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  1. Article ; Online: Postoperative Complications After Retroperitoneal Sarcoma Surgery: Can We Avoid Them?

    Tirotta, Fabio / Ford, Samuel J

    Annals of surgical oncology

    2023  Volume 30, Issue 12, Page(s) 6970–6971

    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13704-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Containing Cumulative Postoperative Morbidity in Patients with Retroperitoneal Sarcoma May Improve Long-Term Prognosis.

    Tirotta, Fabio / Ford, Samuel J

    Annals of surgical oncology

    2021  Volume 28, Issue 12, Page(s) 7950–7951

    MeSH term(s) Humans ; Morbidity ; Prognosis ; Retroperitoneal Neoplasms/surgery ; Sarcoma/surgery ; Soft Tissue Neoplasms
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-10074-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Surveillance Post Surgery for Retroperitoneal Soft Tissue Sarcoma.

    Whitaker, John / Nessim, Carolyn / Almond, Max / Ford, Samuel J

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 3, Page(s) 2781–2791

    Abstract: Complete en bloc surgical resection offers the best opportunity for the cure of primary retroperitoneal sarcomas (RPS). The potential for disease recurrence, in the form of both loco-regional recurrence and distant metastases, underpins the rationale for ...

    Abstract Complete en bloc surgical resection offers the best opportunity for the cure of primary retroperitoneal sarcomas (RPS). The potential for disease recurrence, in the form of both loco-regional recurrence and distant metastases, underpins the rationale for postoperative surveillance. There is a paucity of high-quality evidence underpinning follow-up for RPS patients, and most practice guidelines draw from expert opinion and evidence from soft tissue sarcomas of the extremities. The available observational retrospective data analysis has failed to demonstrate that high-intensity radiological surveillance improves the overall survival in patients. The lack of a robust evidence base has given rise to variations in approaches to post-operative surveillance strategies adopted by specialist centres managing RPS across the world. More high-quality prospective research is needed and planned to more clearly support surveillance approaches that balance oncologic outcomes, patient-centric care, and health service value. Risk stratification tools exist and are available for use in routine practice. Their use will likely support more individualised post-operative surveillance moving forward. Surveillance will likely be underpinned by serial radiological imaging for the medium term. However, developments in genomics offer hope for biomarkers such as ctDNA to impact patient care positively in the future and further support individualised patient care pathways.
    MeSH term(s) Humans ; Retrospective Studies ; Prospective Studies ; Neoplasm Recurrence, Local ; Sarcoma/pathology ; Retroperitoneal Neoplasms ; Soft Tissue Neoplasms
    Language English
    Publishing date 2023-02-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30030211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinician survey of current global practice for sarcoma surveillance following resection of primary retroperitoneal, abdominal, and pelvic sarcoma.

    Maes, Danielle / McMullan, Christel / Aiyegbusi, Olalekan Lee / Ford, Samuel

    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

    2023  Volume 49, Issue 11, Page(s) 107085

    Abstract: Introduction: - Postoperative surveillance following resection of primary retroperitoneal, abdominal, and pelvic sarcoma (RPS) is standard of care in international sarcoma centres and has rapidly evolved without an evidence base to become highly ... ...

