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  1. Article ; Online: Somatotopic organization of STN and DBS implications in Parkinson's disease - A case report of a woman "halved" by DBS stimulation.

    Alimonti, D / Donati, R / Foresti, C / Manara, O / Sessa, M

    Brain stimulation

    2020  Volume 13, Issue 5, Page(s) 1384–1386

    Language English
    Publishing date 2020-07-24
    Publishing country United States
    Document type Letter
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2020.07.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6740: Show issues Location:
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  2. Article ; Online: NAC61 regulates late- and post-ripening osmotic, oxidative, and biotic stress responses in grapevine.

    Foresti, Chiara / Orduña, Luis / Matus, José Tomás / Vandelle, Elodie / Danzi, Davide / Bellon, Oscar / Tornielli, Giovanni Battista / Amato, Alessandra / Zenoni, Sara

    Journal of experimental botany

    2023  Volume 75, Issue 8, Page(s) 2330–2350

    Abstract: During late- and post-ripening stages, grape berry undergoes profound biochemical and physiological changes whose molecular control is poorly understood. Here, we report the role of NAC61, a grapevine NAC transcription factor, in regulating different ... ...

    Abstract During late- and post-ripening stages, grape berry undergoes profound biochemical and physiological changes whose molecular control is poorly understood. Here, we report the role of NAC61, a grapevine NAC transcription factor, in regulating different processes involved in berry ripening progression. NAC61 is highly expressed during post-harvest berry dehydration and its expression pattern is closely related to sugar concentration. The ectopic expression of NAC61 in Nicotiana benthamiana leaves resulted in low stomatal conductance, high leaf temperature, tissue collapse and a higher relative water content. Transcriptome analysis of grapevine leaves transiently overexpressing NAC61 and DNA affinity purification and sequencing analyses allowed us to narrow down a list of NAC61-regulated genes. Direct regulation of the stilbene synthase regulator MYB14, the osmotic stress-related gene DHN1b, the Botrytis cinerea susceptibility gene WRKY52, and NAC61 itself was validated. We also demonstrate that NAC61 interacts with NAC60, a proposed master regulator of grapevine organ maturation, in the activation of MYB14 and NAC61 expression. Overall, our findings establish NAC61 as a key player in a regulatory network that governs stilbenoid metabolism and osmotic, oxidative, and biotic stress responses that are the hallmark of late- and post-ripening grape stages.
    MeSH term(s) Transcription Factors/genetics ; Transcription Factors/metabolism ; Gene Expression Profiling ; Stress, Physiological ; Stilbenes/metabolism ; Vitis/metabolism ; Oxidative Stress ; Fruit/metabolism ; Gene Expression Regulation, Plant
    Chemical Substances Transcription Factors ; Stilbenes
    Language English
    Publishing date 2023-12-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erad507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Z 55/29: Show issues

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  3. Article ; Online: Predictive Value of Preoperative and Intraoperative Neurophysiology in Evaluating Long-term Facial Function Outcome in Acoustic Neuroma Surgery.

    Frigeni, Barbara / Bivona, Rachele / Foresti, Camillo / Guazzo, Emily / Danesi, Giovanni

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2020  Volume 41, Issue 4, Page(s) 530–536

    Abstract: Objective: To determine the role of neurophysiological preoperative and intraoperative parameters in providing prognostic information regarding facial nerve (FN) function at 1 year after translabyrinthine acoustic neuroma (AN) resection surgery.: ... ...

    Abstract Objective: To determine the role of neurophysiological preoperative and intraoperative parameters in providing prognostic information regarding facial nerve (FN) function at 1 year after translabyrinthine acoustic neuroma (AN) resection surgery.
    Study design: Prospective observational study in a tertiary referral center. Patients treated via translabyrinthine surgical approach for sporadic AN microresection between December 2015 and 2018.
    Methods: Patients underwent preoperative (electroneurography-ENG, electromyography-EMG, and Blink Reflex-BR) and intraoperative (FN motor action potential-MAP and continuous EMG traces) neurophysiological studies. FN function was graded postoperatively at 1 year using House-Brackmann Scoring System.
    Results: Sixty-two patients were included in the analysis. Mean age was 53±10 years and average tumor diameter was 23 ± 9 mm. At 1 year a normal facial function was observed in 68% of patients. In the univariate analysis a pathologic BR, low FN MAP values and ratios, and the presence of pathological neurotonic tracing (A-trains) on continuous EMG were associated with a poor facial nerve function outcome at 1 year postoperatively. Pathological preoperative BR testing and intraoperative A-trains showed a statistical significance also in the multivariable analysis, regardless of tumor size.
    Conclusions: Preoperative pathological BR testing and A-train activity on intraoperative EMG are correlated with poor FN outcomes at 1 year postoperative. This may provide important prognostic information to both patients and treating neuro-otologists. In the future this may guide preoperative and postoperative patient counselling and possibly optimize timing of facial nerve reanimation in selected patients.
    MeSH term(s) Adult ; Electromyography ; Facial Nerve/surgery ; Humans ; Middle Aged ; Neuroma, Acoustic/surgery ; Postoperative Complications ; Prospective Studies ; Treatment Outcome
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000002553
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1554: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: A case of severe pharyngeal-cervical-brachial syndrome induced by nivolumab and responding to infliximab therapy.

