway, M. M. / Hassan, M. / Hassan, M. S. E. / Azfar, M. / Bouhuwaish, M. / Taha, M. / Zaieem, M. / Korkoman, M. / Guraieb, M. / Shalaby, M. / Raza, M. A. / Younis, M. U. / Elhadi, M. / Ali, M. Z. / Quazi, N. / Dudi-Venkata, N. N. / Alselaim, N. / Loria, N. / Ramirez, N. V. / Than, N. W. / Smart, N. / Trelles, N. / Pinto, N. / Allievi, N. / Petrucciani, N. / Antonacci, N. / Cillara, N. / Gica, N. / Cristiana, N. D. / Krystek, N. / Falco, N. / Pecorelli, N. / Tamini, N. / Dallas, N. A. / Machairas, N. / Brito, N. / Fieturi, N. A. / Ortega, N. / Mercado, O. A. / Irkorucu, O. / Alsherif, O. / Valles, O. / Ioannidis, O. / Palmas, O. H. / Palmas, O. I. H. / Guadarrama, O. S. / Bozbiyik, O. / Omelanczuk, P. / Ottolino, P. / Rodrigues, P. / Ruiz, P. / Campenni, P. / Chiarade, P. / Olivares, P. P. / Baroffio, P. / Panaccio, P. / Wintringer, P. / Di Fronzo, P. / Talento, P. / Favoriti, P. / Sendino, P. / Marsanic, P. / Mifsut, P. / Andrade, P. / Ajawin, P. / Abadia-Barno, P. / Castaneda, P. A. N. / Arevalos, P. O. S. / Bellver, P. P. / Koh, P. S. / Souza, P. / Major, P. / Bali, R. S. / Khattar, R. M. / Melo, R. B. / Ebrahiminia, R. / Azar, R. / Murga, R. L. / Pirolo, R. / Brady, R. / Davies, R. J. / Dholakia, R. / Rattan, R. / Singhal, R. / Lim, R. / Angelico, R. / Isernia, R. M. / Tutino, R. / Faccincani, R. / Peltrini, R. / Carrera-Ceron, R. / Tejos, R. / Kashyap, R. / Fajardo, R. / Lozito, R. / Pareja, R. M. / Garbarino, S. / Morales-Conde, S. / Benli, S. / Mansour, S. / Flores, S. / Suarez, S. L. / Ben, S. L. / Fuentes, S. / Napetti, S. / de Guzman, S. O. / Awad, S. / Weckmann Lujan, S. A. / Gentilli, S. / Grimaldi, S. / Pizarro, S. O. / Tayar, S. / Nabi, S. / Chan, S. M. / Junaid, S. / Rojas, S. / Monetti, S. / Garcia, S. / Salvans, S. / Tenconi, S. / Shaw, S. / Santoni, S. / Parra, S. A. / Cardenas, S. / Perez-Bertolez, S. / Chiappetta, S. / Dessureault, S. / Delis, S. / Bonapasta, S. A. / Rausei, S. / Scaringi, S. / Keswani, S. / Ali, S. M. / Cetinkunar, S. / Fung, T. L. D. / Rawashdeh, T. / Lopez, T. N. / De Campos, T. / Duque, T. C. / Perra, T. / Liakakos, T. / Daskalakis, T. / Barnes, T. / Koeter, T. / Zalla, T. / Gonzalez, T. E. / Elosua, T. / Campagnaro, T. / Brown, T. / Luoto, T. / Oumar, T. A. / Giustizieri, U. / Grossi, U. / Bracale, U. / Rivas, U. / Sosa, V. / Testa, V. / Andriola, V. / Tonini, V. / Balassone, V. / Celentano, V. / Progno, V. / Raju, V. / Carroni, V. / Cavallaro, V. / Katta, V. R. / De Simone, V. / Romaguera, V. P. / Orozco, V. H. G. / Luraschi, V. / Rachkov, V. / Turrado-L, V. / Visag-Castillo, V. / Dowling, V. / Graham, V. / Papagni, V. / Vigorita, V. / Fonseca, V. C. / Carneros, V. J. / Bellato, V. / Goncalves, W. / Powers, W. F. / Grigg, W. / Bechstein, W. O. / Lim, Y. B. / Altinel, Y. / Golubovic, Z. / Balciscueta, Z.

