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Article ; Online: Let's Talk About Respiratory Swings!

Olschewski, Horst / Zeder, Katarina / Douschan, Philipp / Sassmann, Teresa / Foris, Vasile / Olschewski, Andrea / Kovacs, Gabor

American journal of respiratory and critical care medicine

2023 Volume 208, Issue 12, Page(s) 1338–1340

Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Letter
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202309-1637LE
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Article: Apelin-17 to diagnose idiopathic pulmonary arterial hypertension: A biomarker study.

Foris, Vasile / Kovacs, Gabor / Avian, Alexander / Bálint, Zoltán / Douschan, Philipp / Ghanim, Bahil / Klepetko, Walter / Olschewski, Andrea / Olschewski, Horst

Frontiers in physiology

2023 Volume 13, Page(s) 986295

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.986295
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Article ; Online: Endotyping COPD: hypoxia-inducible factor-2 as a molecular "switch" between the vascular and airway phenotypes?

Myronenko, Oleh / Foris, Vasile / Crnkovic, Slaven / Olschewski, Andrea / Rocha, Sonia / Nicolls, Mark R / Olschewski, Horst

European respiratory review : an official journal of the European Respiratory Society

2023 Volume 32, Issue 167

Abstract: COPD is a heterogeneous disease with multiple clinical phenotypes. COPD endotypes can be determined by different expressions of hypoxia-inducible factors (HIFs), which, in combination with individual susceptibility and environmental factors, may cause ... ...

Abstract	COPD is a heterogeneous disease with multiple clinical phenotypes. COPD endotypes can be determined by different expressions of hypoxia-inducible factors (HIFs), which, in combination with individual susceptibility and environmental factors, may cause predominant airway or vascular changes in the lung. The pulmonary vascular phenotype is relatively rare among COPD patients and characterised by out-of-proportion pulmonary hypertension (PH) and low diffusing capacity of the lung for carbon monoxide, but only mild-to-moderate airway obstruction. Its histologic feature, severe remodelling of the small pulmonary arteries, can be mediated by HIF-2 overexpression in experimental PH models. HIF-2 is not only involved in the vascular remodelling but also in the parenchyma destruction. Endothelial cells from human emphysema lungs express reduced HIF-2α levels, and the deletion of pulmonary endothelial
MeSH term(s)	Animals ; Humans ; Mice ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Emphysema/metabolism ; Emphysema/pathology ; Endothelial Cells/pathology ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/metabolism ; Hypoxia ; Pulmonary Disease, Chronic Obstructive/genetics ; Pulmonary Disease, Chronic Obstructive/metabolism ; Pulmonary Disease, Chronic Obstructive/pathology ; Pulmonary Emphysema/genetics ; Pulmonary Emphysema/metabolism
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; endothelial PAS domain-containing protein 1 (1B37H0967P)
Language	English
Publishing date	2023-01-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1077620-5
ISSN	1600-0617 ; 0905-9180
ISSN (online)	1600-0617
ISSN	0905-9180
DOI	10.1183/16000617.0173-2022
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Article ; Online: Compartment-specific remodeling patterns in end-stage chronic obstructive pulmonary disease with and without severe pulmonary hypertension.

Zeder, Katarina / Marsh, Leigh M / Avian, Alexander / Brcic, Luka / Birnhuber, Anna / Douschan, Philipp / Foris, Vasile / Sassmann, Teresa / Hoetzenecker, Konrad / Boehm, Panja M / Kwapiszewska, Grazyna / Olschewski, Andrea / Olschewski, Horst / Kovacs, Gabor

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2024

Abstract: Background: In patients with end-stage chronic obstructive pulmonary disease (COPD), severe pulmonary hypertension (PH) is frequently associated with less severe airway obstruction as compared to mild or no PH. However, the histologic correlate of this ... ...

