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  1. Article ; Online: A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy.

    Casellas, Nicolás M / Dai, Gaole / Xue, Evelyn Y / Fonseca, Alba / Ng, Dennis K P / García-Iglesias, Miguel / Torres, Tomás

    Chemical communications (Cambridge, England)

    2022  Volume 58, Issue 5, Page(s) 669–672

    Abstract: A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. ...

    Abstract A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. These nanoparticles can be taken up readily by cancer cells and localised predominately in lysosomes where they disassemble gradually, leading to activation in fluorescence emission and, photocytotoxicity, showing IC
    MeSH term(s) Photochemotherapy
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc05977g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy

    Casellas, Nicolás M. / Dai, Gaole / Xue, Evelyn Y. / Fonseca, Alba / Ng, Dennis K. P. / García-Iglesias, Miguel / Torres, Tomás

    Chemical communications. 2022 Jan. 13, v. 58, no. 5

    2022  

    Abstract: A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. ...

    Abstract A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. These nanoparticles can be taken up readily by cancer cells and localised predominately in lysosomes where they disassemble gradually, leading to activation in fluorescence emission and, photocytotoxicity, showing IC₅₀ values of as low as 1.2 μM.
    Keywords fluorescence ; hydrodynamics ; lysosomes ; photochemotherapy
    Language English
    Dates of publication 2022-0113
    Size p. 669-672.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc05977g
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Light-Responsive Elastin-Like Peptide-Based Targeted Nanoparticles for Enhanced Spheroid Penetration.

    Le, Duc H T / Ibrahimova, Vusala / van den Wildenberg, Sebastian A H / Wu, Hanglong / Fonseca, Alba / Torres, Tomas / Garanger, Elisabeth / Leenders, William P J / Brock, Roland / Lecommandoux, Sébastien / van Hest, Jan C M

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 24, Page(s) e202300511

    Abstract: We describe here a near infrared light-responsive elastin-like peptide (ELP)-based targeted nanoparticle (NP) that can rapidly switch its size from 120 to 25 nm upon photo-irradiation. Interestingly, the targeting function, which is crucial for effective ...

    Abstract We describe here a near infrared light-responsive elastin-like peptide (ELP)-based targeted nanoparticle (NP) that can rapidly switch its size from 120 to 25 nm upon photo-irradiation. Interestingly, the targeting function, which is crucial for effective cargo delivery, is preserved after transformation. The NPs are assembled from (targeted) diblock ELP micelles encapsulating photosensitizer TT1-monoblock ELP conjugates. Methionine residues in this monoblock are photo-oxidized by singlet oxygen generated from TT1, turning the ELPs hydrophilic and thus trigger NP dissociation. Phenylalanine residues from the diblocks then interact with TT1 via π-π stacking, inducing the re-formation of smaller NPs. Due to their small size and targeting function, the NPs penetrate deeper in spheroids and kill cancer cells more efficiently compared to the larger ones. This work could contribute to the design of "smart" nanomedicines with deeper penetration capacity for effective anticancer therapies.
    MeSH term(s) Elastin/chemistry ; Peptides/chemistry ; Nanoparticles/chemistry ; Micelles
    Chemical Substances Elastin (9007-58-3) ; Peptides ; Micelles
    Language English
    Publishing date 2023-05-08
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202300511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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