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  1. Article ; Online: A BOSSS platform: using functionalized lipids and click chemistry for new discoveries in lipid research.

    Ford, David A

    Journal of lipid research

    2021  Volume 62, Page(s) 100025

    MeSH term(s) Lipids
    Chemical Substances Lipids
    Language English
    Publishing date 2021-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1016/j.jlr.2021.100025
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book ; Online: Assimilating synthetic Biogeochemical-Argo and ocean colour observations into a global ocean model to inform observing system design

    Ford, David

    eISSN: 1726-4189

    2020  

    Abstract: A set of observing system simulation experiments has been performed to explore the impact on global ocean biogeochemical reanalyses of assimilating chlorophyll from remotely sensed ocean colour, and assess the potential impact of assimilating in situ ... ...

    Abstract A set of observing system simulation experiments has been performed to explore the impact on global ocean biogeochemical reanalyses of assimilating chlorophyll from remotely sensed ocean colour, and assess the potential impact of assimilating in situ observations of chlorophyll, nitrate, oxygen, and pH from a proposed array of Biogeochemical-Argo (BGC-Argo) floats. Two different potential BGC-Argo array distributions were tested: one where biogeochemical sensors are placed on all current Argo floats, and one where biogeochemical sensors are placed on a quarter of current Argo floats. This latter approximately corresponds to the proposed BGC-Argo array of 1000 floats. Different strategies for updating model variables when assimilating ocean colour were assessed. All similarly improved the assimilated variable surface chlorophyll, but had a mixed impact on the wider ecosystem and carbon cycle, degrading some key variables of interest. Assimilating BGC-Argo data gave no added benefit over ocean colour in terms of simulating surface chlorophyll, but for most other variables, including sub-surface chlorophyll, adding BGC-Argo greatly improved results throughout the water column. This included surface partial pressure of carbon dioxide (pCO 2 ), which was not assimilated but is an important output of reanalyses. Both BGC-Argo array distributions gave benefits, with greater improvements seen with more observations. From the point of view of ocean reanalysis, it is recommended to proceed with development of BGC-Argo as a priority. The proposed array of 1000 floats will lead to clear improvements in reanalyses, with a larger array likely to bring further benefits. The ocean colour satellite observing system should also be maintained, as ocean colour and BGC-Argo will provide complementary benefits. There is also much potential to improve the use of existing observations, particularly in terms of multivariate balancing, through improving assimilation methodologies.
    Subject code 551
    Language English
    Publishing date 2020-05-15
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Characterization of N-Acetyl Cysteine Adducts with Exogenous and Neutrophil-Derived 2-Chlorofatty Aldehyde.

    Shakya, Shubha / McGuffee, Reagan M / Ford, David A

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 2

    Abstract: Hypochlorous acid is produced by leukocyte myeloperoxidase activity. 2-Chlorofatty aldehydes (2-ClFALDs) are formed when hypochlorous acid attacks the plasma membrane phospholipid plasmalogen molecular subclass and are thus produced following leukocyte ... ...

    Abstract Hypochlorous acid is produced by leukocyte myeloperoxidase activity. 2-Chlorofatty aldehydes (2-ClFALDs) are formed when hypochlorous acid attacks the plasma membrane phospholipid plasmalogen molecular subclass and are thus produced following leukocyte activation as well as in the lungs of mice exposed to chlorine gas. The biological role of 2-ClFALD is largely unknown. Recently, we used an alkyne analog (2-ClHDyA) of the 2-ClFALD molecular species, 2-chlorohexadecanal (2-ClHDA), to identify proteins covalently modified by 2-ClHDyA in endothelial cells and epithelial cells. Here, we demonstrate that 2-ClHDA reduces the metabolic activity of RAW 264.7 cells in a dose-dependent manner. 2-ClHDyA localizes to the mitochondria, endoplasmic reticulum and Golgi in RAW 264.7 cells and modifies many proteins. The thiol-containing precursor of glutathione, N-acetyl cysteine (NAC), was shown to produce an adduct with 2-ClHDA with the loss of Cl
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12020504
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  4. Article ; Online: Immediate Effects of Semi-Occluded Vocal Tract Exercises on Acoustic, Auditory-Perceptual, and Self-Perceptual Measures of Voice Production.

    Ford, David S / Hunter, Eric J / Deliyski, Dimitar D

    Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

    2023  

    Abstract: Purpose: This study examined the immediate acoustic, auditory-perceptual, and self-perceptual effects of two semi-occluded vocal tract exercises (SOVTs): straw phonation and straw phonation into a cup of water, delivered in a remote setting.: Method: ...

