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  1. Book ; Online: Chapter Another Sicily, tuna-fishing structures and landscape: a diachronic and contemporary photographic journey along the Sicilian western coast

    FONTANA, MAURO

    (Proceedings e report)

    2020  

    Series title Proceedings e report
    Keywords Sicily ; Landscape ; Photography ; Architectural heritage ; Landscape Heritage ; Tonnare ; Tradition ; Tuna-fishing
    Language 0|e
    Size 1 electronic resource (10 pages)
    Publisher Firenze University Press
    Publishing place Florence
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021614165
    ISBN 9788855181471 ; 8855181475
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The changing landscape of heart failure treatment in transthyretin amyloid cardiomyopathy: Is the time ripe for clinical use of sodium-glucose cotransporter 2 inhibitors?

    Porcari, Aldostefano / Fontana, Marianna

    European journal of heart failure

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Editorial
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.3245
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chapter 8: Risk Assessment: Considerations for Coronal Caries.

    Campos, Marcia S / Fontana, Margherita

    Monographs in oral science

    2023  Volume 31, Page(s) 115–128

    Abstract: Caries risk assessment (CRA) is essential to delivering personalized/precision care in caries management. Limited formal evaluation and validation of existing CRA tools affects the ability to accurately predict new lesions. However, this should not ... ...

    Abstract Caries risk assessment (CRA) is essential to delivering personalized/precision care in caries management. Limited formal evaluation and validation of existing CRA tools affects the ability to accurately predict new lesions. However, this should not prevent clinicians from assessing modifiable risk factors to guide preventive measures and address individual needs to personalize care. Since caries is a multifactorial and dynamic disease process, CRA is complex and impacted by multiple variables throughout the life course, demanding periodic re-assessment. Many factors can influence caries risk at the individual, family, and community level; however, unfortunately, caries experience is still considered one of the greatest indicators of future risk for caries. CRA tools that are validated, inexpensive, and easy to use should be developed and prioritized to help support decision-making to implement evidence based, and minimally invasive caries management strategies for coronal caries lesions in children, adults, and older persons. Efforts into developing CRA tools should include evaluation and reporting of internal and external validation information. In the future, approaches using big data and artificial intelligence may drive risk predictions, and cost-effectiveness analyses may help derive the selection of appropriate risk thresholds for decision-making. Because of the importance of CRA in the treatment planning and decision-making process, challenges for implementation including how to communicate risk to drive behavior change, development of tools that are quick and easy to integrate seamlessly into the busy clinical flow, and reimbursement for the time needed to implement should be considered.
    MeSH term(s) Adult ; Child ; Humans ; Aged ; Aged, 80 and over ; Artificial Intelligence ; Dental Caries Susceptibility ; Dental Caries/diagnosis ; Dental Caries/prevention & control ; Risk Assessment ; Risk Factors
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-3843
    ISSN (online) 1662-3843
    DOI 10.1159/000530563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Nonrestorative Management of Cavitated and Noncavitated Caries Lesions.

    Fontana, Margherita

    Dental clinics of North America

    2019  Volume 63, Issue 4, Page(s) 695–703

    Abstract: The objective of this article is to review evidence-based strategies available for the nonrestorative management of caries lesions, both cavitated and noncavitated. The goal is to help clinicians make appropriate decisions regarding nonrestorative ... ...

    Abstract The objective of this article is to review evidence-based strategies available for the nonrestorative management of caries lesions, both cavitated and noncavitated. The goal is to help clinicians make appropriate decisions regarding nonrestorative management of caries lesions. In addition, in the decision-making process, clinicians must consider thresholds for restorative and nonrestorative care and strategies for nonrestorative management that are supported by best available evidence. It is important that this information be considered taking into account a provider's clinical expertise and a patient's treatment needs and preferences, in order to maintain health and preserve tooth structure.
    MeSH term(s) Dental Caries ; Humans ; Tooth
    Language English
    Publishing date 2019-07-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 392075-6
    ISSN 1558-0512 ; 0011-8532
    ISSN (online) 1558-0512
    ISSN 0011-8532
    DOI 10.1016/j.cden.2019.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Thesis ; Online: On the interaction between ARFs and AuxREs

    Fontana, Mattia

    from methods to models

    2021  

    Abstract: The plant hormone auxin is a key regulator of many growth and developmental processes. The presence of auxin changes the gene expression of the cell via a short pathway called the nuclear auxin pathway (NAP). The NAP contains three players: TIR1/AFB, Aux/ ...

