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Book ; Conference proceedings: Frontiers in disease prevention

Ford, Daniel E.

(Journal of general internal medicine ; 5,5, Suppl.)

1990

Event/congress	Conference Frontiers in Disease Prevention (1989, BaltimoreMd.)
Author's details	[Conference Frontiers in Disease Prevention]: National Conference on the Impacts of the U.S. Preventive Services Task Force Guidelines, 5 - 6 June 1989, [Baltimore, Md.]. Course directors: Daniel E. Ford
Series title	Journal of general internal medicine ; 5,5, Suppl.
Collection
Keywords	Preventive Medicine / congresses
Size	S139 S. : graph. Darst.
Publisher	Hanley & Belfus
Publishing place	Philadelphia, Pa
Publishing country	United States
Document type	Book ; Conference proceedings
Note	Auf dem Umschlag fälschl. als 4,6, Suppl. bezeichnet
HBZ-ID	HT003649259
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
Zs A 2205 -5,5,Suppl.-	verfügbar in Königswinter	Königswinter

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Article ; Online: Approaches to Measuring Trends in Interdisciplinary Research Publications at One Academic Medical Center.

Weston, Christine M / Terkowitz, Mia S / Thompson, Carol B / Ford, Daniel E

Academic medicine : journal of the Association of American Medical Colleges

2021 Volume 95, Issue 4, Page(s) 637–643

Abstract: Purpose: To determine if interdisciplinary research has increased between 2005 and 2015, based on an analysis of journal articles containing at least 1 author from Johns Hopkins University, and to compare different methods for determining the ... ...

Abstract	Purpose: To determine if interdisciplinary research has increased between 2005 and 2015, based on an analysis of journal articles containing at least 1 author from Johns Hopkins University, and to compare different methods for determining the disciplinarity of research articles. Method: In 2017-2018, 100 peer-reviewed biomedical science articles were randomly selected from years 2005, 2010, and 2015 and classified as unidisciplinary or interdisciplinary based on Scopus author affiliation data (method 1). The corresponding authors of the 2010 and 2015 articles were sent a survey asking them to describe the disciplines involved in their research (method 2) and to define their research as unidisciplinary or interdisciplinary based on provided definitions (method 3). Results: There was a statistically significant increase in the proportion of interdisciplinary articles in 2015 compared with both 2005 and 2010 (P = .02). Comparison of the 3 methods indicated that 45% of the articles were classified as interdisciplinary based on author affiliation data (method 1), 40% based on the corresponding author's description of the disciplines involved in their research (method 2), and 71% based on the corresponding author's definition of their article's disciplinarity (method 3). There was a statistically significant difference in the proportion of articles classified as interdisciplinary between methods 1 and 3 (P < .001) and between methods 2 and 3 (P < .001). Conclusions: This study found that interdisciplinary research increased at Johns Hopkins University over the past decade and highlights the difference between corresponding authors' views of their own research and other methods for determining interdisciplinarity.
MeSH term(s)	Academic Medical Centers ; Humans ; Interdisciplinary Research/trends ; Publishing/trends ; Research Personnel ; Surveys and Questionnaires
Language	English
Publishing date	2021-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000003084
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Article ; Online: Implementing an EMR-Based Referral for Smoking Quitline Services with Additional Provider Education, a Cluster-Randomized Trial.

Wadlin, Joshua / Ford, Daniel E / Albert, Michael C / Wang, Nae-Yuh / Chander, Geetanjali

Journal of general internal medicine

2022 Volume 37, Issue 10, Page(s) 2438–2445

Abstract: Background: Despite evidence of their effectiveness, free smoking quitlines are underused. The best way to educate providers about and encourage use of quitlines is not established. We examined if electronic medical record (EMR)-integrated best ... ...

