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  1. Article ; Online: Shedding Light on Bone Morphogenetic Protein (BMP) Signaling Modifiers to Modulate Fibrodysplasia Ossificans Progressiva Severity.

    Forlino, Antonella

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2022  Volume 37, Issue 11, Page(s) 2055–2057

    MeSH term(s) Humans ; Myositis Ossificans/metabolism ; Bone Morphogenetic Proteins/metabolism ; Bone Morphogenetic Protein 4 ; Signal Transduction ; Activin Receptors, Type I/genetics ; Activin Receptors, Type I/metabolism
    Chemical Substances Bone Morphogenetic Proteins ; Bone Morphogenetic Protein 4 ; Activin Receptors, Type I (EC 2.7.11.30)
    Language English
    Publishing date 2022-11-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Outer Membrane Vesicles (OMVs) as Biomedical Tools and Their Relevance as Immune-Modulating Agents against

    Ahmed, Abeer Ahmed Qaed / Besio, Roberta / Xiao, Lin / Forlino, Antonella

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: Outer membrane vesicles (OMVs) are lipid-membrane-bounded nanoparticles that are released from Gram-negative bacteria via vesiculation of the outer membrane. They have vital roles in different biological processes and recently, they have received ... ...

    Abstract Outer membrane vesicles (OMVs) are lipid-membrane-bounded nanoparticles that are released from Gram-negative bacteria via vesiculation of the outer membrane. They have vital roles in different biological processes and recently, they have received increasing attention as possible candidates for a broad variety of biomedical applications. In particular, OMVs have several characteristics that enable them to be promising candidates for immune modulation against pathogens, such as their ability to induce the host immune responses given their resemblance to the parental bacterial cell.
    MeSH term(s) Humans ; Helicobacter pylori/physiology ; Gram-Negative Bacteria ; Extracellular Vesicles ; Helicobacter Infections/microbiology
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24108542
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  3. Article: Editorial: Molecular Mechanisms of Heritable Connective Tissue Disorders.

    Malfait, Fransiska / Forlino, Antonella / Sengle, Gerhard / Van Agtmael, Tom

    Frontiers in genetics

    2022  Volume 13, Page(s) 866665

    Language English
    Publishing date 2022-04-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.866665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Appendage Regeneration in Vertebrates: What Makes This Possible?

    Daponte, Valentina / Tylzanowski, Przemko / Forlino, Antonella

    Cells

    2021  Volume 10, Issue 2

    Abstract: The ability to regenerate amputated or injured tissues and organs is a fascinating property shared by several invertebrates and, interestingly, some vertebrates. The mechanism of evolutionary loss of regeneration in mammals is not understood, yet from ... ...

    Abstract The ability to regenerate amputated or injured tissues and organs is a fascinating property shared by several invertebrates and, interestingly, some vertebrates. The mechanism of evolutionary loss of regeneration in mammals is not understood, yet from the biomedical and clinical point of view, it would be very beneficial to be able, at least partially, to restore that capability. The current availability of new experimental tools, facilitating the comparative study of models with high regenerative ability, provides a powerful instrument to unveil what is needed for a successful regeneration. The present review provides an updated overview of multiple aspects of appendage regeneration in three vertebrates: lizard, salamander, and zebrafish. The deep investigation of this process points to common mechanisms, including the relevance of Wnt/β-catenin and FGF signaling for the restoration of a functional appendage. We discuss the formation and cellular origin of the blastema and the identification of epigenetic and cellular changes and molecular pathways shared by vertebrates capable of regeneration. Understanding the similarities, being aware of the differences of the processes, during lizard, salamander, and zebrafish regeneration can provide a useful guide for supporting effective regenerative strategies in mammals.
    MeSH term(s) Animals ; Body Patterning/genetics ; Epigenesis, Genetic ; Extremities/physiology ; Phylogeny ; Regeneration/genetics ; Regeneration/physiology ; Vertebrates/physiology
    Language English
    Publishing date 2021-01-27
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10020242
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  5. Article: Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells.

    Lewoniewska, Sylwia / Oscilowska, Ilona / Forlino, Antonella / Palka, Jerzy

    Biology

    2021  Volume 10, Issue 12

    Abstract: It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity. Although the role of estrogens in estrogen receptor-positive ... ...

