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  1. Article ; Online: Pax4 in Health and Diabetes.

    Ko, Jenna / Fonseca, Vivian A / Wu, Hongju

    International journal of molecular sciences

    2023  Volume 24, Issue 9

    Abstract: Paired box 4 (Pax4) is a key transcription factor involved in the embryonic development of the pancreatic islets of Langerhans. Consisting of a conserved paired box domain and a homeodomain, this transcription factor plays an essential role in early ... ...

    Abstract Paired box 4 (Pax4) is a key transcription factor involved in the embryonic development of the pancreatic islets of Langerhans. Consisting of a conserved paired box domain and a homeodomain, this transcription factor plays an essential role in early endocrine progenitor cells, where it is necessary for cell-fate commitment towards the insulin-secreting β cell lineage. Knockout of Pax4 in animal models leads to the absence of β cells, which is accompanied by a significant increase in glucagon-producing α cells, and typically results in lethality within days after birth. Mutations in Pax4 that cause an impaired Pax4 function are associated with diabetes pathogenesis in humans. In adulthood, Pax4 expression is limited to a distinct subset of β cells that possess the ability to proliferate in response to heightened metabolic needs. Upregulation of Pax4 expression is known to promote β cell survival and proliferation. Additionally, ectopic expression of Pax4 in pancreatic islet α cells or δ cells has been found to generate functional β-like cells that can improve blood glucose regulation in experimental diabetes models. Therefore, Pax4 represents a promising therapeutic target for the protection and regeneration of β cells in the treatment of diabetes. The purpose of this review is to provide a thorough and up-to-date overview of the role of Pax4 in pancreatic β cells and its potential as a therapeutic target for diabetes.
    MeSH term(s) Animals ; Humans ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Paired Box Transcription Factors/genetics ; Paired Box Transcription Factors/metabolism ; Islets of Langerhans/metabolism ; Cell Differentiation ; Gene Expression Regulation ; Diabetes Mellitus/genetics
    Chemical Substances Homeodomain Proteins ; Paired Box Transcription Factors ; PAX4 protein, human
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24098283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ethnic disparities of vascular complications in pre-diabetes, undiagnosed diabetes, and newly diagnosed diabetes.

    Yoshida, Yilin / Zu, Yuanhao / Fonseca, Vivian A

    Primary care diabetes

    2023  Volume 17, Issue 6, Page(s) 661–664

    Abstract: In the U.S., ethnic minorities with pre-diabetes, undiagnosed type 2 diabetes (T2D), and newly diagnosed T2D had a higher prevalence of microvascular complications than non-Hispanic Whites and exhibited distinct risk factors, whereas Whites had a higher ... ...

    Abstract In the U.S., ethnic minorities with pre-diabetes, undiagnosed type 2 diabetes (T2D), and newly diagnosed T2D had a higher prevalence of microvascular complications than non-Hispanic Whites and exhibited distinct risk factors, whereas Whites had a higher rate of cardiovascular disease.
    MeSH term(s) Humans ; United States/epidemiology ; Prediabetic State/diagnosis ; Prediabetic State/epidemiology ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Risk Factors ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Prevalence ; White
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2273997-X
    ISSN 1878-0210 ; 1751-9918
    ISSN (online) 1878-0210
    ISSN 1751-9918
    DOI 10.1016/j.pcd.2023.09.008
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  3. Book: Exploring the spectrum of incretin therapies

    Fonseca, Vivian A.

    the potential for optimizing patient outcomes

    (The American journal of medicine ; 124,1A = Suppl.)

    2011  

    Author's details guest ed. Vivian A. Fonseca
    Series title The American journal of medicine ; 124,1A = Suppl.
    Collection
    Language English
    Size S61 S. : graph. Darst.
    Publisher Elsevier
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016683710
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ua VI Zs 289 -124,1A- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Optimizing treatment goals for long-term health outcomes among patients with type 2 diabetes mellitus.