Abstract	Background: In patients with end-stage chronic obstructive pulmonary disease (COPD), severe pulmonary hypertension (PH) is frequently associated with less severe airway obstruction as compared to mild or no PH. However, the histologic correlate of this finding is not clear. We aimed to quantify remodeling of pulmonary arteries, airways, and parenchyma in random samples of explanted end-stage COPD lungs. Methods: We quantified remodeling of small pulmonary arteries, small airways, and the degree of emphysema (mean interseptal distance [MID]) with dedicated software. As primary objective, we compared COPD patients with severe PH (SevPH-COPD) with age- and sex-matched MildPH-COPD. For comparison, we also investigated COPD lungs with no PH (NoPH-COPD), idiopathic PAH (IPAH), and healthy donors. Results: We included n = 17 SevPH-COPD (mPAP = 43 [39-45]mm Hg), n = 17 MildPH-COPD (mPAP = 28 [24-31]mm Hg), n = 5 NoPH-COPD (mPAP = 18 [16-19]mm Hg), n = 10 IPAH (mPAP = 72 [65-91]mm Hg), and n = 10 healthy donor lungs. SevPH-COPD versus MildPH-COPD was characterized by better preserved forced vital capacity (51% vs 40% predicted, p < 0.05), less emphysema (MID 169 µm vs 279 µm, p < 0.001), and less PAS-positive and CD45-positive mucosa cells (15% vs 22%, p = 0.063% and 5% vs 7%, p = 0.058) suggesting less airway inflammation. In COPD patients, intimal and medial thickening were strongly correlated with mPAP (r = 0.676, p < 0.001 and r = 0.595, p < 0.001). MID was negatively correlated with mPAP (r = -0.556, p < 0.001) and was highest in NoPH-COPD (mean 281 µm), suggesting that emphysema per se is not associated with PH. Conclusions: End-stage COPD with severe PH is characterized by pronounced pulmonary vascular remodeling, less inflammation of small airways, and less emphysema as compared to COPD with mild PH or no PH, suggesting that COPD with severe PH may represent a unique phenotype of COPD.
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2024.02.1044
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Article ; Online: Prognostic Value of Exercise as Compared to Resting Pulmonary Hypertension in Patients with Normal or Mildly Elevated Pulmonary Arterial Pressure.

Douschan, Philipp / Avian, Alexander / Foris, Vasile / Sassmann, Teresa / Bachmaier, Gerhard / Rosenstock, Piet / Zeder, Katarina / Olschewski, Horst / Kovacs, Gabor

American journal of respiratory and critical care medicine

2022 Volume 206, Issue 11, Page(s) 1418–1423

MeSH term(s)	Humans ; Hypertension, Pulmonary ; Arterial Pressure ; Prognosis ; Pulmonary Artery ; Exercise ; Hemodynamics ; Exercise Test
Language	English
Publishing date	2022-08-04
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202112-2856LE
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Article ; Online: Pulmonale Hypertonie assoziiert mit Lungenerkrankungen.

Halank, Michael / Zeder, Katarina E / Sommer, Natascha / Ulrich, Silvia / Held, Matthias / Köhler, Thomas / Foris, Vasile / Heberling, Melanie / Neurohr, Claus / Ronczka, Julia / Holt, Stephan / Skowasch, Dirk / Kneidinger, Nikolaus / Behr, Jürgen

Pneumologie (Stuttgart, Germany)

2023 Volume 77, Issue 11, Page(s) 916–925

Abstract: Lung diseases and hypoventilation syndromes are often associated with pulmonary hypertension (PH). In most cases, PH is not severe. This is defined hemodynamically by a mean pulmonary arterial pressure (PAPm) > 20 mmHg, a pulmonary arterial wedge ... ...