    Indini, Alice / Sessa, Maria / Merelli, Barbara / Foresti, Camillo / Mandalà, Mario

    European journal of cancer (Oxford, England : 1990)

    2020  Volume 129, Page(s) 1–3

    MeSH term(s) Aged ; Antineoplastic Agents, Immunological/adverse effects ; Antirheumatic Agents/therapeutic use ; Diagnosis, Differential ; Eye Enucleation ; Guillain-Barre Syndrome/chemically induced ; Guillain-Barre Syndrome/diagnosis ; Guillain-Barre Syndrome/drug therapy ; Guillain-Barre Syndrome/immunology ; Humans ; Infliximab/therapeutic use ; Liver Neoplasms/drug therapy ; Liver Neoplasms/secondary ; Male ; Melanoma/therapy ; Nivolumab/adverse effects ; Radiosurgery ; Radiotherapy, Adjuvant ; Treatment Outcome ; Uveal Neoplasms/therapy
    Chemical Substances Antineoplastic Agents, Immunological ; Antirheumatic Agents ; Nivolumab (31YO63LBSN) ; Infliximab (B72HH48FLU)
    Language English
    Publishing date 2020-02-21
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2020.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 456: Show issues Location:
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    Zs.MO 583: Show issues

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  5. Article ; Online: VviNAC61 promotes molecular processes associated with late grapevine organ development

    Foresti, Chiara / Orduña, Luis / Matus, José Tomás / Tornielli, Giovanni Battista / Zenoni, Sara / Amato, Alessandra

    2022  

    Keywords Text ; abstract_or_summary ; ddc:630 ; NACs ; VviNAC61 ; cistrome ; late organ development
    Language English
    Publisher Julius Kühn-Institut
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: COVID-19 provoking Guillain-Barré syndrome: the Bergamo case series

    Foresti, C / Servalli, M C / Frigeni, B / Rifino, N / Storti, B / Gritti, P / Fabretti, F / Grazioli, L / Sessa, M

    Eur. j. neurol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #780861
    Database COVID19

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  7. Article ; Online: The transcription factor VviNAC60 regulates senescence- and ripening-related processes in grapevine.

    D'Incà, Erica / Foresti, Chiara / Orduña, Luis / Amato, Alessandra / Vandelle, Elodie / Santiago, Antonio / Botton, Alessandro / Cazzaniga, Stefano / Bertini, Edoardo / Pezzotti, Mario / Giovannoni, James J / Vrebalov, Julia T / Matus, José Tomás / Tornielli, Giovanni Battista / Zenoni, Sara

    Plant physiology

    2023  Volume 192, Issue 3, Page(s) 1928–1946

    Abstract: Grapevine (Vitis vinifera L.) is one of the most widely cultivated fruit crops because the winemaking industry has huge economic relevance worldwide. Uncovering the molecular mechanisms controlling the developmental progression of plant organs will prove ...

    Abstract Grapevine (Vitis vinifera L.) is one of the most widely cultivated fruit crops because the winemaking industry has huge economic relevance worldwide. Uncovering the molecular mechanisms controlling the developmental progression of plant organs will prove essential for maintaining high-quality grapes, expressly in the context of climate change, which impairs the ripening process. Through a deep inspection of transcriptomic data, we identified VviNAC60, a member of the NAC transcription factor family, as a putative regulator of grapevine organ maturation. We explored VviNAC60 binding landscapes through DNA affinity purification followed by sequencing and compared bound genes with transcriptomics datasets from grapevine plants stably and transiently overexpressing VviNAC60 to define a set of high-confidence targets. Among these, we identified key molecular markers associated with organ senescence and fruit ripening. Physiological, metabolic, and promoter activation analyses showed that VviNAC60 induces chlorophyll degradation and anthocyanin accumulation through the upregulation of STAY-GREEN PROTEIN 1 (VviSGR1) and VviMYBA1, respectively, with the latter being upregulated through a VviNAC60-VviNAC03 regulatory complex. Despite sharing a closer phylogenetic relationship with senescence-related homologs to the NAC transcription factor AtNAP, VviNAC60 complemented the nonripening(nor) mutant phenotype in tomato (Solanum lycopersicum), suggesting a dual role as an orchestrator of both ripening- and senescence-related processes. Our data support VviNAC60 as a regulator of processes initiated in the grapevine vegetative- to mature-phase organ transition and therefore as a potential target for enhancing the environmental resilience of grapevine by fine-tuning the duration of the vegetative phase.
    MeSH term(s) Transcription Factors/genetics ; Transcription Factors/metabolism ; Phylogeny ; Gene Expression Regulation, Plant ; Transcriptome ; Gene Expression Profiling ; Fruit/metabolism ; Plant Proteins/metabolism ; Vitis/physiology
    Chemical Substances Transcription Factors ; Plant Proteins
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208914-2
    ISSN 1532-2548 ; 0032-0889
    ISSN (online) 1532-2548
    ISSN 0032-0889
    DOI 10.1093/plphys/kiad050
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    In stock of ZB MED Bonn / Germany

    Z 1193: Show issues

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  8. Article: VviNAC33 promotes organ de-greening and represses vegetative growth during the vegetative-to-mature phase transition in grapevine

    D'Inca, E. / Cazzaniga, S. / Foresti, C. / Vitulo, N. / Bertini, E. / Galli, M. / Gallavotti, A. / Pezzotti, M. / Tornielli, G. B. / Zenoni, S.

