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  1. Article ; Online: Tall man lettering application in medication information systems as a quality and safety strategy in hospital organization.

    Iglesias Gomez, Ruben / Font Noguera, Isabel / Correa Ballester, Marta / Ruiz Caldes, Maria Jose / Poveda Andres, Jose Luis

    Journal of clinical pharmacy and therapeutics

    2022  Volume 47, Issue 10, Page(s) 1570–1575

    Abstract: What is known and objective: The technique of highlighted capital letters, Tall Man lettering, is a tool that allows differentiating the names of similar drugs in a way that contributes to reduce medication errors related to the drug identification. The ...

    Abstract What is known and objective: The technique of highlighted capital letters, Tall Man lettering, is a tool that allows differentiating the names of similar drugs in a way that contributes to reduce medication errors related to the drug identification. The objective was to implement and monitor the application protocol of the Tall Man lettering tool in drug information systems in the healthcare environment to improve the quality of care and patient safety in the pharmacy service and the medical institution.
    Methods: Scope: Tertiary general hospital with 1000 beds in which a Tall Man lettering application protocol was approved in the pharmacy service information systems.
    Design: Retrospective observational study.
    Period: 2019-2021.
    Population: Information systems and databases used in the pharmacy service. Working group: Made up of people in charge of information areas and systems.
    Implementation: Five phases were defined: organization of the working group, selection of drug names and information systems, establishment of actions, their execution, and results monitoring.
    Variables: Number of pharmaceutical specialties, names of active ingredient and brands incorporated in the information systems.
    Results and discussion: The application of Tall Man lettering was authorized in 13/13 information systems, six have been fully implemented and seven are in the database update phase. Of the implanted systems, a total of 210 drug names have been modified (168/210 active ingredient and 42/210 brand names), corresponding to 659 pharmaceutical specialties.
    What is new and conclusion: The application of Tall Man lettering in hospital information systems is a tool for improving the quality of the pharmacy service and guarantees the safety of medicines in the hospital.
    MeSH term(s) Databases, Factual ; Drug Labeling ; Hospitals ; Humans ; Male ; Medication Errors/prevention & control ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 639006-7
    ISSN 1365-2710 ; 0269-4727
    ISSN (online) 1365-2710
    ISSN 0269-4727
    DOI 10.1111/jcpt.13703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1313: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Monitoring the quality of the hospital pharmacoterapeutic process by sentinel patient program.

    Fernández-Megía, María José / Font Noguera, Isabel / Merino Sanjuán, Matilde / Poveda Andrés, José Luis

    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

    2018  Volume 42, Issue 2, Page(s) 45–52

    Abstract: Objective: To analyze the results of sentinel patient program to monitoring the  quality pharmacoterapeutic process in the hospitalized patient through  medication errors.: Method: Design: Observational, prospective and transversal study. Ambit: ... ...

    Title translation Monitorizacion de la calidad del proceso farmacoterapéutico hospitalario mediante el programa paciente centinela.
    Abstract Objective: To analyze the results of sentinel patient program to monitoring the  quality pharmacoterapeutic process in the hospitalized patient through  medication errors.
    Method: Design: Observational, prospective and transversal study. Ambit: General hospital of 1,000 beds.
    Period: From May 2011 to June 2016.  Sample: Patients with treatment prescribe within 24 hours of being admitted  with 4 or more medications.
    Variables: Medication error, drugs prescribed,  medications and doses dispensing, drugs administered. Safety indicators were  defined based on medication errors at each stage of the pharmacotherapeutic  process.
    Results: Of the 746 patients studied, 334 had at least 1 medication error  (44.8%; IC95%: 41.7-47.8). In the 746 treatments, 564 medication errors were  detected (0.75 errors by patient; IC95%: 0.7-0.8). The safety indicators  (medication error by stage) were: 5.1% (38/746 patients) for omission of  allergy record; 2.3% (156/6 724 drugs) for prescription; 0.6% (38/6 724 drugs)  for validation, 2.6% for dispensing (142/5 465 drugs) y 3.7% (190/5  111 administered drugs observed) for administration. The temporal evolution of  the indicators, with graphs of statistical control showed stable processes, except  for the administration. The proposed improvement actions were of a training,  standardization and organizational type.
    Conclusions: The sentinel patient program provides an overview of the quality  of the pharmacotherapeutic process and promotes the safety culture at the  center. Statistical control charts have been a useful tool for monitoring  medication errors. The analysis of medication errors has served to propose  improvement actions in each stage of the pharmacotherapeutic process.
    MeSH term(s) Drug Hypersensitivity/prevention & control ; Drug Prescriptions/standards ; Humans ; Medication Errors/prevention & control ; Medication Errors/statistics & numerical data ; Patient Safety ; Pharmacy Service, Hospital/organization & administration ; Prospective Studies ; Quality Improvement ; Quality of Health Care
    Language English
    Publishing date 2018-03-01
    Publishing country Spain
    Document type Journal Article ; Observational Study
    ZDB-ID 1122680-8
    ISSN 2171-8695 ; 1130-6343
    ISSN (online) 2171-8695
    ISSN 1130-6343
    DOI 10.7399/fh.10793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3450: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Reduction in alert fatigue in an assisted electronic prescribing system, through the Lean Six Sigma methodology.