    Shi, Qian / Lin, Yilu / Fonseca, Vivian A / Shi, Lizheng

    BMJ open diabetes research & care

    2023  Volume 9, Issue 1

    Abstract: Introduction: Considerable confusions on treatment target have resulted from recent changes in guidelines. Evidence in medical guidelines came from clinical trials with highly selected patients, whereas treatment goals may differ in some subgroups. This ...

    Abstract Introduction: Considerable confusions on treatment target have resulted from recent changes in guidelines. Evidence in medical guidelines came from clinical trials with highly selected patients, whereas treatment goals may differ in some subgroups. This study aimed to assess optimal treatment goals (A1C, blood pressure, low-density lipoprotein cholesterol (LDL-C)) for patients with type 2 diabetes mellitus (T2DM), which lead to optimal health outcomes by different treatment strategies.
    Research design and methods: A retrospective longitudinal study was conducted for veterans with T2DM by using US Veterans Affairs Administrative Database (2005-2015). Medical records were prepared for repeated evaluation performed at 6-month intervals and multivariate longitudinal regression was used to estimate the risk of microvascular and macrovascular complication events. Second-degree polynomial and splines were applied to identify the optimal goals in their associations with lowest risk of clinical outcomes, controlling for demographic characteristics, medical history, and medications.
    Results: A total of 124 651 patients with T2DM were selected, with mean of 6.72 follow-up years. In the general population, to achieve the lowest risk of microvascular and macrovascular complication, the optimal goals were A1C=6.81%, LDL-C=109.10 mg/dL; and A1C=6.76%, LDL-C=111.65 mg/dL, systolic blood pressure (SBP)=130.60 mmHg, respectively. The optimal goals differed between age and racial subgroups. Lower SBP for younger patients and lower LDL-C for black patients were associated with better health outcomes.
    Conclusions: Optimal treatment goals were identified and multi-faceted treatment strategies targeting hyperglycemia and hyperlipidemia and hypertension may improve health outcome in veterans with T2DM. In addition to guidelines' recommended goals, health systems may examine their own large diverse patients with T2DM for better quality of care.
    MeSH term(s) Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/epidemiology ; Glycated Hemoglobin/analysis ; Goals ; Humans ; Longitudinal Studies ; Outcome Assessment, Health Care ; Retrospective Studies
    Chemical Substances Glycated Hemoglobin A
    Language English
    Publishing date 2023-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2732918-5
    ISSN 2052-4897 ; 2052-4897
    ISSN (online) 2052-4897
    ISSN 2052-4897
    DOI 10.1136/bmjdrc-2021-002396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Glycated Albumin Correlates With Time-in-Range Better Than HbA1c or Fructosamine.

    Desouza, Cyrus V / Rosenstock, Julio / Kohzuma, Takuji / Fonseca, Vivian A

    The Journal of clinical endocrinology and metabolism

    2023  Volume 108, Issue 11, Page(s) e1193–e1198

    Abstract: Context: Intermediate-term glycemic control metrics may represent a viable alternative to continuous glucose monitoring (CGM) in patients without access to CGM.: Objective: This work aimed to compare the relationship between CGM parameters and ... ...