    New Phytologist

    2021  Volume 231, Issue 2, Page(s) 726–746

    Abstract: Plants undergo several developmental transitions during their life cycle. In grapevine, a perennial woody fruit crop, the transition from vegetative/green-to-mature/woody growth involves transcriptomic reprogramming orchestrated by a small group of genes ...

    Institution Department of Biotechnology, University of Verona, Verona 37134, Italy
    Abstract Plants undergo several developmental transitions during their life cycle. In grapevine, a perennial woody fruit crop, the transition from vegetative/green-to-mature/woody growth involves transcriptomic reprogramming orchestrated by a small group of genes encoding regulators, but the underlying molecular mechanisms are not fully understood. We investigated the function of the transcriptional regulator VviNAC33 by generating and characterizing transgenic overexpressing grapevine lines and a chimeric repressor, and by exploring its putative targets through a DNA affinity purification sequencing (DAP-seq) approach combined with transcriptomic data. We demonstrated that VviNAC33 induces leaf de-greening, inhibits organ growth and directly activates the expression of STAY-GREEN PROTEIN 1 (SGR1), which is involved in Chl and photosystem degradation, and AUTOPHAGY 8f (ATG8f), which is involved in the maturation of autophagosomes. Furthermore, we show that VviNAC33 directly inhibits AUXIN EFFLUX FACILITATOR PIN1, RopGEF1 and ATP SYNTHASE GAMMA CHAIN 1T (ATPC1), which are involved in photosystem II integrity and activity. Our results show that VviNAC33 plays a major role in terminating photosynthetic activity and organ growth as part of a regulatory network governing the vegetative-to-mature phase transition.
    Language English
    Document type Article
    ZDB-ID 208885-x
    ISSN 1469-8137 ; 0028-646X
    ISSN (online) 1469-8137
    ISSN 0028-646X
    Database Viticulture and Oenology Abstracts

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  9. Article ; Online: COVID-19 provoking Guillain-Barré syndrome: The Bergamo case series.

    Foresti, Camillo / Servalli, Maria Cristina / Frigeni, Barbara / Rifino, Nicola / Storti, Benedetta / Gritti, Paolo / Fabretti, Fabrizio / Grazioli, Lorenzo / Sessa, Maria

    European journal of neurology

    2020  Volume 28, Issue 10, Page(s) e84–e85

    MeSH term(s) COVID-19 ; Guillain-Barre Syndrome/diagnosis ; Guillain-Barre Syndrome/therapy ; Humans ; Plasma Exchange ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-14
    Publishing country England
    Document type Letter
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.14549
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4738: Show issues Location:
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    Zs.MO 592: Show issues

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  10. Article: Transarticular laser discal fragmentectomy. A new minimally invasive surgical approach for challenging disc herniations in the elderly.

    Bonaldi, Giuseppe / Brembilla, Carlo / Foresti, Camillo / Cianfoni, Alessandro

    Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences

    2014  Volume 20, Issue 5, Page(s) 555–563

    Abstract: This report describes two elderly patients with large disc fragments extruded into lumbar radicular recesses not treatable by any conventional conservative, minimally invasive or surgical approach. Direct access to the disc fragments was obtained ... ...

    Abstract This report describes two elderly patients with large disc fragments extruded into lumbar radicular recesses not treatable by any conventional conservative, minimally invasive or surgical approach. Direct access to the disc fragments was obtained crossing the articular zygapophyseal cavity instead of the interlaminar space and spinal canal, using a small needle through which a laser fibre was inserted to deliver energy for tissue ablation. The procedures obtained regression of both symptoms and the bulk of the fragments at early and late clinical and MR follow-ups.
    MeSH term(s) Aged ; Aged, 80 and over ; Anesthesia, Local ; Cartilage, Articular/surgery ; Electromyography ; Female ; Humans ; Intervertebral Disc Displacement/complications ; Intervertebral Disc Displacement/diagnostic imaging ; Intervertebral Disc Displacement/surgery ; Intraoperative Neurophysiological Monitoring ; Laser Therapy/methods ; Magnetic Resonance Imaging ; Male ; Minimally Invasive Surgical Procedures/methods ; Neurosurgical Procedures/methods ; Pain/etiology ; Pain/surgery ; Surgery, Computer-Assisted ; Tomography, X-Ray Computed ; Treatment Outcome
    Language English
    Publishing date 2014-10-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1354913-3
    ISSN 1591-0199 ; 1123-9344
    ISSN 1591-0199 ; 1123-9344
    DOI 10.15274/INR-2014-10085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6325: Show issues Location:
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