    Cuéllar Monreal, Mª Jesús / Reig Aguado, Jorge / Font Noguera, Isabel / Poveda Andrés, José Luis

    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria

    2017  Volume 41, Issue n01, Page(s) 14–30

    Abstract: Objective: To reduce the alert fatigue in our Assisted Electronic Prescribing System (AEPS), through the Lean Six Sigma (LSS) methodology.: Method: An observational (transversal) and retrospective study, in a general hospital with 850 beds and AEPS. ... ...

    Title translation Reducción de la fatiga por alertas en un sistema de prescripción electrónica asistida, mediante la metodología Lean Six Sigma.
    Abstract Objective: To reduce the alert fatigue in our Assisted Electronic Prescribing System (AEPS), through the Lean Six Sigma (LSS) methodology.
    Method: An observational (transversal) and retrospective study, in a general hospital with 850 beds and AEPS. The LSS methodology was followed in order to evaluate the alert fatigue situation in the AEPS system, to implement improvements, and to assess outcomes. The alerts generated during two trimesters studied (before and after the intervention) were analyzed. In order to measure the qualitative indicators, the most frequent alert types were analyzed, as well as the molecules responsible for over 50% of each type of alert. The action by the prescriber was analyzed in a sample of 496 prescriptions that generated such alerts. For each type of alert and molecule, there was a prioritization of the improvements to be implemented according to the alert generated and its quality. A second survey evaluated the pharmacist action for the alerts most highly valued by physicians.
    Results: The problem, the objective, the work team and the project schedule were defined. A survey was designed in order to understand the opinion of the client about the alert system in the program. Based on the surveys collected (n = 136), the critical characteristics and the quanti/qualitative indicators were defined. Sixty (60) fields in the alert system were modified, corresponding to 32 molecules, and this led to a 28% reduction in the total number of alerts. Regarding quality indicators, false po sitive results were reduced by 25% (p < 0.05), 100% of those alerts ignored with justification were sustained, and there were no significant differences in user adherence to the system. The project improvements and outcomes were reviewed by the work team.
    Conclusions: LSS methodology has demonstrated being a valid tool for the quantitative and qualitative improvement of the alert system in an Assisted Electronic Prescription Program, thus reducing alert fatigue.
    MeSH term(s) Clinical Alarms ; Electronic Prescribing ; Fatigue/psychology ; Humans ; Pharmacy Service, Hospital/organization & administration ; Quality Improvement ; Retrospective Studies ; Total Quality Management
    Language English
    Publishing date 2017-01-01
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1122680-8
    ISSN 0214-753X ; 2171-8695 ; 1130-6343
    ISSN (online) 0214-753X ; 2171-8695
    ISSN 1130-6343
    DOI 10.7399/fh.2017.41.1.10434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3450: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Baricitinib against severe COVID-19: effectiveness and safety in hospitalised pretreated patients.

    Iglesias Gómez, Rubén / Méndez, Raúl / Palanques-Pastor, Tomás / Ballesta-López, Octavio / Borrás Almenar, Conxa / Megías Vericat, Juan Eduardo / López-Briz, Eduardo / Font-Noguera, Isabel / Menéndez Villanueva, Rosario / Román Iborra, José Andrés / Poveda Andrés, José Luis

    European journal of hospital pharmacy : science and practice

    2021  Volume 29, Issue e1, Page(s) e41–e45

    Abstract: Objectives: To analyse the effectiveness and safety of baricitinib for severe COVID-19 in cytokine storm syndrome based on its potential role as an anti-inflammatory immunomodulator and inhibitor of viral endocytosis.: Methods: This was an ... ...