Abstract	Background: Despite evidence of their effectiveness, free smoking quitlines are underused. The best way to educate providers about and encourage use of quitlines is not established. We examined if electronic medical record (EMR)-integrated best practices alerts (BPAs) with or without additional provider education resulted in increased quitline referrals. Methods: Waitlist-controlled, cluster-randomized trial of primary care practices assigned to three arms. Providers in participating sites received a new EMR-based BPA for quitline referral and additional education outreach visits, the BPA alone, or usual care. The study was conducted in 2 phases: phase 1 from April 17 to October 16, 2017, and phase 2 from November 9, 2017, to May 8, 2018. In phase 2, the usual-care sites were randomized to either of the two intervention arms. The unit of randomization was primary care practice site. All in-office, primary care provider visits with smokers were included. The primary outcome was referral to the quitline. Secondary outcomes included patient acceptance and enrollment in quitline services. Results: Twenty-two practice sites were enrolled. Smoking prevalence at sites ranged from 4.4 to 23%. In phase 1, the BPA-plus-education arm had 5636 eligible encounters and 405 referrals (referral rate 7.2%) while the BPA-only arm had 6857 eligible encounters and 623 referrals (referral rate 9.1%). The usual-care arm had 7434 encounters but no referrals. Comparing the BPA-plus arm to the BPA-only arm, the odds ratio of referral was 0.76 (CI 0.3-1.8). In phase 2, the combined BPA-plus-education sites had 8516 eligible encounters and 475 referrals (rate 5.6%). The BPA-only sites had 9134 eligible encounters and 470 referrals (rate 5.2%). The odds ratio comparing the 2 groups in phase 2 was 1.06 (0.5-2.2). Conclusions: An EMR-based BPA can improve the number of referrals to quitline services, though more work is needed to improve providers' use of quitlines and low patient acceptance of services. Trial Registration NIH Clinicaltrials.gov identifier: NCT03229356.
MeSH term(s)	Electronic Health Records ; Hotlines ; Humans ; Referral and Consultation ; Smoking ; Smoking Cessation/methods
Language	English
Publishing date	2022-03-08
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	639008-0
ISSN	1525-1497 ; 0884-8734
ISSN (online)	1525-1497
ISSN	0884-8734
DOI	10.1007/s11606-021-07275-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mechanical thrombectomy in patients with acute ischemic stroke in the USA before and after time window expansion.

Kwok, Chun Shing / Gillani, Syed A / Bains, Navpreet K / Gomez, Camilo R / Hanley, Daniel F / Ford, Daniel E / Hassan, Ameer E / Nguyen, Thanh N / Siddiq, Farhan / Spiotta, Alejandro M / Qureshi, Adnan I

Journal of neurointerventional surgery

2024 Volume 16, Issue 5, Page(s) 447–452

Abstract: Background: In 2018, the time window for mechanical thrombectomy eligibility in patients with acute ischemic stroke increased from within 6 hours to within 24 hours of symptom onset. The purpose of this study was to evaluate the effect of window ... ...

Abstract	Background: In 2018, the time window for mechanical thrombectomy eligibility in patients with acute ischemic stroke increased from within 6 hours to within 24 hours of symptom onset. The purpose of this study was to evaluate the effect of window expansion on procedural and hospital volumes and patient outcomes at a national level. Methods: We conducted a retrospective cohort study of patients with acute ischemic stroke undergoing mechanical thrombectomy using data from the National Inpatient Sample. We compared the numbers of mechanical thrombectomy procedures and performing hospitals between 2017 and 2019 in the USA, and the proportion of patients discharged home/self-care, those with in-hospital mortality and post-procedural intracranial hemorrhage (2019 vs 2017) after adjustment for potential confounders. Results: The number of patients with ischemic stroke who underwent mechanical thrombectomy increased from 16 960 in 2017 to 28 120 in 2019. There was an increase in the number of hospitals performing mechanical thrombectomy (501 in 2017, 585 in 2019) and those performing ≥50 procedures/year (97 in 2017, 199 in 2019; P<0.001). The odds of in-hospital mortality decreased (OR 0.79, 95% CI 0.66 to 0.94, P=0.008) and the odds of intracranial hemorrhage increased (OR 1.18, 95% CI 1.06 to 1.31, P=0.003) in 2019 compared with 2017, with no change in odds of discharge to home. Conclusions: The window expansion for mechanical thrombectomy for patients with acute ischemic stroke was associated with an increase in the numbers of mechanical thrombectomy procedures and performing hospitals with a reduction of in-hospital mortality in the USA.
MeSH term(s)	Humans ; Ischemic Stroke/surgery ; Ischemic Stroke/mortality ; Ischemic Stroke/therapy ; Male ; Female ; Aged ; Retrospective Studies ; United States/epidemiology ; Middle Aged ; Thrombectomy/statistics & numerical data ; Thrombectomy/methods ; Hospital Mortality ; Aged, 80 and over ; Time-to-Treatment/statistics & numerical data ; Cohort Studies ; Treatment Outcome
Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/jnis-2023-020286
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Article ; Online: Challenges and lessons learned for institutional review board procedures during the COVID-19 pandemic.

