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  1. Article ; Online: Train your T cells: How skeletal muscles and T cells keep each other fit during aging.

    Slaets, Helena / Fonteyn, Lena / Eijnde, Bert O / Hellings, Niels

    Brain, behavior, and immunity

    2023  Volume 110, Page(s) 237–244

    Abstract: Frailty and a failing immune system lead to significant morbidities in the final years of life and bring along a significant burden on healthcare systems. The good news is that regular exercise provides an effective countermeasure for losing muscle ... ...

    Abstract Frailty and a failing immune system lead to significant morbidities in the final years of life and bring along a significant burden on healthcare systems. The good news is that regular exercise provides an effective countermeasure for losing muscle tissue when we age while supporting proper immune system functioning. For a long time, it was assumed that exercise-induced immune responses are predominantly mediated by myeloid cells, but it has become evident that they receive important help from T lymphocytes. Skeletal muscles and T cells interact, not only in muscle pathology but also during exercise. In this review article, we provide an overview of the most important aspects of T cell senescence and discuss how these are modulated by exercise. In addition, we describe how T cells are involved in muscle regeneration and growth. A better understanding of the complex interactions between myocytes and T cells throughout all stages of life provides important insights needed to design strategies that effectively combat the wave of age-related diseases the world is currently faced with.
    MeSH term(s) T-Lymphocytes ; Muscle, Skeletal/physiology ; Exercise/physiology
    Language English
    Publishing date 2023-03-07
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2023.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis.

    Spaas, Jan / Goulding, Richie P / Keytsman, Charly / Fonteyn, Lena / van Horssen, Jack / Jaspers, Richard T / Eijnde, Bert O / Wüst, Rob C I

    Journal of cachexia, sarcopenia and muscle

    2022  Volume 13, Issue 5, Page(s) 2537–2550

    Abstract: Background: Patients with multiple sclerosis (MS) experience reduced exercise tolerance that substantially reduces quality of life. The mechanisms underpinning exercise intolerance in MS are not fully clear. This study aimed to determine the ... ...

    Abstract Background: Patients with multiple sclerosis (MS) experience reduced exercise tolerance that substantially reduces quality of life. The mechanisms underpinning exercise intolerance in MS are not fully clear. This study aimed to determine the contributions of the cardiopulmonary system and peripheral muscle in MS-induced exercise intolerance before and after exercise training.
    Methods: Twenty-three patients with MS (13 women) and 20 age-matched and sex-matched healthy controls (13 women) performed a cardiopulmonary exercise test. Muscle fibre type composition, size, succinate dehydrogenase (SDH) activity, capillarity, and gene expression and proteins related to mitochondrial density were determined in vastus lateralis muscle biopsies. Nine MS patients (five women) were re-examined following a 12 week exercise training programme consisting of high-intensity cycling interval and resistance training.
    Results: Patients with MS had lower maximal oxygen uptake compared with healthy controls (V̇O
    Conclusions: Skeletal muscle oxidative phenotype (mitochondrial complex I and II content, SDH activity) is lower in patients with MS, contributing to reduced exercise tolerance. However, skeletal muscle mitochondria appeared resistant to the beneficial effects of exercise training, suggesting that other physiological systems, at least in part, drive the improvements in exercise capacity following exercise training in MS.
    MeSH term(s) Exercise ; Exercise Tolerance/physiology ; Female ; Humans ; Male ; Multiple Sclerosis/metabolism ; Muscle, Skeletal/metabolism ; Oxidative Stress ; Oxygen/metabolism ; Oxygen Consumption/physiology ; PPAR gamma/metabolism ; Phenotype ; Quality of Life ; Succinate Dehydrogenase/metabolism
    Chemical Substances PPAR gamma ; Succinate Dehydrogenase (EC 1.3.99.1) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-08-04
    Publishing country Germany
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.13050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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