    Abstract Purpose: This study examined the immediate acoustic, auditory-perceptual, and self-perceptual effects of two semi-occluded vocal tract exercises (SOVTs): straw phonation and straw phonation into a cup of water, delivered in a remote setting.
    Method: 36 participants (19 females and 17 males) completed a baseline battery of acoustic recordings, followed by one of two SOVTs, and an identical post-task battery. The procedure repeated itself to include the other SOVT. Participants were also asked to rate their self-perceived vocal effort and quality following each condition. Recordings were presented to three expert listeners for completion of auditory-perceptual analysis.
    Results: Acoustically, a significant decrease in shimmer was noted following straw phonation. Auditory-perceptual analysis revealed a significant increase in the perception of strain following straw phonation into a cup of water. While no significant differences were found between SOVT tasks in self-perception of vocal effort, a significant increase in self-perception of vocal loudness was reported following straw phonation into a cup of water.
    Conclusions: SOVTs have a varied, yet significant short-term impact across acoustic, auditory-perceptual, and self-perceptual measures of voice production. Straw phonation provided consistently significant acoustic results, with nearly every variable improving to some degree. Results also support the notion that shimmer is an acoustic measure that is particularly susceptible to change following modest manipulation. These results, in addition to the auditory-perceptual and self-perceptual findings, have a direct impact on how SOVTs are being used clinically and may generalize to inform the way voice metrics are collected and analyzed.
    Language English
    Publishing date 2023-12-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1179765-4
    ISSN 1421-9972 ; 1021-7762
    ISSN (online) 1421-9972
    ISSN 1021-7762
    DOI 10.1159/000536002
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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.124: Show issues Location:
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  5. Article ; Online: Lipid biology of plasmalogen-derived halolipids: Signature molecules of myeloperoxidase and eosinophil peroxidase activity.

    McGuffee, Reagan M / Hadfield, Christy M / Ford, David A

    Redox Biochemistry and Chemistry

    2023  Volume 5-6

    Abstract: Myeloperoxidase and eosinophil peroxidase exert their antimicrobial functions through the oxidative actions of their hypohalous acid products. Plasmalogen phospholipids are particularly susceptible to oxidation of their vinyl ether functional group by ... ...

    Abstract Myeloperoxidase and eosinophil peroxidase exert their antimicrobial functions through the oxidative actions of their hypohalous acid products. Plasmalogen phospholipids are particularly susceptible to oxidation of their vinyl ether functional group by hypohalous acids. This produces a family of halogenated lipid products with pro-inflammatory roles and potential biomarker utility. The initial product of plasmalogen oxidation by HOCl is 2-chlorofatty aldehyde, which has been shown to play a key role at the blood-endothelium interface.
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article
    ISSN 2773-1766
    ISSN (online) 2773-1766
    DOI 10.1016/j.rbc.2023.100011
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  6. Article ; Online: The Community and Public Well-being Model: A New Framework and Graduate Curriculum for Addressing Adverse Childhood Experiences.

    Ford, David E

    Academic pediatrics

    2017  Volume 17, Issue 7S, Page(s) S9–S11

    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2483385-X
    ISSN 1876-2867 ; 1876-2859
    ISSN (online) 1876-2867
    ISSN 1876-2859
    DOI 10.1016/j.acap.2017.04.011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5914: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article: Clinical outcome of open ankle fractures in patients above 70 years of age.

    Zahra, Wajiha / Seifo, Mina / Cool, Paul / Ford, David / Okoro, Tosan

    World journal of orthopedics

    2023  Volume 14, Issue 7, Page(s) 554–561

    Abstract: Background: Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and mortality. However, data on the clinical outcomes of open ankle fracture management in patients older than ... ...

    Abstract Background: Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and mortality. However, data on the clinical outcomes of open ankle fracture management in patients older than 70 is minimal.
    Aim: To evaluate the clinical outcomes following open ankle fracture management in patients older than 70. Our secondary aim is to look at predictors of poor outcomes.
    Methods: Following local research and audit department registration, 22 years of prospectively collated data from an electronic database in a district general hospital were assessed. All patients older than 70 years of age with an open ankle fracture requiring surgical intervention were identified. Demographic information, the nature, and the number of surgical interventions were collated. Complications, including surgical site infection (SSI), venous thromboembolic events (VTEs) during hospital stay, and mortality rate, were reviewed.
    Results: A total of 37 patients were identified (median age: 84 years, range: 70-98);
    Conclusion: An open ankle fracture in a patient older than 70 years has at least a 20% chance of requiring repeated surgical intervention due to deep SSIs. The presence of a cardiac history appears to be the main predictor for wound complications.
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649712-8
    ISSN 2218-5836
    ISSN 2218-5836
    DOI 10.5312/wjo.v14.i7.554
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  8. Article ; Online: Early Origins of Divergent Patterns of Morphological Evolution on the Mammal and Reptile Stem-Lineages.