Ford, Daniel E / Johnson, Ann / Nichols, Jason J / Rothwell, Erin / Dubinett, Steve / Naeim, Arash

Journal of clinical and translational science

2021 Volume 5, Issue 1, Page(s) e107

Abstract: The COVID-19 pandemic changed the clinical research landscape in America. The most urgent challenge has been to rapidly review protocols submitted by investigators that were designed to learn more about or intervene in COVID-19. International Review ... ...

Abstract	The COVID-19 pandemic changed the clinical research landscape in America. The most urgent challenge has been to rapidly review protocols submitted by investigators that were designed to learn more about or intervene in COVID-19. International Review Board (IRB) offices developed plans to rapidly review protocols related to the COVID-19 pandemic. An online survey was conducted with the IRB Directors at Clinical and Translational Science Awards (CTSA) institutions as well as two focus groups. Across the CTSA institutions, 66% reviewed COVID-19 protocols across all their IRB committees, 22% assigned protocols to just one committee, and 10% created a new committee for COVID-19 protocols. Fifty-two percent reported COVID-19 protocols were reviewed much faster, 41% somewhat faster, and 7% at the same speed as other protocols. Three percent reported that the COVID-19 protocols were reviewed with much better quality, 32% reported slightly better quality, and 65% reported the reviews were of the same quality as similar protocols before the COVID-19 pandemic. IRBs were able to respond to the emergent demand for reviewing COVID-19 protocols. Most of the increased review capacity was due to extra effort by IRB staff and members and not changes that will be easily implemented across all research going forward.
Language	English
Publishing date	2021-03-16
Publishing country	England
Document type	Journal Article
ISSN	2059-8661
ISSN (online)	2059-8661
DOI	10.1017/cts.2021.27
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Article ; Online: Kidney and Cardiovascular Effectiveness of Empagliflozin Compared With Dipeptidyl Peptidase-4 Inhibitors in Patients With Type 2 Diabetes.

Edmonston, Daniel / Mulder, Hillary / Lydon, Elizabeth / Chiswell, Karen / Lampron, Zachary / Shay, Christina / Marsolo, Keith / Jones, W Schuyler / Butler, Javed / Shah, Raj C / Chamberlain, Alanna M / Ford, Daniel E / Gordon, Howard S / Hwang, Wenke / Chang, Alexander / Rao, Ajaykumar / Bosworth, Hayden B / Pagidipati, Neha

The American journal of cardiology

2024

Abstract: Placebo-controlled trials of sodium-glucose co-transporter-2 inhibitors demonstrate kidney and cardiovascular benefits for patients with type 2 diabetes and chronic kidney disease (CKD). We used real-world data to compare the kidney and cardiovascular ... ...