    ACIE Appy Study

    2020  

    Abstract: Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a ... ...

    Abstract Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to appendicitis. Methods: The Association of Italian Surgeons in Europe designed an online survey to assess the current attitude of surgeons globally regarding the management of patients with acute appendicitis during the pandemic. Questions were divided into baseline information, hospital organization and screening, personal protective equipment, management and surgical approach, and patient presentation before versus during the pandemic. Results: Of 744 answers, 709 (from 66 countries) were complete and were included in the analysis. Most hospitals were treating both patients with and those without COVID. There was variation in screening indications and modality used, with chest X-ray plus molecular testing (PCR) being the commonest (19·8 per cent). Conservative management of complicated and uncomplicated appendicitis was used by 6·6 and 2·4 per cent respectively before, but 23·7 and 5·3 per cent, during the pandemic (both P < 0·001). One-third changed their approach from laparoscopic to open surgery owing to the popular (but evidence-lacking) advice from expert groups during the initial phase of the pandemic. No agreement on how to filter surgical smoke plume during laparoscopy was identified. There was an overall reduction in the number of patients admitted with appendicitis and one-third felt that patients who did present had more severe appendicitis than they usually observe. Conclusion: Conservative management of mild appendicitis has been possible during the pandemic. The fact that some surgeons switched to open appendicectomy may reflect the poor guidelines that emanated in the early phase of SARS-CoV-2.
    Keywords covid19
    Subject code 610
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Global attitudes in the management of acute appendicitis during COVID-19 pandemic

    B, Ielpo / M, Podda / G, Pellino / F, Pata / R, Caruso / G, Gravante / Saverio, Di / Orengia, Adam / Chowdary, Aditya / Kulkarni, Aditya / Kuvvetli, Adnan / Navarro, Adolfo / Pisanu, Adolfo / Smith, Adrian / Cavero Ibiricu, Adriana / Nacion, Aeris Jane D. / Alsaleh, Ahmad / Alhazmi, Ahmad / Elmabri, Ahmad /
    Wani, Ajaz / Rencuzogullari, Ahmet / Sarriugarte Lasarte, Aingeru / Valle Rubio, Ainhoa / Bavikatte, Akshay / Kumar, Akshay / Jamiri, Al-radjid / Michel Alvarado Padilla, Alain / Cacurri, Alban / de San Ildefonso, Alberto / Porcu, Alberto / Sartori, Alberto / Rocca, Aldo / Paz Yáñez, Alejandro / Becaria, Alejandro / Solís-Peña, Alejandro / Sretenović, Aleksandar / Urbistondo, Alex / Bandin, Alfonso / Najar, Alfonso / De Luca, Alessandro / Boddy, Alex / Charalabopoulos, Alexandros / Tzivanakis, Alexios / Amendola, Alfonso / Ramirez-Gutierrez de Velasco, Alfredo / Cihat Yildirim, Ali / Frontali, Alice / Oumar Toure, Alpha / García-Granero, Alvaro / Martínez