    Abstract The plant hormone auxin is a key regulator of many growth and developmental processes. The presence of auxin changes the gene expression of the cell via a short pathway called the nuclear auxin pathway (NAP). The NAP contains three players: TIR1/AFB, Aux/IAA and the transcription factor ARF. Under conditions of low auxin, Aux/IAA binds ARF repressing it. At higher concentrations of auxin, TIR1/AFB binds Aux/IAA and marks it for degradation, thereby freeing ARF. Members of the ARF family bind a DNA motif called AuxRE (TGTCTC) and their DNA binding domains (DBDs) are known to dimerize and bind cooperatively on response elements composed by two AuxREs present in an inverted orientation. Although the affinities at play inside the NAP and between ARFs and AuxREs had been studied extensively with a range of techniques, a quantitative view on this system was still lacking. Throughout this thesis, we therefore developed and applied methods with the goal of obtaining a quantitative understanding of ARF-ARF and ARF-AuxRE interactions.In chapter 2 we developed and utilized a method based on smFRET and smPIFE-FRET to study the interaction between ARF and composite DNA response elements. We tested several A. thaliana ARF-DBDs and showed that the differences in binding stability and kinetics are quantitatively captured by the method. The smFRET and smPIFE-FRET experiments in which the affinity of a DNA-binding deficient mutant of AtARF5-DBD (R215A) was probed, proved that the shift in FRET efficiency seen when wt AtARF5-DBD is added in concentration of tens on nM is due to the specific protein interaction with the DNA motif. We then tested the binding preferences of Marchantia polymorpha ARF1 and ARF2, which are, respectively, the only members of the phylogenetically conserved class A-ARF and B-ARF in the species. Whereas A-ARFs are considered activators, B-ARFs are considered repressors. In M. polymorpha, a mechanism in which B-ARFs repression is based on competition for the same AuxREs bound by A-ARFs had been proposed as ...
    Keywords Life Science
    Subject code 612
    Language English
    Publisher Wageningen University
    Publishing country nl
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Caries Management in Special Care Dentistry.

    Campos, Marcia S / Fontana, Margherita

    Dental clinics of North America

    2022  Volume 66, Issue 2, Page(s) 169–179

    Abstract: The objective of this article is to provide a summary of the current evidence-based recommendations for caries management in patients with special health care needs (SHCNs). Considerations regarding caries risk assessment and preventive measures are also ...

    Abstract The objective of this article is to provide a summary of the current evidence-based recommendations for caries management in patients with special health care needs (SHCNs). Considerations regarding caries risk assessment and preventive measures are also discussed with the goal of helping clinicians to manage the caries disease process using a person-centered approach and risk-based interventions. Importantly, most of the evidence is still based on the general population, because the evidence for those with SHCNs is still limited.
    MeSH term(s) Dental Caries/etiology ; Dental Caries/prevention & control ; Dental Caries Susceptibility ; Dentistry ; Humans ; Risk Assessment
    Language English
    Publishing date 2022-03-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 392075-6
    ISSN 1558-0512 ; 0011-8532
    ISSN (online) 1558-0512
    ISSN 0011-8532
    DOI 10.1016/j.cden.2021.12.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Optimizing the Timing of Aortic Valve Surgery: A Multiparametric Approach.

    Fontana, Marianna / Ioannou, Adam

    Circulation. Cardiovascular imaging

    2022  Volume 15, Issue 12, Page(s) e015004

    MeSH term(s) Humans ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Insufficiency/surgery ; Transcatheter Aortic Valve Replacement
    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 2435045-X
    ISSN 1942-0080 ; 1941-9651
    ISSN (online) 1942-0080
    ISSN 1941-9651
    DOI 10.1161/CIRCIMAGING.122.015004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6743: Show issues Location:
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  8. Article ; Online: Assessment of potential maladaptive pain in dogs with elbow osteoarthritis using a von Frey aesthesiometer.

    Dalla Fontana, Maria / Anesi, Simone / Czopowicz, Michal / Corr, Sandra A

    The Veterinary record

    2024  , Page(s) e4043

    Abstract: Background: This study aimed to investigate the possible presence of maladaptive pain in the thoracic limbs of dogs with elbow osteoarthritis (OA) using an electronic von Frey aesthesiometer (eVFA).: Methods: Twenty-eight client- and staff-owned dogs ...