Abstract	Placebo-controlled trials of sodium-glucose co-transporter-2 inhibitors demonstrate kidney and cardiovascular benefits for patients with type 2 diabetes and chronic kidney disease (CKD). We used real-world data to compare the kidney and cardiovascular effectiveness of empagliflozin to dipeptidyl peptidase-4 inhibitors (DPP4is), a commonly prescribed antiglycemic medication, in a diverse population with and without CKD. Using electronic health record data from 20 large US health systems, we leveraged propensity overlap weighting to compare the outcomes for empagliflozin and DPP4i initiators with type 2 diabetes between 2016 and 2020. The primary composite kidney outcome included 40% estimated glomerular filtration rate decrease, incident end-stage kidney disease, or all-cause mortality through 2 years or censoring. We also assessed cardiovascular and safety outcomes. Of 62,197 new users, 20,279 initiated empagliflozin and 41,918 initiated DPP4i. Over a median follow-up of 1.1 years, empagliflozin prescription was associated with a lower risk of the primary outcome (hazard ratio [HR] 0.75, 95% confidence interval [CI] 0.65 to 0.87) than DPP4is. The risks for mortality (HR 0.76, 95% CI 0.62 to 0.92) and a cardiovascular composite of stroke, myocardial infarction, or all-cause mortality (HR 0.81, 95% CI 0.70 to 0.95) were also lower for empagliflozin initiators. No difference in heart failure hospitalization risk between groups was observed. Genital mycotic infections were more common in patients prescribed empagliflozin (HR 1.72, 95% CI 1.58 to 1.88). Empagliflozin was associated with a lower risk of the primary outcome in patients with CKD (HR 0.68, 95% CI 0.53 to 0.88) and those without CKD (HR 0.79, 95% CI 0.67 to 0.94). In conclusion, the initiation of empagliflozin was associated with a significantly lower risk of kidney and cardiovascular outcomes than DPP4is over a median of just over 1 year. The association with a lower risk for clinical outcomes was apparent even for patients without known CKD at baseline.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/j.amjcard.2024.04.011
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Article ; Online: Creating a Program to Support Registering and Reporting Clinical Trials at Johns Hopkins University.

Keyes, Anthony / Mayo-Wilson, Evan / Nuamah, Prince / Lalji, Aliya / Tetteh, Oswald / Ford, Daniel E

Academic medicine : journal of the Association of American Medical Colleges

2020 Volume 96, Issue 4, Page(s) 529–533

Abstract: Problem: The Food and Drug Administration Amendments Act of 2007 (FDAAA) and the National Institutes of Health (NIH) require that many clinical trials register and report results on ClinicalTrials.gov. Noncompliance with these policies denies research ... ...

Abstract	Problem: The Food and Drug Administration Amendments Act of 2007 (FDAAA) and the National Institutes of Health (NIH) require that many clinical trials register and report results on ClinicalTrials.gov. Noncompliance with these policies denies research participants and scientists access to potentially relevant findings and could lead to monetary penalties or loss of funding. After discovering hundreds of potentially noncompliant trials affiliated with the institution, the Johns Hopkins University School of Medicine (JHUSOM) sought to develop a program to support research teams with registration and reporting requirements. Approach: JHUSOM conducted a baseline assessment of institutional compliance in 2015, launched the ClinicalTrials.gov Program in June 2016, and expanded the program to the Sidney Kimmel Comprehensive Cancer Center in April 2018. The program is innovative in its comprehensive approach, and it was among the first to bring a large number of trials into compliance. Outcomes: From September 2015 to September 2020, JHUSOM brought completed and ongoing trials into compliance with FDAAA and NIH policies and maintained almost perfect compliance for new trials. During this period, the proportion of trials potentially noncompliant with the FDAAA decreased from 44% (339/774) to 2% (32/1,304). Next steps: JHUSOM continues to develop and evaluate tools and procedures that facilitate trial registration and results reporting. In collaboration with other academic medical centers, JHUSOM plans to share resources and to identify and disseminate best practices. This report identifies practical lessons for institutions that might develop similar programs.
MeSH term(s)	Academic Medical Centers/standards ; Academic Medical Centers/statistics & numerical data ; Adult ; Clinical Trials as Topic/standards ; Clinical Trials as Topic/statistics & numerical data ; Female ; Guideline Adherence/standards ; Guideline Adherence/statistics & numerical data ; Guidelines as Topic ; Humans ; Male ; Maryland ; Middle Aged ; Registries/standards ; Registries/statistics & numerical data ; Research Report/standards ; Schools, Medical/standards ; Schools, Medical/statistics & numerical data ; Surveys and Questionnaires
Language	English
Publishing date	2020-10-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	96192-9
ISSN	1938-808X ; 1040-2446
ISSN (online)	1938-808X
ISSN	1040-2446
DOI	10.1097/ACM.0000000000003806
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Zs.A 112: Show issues