Roldan, Amaia / Sanz Larrainzar, Amaia / Sanjiva Ratnayake, Amila / María Gonzalez-Ganso, Ana / Minaya-Bravo, Ana M. / Das, Andre / Bondurri, Andrea / Costanzi, Andrea / Lucchi, Andrea / Mazzari, Andrea / Musig, Andrea / Peloso, Andrea / Piano, Andrea / Police, Andrea / Mihailescu, Andrei / Pouy, Andrés / Romano, Angela / Iossa, Angelo / Carmen Leonetti, Anna / Guariniello, Anna / Isaac, Anna / Pia Delli Bovi, Anna / Chessa, Antonella / Tromba, Antonella / Álvarez Martínez, Antonio / Brillantino, Antonio / Caira, Antonio / Castaldi, Antonio / Ferronetti, Antonio / Giuliani, Antonio / Prestera, Antonio / Ramos-De la Medina, Antonio / Tarasconi, Antonio / Tornambè, Antonino / Picciariello, Arcangelo / Ioannidis, Argyrios / Leppäniemi, Ari / Khan, Arshad / Rashid, Arshad / Luis Eduardo Pérez-Sánchez, Arteaga / Mittal, Ashok / Rahman Mitul, Ashrarur / Mehraj, Asif / Laharwal, Asim / Dorismé, Asnel / Marinis, Athanasios / Iqbal, Atif / Moncada, Augusto / Braccio, Bartolomeo / Alkhafaji, Basim / de Andrés Asenjo, Beatriz / Martin-Perez, Beatriz / De Simone, Belinda / Sánchez Pérez, Belinda / Creavin, Ben / Calì, Benedetto / Cali, Benedetto / Pascotto, Beniamino / Stubbs, Benjamin / Zavala Retes, Benjamin / Jovanovic, Branislav / KP Goh, Brian / Sensi, Bruno / Biddau, Carlo / Gazia, Carlo / Vallicelli, Carlo / Alberto Fagundes, Carlos / Cerdán Santacruz, Carlos / Chirico, Carlos / Javier Gómez Díaz, Carlos / Petrola, Carlos / Sánchez Rodriguez, Carlos / Yánez Benítez, Carlos / Dammaro, Carmelisa / Lo Faro, Carmelo / Reinke, Caroline / Dominguez Paez, Casandra / Oliva, Catalina / Paranjape, Charudutt / Thomas, Charlotte / Fung Chia, Chi / Kwan Kong, Chi / De Lucia, Chiara / Ovalle Chao, Christian / Arcudi, Claudio / Guerci, Claudio / Chia, Clement / Parise, Cristiano / Folliero, Cristina / Varela, Cristopher / Ferguson, Dalya M. / Camacho, Daniel / Popowich, Daniel / Souza Lima, Daniel / Rega, Daniela / Delogu, Daniele / Zigiotto, Daniele / Vinci, Danilo / D’Antonio, Dario / Parini, Dario / Alessio Merlini, David / DE Zimmerman, David / Moro-Valdezate, David / Pertile, Davide / Maria Giusti, Deborah / Keller, Deborah S. / Tarik, Delko / Kalivaçi, Denis / Mazingi, Dennis / Gabriela Maldonado-Pintado, Diana / Sasia, Diego / Linardoutsos, Dimitrios / Osilli, Dixon / Murrone, Domenico / Russello, Domenico / Rodas, Edgar / Alberto Acuña Roa, Edisson / Ricciardi, Edoardo / Rosso, Edoardo / Saladino, Edoardo / Flores-Villalba, Eduardo / Ruiz Ajs, Eduardo / Smith-Singares, Eduardo / Baili, Efstratia / Kouroumpas, Efstratios / Bourmpouteli, Eirini / Douka, Eleftheria / Martin-Perez, Elena / Guaitoli, Eleonora / Samadov, Elgun / Francone, Elisa / Vaterlini, Elisa / Morales, Emilio / Peña, Emilio / Zhao, Enhao / Del Pozo Andres, Eneko / Benzoni, Enrico / Erdas, Enrico / Pinotti, Enrico / Colás-Ruiz, Enrique / Aytac, Erman / Laterza, Ernesto / Agastra, Ervis / Foianini, Esteban / Moscoso, Esteban / Laviano, Estefania / Marra, Ester / Cardamone, Eugenia / Licardie, Eugenio / Mpaili, Eustratia / Pinna, Eva / Varo, Evaristo / Martín Navarro, Fabian / Marino, Fabio / Medas, Fabio / Romano, Fabio / Maraska, Fatlum / Saliu, Fatmir / Madrid, Fausto / Rosa, Fausto / Mastella, Federica / Gheza, Federico / Luvisetto, Federico / Alconchel, Felipe / Monge Vieira, Felipe / Pareja, Felipe / Agresta, Ferdinando / Luna, Fernanda / Bonilla, Fernando / Cordera, Fernando / Burdió, Fernando / Mendoza-Moreno, Fernando / Muñoz Flores, Fernando / Pardo Aranda, Fernando / Taylor, Fiona / Ramos, Flavia L. / Fernandes, Flavio / Paola Tropeano, Francesca / Balestra, Francesco / Bianco, Francesco / Ceci, Francesco / Colombo, Francesco / Di Marzo, Francesco / Ferrara, Francesco / Lancellotti, Francesco / Lazzarin, Francesco / Litta, Francesco / Martini, Francesco / Pizza, Francesco / Roscio, Francesco / Virdis, Francesco / Blanco Antona, Francisco / Cervantes Ramírez, Francisco / Miguel Fernandez, Francisco / Oliver Llinares, Francisco / Quezada, Francisco / Schlottmann, Francisco / Quezada, Fransisco / Herrera-Almario, Gabriel / Massaferro, Gabriel / Bislenghi, Gabriele / van Ramshorst, Gabrielle / Gallo, Gaetano / Luglio, Gaetano / Bointas, Georgios / Kampouroglou, Georgios / Papadopoulos, Georgios / Arredondo Manrique, Gerardo / Calini, Giacomo / Nastri, Giacomo / Formisano, Giampaolo / Galiffa, Giampaolo / Marco Palini, Gian / Colucci, Gianluca / Pagano, Gianluca / Pellino, Gianluca / Vanni, Gianluca / Casoni Pattacini, Gianmaria / Gravante, Gianpiero / De Paola, Gilda / Lisi, Giorgio / Partida, Giovanna / Bellanova, Giovanni / De Nobili, Giovanni / Sammy Necchi, Giovanni / Sinibaldi, Giovanni / Tebala, Giovanni / Bagaglini, Giulia / Izzo, Giuliano / Argenio, Giulio / Brisinda, Giuseppe / Candilio, Giuseppe / Di Grezia, Giuseppe / Esposito, Giuseppe / Faillace, Giuseppe / Frazzetta, Giuseppe / La Gumina, Giuseppe / Nigri, Giuseppe / Romeo, Giuseppe / Chocarro Amatriaín, Gloria / Ortega, Gloria / Martin-Martin, Gonzalo / Stavrou, Gregor A. / Gunadi, / Armand Ugon, Gustavo / Machain, Gustavo / Marcucci, Gustavo / Martínez-Mier, Gustavo / Miguel Machain, Gustavo / Nari, Gustavo / Calvo, Haydée / Fathy, Hamada / Hamilto, / Ahmed, Hazem / Faraj, Hazem / Nava, Hector / Ordas Macias, Hector / Nikaj, Herald / Solano, Heriberto / Ahmed Khan, Huma / Sánchez Alarcón, Humberto / Ebied, Husam / Giani, Iacopo / Villalabeitia Ateca, Ibabe / Neri, Ignacio / Alberdi San Roman, Igor / Fidoshev, Iliya / Martinez Rodriguez, Iñaki / Negoi, Ionut / Ortega, Irene / Bernescu, Irina / Shari Russo, Iris / Vincente Rodríguez, Irune / Palomares, Irving / Baltazar, Isaac / Jaén Torrejimeno, Isabel / María Cornejo Jurado, Isabel / Reccia, Isabella / Hussain, Ishtiyaq / Brito Toledo, Ismael / Mora-Guzmán, Ismael / al-Najami, Issam / Dogaru, Iulia / Romic, Ivan / Balciscueta, Izaskun / Cleo Kenington, J / Sagolsem, Jackison / Y Jang, Jae / Olivier, James / Lammel-Lindemann, Jan / Dziakova, Jana / Ismael Roldán