    Abstract Background: This study aimed to investigate the possible presence of maladaptive pain in the thoracic limbs of dogs with elbow osteoarthritis (OA) using an electronic von Frey aesthesiometer (eVFA).
    Methods: Twenty-eight client- and staff-owned dogs (OA, n = 14; controls, n = 14) were enrolled in the study. Every dog underwent a full orthopaedic examination, and then five von Frey measurements were obtained from each carpal pad of each dog. A maximum test threshold of 400 g was set and approved by an ethics committee.
    Results: eVFA thresholds were significantly lower (p < 0.001) in dogs with OA (median 248 g, range 128-369 g) than in control dogs (median 390 g, range 371-400 g). In the OA group, the sensory threshold was significantly lower (p = 0.048) in the more severely affected limb than the less severely affected limb.
    Limitation: The low maximum threshold required for ethical approval may influence the variability in the control group.
    Conclusions: Dogs with elbow OA had significantly lower sensory thresholds than control dogs, which is compatible with the presence of maladaptive pain, potentially due to central sensitisation. Further research is required to evaluate the potential use of the eVFA for monitoring clinical progression and treatment response in dogs with elbow OA.
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 390015-0
    ISSN 2042-7670 ; 0042-4900
    ISSN (online) 2042-7670
    ISSN 0042-4900
    DOI 10.1002/vetr.4043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 645: Show issues Location:
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  9. Article ; Online: Standardising Care and Treatment of Transthyretin Amyloid Cardiomyopathy.

    Fontana, Marianna / Porcari, Aldostefano / Hawkins, Philip N

    Global heart

    2023  Volume 18, Issue 1, Page(s) 63

    Abstract: Transthyretin cardiac amyloidosis (ATTR-CA) has been traditionally considered a rare and inexorably fatal condition. ATTR-CA now is an increasingly recognised cause of heart failure and mortality worldwide with effective pharmacological treatments. ... ...

    Abstract Transthyretin cardiac amyloidosis (ATTR-CA) has been traditionally considered a rare and inexorably fatal condition. ATTR-CA now is an increasingly recognised cause of heart failure and mortality worldwide with effective pharmacological treatments. Advances in non-invasive diagnosis, coupled with the development of effective treatments, have transformed the diagnosis of ATTR-CA, which is now possible without recourse to endomyocardial biopsy in around 70% of cases. Many patients are now diagnosed at an earlier stage. Echocardiography and cardiac magnetic resonance have enabled identification of patients with possible ATTR-CA and more accurate prognostic stratification. Therapies able to slow or halt ATTR-CA progression and increase survival are now available and there is also evidence that patients may benefit from specific conventional heart failure medications. A wide horizon of possibilities is unfolding and awaits discovery.
    MeSH term(s) Humans ; Prealbumin/genetics ; Amyloidosis/diagnosis ; Amyloidosis/therapy ; Heart Failure/diagnosis ; Heart Failure/etiology ; Heart Failure/therapy ; Prognosis ; Cardiomyopathies/diagnosis ; Cardiomyopathies/therapy
    Chemical Substances Prealbumin
    Language English
    Publishing date 2023-11-20
    Publishing country England
    Document type Editorial
    ZDB-ID 2629633-0
    ISSN 2211-8179 ; 2211-8160
    ISSN (online) 2211-8179
    ISSN 2211-8160
    DOI 10.5334/gh.1275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Non-invasive left ventricle pressure-volume loops: a new tool to track treatment response in cardiac transthyretin amyloidosis?

    Fontana, Marianna / Ioannou, Adam / Bandera, Francesco

    European journal of heart failure

    2023  Volume 25, Issue 5, Page(s) 737–739

    MeSH term(s) Humans ; Heart Ventricles/diagnostic imaging ; Heart Failure/etiology ; Amyloid Neuropathies, Familial/drug therapy ; Heart ; Cardiomyopathies/drug therapy
    Language English
    Publishing date 2023-04-10
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1483672-5
    ISSN 1879-0844 ; 1388-9842
    ISSN (online) 1879-0844
    ISSN 1388-9842
    DOI 10.1002/ejhf.2841
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