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Article ; Online: Optimizing outcomes for patients with depression and chronic medical illnesses.

Ford, Daniel E

The American journal of medicine

2008 Volume 121, Issue 11 Suppl 2, Page(s) S38–44

Abstract: Depression and comorbid chronic medical conditions such as coronary heart disease, diabetes mellitus, and osteoarthritis are frequently seen in the primary care setting, and the interaction of these illnesses can complicate diagnostic and treatment ... ...

Abstract	Depression and comorbid chronic medical conditions such as coronary heart disease, diabetes mellitus, and osteoarthritis are frequently seen in the primary care setting, and the interaction of these illnesses can complicate diagnostic and treatment efforts. Although the etiologies of these bidirectional associations are not well understood, a number of negative outcomes are apparent, and challenges exist at patient, provider, and healthcare system levels to better recognize and treat depression in patients with chronic medical comorbidity. Such patients are more likely to present with somatic complaints, engage in unhealthy behaviors, harbor unhealthy thoughts or cognitions, and are less likely to comply with therapeutic recommendations. Primary care encounters often represent the only opportunities for these patients to address these issues and obtain the professional attention their depression requires. For clinicians, forging empathetic partnerships with patients, prescribing appropriate treatments, and closely monitoring symptoms and therapeutic progress are invaluable for optimal management of both affective and medical disorders. Further opportunities to improve care also exist at the healthcare system level, such as developing, funding, and implementing multimodal collaborative care models in the primary care setting.
MeSH term(s)	Chronic Disease/psychology ; Depression/complications ; Depression/psychology ; Depression/therapy ; Empathy ; Health Behavior ; Humans ; Myocardial Infarction/etiology ; Office Visits ; Physician-Patient Relations ; Primary Health Care ; Sleep Initiation and Maintenance Disorders/complications ; Sleep Initiation and Maintenance Disorders/prevention & control ; Stroke/etiology ; Surveys and Questionnaires
Language	English
Publishing date	2008-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2008.09.012
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Article ; Online: Mechanical thrombectomy with intra-arterial thrombolysis versus mechanical thrombectomy alone in patients with acute ischemic stroke: A systematic review and meta-analysis.

Qureshi, Adnan I / Lodhi, Abdullah / Akhtar, Iqra N / Ma, Xiaoyu / Kherani, Danish / Kwok, Chun Shing / Ford, Daniel E / Hanley, Daniel F / Hassan, Ameer E / Nguyen, Thanh N / Spiotta, Alejandro M / Zaidi, Syed F

International journal of stroke : official journal of the International Stroke Society

2023 Volume 19, Issue 1, Page(s) 16–28

Abstract: Background: There is conflicting evidence as to whether intra-arterial thrombolysis (IAT) adds benefit in patients with acute stroke who undergo mechanical thrombectomy (MT).: Methods: We conducted a systematic review to identify studies that ... ...

