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  1. Book ; Online: Suite on Spiritus Silvestre: For Symphony

    Ford, Denzil

    2012  

    Abstract: Charles D. Keeling, climate science, oceanography, ... ...

    Abstract Charles D. Keeling, climate science, oceanography, music
    Keywords Music
    Size 1 electronic resource (44 p.)
    Publisher punctum books
    Publishing place Verlagsort nicht ermittelbar
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020195681
    ISBN 9780615747101 ; 0615747108
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Micrometers.

    Ford, D R

    The Bistoury

    2023  Volume 21, Issue 2, Page(s) 140–141

    Language English
    Publishing date 2023-04-13
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The effect of value on context and target recollection in memory for truth and falsity.

    Ford, Daria / Nieznański, Marek

    Memory & cognition

    2024  

    Abstract: Memory for truth and falsity has recently been investigated from the perspective of the dual-recollection theory, showing better context and target recollection for truth than falsity. In this paper, we examine whether these memory effects obtained for ... ...

    Abstract Memory for truth and falsity has recently been investigated from the perspective of the dual-recollection theory, showing better context and target recollection for truth than falsity. In this paper, we examine whether these memory effects obtained for true statements are similar to the value effect, whereby true statements are given higher priority in encoding. For this purpose, we implemented value-directed remembering (VDR) into the conjoint-recognition paradigm. In our first experiment, the primary goal was to verify how VDR influences the processes defined by dual-recollection theory. At study, prioritized/important items were linked to higher numerical values (e.g., 10), while unimportant ones had lower values (e.g., 1). At test, the participants' task was to recognize whether a particular sentence was important, unimportant, or new. We found that both context and target recollection were better for important items. In the second experiment, the main goal was to study the combined effects of importance and veracity on memory. In the between-subjects design, participants were monetarily rewarded for memorizing true or false sentences. The results demonstrated differences in the ability to prioritize truth over falsity. Specifically, we found a substantial increase in context recollection for prioritized true information but not for prioritized false information. Moreover, we found higher context recollection for true than false sentences in the true-prioritized condition, but not in the false-prioritized condition. These results indicated that people are able to prioritize true information better than false, and suggested that memory for truth may be a special case of the value effect.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 185691-1
    ISSN 1532-5946 ; 0090-502X
    ISSN (online) 1532-5946
    ISSN 0090-502X
    DOI 10.3758/s13421-024-01554-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ribosomal heterogeneity - A new inroad for pharmacological innovation.

    Ford, Dianne

    Biochemical pharmacology

    2020  Volume 175, Page(s) 113874

    Abstract: The paradigm of ribosome usage in protein translation has shifted from a stance proposed as scientists began to unpick the genetic code that each mRNA was partnered by its own, unique ribosome to a rapid reversal of this view that ribosomes are ... ...

    Abstract The paradigm of ribosome usage in protein translation has shifted from a stance proposed as scientists began to unpick the genetic code that each mRNA was partnered by its own, unique ribosome to a rapid reversal of this view that ribosomes are completely interchangeable and simply recruited to mRNAs from a completely homogenous cellular pool. Evidence that the ribosomal proteome, ribosomal gene transcriptome and ribosome protein and RNA modifications differ between cells and tissues points to the fact that ribosomes are heterogeneous in their composition and have a degree of specialisation in their function. It has also been posited that the tissue-specificity of ribosome diseases provides an indication of functional ribosome heterogeneity, but there are substantial caveats to this interpretation. Only now have proteomic technologies developed to a level enabling accurate stoichiometric comparison of the abundance of specific ribosomal proteins in actively translating ribosomes and to measure protein in non-denatured ribosomes. This poises the field for the provocation that ribosome heterogeneity offers a novel and powerful inroad for the pharmacological targeting of disease. Such ribosome-targeted treatments may extend beyond specific ribosomopathies through strategies such as targeting features of ribosomes that are unique to diseased cells, particularly cancer cells, or to activated immune cells, as well as augmenting the action of other drugs through weakening the production of new proteins in target tissues. We may also be able to harness the potential power in ribosome diversity and specialism to better tune synthetic biology for the production of pharmaceutical proteins.
    MeSH term(s) Animals ; Drug Therapy ; Genetic Heterogeneity/drug effects ; Humans ; Protein Biosynthesis ; Protein Processing, Post-Translational/drug effects ; Proteome/genetics ; Proteomics ; RNA, Ribosomal/genetics ; Ribosomal Proteins/biosynthesis ; Ribosomal Proteins/genetics ; Ribosomal Proteins/metabolism ; Ribosomes/genetics ; Ribosomes/metabolism ; Transcriptome/genetics
    Chemical Substances Proteome ; RNA, Ribosomal ; Ribosomal Proteins
    Language English
    Publishing date 2020-02-24
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2020.113874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Sustainable Digital Health Demands Cybersecurity Transformation.