    Abstract Introduction: - Postoperative surveillance following resection of primary retroperitoneal, abdominal, and pelvic sarcoma (RPS) is standard of care in international sarcoma centres and has rapidly evolved without an evidence base to become highly intensive and prolonged. This clinician survey aims to capture a global, contemporary snapshot of international guidelines used to inform sarcoma surveillance following resection of primary RPS.
    Materials and methods: - Between July 2022 and March 2023, an online, anonymous, clinician survey to assess the current duration, imaging intervals and imaging modalities used for postoperative surveillance following resection of primary RPS was distributed among clinicians working at centres which are members of the TransAtlantic Australasian Retroperitoneal Working Group (TARPSWG).
    Results: - Responses were received from 58 different TARPSWG centres. The majority of centres use institutional guidelines to guide surveillance intensity (n = 43, 74%) and the surveillance imaging modality (n = 39, 67%) used. For surveillance intensity and imaging modality, institutional guidelines are partially or entirely based on international guidelines in 81% (n = 47) and 78% (n = 45) of centres, respectively. Commonly used imaging modalities are contrast-enhanced CT abdomen-pelvis (n = 51, 88%) for abdominal surveillance and non-contrast enhanced CT (n = 25, 43%) for chest surveillance. Imaging intervals, timing of de-escalation of imaging frequency and total duration of surveillance for low-grade and high-grade RPS are reported.
    Conclusion: - This global survey among TARPSWG members demonstrates the heterogeneity in sarcoma surveillance strategies worldwide and emphasises the need for a randomised controlled trial to provide an evidence base for the optimal surveillance schedule following primary resection of RPS.
    MeSH term(s) Humans ; Retroperitoneal Neoplasms/diagnostic imaging ; Retroperitoneal Neoplasms/surgery ; Retroperitoneal Space ; Sarcoma/diagnostic imaging ; Sarcoma/surgery ; Pelvic Neoplasms/diagnostic imaging ; Pelvic Neoplasms/surgery ; Soft Tissue Neoplasms/surgery
    Language English
    Publishing date 2023-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 632519-1
    ISSN 1532-2157 ; 0748-7983
    ISSN (online) 1532-2157
    ISSN 0748-7983
    DOI 10.1016/j.ejso.2023.107085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Evaluation and Management of Adolescents With a Stiff Flatfoot.

    Ford, Samuel E / Zide, Jacob R / Riccio, Anthony I

    The Journal of the American Academy of Orthopaedic Surgeons

    2022  Volume 30, Issue 16, Page(s) 757–766

    Abstract: While flatfeet are normal in children, persistence into adolescence with associated pain or asymmetry warrants additional evaluation. Rigidity of a flatfoot deformity, whether a clinical report or evident on examination, should raise suspicion for ... ...

    Abstract While flatfeet are normal in children, persistence into adolescence with associated pain or asymmetry warrants additional evaluation. Rigidity of a flatfoot deformity, whether a clinical report or evident on examination, should raise suspicion for pathology. The differential diagnosis includes tarsal coalition, neurogenic planovalgus, and peroneal spasticity. History must include pointed inquiry into birth and neurologic histories to probe for a source of central spasticity. Examination must include standing assessment of hindfoot and midfoot alignment. Hindfoot rigidity may be assessed by the double limb heel rise test and manual examination. Radiographs should include standing ankle (anterior-posterior and mortise) and whole foot (anterior-posterior, external rotation oblique, and lateral) images. Magnetic resonance imaging is more sensitive for identifying coalitions and better characterizes adjacent cartilage, subchondral edema, and tendon pathology, yet CT better characterizes the anatomy of a bony coalition. Conservative treatments are pathology-dependent and play a more prominent role in neurogenic or peroneal spastic flatfoot. Surgical management of coalitions is centered on coalition resection coupled with arthrodesis in the case of a talocalcaneal coalition with a dysplastic subtalar joint; concomitant planovalgus reconstruction is considered on a case-by-case basis.
    MeSH term(s) Adolescent ; Arthrodesis/methods ; Child ; Flatfoot/diagnostic imaging ; Flatfoot/therapy ; Humans ; Osteotomy/methods ; Subtalar Joint/surgery ; Tarsal Bones/surgery
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200524-1
    ISSN 1940-5480 ; 1067-151X
    ISSN (online) 1940-5480
    ISSN 1067-151X
    DOI 10.5435/JAAOS-D-21-00448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluation of outcomes in the management of primary sporadic desmoid-type fibromatosis at a specialist soft tissue sarcoma unit.