Abstract	Background: There is conflicting evidence as to whether intra-arterial thrombolysis (IAT) adds benefit in patients with acute stroke who undergo mechanical thrombectomy (MT). Methods: We conducted a systematic review to identify studies that evaluate IAT in patients with acute stroke who undergo MT. Data were extracted from relevant studies found through a search of PubMed, Scopus, and Web of Science until February 2023. Statistical pooling with random effects meta-analysis was undertaken to evaluate odds of functional independence, mortality, and near-complete or complete angiographic recanalization with IAT compared to no IAT. Results: A total of 18 studies were included (3 matched, 14 unmatched, and 1 randomized). The odds ratio (OR) for functional independence (modified Rankin Scale: 0-2) at 90 days was 1.14 (95% confidence interval (CI): 0.95-1.37, p = 0.17, 16 studies involving 7572 patients) with IAT with moderate between-study heterogeneity (I Conclusion: Although the odds of functional independence appeared to be higher with IAT and MT compared with MT alone, none of the results were statistically significant. A prominent effect of the design and quality of the studies was observed on the association between IAT and functional independence at 90 days.
MeSH term(s)	Humans ; Stroke/drug therapy ; Ischemic Stroke ; Thrombectomy/methods ; Functional Status ; Thrombolytic Therapy/methods ; Brain Ischemia/therapy ; Brain Ischemia/drug therapy ; Treatment Outcome ; Mechanical Thrombolysis
Language	English
Publishing date	2023-07-08
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2303728-3
ISSN	1747-4949 ; 1747-4930
ISSN (online)	1747-4949
ISSN	1747-4930
DOI	10.1177/17474930231184369
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Article: Intensive Mindfulness Meditation Reduces Frequency and Burden of Migraine: An Unblinded Single-Arm Trial.

Goyal, Madhav / Haythornthwaite, Jennifer A / Jain, Sharat / Peterlin, Barbara Lee / Mehrotra, Megha / Levine, David / Rosenberg, Jason D / Minges, Mary / Seminowicz, David A / Ford, Daniel E

Mindfulness

2023 Volume 14, Issue 2, Page(s) 406–417

Abstract: Objectives: Preventing migraine headaches and improving the quality of life for patients with migraine remains a challenge. We hypothesized intensive meditation training would reduce the disease burden of migraine.: Method: An unblinded trial was ... ...

Abstract	Objectives: Preventing migraine headaches and improving the quality of life for patients with migraine remains a challenge. We hypothesized intensive meditation training would reduce the disease burden of migraine. Method: An unblinded trial was analyzed as a single cohort exposed to a silent 10-day Vipassana meditation retreat that included 100 hr of sitting meditation. Participants with chronic or episodic migraine were enrolled and followed for 1 year. The primary outcome was a change in mean monthly migraine days at 12 months from baseline. Secondary outcomes included headache frequency and intensity, acute medication use, work days missed, home meditation, sleep quality, general health, quality of life, migraine impact, positive and negative affect, perceived stress, mindfulness, and pain catastrophizing. Results: Three hundred people were screened and 58 (19%) agreed to participate and enrolled in the intensive meditation training. Forty-six participants with chronic migraine (≥ 15 headaches/month of which ≥ 8 were migraines) and 12 with episodic migraine (< 15 and ≥ 4 migraines/month) attended and 45 (78%) completed the retreat. At 12 months, the average migraine frequency was reduced by 2.7 days (from 16.6 at baseline) per 28 days (95%CI - 4.3, - 1.3) and headaches by 3.4 (20.1 at baseline) per 28 days (- 4.9, - 1.9). Fifty percent responder rate was 29% for migraine. Acute medication use dropped by an average of 2.2 days (- 3.9, - 0.5) per 28 days, and participants reported 2.3 fewer days (- 4.0, - 0.5) on which they reduced their activity due to migraines. The most striking and promising effects were in several secondary outcomes, including migraine-specific quality of life, pain catastrophizing, and perceived stress. The significant improvements observed immediately following the intervention were sustained at 12 months follow-up. Conclusions: Training in Vipassana meditation via a 10-day retreat may reduce the frequency and burden of migraine. Preregistration: ClinicalTrials.gov: NCT00663585.
Language	English
Publishing date	2023-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2543424-X
ISSN	1868-8535 ; 1868-8527
ISSN (online)	1868-8535
ISSN	1868-8527
DOI	10.1007/s12671-023-02073-z
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