    DeFord, Drexel

    Frontiers of health services management

    2022  Volume 38, Issue 3, Page(s) 31–38

    Abstract: Summary: Technology has become a mission-critical part of healthcare business operations. The electronic health record, medical equipment, revenue cycle, enterprise resource planning, marketing, legal, planning and building new facilities… every ... ...

    Abstract Summary: Technology has become a mission-critical part of healthcare business operations. The electronic health record, medical equipment, revenue cycle, enterprise resource planning, marketing, legal, planning and building new facilities… every component today is dependent on automated tools. When computer systems go offline, everyone feels the stress of conducting business and delivering care without access to all the information they need. Downtimes are especially dangerous for patients.While there are many reasons that these systems go offline, cybersecurity breaches are primary culprits. Logically then, digital innovation becomes unsustainable in healthcare without cybersecurity transformation. What was good enough at one time is not acceptable anymore. As healthcare has accelerated toward digital dependence, particularly through the COVID-19 pandemic, cybersecurity threats have also increased. The time to transform cybersecurity is now.The first thing for healthcare leaders to understand is this: You do not have a malware problem or a ransomware problem-you have a cybersecurity adversary problem. It is important to learn everything about the organizations attacking you, including their structure, motivation, and goals. Armed with those insights, you are more likely to be able to defend your health system. By transforming your cybersecurity program, you will build a foundation on which you can thrive as a modern healthcare operation.
    MeSH term(s) COVID-19 ; Computer Security ; Electronic Health Records ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632858-1
    ISSN 0748-8157
    ISSN 0748-8157
    DOI 10.1097/HAP.0000000000000137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Scoping Review of the Biological, Socioeconomic and Environmental Determinants of Overweight and Obesity Among Middle Eastern and Northern African Nationalities.

    Valdez, Glenn Ford D / Ajzoon, Muna / Zuwameri, Noor Al

    Sultan Qaboos University medical journal

    2024  Volume 24, Issue 1, Page(s) 20–27

    Abstract: Objectives: Globally, and particularly in the Middle East and North Africa (MENA) region, overweight and obesity have become serious public health concerns. This scoping review aimed to identify and summarise the available data on the determinants of ... ...

    Abstract Objectives: Globally, and particularly in the Middle East and North Africa (MENA) region, overweight and obesity have become serious public health concerns. This scoping review aimed to identify and summarise the available data on the determinants of overweight and obesity among MENA nationalities.
    Methods: An extensive search of electronic databases, including Google Scholar, PubMed and ProQuest, for articles published from 2007 until 2022 was conducted. A total of 10 articles, of the 333 that were found in the original search, met the inclusion criteria. Data extraction and quality assessment were applied to each of the selected studies.
    Results: There is an intricate interplay of anthropometric, behavioural, sociodemographic and environmental factors that caused overweight and obesity in this population.
    Conclusions: A thorough synthesis of the factors influencing overweight and obesity in MENA nationalities was provided by this scoping review.
    MeSH term(s) Humans ; Overweight/epidemiology ; Overweight/etiology ; Obesity/epidemiology ; Anthropometry ; Middle East/epidemiology ; Socioeconomic Factors
    Language English
    Publishing date 2024-02-28
    Publishing country Oman
    Document type Journal Article ; Review
    ZDB-ID 2650196-X
    ISSN 2075-0528 ; 2075-0528
    ISSN (online) 2075-0528
    ISSN 2075-0528
    DOI 10.18295/squmj.10.2023.059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Optimising Health-Related Quality of Life in Children With Osteogenesis Imperfecta.

    Hill, Claire L / Ford, Davina / Baker, Jill

    Calcified tissue international

    2024  

    Abstract: Osteogenesis Imperfecta is a rare, hereditary bone condition with an incidence of 1/15,000-20,000. Symptoms include bone fragility, long bone deformity, scoliosis, hypermobility, alongside secondary features such as short stature, basilar invagination, ... ...

    Abstract Osteogenesis Imperfecta is a rare, hereditary bone condition with an incidence of 1/15,000-20,000. Symptoms include bone fragility, long bone deformity, scoliosis, hypermobility, alongside secondary features such as short stature, basilar invagination, pulmonary and cardiac complications, hearing loss, dentinogenesis imperfecta and malocclusion. Osteogenesis Imperfecta can have a large impact on the child and their family; this impact starts immediately after diagnosis. Fractures, pain, immobility, hospital admissions and the need for equipment and adaptations all influence the health-related quality of life of the individual and their family. This narrative review article aims to examine the impact the diagnosis and management of osteogenesis imperfecta has on the health-related quality of life of a child. It will touch on the effect this may have on the quality of life of their wider family and friends and identify strategies to optimise health-related quality of life in this population. Optimising health-related quality of life in children with Osteogenesis Imperfecta is often a complicated, multifaceted journey that involves the child, their extended family, school, extracurricular staff and numerous health professionals.
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 304266-2
    ISSN 1432-0827 ; 0944-0747 ; 0008-0594 ; 0171-967X
    ISSN (online) 1432-0827
    ISSN 0944-0747 ; 0008-0594 ; 0171-967X
    DOI 10.1007/s00223-024-01205-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 317: Show issues Location:
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  8. Article ; Online: The evolution of familial polyposis coli.