Title translation	Pulmonary hypertension associated with lung disease.
Abstract	Lung diseases and hypoventilation syndromes are often associated with pulmonary hypertension (PH). In most cases, PH is not severe. This is defined hemodynamically by a mean pulmonary arterial pressure (PAPm) > 20 mmHg, a pulmonary arterial wedge pressure (PAWP) ≤ 15 mmHg and a pulmonary vascular resistance of ≤ 5 Wood units (WU). Both the non-severe (PVR ≤ 5 WU) and much more the severe PH (PVR > 5 WU) have an unfavorable prognosis.If PH is suspected, it is recommended to primarily check whether risk factors for pulmonary arterial hypertension (PAH, group 1 PH) or chronic thromboembolic pulmonary hypertension (CTEPH, group 4 PH) are present. If risk factors are present or there is a suspicion of severe PH in lung patients, it is recommended that the patient should be presented to a PH outpatient clinic promptly.For patients with severe PH associated with lung diseases, personalized, individual therapy is recommended - if possible within the framework of therapy studies. Currently, a therapy attempt with PH specific drugs should only be considered in COPD patients if the associated PH is severe and a "pulmonary vascular" phenotype (severe precapillary PH, but typically only mild to moderate airway obstruction, no or mild hypercapnia and DLCO < 45 % of predicted value) is present. In patients with severe PH associated with interstitial lung disease phosphodiesterase-5-inhibitors may be considered in individual cases. Inhaled treprostinil may be considered also in non-severe PH in this patient population.
MeSH term(s)	Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Lung ; Vascular Resistance ; Prognosis ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/therapy ; Lung Diseases, Interstitial/complications
Language	German
Publishing date	2023-11-14
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	607630-0
ISSN	1438-8790 ; 0934-8387
ISSN (online)	1438-8790
ISSN	0934-8387
DOI	10.1055/a-2145-4756
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Uh II Zs.142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 54: Show issues

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Article ; Online: Genetische Diagnostik und molekulare Ansätze bei pulmonalarterieller Hypertonie.

Eichstaedt, Christina A / Bikou, Olympia / Sommer, Natascha / Schermuly, Ralph T / Pullamsetti, Soni S / Weissmann, Norbert / Harbaum, Lars / Tabeling, Christoph / Wißmüller, Max / Foris, Vasile / Kuebler, Wolfgang M / Hinderhofer, Katrin / Olschewski, Andrea / Kwapiszewska, Grazyna

Pneumologie (Stuttgart, Germany)

2023 Volume 77, Issue 11, Page(s) 862–870

Abstract: The recently published new European guidelines for diagnosis and treatment of pulmonary hypertension now offer the so far most extensive description of genetic testing and counselling for pulmonary arterial hypertension patients. In addition, the ... ...

Title translation	Genetic diagnostics and molecular approaches in pulmonary arterial hypertension.
Abstract	The recently published new European guidelines for diagnosis and treatment of pulmonary hypertension now offer the so far most extensive description of genetic testing and counselling for pulmonary arterial hypertension patients. In addition, the importance of a clinical screening of healthy mutation carriers is highlighted as well as the genetic testing of patients with a suspicion of pulmonary veno-occlusive disease. We frame the respective parts of the guidelines on genetic testing and counselling in the context of recent data and provide comments. Finally, we give an outlook on novel molecular approaches starting from Sotatercept, addressing ion channels and novel therapeutic developments.
MeSH term(s)	Humans ; Pulmonary Arterial Hypertension ; Familial Primary Pulmonary Hypertension/diagnosis ; Familial Primary Pulmonary Hypertension/genetics ; Familial Primary Pulmonary Hypertension/therapy ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/therapy ; Pulmonary Veno-Occlusive Disease/diagnosis ; Pulmonary Veno-Occlusive Disease/genetics ; Pulmonary Veno-Occlusive Disease/therapy
Language	German
Publishing date	2023-11-14
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	607630-0
ISSN	1438-8790 ; 0934-8387
ISSN (online)	1438-8790
ISSN	0934-8387
DOI	10.1055/a-2145-4663
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Article: Association of amino acids and parameters of bone metabolism with endothelial dysfunction and vasculopathic changes in limited systemic sclerosis.

Jud, Philipp / Meinitzer, Andreas / Strohmaier, Heimo / Arefnia, Behrouz / Wimmer, Gernot / Obermayer-Pietsch, Barbara / Foris, Vasile / Kovacs, Gabor / Odler, Balazs / Moazedi-Fürst, Florentine / Brodmann, Marianne / Hafner, Franz

Frontiers in medicine

2023 Volume 10, Page(s) 1193121

Abstract: Objectives: Pathways contributing to endothelial dysfunction in patients with limited cutaneous systemic sclerosis (lcSSc) are largely unknown. The aim of this study was to investigate potential associations of amino acids and parameters of bone ... ...