    Khan, Misbah / Almond, Max / Ford, Samuel / Desai, Anant

    European journal of medical research

    2022  Volume 27, Issue 1, Page(s) 123

    Abstract: Background: Desmoids are rare fibroblastic tumours whose treatment in any individual case presents a persistent challenge. We endeavoured to evaluate various clinicopathological factors contributing to tumour behaviour.: Methods: This is a ... ...

    Abstract Background: Desmoids are rare fibroblastic tumours whose treatment in any individual case presents a persistent challenge. We endeavoured to evaluate various clinicopathological factors contributing to tumour behaviour.
    Methods: This is a retrospective review of 95 primary truncal sporadic fibromatosis managed between 2011 and 2020. We studied progression rate for wait and watch (WW) and recurrence rate for the surgically treated group as adverse events. Relevant event-free survivals and potential risk factors were analysed over a median follow-up of 27 months.
    Results: 66 patients (69.5%) received watchful surveillance and 28 upfront surgery. 2-year progression-free survival in WW group (88.9%) was higher than RFS in the surgical group (77.1%) p = 0.02. Adverse event rate compared favourably, 28.8% in WW and 28.6% in surgical group. At final follow-up, rate of stable disease for WW was 47%, and the regression rate was 24.2%. On Cox regression analysis, meantime to progress was 14 ± 2.0 months, with larger tumour size as a significant prognostic indicator (p = 0.05). Surgical group's mean time to recurrence was 13.8 ± 2.76 months, with tumour location a significant contributing factor (p = 0.05).
    Conclusions: This study confirms to the safety of both treatment approaches. Adverse event rates remained comparable, but event-free survival was longer for the watchful surveillance group.
    MeSH term(s) Fibromatosis, Aggressive/pathology ; Fibromatosis, Aggressive/surgery ; Humans ; Neoplasm Recurrence, Local ; Prognosis ; Retrospective Studies ; Sarcoma
    Language English
    Publishing date 2022-07-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-022-00751-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Experiences of patients and their relatives of postoperative radiological surveillance and surveillance intensity following primary resection of a soft tissue sarcoma and its impact on their quality of life: a systematic review protocol.

    Maes, Danielle / McMullan, Christel / Ford, Samuel J / Wilson, Roger / Oppong, Raymond / Aiyegbusi, Olalekan Lee

    BMJ open

    2023  Volume 13, Issue 5, Page(s) e070327

    Abstract: Introduction: Postoperative radiological surveillance following primary resection of a soft tissue sarcoma (sarcoma of the retroperitoneum, abdomen, pelvis, trunk or extremities) is standard of care in all international high-volume sarcoma centres in ... ...

    Abstract Introduction: Postoperative radiological surveillance following primary resection of a soft tissue sarcoma (sarcoma of the retroperitoneum, abdomen, pelvis, trunk or extremities) is standard of care in all international high-volume sarcoma centres in the world. The intensity of postoperative surveillance imaging is highly varied and knowledge of the impact of surveillance and surveillance intensity on patients' quality of life is limited. The aim of this systematic review is to summarise the experiences of patients and their relatives/caregivers of postoperative radiological surveillance following resection of a primary soft tissue sarcoma and its impact on their quality of life.
    Methods and analysis: We will systematically search MEDLINE, EMBASE, PsycINFO, CINAHL Plus and Epistemonikos. Hand searching of reference lists of included studies will be conducted. Further searches will be performed via Google Scholar, to reveal further studies within unpublished 'grey' literature. Two reviewers will independently screen the titles and abstracts following the eligibility criteria. After retrieval of the full text of the selected studies, the methodological quality will be appraised using the Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research and the Center for Evidence-Based Management checklist for Critical Appraisal of a Cross-Sectional Study. Data on the study population, relevant themes and conclusions will be extracted from the selected papers, and a narrative synthesis will be conducted.
    Ethics and dissemination: The systematic review does not require ethics approval. The findings of the proposed work will be published in a peer-reviewed journal and disseminated widely to patients, clinicians and allied health professionals through the Sarcoma UK website, the Sarcoma Patient Advocacy Global Network and the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group. In addition, the outcomes of this research will be presented at national and international conferences.
    Prospero registration number: CRD42022375118.
    MeSH term(s) Humans ; Quality of Life ; Cross-Sectional Studies ; Qualitative Research ; Radiography ; Sarcoma/diagnostic imaging ; Sarcoma/surgery ; Systematic Reviews as Topic
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-070327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Transition from training to practice.