    Ford, Debra

    American journal of surgery

    2018  Volume 215, Issue 6, Page(s) 1066–1067

    MeSH term(s) Adenomatous Polyposis Coli/genetics ; Adenomatous Polyposis Coli/surgery ; Digestive System Surgical Procedures/methods ; Disease Management ; Genotype ; Humans
    Language English
    Publishing date 2018-03-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2953-1
    ISSN 1879-1883 ; 0002-9610
    ISSN (online) 1879-1883
    ISSN 0002-9610
    DOI 10.1016/j.amjsurg.2018.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.42: Show issues Location:
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  9. Book ; Online: Assimilating synthetic Biogeochemical-Argo and ocean colour observations into a global ocean model to inform observing system design

    Ford, David

    eISSN: 1726-4189

    2020  

    Abstract: A set of observing system simulation experiments has been performed to explore the impact on global ocean biogeochemical reanalyses of assimilating chlorophyll from remotely sensed ocean colour, and assess the potential impact of assimilating in situ ... ...

    Abstract A set of observing system simulation experiments has been performed to explore the impact on global ocean biogeochemical reanalyses of assimilating chlorophyll from remotely sensed ocean colour, and assess the potential impact of assimilating in situ observations of chlorophyll, nitrate, oxygen, and pH from a proposed array of Biogeochemical-Argo (BGC-Argo) floats. Two different potential BGC-Argo array distributions were tested: one where biogeochemical sensors are placed on all current Argo floats, and one where biogeochemical sensors are placed on a quarter of current Argo floats. This latter approximately corresponds to the proposed BGC-Argo array of 1000 floats. Different strategies for updating model variables when assimilating ocean colour were assessed. All similarly improved the assimilated variable surface chlorophyll, but had a mixed impact on the wider ecosystem and carbon cycle, degrading some key variables of interest. Assimilating BGC-Argo data gave no added benefit over ocean colour in terms of simulating surface chlorophyll, but for most other variables, including sub-surface chlorophyll, adding BGC-Argo greatly improved results throughout the water column. This included surface partial pressure of carbon dioxide (pCO 2 ), which was not assimilated but is an important output of reanalyses. Both BGC-Argo array distributions gave benefits, with greater improvements seen with more observations. From the point of view of ocean reanalysis, it is recommended to proceed with development of BGC-Argo as a priority. The proposed array of 1000 floats will lead to clear improvements in reanalyses, with a larger array likely to bring further benefits. The ocean colour satellite observing system should also be maintained, as ocean colour and BGC-Argo will provide complementary benefits. There is also much potential to improve the use of existing observations, particularly in terms of multivariate balancing, through improving assimilation methodologies.
    Subject code 551
    Language English
    Publishing date 2020-05-15
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A systems-approach to NAD+ restoration.

    Conlon, Nichola / Ford, Dianne

    Biochemical pharmacology

    2022  Volume 198, Page(s) 114946

    Abstract: A decline in NAD+ is a feature of ageing and may play a causal role in the process. NAD+ plays a pivotal role in myriad processes important in cellular metabolism and is a cosubstrate for enzymes that play key roles in pathways that modify ageing. Thus, ... ...

    Abstract A decline in NAD+ is a feature of ageing and may play a causal role in the process. NAD+ plays a pivotal role in myriad processes important in cellular metabolism and is a cosubstrate for enzymes that play key roles in pathways that modify ageing. Thus, interventions that increase NAD+ may slow aspects of the ageing trajectory and there is great interest in pharmacological NAD+ restoration. Dietary supplementation with NAD+ precursors, particularly nicotinamide riboside, has increased NAD+ levels in several human intervention studies and arguably been the most robust approach to date. However, consistency and reliability of such approaches to increase NAD+, and also impact on markers of efficacy to slow or reverse features of ageing, has been inconsistent. We argue that a major element of this variability may arise from the use of single-target approaches that do not consider the underlying biological complexity leading to NAD+ decline. Thus, a systems approach - targeting multiple key nodes in the NAD+ interactome - is likely to be more efficacious and reliable.
    MeSH term(s) Aging ; Humans ; NAD/metabolism ; Niacinamide/metabolism ; Niacinamide/pharmacology ; Reproducibility of Results
    Chemical Substances NAD (0U46U6E8UK) ; Niacinamide (25X51I8RD4)
    Language English
    Publishing date 2022-02-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208787-x
    ISSN 1873-2968 ; 0006-2952
    ISSN (online) 1873-2968
    ISSN 0006-2952
    DOI 10.1016/j.bcp.2022.114946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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