    Brocklehurst, Neil / Ford, David P / Benson, Roger B J

    Systematic biology

    2022  Volume 71, Issue 5, Page(s) 1195–1209

    Abstract: The origin of amniotes 320 million years ago signaled independence from water in vertebrates and was closely followed by divergences within the mammal and reptile stem lineages (Synapsida and Reptilia). Early members of both groups had highly similar ... ...

    Abstract The origin of amniotes 320 million years ago signaled independence from water in vertebrates and was closely followed by divergences within the mammal and reptile stem lineages (Synapsida and Reptilia). Early members of both groups had highly similar morphologies, being superficially "lizard-like" forms with many plesiomorphies. However, the extent to which they might have exhibited divergent patterns of evolutionary change, with the potential to explain the large biological differences between their living members, is unresolved. We use a new, comprehensive phylogenetic dataset to quantify variation in rates and constraints of morphological evolution among Carboniferous-early Permian amniotes. We find evidence for an early burst of evolutionary rates, resulting in the early origins of morphologically distinctive subgroups that mostly persisted through the Cisuralian. Rates declined substantially through time, especially in reptiles. Early reptile evolution was also more constrained compared with early synapsids, exploring a more limited character state space. Postcranial innovation in particular was important in early synapsids, potentially related to their early origins of large body size. In contrast, early reptiles predominantly varied the temporal region, suggesting disparity in skull and jaw kinematics, and foreshadowing the variability of cranial biomechanics seen in reptiles today. Our results demonstrate that synapsids and reptiles underwent an early divergence of macroevolutionary patterns. This laid the foundation for subsequent evolutionary events and may be critical in understanding the substantial differences between mammals and reptiles today. Potential explanations include an early divergence of developmental processes or of ecological factors, warranting cross-disciplinary investigation. [Amniote; body size; constraint; phylogeny; rate.].
    MeSH term(s) Animals ; Biological Evolution ; Fossils ; Mammals ; Phylogeny ; Reptiles ; Vertebrates/anatomy & histology
    Language English
    Publishing date 2022-03-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1482572-7
    ISSN 1076-836X ; 1063-5157
    ISSN (online) 1076-836X
    ISSN 1063-5157
    DOI 10.1093/sysbio/syac020
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  9. Article: A Rare Presentation of a Solitary Melanoma Bone Metastasis.

    Reipond, Lucy / Ford, David / Cool, Paul

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21479

    Abstract: A 74-year-old woman presented with sudden onset pain and swelling in her right wrist. Plain radiographs showed a pathological fracture through a lytic lesion. The patient had a past medical history of melanoma on her right thigh, which had been excised ... ...

    Abstract A 74-year-old woman presented with sudden onset pain and swelling in her right wrist. Plain radiographs showed a pathological fracture through a lytic lesion. The patient had a past medical history of melanoma on her right thigh, which had been excised two years previously. She was referred to the bone cancer unit to undergo a series of investigations that included a magnetic resonance imaging scan, bone scintigraphy and a computed tomography-guided biopsy. Collectively, all investigations revealed a solitary bone metastasis from her previous melanoma in the right distal radius. The patient was treated symptomatically and underwent internal fixation with cement augmentation for symptom control. With the incidence of melanoma increasing, this case demonstrates the importance of being vigilant of unusual presentations.
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21479
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  10. Article: E. coli

    Amunugama, Kaushalya / Pike, Daniel P / Ford, David A

    Frontiers in physiology

    2022  Volume 13, Page(s) 980460

    Abstract: Dysregulated lipid metabolism is common in infection and inflammation and is a part of the complex milieu underlying the pathophysiological sequelae of disease. Sepsis is a major cause of mortality and morbidity in the world and is characterized by an ... ...

    Abstract Dysregulated lipid metabolism is common in infection and inflammation and is a part of the complex milieu underlying the pathophysiological sequelae of disease. Sepsis is a major cause of mortality and morbidity in the world and is characterized by an exaggerated host response to an infection. Metabolic changes, including alterations in lipid metabolism, likely are important in sepsis pathophysiology. Here, we designed an
    Language English
    Publishing date 2022-09-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.980460
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