    Abstract Context: Intermediate-term glycemic control metrics may represent a viable alternative to continuous glucose monitoring (CGM) in patients without access to CGM.
    Objective: This work aimed to compare the relationship between CGM parameters and glycated albumin (GA), glycated hemoglobin A1c (HbA1c), and fructosamine for 24 weeks.
    Methods: We conducted exploratory comparative analyses of CGM subgroup data from a previously published 24-week prospective study of assay performance in 8 US clinics. Participants included 34 individuals with type 1 (n = 18) and type 2 diabetes (n = 16) undergoing changes to improve glycemic control (n = 22; group 1) or with stable diabetes therapy (n = 12; group 2). Main outcome measures included Pearson correlations between CGM and glycemic indices and receiver operating characteristic (ROC) analysis of glycemic index values predictive of time in range (TIR) greater than 70%.
    Results: At weeks 4 and 8, GA correlations with TIR were higher than HbA1c correlations in group 1. In group 2, GA correlations with TIR were statistically significant, whereas HbA1c correlations were not. In both groups over the first 12 weeks, GA correlations with TIR were higher than fructosamine-TIR correlations. In the ROC analysis, GA predicted a TIR greater than 70% during weeks 2 to 24 (area under the curve >0.80); HbA1c was predictive during weeks 12 to 24. Cutoff values for TIR greater than 70% were 17.5% (sensitivity and specificity, 0.88) for GA and 7.3% (0.86) for HbA1c.
    Conclusion: GA is the most accurate predictor of TIR over 8 weeks compared with other glycemic indices, which may assist in clinical evaluation of changes in treatment where CGM is not possible and it is too early to use HbA1c (NCT02489773).
    MeSH term(s) Humans ; Glycated Hemoglobin ; Diabetes Mellitus, Type 2/drug therapy ; Fructosamine ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring ; Prospective Studies ; Glycated Serum Albumin ; Glycation End Products, Advanced ; Serum Albumin
    Chemical Substances Glycated Hemoglobin ; Fructosamine (4429-04-3) ; Blood Glucose ; Glycated Serum Albumin ; Glycation End Products, Advanced ; Serum Albumin
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad298
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.134: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Sex differences in cardiometabolic biomarkers during the pre-diabetes stage.

    Yoshida, Yilin / Chen, Zhipeng / Fonseca, Vivian A / Mauvais-Jarvis, Franck

    Diabetes research and clinical practice

    2023  Volume 203, Page(s) 110856

    Abstract: Using two large prospective epidemiological studies in the U.S., we examined biomarkers that reflect sex-specific pathophysiological pathways to cardiovascular complications among people with pre-diabetes. Women with pre-diabetes exhibited higher levels ... ...

    Abstract Using two large prospective epidemiological studies in the U.S., we examined biomarkers that reflect sex-specific pathophysiological pathways to cardiovascular complications among people with pre-diabetes. Women with pre-diabetes exhibited higher levels of adipokines, while men had lower eGFR. Sex differences in lipoproteins and vascular inflammatory markers during pre-diabetes indicate sex-specific lipoprotein and inflammatory mechanisms to cardiovascular complications.
    MeSH term(s) Humans ; Male ; Female ; Prediabetic State/complications ; Prospective Studies ; Sex Characteristics ; Sex Factors ; Biomarkers ; Lipoproteins ; Heart Diseases/complications ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Risk Factors
    Chemical Substances Biomarkers ; Lipoproteins
    Language English
    Publishing date 2023-07-26
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2023.110856
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Sex Differences in Cardiovascular Risk Associated With Prediabetes and Undiagnosed Diabetes.

    Yoshida, Yilin / Chen, Zhipeng / Fonseca, Vivian A / Mauvais-Jarvis, Franck

    American journal of preventive medicine

    2023  Volume 65, Issue 5, Page(s) 854–862

    Abstract: Introduction: Women with Type 2 diabetes (T2D) face up to 50% higher risk of cardiovascular disease than men. This study evaluated the extent to which prediabetes and undiagnosed T2D are associated with a greater excess risk of cardiovascular disease in ...