Abstract	Objectives: Pathways contributing to endothelial dysfunction in patients with limited cutaneous systemic sclerosis (lcSSc) are largely unknown. The aim of this study was to investigate potential associations of amino acids and parameters of bone metabolism with endothelial dysfunction and vasculopathy-related changes in patients with lcSSc and early-stage vasculopathy. Methods: Amino acids, calciotropic parameters, including 25-hydroxyvitamin D and parathyroid hormone (PTH), and bone turnover parameters, including osteocalcin and N-terminal peptide of procollagen-3 (P3NP), were measured in 38 lcSSc patients and 38 controls. Endothelial dysfunction was assessed by biochemical parameters, pulse-wave analysis, flow-mediated and nitroglycerine-mediated dilation. Additionally, vasculopathy-related and SSc-specific clinical changes including capillaroscopic, skin, renal, pulmonary, gastrointestinal and periodontal parameters were recorded. Results: No significant differences in amino acids, calciotropic and bone turnover parameters were observed between lcSSc patients and controls. In patients with lcSSc, several significant correlations were found between selected amino acids, parameters of endothelial dysfunction, vasculopathy-related and SSc-specific clinical changes (all with Conclusion: Selected amino acids may affect endothelial function and may be associated to vasculopathy-related and clinical changes in lcSSc patients, while the association with parameters of bone metabolism seems to be minor.
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1193121
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Article ; Online: Clinical Impact of the New Definition of Precapillary Pulmonary Hypertension.

Kovacs, Gabor / Zeder, Katarina / Rosenstock, Piet / Avian, Alexander / Bachmaier, Gerhard / Douschan, Philipp / Foris, Vasile / Sassmann, Teresa / Olschewsk, Horst

Chest

2021 Volume 159, Issue 5, Page(s) 1995–1997

MeSH term(s)	Aged ; Cardiac Catheterization ; Consensus ; Female ; Humans ; Hypertension, Pulmonary/classification ; Male ; Middle Aged ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2021-01-05
Publishing country	United States
Document type	Letter
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2020.11.070
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Ui III Zs.45: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Advanced interstitial lung fibrosis with emphysema and pulmonary hypertension with no evidence for interstitial lung disease on high resolution CT.

Foris, Vasile / Brcic, Luka / Douschan, Philipp / Kovacs, Gabor / Stacher-Priehse, Elvira / Olschewski, Horst

Pulmonary circulation

2019 Volume 9, Issue 3, Page(s) 2045894019832214

Abstract: The diagnosis of idiopathic pulmonary arterial hypertension (iPAH) is complex and, besides invasive hemodynamic evaluation, includes several diagnostic steps to exclude any underlying diseases. The role of a decreased diffusion capacity of the lung for ... ...

Abstract	The diagnosis of idiopathic pulmonary arterial hypertension (iPAH) is complex and, besides invasive hemodynamic evaluation, includes several diagnostic steps to exclude any underlying diseases. The role of a decreased diffusion capacity of the lung for carbon monoxide (DLCO) is a matter of discussion. Here, we present a 76-year-old man with a smoking history of 30 pack-years who was diagnosed with iPAH after chronic thromboembolic pulmonary hypertension was excluded based on a negative perfusion scan, an underlying heart disease was excluded based on echocardiography and right heart catheterization, and a significant lung disease was excluded based on lung function test (FVC = 101% predicted, FEV1 = 104% predicted, FEV1/FVC = 77, TLC = 97% predicted) and thin-slice computed tomography (CT) scan. Just DLCO was reduced to 40% predicted, suggesting a possible structural lung disease. Postmortem examination demonstrated severe interstitial lung fibrosis combined with microscopic emphysema. This indicates that both CT imaging and pulmonary function test may be insensitive to a diffuse peripheral combined pattern of fibrosis and emphysema and that DLCO may be the only sensitive marker of this significant lung pathology.
Language	English
Publishing date	2019-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2638089-4
ISSN	2045-8940 ; 2045-8932
ISSN (online)	2045-8940
ISSN	2045-8932
DOI	10.1177/2045894019832214
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