    Abstract Objectives: To analyse the effectiveness and safety of baricitinib for severe COVID-19 in cytokine storm syndrome based on its potential role as an anti-inflammatory immunomodulator and inhibitor of viral endocytosis.
    Methods: This was an observational retrospective study of hospitalised patients treated with baricitinib for severe COVID-19. Outcomes were clinical improvement on an ordinal scale of 1-8 on day 1 of baricitinib compared with day 14 (where 8=death and 1=not hospitalised with no limitations of activities), overall survival, time to recovery since baricitinib treatment started (days until hospital discharge) and laboratory parameters related to COVID-19 poor prognosis. Adverse events related to baricitinib during the admission period were also reported.
    Results: Forty-three patients (70% men, mean age 70 years (IQR 54-79)) treated with baricitinib daily for 6 days (IQR 5-7) were included. Thirty-six patients were treated with corticosteroids (84%). Clinical improvement was 3 points (IQR 1-4) in patients on an ordinal scale of 4-6, overall survival was 100% at day 30 and day 60 with a mean time to recovery of 12 days (IQR 9-25) from start of baricitinib treatment. No adverse events of interest were found and all poor prognosis risk factors improved at day 14: interleukin-6, C-reactive protein, ferritin, lymphocytes, platelets and D-dimers.
    Conclusions: Patients treated with baricitinib for severe COVID-19 showed improvements in clinical and analytical values without relevant adverse events and 100% overall survival. Clinical randomised trials are needed to confirm the clinical benefit of baricitinib.
    MeSH term(s) Aged ; Azetidines ; COVID-19/drug therapy ; Female ; Humans ; Male ; Purines ; Pyrazoles ; Retrospective Studies ; SARS-CoV-2 ; Sulfonamides
    Chemical Substances Azetidines ; Purines ; Pyrazoles ; Sulfonamides ; baricitinib (ISP4442I3Y)
    Language English
    Publishing date 2021-07-28
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2650179-X
    ISSN 2047-9964 ; 2047-9956
    ISSN (online) 2047-9964
    ISSN 2047-9956
    DOI 10.1136/ejhpharm-2021-002741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Study on the Linezolid Prescription According to the Approval of Indication in a University Hospital.

    Pérez-Cebrián, Manuela / Suárez-Varela, María M Morales / Font-Noguera, Isabel / Monte-Boquet, Emilio / Poveda-Andrés, Jose Luís / Martín-Moreno, Jose María / Rubio-López, Nuria / Ruiz-Rojo, Elias / Llopis-González, Agustín

    Iranian journal of pharmaceutical research : IJPR

    2015  Volume 14, Issue 3, Page(s) 857–864

    Abstract: Indications for linezolid use are nosocomial or community-acquired pneumonia and skin infections or soft tissue infection caused by gram-positive microorganisms, but new recommendations may emerge. It is important to balance benefits with risks because ... ...

    Abstract Indications for linezolid use are nosocomial or community-acquired pneumonia and skin infections or soft tissue infection caused by gram-positive microorganisms, but new recommendations may emerge. It is important to balance benefits with risks because severe adverse events have been described in patients taking linezolid treatment. Accordingly, we evaluated the suitability of linezolid prescription according to approval of indication by evaluating the presence of drug-related problems (DRP) in a University hospital. DRP were identified in 36 patients (50.0%). In most cases, they were related to known or established indications (15 patients, 20.8%), to safety (5 patients, 6.9%), and to both in others (16 patients, 22.2%). No DRP were recorded, which modified linezolid efficacy. DRP were significantly higher in the patients treated by an approved indication in Spain (63.3%) than in those treated by an unapproved indication in Spain (28.6%). We concluded that new studies about extending linezolid indications may be necessary.
    Language English
    Publishing date 2015-08-26
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2578271-X
    ISSN 1726-6890 ; 1735-0328 ; 1735-0328
    ISSN (online) 1726-6890 ; 1735-0328
    ISSN 1735-0328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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