    Cooper, M Truitt / Clements, J Randolph / Millonig, Kelsey J / Ford, Samuel E / Hofbauer, Mark

    Foot & ankle specialist

    2022  Volume 15, Issue 6, Page(s) 563–565

    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2488579-4
    ISSN 1938-7636 ; 1938-6400
    ISSN (online) 1938-7636
    ISSN 1938-6400
    DOI 10.1177/19386400221136950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Pediatric Flatfoot: Pearls and Pitfalls.

    Ford, Samuel E / Scannell, Brian P

    Foot and ankle clinics

    2017  Volume 22, Issue 3, Page(s) 643–656

    Abstract: Pediatric flatfeet are common, are usually asymptomatic, and typically improve over time as young children age. It is critical to differentiate flexible from rigid flatfeet and to assess for associated Achilles contracture with a careful history, ... ...

    Abstract Pediatric flatfeet are common, are usually asymptomatic, and typically improve over time as young children age. It is critical to differentiate flexible from rigid flatfeet and to assess for associated Achilles contracture with a careful history, physical examination, and initial radiographs. Although there are limited data, nonsurgical management of symptomatic flatfeet, both flexible and rigid, should be exhausted before considering surgical intervention. If patients fail conservative treatment, surgical management with joint-preserving, deformity-corrective techniques is typically used for pediatric flexible flatfeet in conjunction with deformity-specific soft tissue procedures.
    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2051688-5
    ISSN 1558-1934 ; 1083-7515
    ISSN (online) 1558-1934
    ISSN 1083-7515
    DOI 10.1016/j.fcl.2017.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Management of Distal Tibial Metaphyseal Bone Defects With an Intramedullary Nitinol Scaffold: A Novel Technique.

    Ford, Samuel E / Ellington, J Kent

    Foot & ankle specialist

    2017  Volume 10, Issue 4, Page(s) 368–371

    Abstract: Difficult problems that are faced when reconstructing severe pilon fractures include filling metaphyseal defects and supporting an impacted, multifragmented articular surface. Supplements to plate fixation currently available in a surgeon's armamentarium ...

    Abstract Difficult problems that are faced when reconstructing severe pilon fractures include filling metaphyseal defects and supporting an impacted, multifragmented articular surface. Supplements to plate fixation currently available in a surgeon's armamentarium include cancellous bone autograft, structural bone allograft, demineralized bone matrix, and calcium-based cements. Cancellous autograft possesses limited inherent mechanical stability and is associated with graft site morbidity. Structural allografts incorporate inconsistently and are plagued by late resorption. Demineralized bone matrix also lacks inherent structural stability. Calcium phosphate cements are not rigidly fixed to bone unless fixation is applied from cortical bone or through a plate, which must be taken into consideration when planning fixation. The Conventus DRS (Conventus Orthopaedics, Maple Grove, MN) implant is an expandable nitinol scaffold that takes advantage of the elasticity and shape memory of nitinol alloy. Once deployed and locked, it serves as a stable intramedullary base for fragment-specific periarticular fracture fixation, even in the face of metaphyseal bone loss. Two cases of successful implant use are presented. In both cases, the implant is used to fill a metaphyseal void and provide stable articular support to the distal tibial plafond.
    Levels of evidence: Therapeutic Level V: Case Report, Expert Opinion.
    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2488579-4
    ISSN 1938-7636 ; 1938-6400
    ISSN (online) 1938-7636
    ISSN 1938-6400
    DOI 10.1177/1938640016679708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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