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  1. Article: Labeled breath tests in patients with NASH: Octanoate oxidation relates best to measures of glucose metabolism.

    Mucinski, Justine M / Perry, Alisha M / Fordham, Talyia M / Diaz-Arias, Alberto / Ibdah, Jamal A / Rector, R Scott / Parks, Elizabeth J

    Frontiers in physiology

    2023  Volume 14, Page(s) 1172675

    Abstract: ... In ... ...

    Abstract In vivo
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1172675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Metabolic effects of an essential amino acid supplement in adolescents with PCOS and obesity.

    Fordham, Talyia M / Morelli, Nazeen S / Garcia-Reyes, Yesenia / Ware, Meredith A / Rahat, Haseeb / Sundararajan, Divya / Fuller, Kelly N Z / Severn, Cameron / Pyle, Laura / Malloy, Craig R / Jin, Eunsook S / Parks, Elizabeth J / Wolfe, Robert R / Cree, Melanie G

    Obesity (Silver Spring, Md.)

    2024  Volume 32, Issue 4, Page(s) 678–690

    Abstract: Objective: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, insulin resistance, and hepatic steatosis (HS). Because dietary essential amino acid (EAA) supplementation has been shown to decrease HS in various populations, this study' ...

    Abstract Objective: Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, insulin resistance, and hepatic steatosis (HS). Because dietary essential amino acid (EAA) supplementation has been shown to decrease HS in various populations, this study's objective was to determine whether supplementation would decrease HS in PCOS.
    Methods: A randomized, double-blind, crossover, placebo-controlled trial was conducted in 21 adolescents with PCOS (BMI 37.3 ± 6.5 kg/m
    Results: Compared to placebo, EAA was associated with no difference in body weight (p = 0.673). Two markers of liver health improved: HS was lower (-0.8% absolute, -7.5% relative reduction, p = 0.013), as was plasma aspartate aminotransferase (AST) (-8%, p = 0.004). Plasma TG (-9%, p = 0.015) and VLDL-TG (-21%, p = 0.031) were reduced as well. VLDL-TG palmitate derived from lipogenesis was not different between the phases, nor was insulin sensitivity (p > 0.400 for both). Surprisingly, during the EAA phase, participants reported consuming fewer carbohydrates (p = 0.038) and total sugars (p = 0.046).
    Conclusions: Similar to studies in older adults, short-term EAA supplementation in adolescents resulted in significantly lower liver fat, AST, and plasma lipids and thus may prove to be an effective treatment in this population. Additional research is needed to elucidate the mechanisms for these effects.
    MeSH term(s) Adolescent ; Female ; Humans ; Fatty Liver ; Hyperandrogenism/complications ; Insulin ; Insulin Resistance ; Lipoproteins, VLDL ; Obesity/complications ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/complications
    Chemical Substances Insulin ; Lipoproteins, VLDL
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.23988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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