Villavicencio, Javier / Salinas, Javier / Pejanovic Jose Gustavo Parreira, Jelena / Jovanovic, / Rincón Pérez, Jeny / AS Reyes, Jeryl / Antonio Medina Luque, Jesus / Mak, Joanna / Salas Rodriguez, Joanne / Henry Herrera Kok, Johnn / Krook, Jon / Antonio Diaz-Elizondo, Jose / Castell, Jose / Eduardo García-Flores, José / María Jover Navalón, José / Mauro Silva Rodrigues, Jose / Pereira Pinto, José / Tomas Castell Gómez, José / Bellido Luque, Juan / Carlos Martín del Olmo, Juan / Carlos Salamea, Juan / Francisco Coronel Olivier, Juan / Luis Blas Laina, Juan / Maria Ordoñez, Juliana / Gutierrez, Julieta / Abba, Julio / Ahmad Sofi, Junaid / Sherafgan, Kashaf / Sahnan, Kapil / Yanaga, Katsuhiko / Beatson, Kevin / Asim, Laharwal / Alvarez, Laura / Siragusa, Leandro / Farber, Lee / Ong, Lester / Athanasios, Liarakos / García-Bruña, Lorena / De Martino, Luca / Ferrario, Luca / Giordano, Luca / Gordini, Luca / Pio, Luca / Ponchietti, Luca / Moletta, Lucia / Curella, Luciano / Poggi, Luciano / Taglietti, Lucio / Bonavina, Luigi / Conti, Luigi / Goffredi, Luigi / Angel Garcia Ruiz, Luis / Barrionuevo, Luis / Enrique Fregoso, Luis / Cabrera, Luis F. / G Rodriguez, Luis / Grande, Luis / Gregorio Osoria, Luis / Javier Kantun Gonzalez, Luis / Sánchez-Guillén, Luis / Tallon-Aguilar, Luis / Tresierra, Luis / Giavarini, Luisa / Hasabelnabi, Mahmoud / Odovic, Maja / Uemura, Mamoru / Khan, Mansoor / Artiles-Armas, Manuel / David, Mara / Di Martino, Marcello / Giuseppe Spampinato, Marcello / Ribeiro Jr, Marcelo A. F. / Viola, Marcelo / Angrisani, Marco / Calussi, Marco / Cannistrà, Marco / Catarci, Marco / Cereda, Marco / Conte, Marco / Giordano, Marco / Pellicciaro, Marco / Vito Marino, Marco / E Vaterlini, Maria / Jiménez, María F. / Giulia Lolli, María / Irene Bellini, Maria / Lemma, Maria / Michela Chiarello, Maria / Nicola, Maria / Arrigo, Mario / Caneda Mejia, Mario / Montes Manrique, Mario / Rodriguez-Lopez, Mario / Serradilla-Martín, Mario / Zambrano Lara, Mario / Martínez, Marisa / Bagnall, Mark / Peter, Mark / Cañón Lara, Marta / Jimenez Gomez, Marta / Paniagua-Garcia-Señorans, Marta / Perez Gonzalez, Marta / Rutegård, Martin / Salö, Martin / Franceschilli, Marzia / Silveri, Massimiliano / Veroux, Massimiliano / Pezzulo, Massimo / Nardi, Matteo / Rottoli, Matteo / Tolonen, Matti / Pedraza Ciro, Mauricio / Zuluagua, Mauricio / Cannavò, Maurizio / Cervellera, Maurizio / Iacobone, Maurizio / Montuori, Mauro / Podda, Mauro / García Domínguez, Melody / Bingol-Kologlu, Meltem / Tahir, Mian / Lim, Michael / Sj Wilson, Michael / Wilson, Michael / Campanelli, Michela / Bisaccia, Michele / De Rosa, Michele / Maruccia, Michele / Paterno, Michele / Pisano, Michele / Torre, Michele / Treviño, Michelle / Zuolo, Michele / Hernandez Bartolome, Miguel A. / Farina, Miguel / Pera, Miguel / Prieto Calvo, Mikel / Sotelo, Milagros / Myat Thway, Min / Hassan, Mohamed / Salah Eldin Hassan, Mohamed / Azfar, Mohammad / Bouhuwaish, Mohammad / Taha, Mohammad / Zaieem, Mohammad / Korkoman, Mohammed / Guraieb, Montserrat / Shalaby, Mostafa / Asif Raza, Muhammad / Umar Younis, Muhammad / Elhadi, Muhammed / Zulfiqar Ali, Mujahid / Quazi, Nadeem / Dudi-Venkata, Nagendra N. / Alselaim, Nahar / Loria, Natasha / Villan Ramírez, Nathalie / Win Than, Nay / Smart, Neil / Trelles, Nelson / Pinto, Nicanor / Allievi, Niccolò / Petrucciani, Niccolo / Antonacci, Nicola / Cillara, Nicola / de'Angelis, Nicola / Gica, Nicolae / Diana Cristiana, Nicolaescu / Krystek, Nicolás / Falco, Nicolò / Pecorelli, Nicolò / Tamini, Nicolò / Andreas Dallas, Nikolaos / Machairas, Nikolaos / Brito, Noelia / Ahmed Fieturi, Nura / Ortega, Nuria / Avila Mercado, Octavio / Irkorucu, Oktay / Alsherif, Omar / Valles, Orestes / Ioannidis, Orestis / Hernández Palmas, Oscar / Isaac Hernandez Palmas, Oscar / Sanz Guadarrama, Oscar / Bozbiyik, Osman / Omelanczuk, Pablo / Ottolino, Pablo / Rodrigues, Pablo / Ruiz, Pablo / Campenni, Paola / Chiarade, Paola / Prieto Olivares, Paola / Baroffio, Paolo / Panaccio, Paolo / Wintringer, Pascal / Di Fronzo, Pasquale / Talento, Pasquale / Favoriti, Pasqualino / Sendino, Patricia / Marsanic, Patrizia / Mifsut, Patricia / Andrade, Paúl / Ajawin, Pawel / Abadía-Barnó, Pedro / Alfonso Najar Castañeda, Pedro / Omar Sillas Arevalos, Pedro / Palazón Bellver, Pedro / Soon Koh, Peng / Souza, Petry / Major, Piotr / Singh Bali, Rajandeep / Mohan Khattar, Rakesh / Bessa Melo, Renato / Ebrahiminia, Reza / Azar, Ricardo / López Murga, Ricardo / Caruso, Riccardo / Pirolo, Riccardo / Brady, Richard / Justin Davies, Richard / Dholakia, Rishi / Rattan, Rishi / Singhal, Rishi / Lim, Robert / Angelico, Roberta / Maria Isernia, Roberta / Tutino, Roberta / Faccincani, Roberto / Peltrini, Roberto / Carrera-Ceron, Rocio / Tejos, Rodrigo / Kashyap, Rohit / Fajardo, Roosevelt / Lozito, Rosa / Madariaga Pareja, Royer / Garbarino, Sabrina / Di Saverio, Salomone / Morales-Conde, Salvador / Benli, Sami / Mansour, Sami / Flores, Samir / Limon Suarez, Samuel / Lopez Ben, Santiago / Fuentes, Sara / Gortazar de las Casas, Sara / Napetti, Sara / Ortiz de Guzmán, Sara / Awad, Selmy / Weckmann Luján, Sergio A. / Gentilli, Sergio / Grimaldi, Sergio / Olivares Pizarro, Sergio / Tayar, Serkan / Nabi, Shakeeb / M Chan, Shannon / Junaid, Sheikh / Rojas, Sidney / Monetti, Silvana / García, Silvia / Salvans, Silvia / Tenconi, Silvia / Shaw, Simon / Santoni, Simone / Andrea Parra, Sofia / Cárdenas, Sofía / Pérez-Bertólez, Sonia / Chiappetta, Sonja / Dessureault, Sophie / Delis, Spiros / Amore Bonapasta, Stefano / Rausei, Stefano / Scaringi, Stefano / Keswani, Sundeep / Muhammad Ali, Syed / Cetinkunar, Süleyman / Lit Derek Fung, Tak / Rawashdeh, Tariq / Nicolás López, Tatiana / De Campos, Tercio / Calderon Duque, Teresa / Perra, Teresa / Liakakos, Theodore / Daskalakis, Theodoros / Liakakos, Theodoros / Barnes, Thomas / Koëter, Tijmen / Zalla, Tiku / González, Tomás E. / Elosua, Tomás / Campagnaro, Tommaso / Brown, Tommy / Luoto, Topi / Alpha Oumar, Touré / Giustizieri, Ugo / Grossi, Ugo / Bracale, Umberto / Rivas, Uriel / Sosa, Valentina / Testa, Valentina / Andriola, Valeria / Tonini, Valeria / Balassone, Valerio / Celentano, Valerio / Progno, Valerio / Raju, Varun / Carroni, Vanessa / Cavallaro, Venera / Rao Katta, Venkateswara / De Simone, Veronica / Primo Romaguera, Vicent / Hugo García Orozco, Victor / Luraschi, Victor / Rachkov, Victor / Turrado-L, Victor / Visag-Castillo, Victor / Dowling, Victoria / Graham, Victoria / Papagni, Vincenzo / Vigorita, Vincenzo / Cordeiro Fonseca, Vinicius / Jimenez Carneros, Virginia / Bellato, Vittoria / Gonçalves, Walyson / Powers, William F. / Grigg, William / Bechstein, Wolf O. / Bing Lim, Yu / Altinel, Yuksel / Golubović, Zoran / Balciscueta, Zutoia

    ACIE Appy Study

    2020  

    Abstract: Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a ... ...

    Abstract Background: Surgical strategies are being adapted to face the COVID-19 pandemic. Recommendations on the management of acute appendicitis have been based on expert opinion, but very little evidence is available. This study addressed that dearth with a snapshot of worldwide approaches to appendicitis. Methods: The Association of Italian Surgeons in Europe designed an online survey to assess the current attitude of surgeons globally regarding the management of patients with acute appendicitis during the pandemic. Questions were divided into baseline information, hospital organization and screening, personal protective equipment, management and surgical approach, and patient presentation before versus during the pandemic. Results: Of 744 answers, 709 (from 66 countries) were complete and were included in the analysis. Most hospitals were treating both patients with and those without COVID. There was variation in screening indications and modality used, with chest X-ray plus molecular testing (PCR) being the commonest (19·8 per cent). Conservative management of complicated and uncomplicated appendicitis was used by 6·6 and 2·4 per cent respectively before, but 23·7 and 5·3 per cent, during the pandemic (both P < 0·001). One-third changed their approach from laparoscopic to open surgery owing to the popular (but evidence-lacking) advice from expert groups during the initial phase of the pandemic. No agreement on how to filter surgical smoke plume during laparoscopy was identified. There was an overall reduction in the number of patients admitted with appendicitis and one-third felt that patients who did present had more severe appendicitis than they usually observe. Conclusion: Conservative management of mild appendicitis has been possible during the pandemic. The fact that some surgeons switched to open appendicectomy may reflect the poor guidelines that emanated in the early phase of SARS-CoV-2.
    Keywords covid19
    Subject code 610
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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