    Abstract Introduction: Women with Type 2 diabetes (T2D) face up to 50% higher risk of cardiovascular disease than men. This study evaluated the extent to which prediabetes and undiagnosed T2D are associated with a greater excess risk of cardiovascular disease in women versus in men.
    Methods: Data were pooled from 18,745 cardiovascular disease-free individuals from the Atherosclerosis Risk in Communities Study, the Multi-Ethnic Study of Atherosclerosis, and the Jackson Heart Study. The risk of coronary heart disease, ischemic stroke, and atherosclerotic cardiovascular disease (coronary heart disease or stroke) associated with prediabetes or undiagnosed T2D was estimated using Cox models adjusting for sociodemographic factors, concomitant risk factors, medication use, and menopausal status. Data were collected in 2022, and the analysis was performed in 2023.
    Results: During a median follow-up of 18.6 years, the associations between prediabetes and risk of atherosclerotic cardiovascular disease were only significant in women (hazard ratio=1.18, 95% CI=1.01, 1.34, p=0.03) but not in men (hazard ratio=1.08, 95% CI=1.00, 1.28, p=0.06) (p-interaction=0.18). The associations between undiagnosed T2D and cardiovascular disease outcomes were significant in both sexes, but the effect was more pronounced in women (coronary heart disease: hazard ratio=1.83, 95% CI=1.4, 2.41, p<0.0001 in women vs hazard ratio=1.6, 95% CI=1.38, 2.07, p=0.007 in men; stroke: hazard ratio=1.99, 95% CI=1.39, 2.72, p<0.0001 vs hazard ratio=1.81, 95% CI=1.36, 2.6, p<0.0001; atherosclerotic cardiovascular disease: hazard ratio=1.86, 95% CI=1.5, 2.28, p<0.0001 vs hazard ratio=1.65, 95% CI=1.4, 1.98, p<0.0001) (all p-interactions≤0.2). Both White and Black patients exhibit similar sex differences.
    Conclusions: Prediabetes or undiagnosed T2D was associated with a greater excess risk of cardiovascular disease in women than in men. The sex differential in cardiovascular disease risk among those without the T2D diagnosis suggests the need for sex-specific guidelines in T2D screening and treatment.
    Language English
    Publishing date 2023-05-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632646-8
    ISSN 1873-2607 ; 0749-3797
    ISSN (online) 1873-2607
    ISSN 0749-3797
    DOI 10.1016/j.amepre.2023.05.011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2096: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Diabetes control in Asian Americans - Disparities and the role of acculturation.

    Yoshida, Yilin / Fonseca, Vivian A

    Primary care diabetes

    2020  Volume 15, Issue 1, Page(s) 187–190

    Abstract: Asian Americans (AA) are disproportionately affected by diabetes (DM) and its complications than non-Hispanic whites (whites). We examined white-AA disparities in glycemic, cholesterol and blood pressure control, known as 'ABCs of DM', and evaluated if ... ...

    Abstract Asian Americans (AA) are disproportionately affected by diabetes (DM) and its complications than non-Hispanic whites (whites). We examined white-AA disparities in glycemic, cholesterol and blood pressure control, known as 'ABCs of DM', and evaluated if acculturation plays a role in DM control in AA with DM. Using data from NHANES 2011-2016, we found AA patients were significantly less likely to meet glycemic, cholesterol and the collective 'ABCs' goals than their white counterparts. Acculturation was positively associated with glycemic goal achievement in AA patients. This study identified disparities and pointed to strategies related to acculturation to improve DM control for AA.
    MeSH term(s) Acculturation ; Asian Americans ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; European Continental Ancestry Group ; Hispanic Americans ; Humans ; Nutrition Surveys ; United States/epidemiology
    Language English
    Publishing date 2020-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2273997-X
    ISSN 1878-0210 ; 1751-9918
    ISSN (online) 1878-0210
    ISSN 1751-9918
    DOI 10.1016/j.pcd.2020.01.010
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  9. Book: Cardiovascular endocrinology

    Fonseca, Vivian A.

    shared pathways and clinical crossroads

    (Contemporary endocrinology)

    2009  

    Author's details ed. by Vivian A. Fonseca
    Series title Contemporary endocrinology
    Language English
    Size XI, 257 S. : Ill., graph. Darst., 26cm
    Publisher Humana Press
    Publishing place Totowa, N.J
    Publishing country United States
    Document type Book
    HBZ-ID HT015743800
    ISBN 1-588-29850-7 ; 978-1-588-29850-8 ; 9781597451413 ; 159745141X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 5954 order for loan Magazin

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  10. Book: Demystifying incretin therapy for type 2 diabetes

    Fonseca, Vivian A.

    (European journal of internal medicine ; 20, Suppl. 2)

    2009  

    Author's details guest ed. Vivian A. Fonseca
    Series title European journal of internal medicine ; 20, Suppl. 2
    Collection
    Language English
    Size S. S302 - S339 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT016026515
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 2608 -20,Suppl.2- not available for loan Zeitschriften-Lesesaal

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