    Abstract It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity. Although the role of estrogens in estrogen receptor-positive breast cancer progression has been well established, the mechanism of their effect on apoptosis is not fully understood. It has been considered that ER status of breast cancer cells and estrogen availability might determine proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis. PRODH/POX is a mitochondrial enzyme that converts proline into pyrroline-5-carboxylate (P5C). During this process, ATP (adenosine triphosphate) or ROS (reactive oxygen species) are produced, facilitating cell survival or death, respectively. However, the critical factor in driving PRODH/POX-dependent functions is proline availability. The amount of this amino acid is regulated at the level of prolidase (proline releasing enzyme), collagen biosynthesis (proline utilizing process), and glutamine, glutamate, α-ketoglutarate, and ornithine metabolism. Estrogens were found to upregulate prolidase activity and collagen biosynthesis. It seems that in estrogen receptor-positive breast cancer cells, prolidase supports proline for collagen biosynthesis, limiting its availability for PRODH/POX-dependent apoptosis. Moreover, lack of free proline (known to upregulate the transcriptional activity of hypoxia-inducible factor 1, HIF-1) contributes to downregulation of HIF-1-dependent pro-survival activity. The complex regulatory mechanism also involves PRODH/POX expression and activity. It is induced transcriptionally by p53 and post-transcriptionally by AMPK (AMP-activated protein kinase), which is regulated by ERs. The review also discusses the role of interconversion of proline/glutamate/ornithine in supporting proline to PRODH/POX-dependent functions. The data suggest that PRODH/POX-induced apoptosis is dependent on ER status in breast cancer cells.
    Language English
    Publishing date 2021-12-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10121314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Understanding the Role of Estrogen Receptor Status in PRODH/POX-Dependent Apoptosis/Survival in Breast Cancer Cells

    Lewoniewska, Sylwia / Oscilowska, Ilona / Forlino, Antonella / Palka, Jerzy

    Biology. 2021 Dec. 10, v. 10, no. 12

    2021  

    Abstract: It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity. Although the role of estrogens in estrogen receptor-positive ... ...

    Abstract It has been suggested that activation of estrogen receptor α (ER α) stimulates cell proliferation. In contrast, estrogen receptor β (ER β) has anti-proliferative and pro-apoptotic activity. Although the role of estrogens in estrogen receptor-positive breast cancer progression has been well established, the mechanism of their effect on apoptosis is not fully understood. It has been considered that ER status of breast cancer cells and estrogen availability might determine proline dehydrogenase/proline oxidase (PRODH/POX)-dependent apoptosis. PRODH/POX is a mitochondrial enzyme that converts proline into pyrroline-5-carboxylate (P5C). During this process, ATP (adenosine triphosphate) or ROS (reactive oxygen species) are produced, facilitating cell survival or death, respectively. However, the critical factor in driving PRODH/POX-dependent functions is proline availability. The amount of this amino acid is regulated at the level of prolidase (proline releasing enzyme), collagen biosynthesis (proline utilizing process), and glutamine, glutamate, α-ketoglutarate, and ornithine metabolism. Estrogens were found to upregulate prolidase activity and collagen biosynthesis. It seems that in estrogen receptor-positive breast cancer cells, prolidase supports proline for collagen biosynthesis, limiting its availability for PRODH/POX-dependent apoptosis. Moreover, lack of free proline (known to upregulate the transcriptional activity of hypoxia-inducible factor 1, HIF-1) contributes to downregulation of HIF-1-dependent pro-survival activity. The complex regulatory mechanism also involves PRODH/POX expression and activity. It is induced transcriptionally by p53 and post-transcriptionally by AMPK (AMP-activated protein kinase), which is regulated by ERs. The review also discusses the role of interconversion of proline/glutamate/ornithine in supporting proline to PRODH/POX-dependent functions. The data suggest that PRODH/POX-induced apoptosis is dependent on ER status in breast cancer cells.
    Keywords AMP-activated protein kinase ; adenosine triphosphate ; apoptosis ; biosynthesis ; breast neoplasms ; cell proliferation ; cell viability ; collagen ; death ; estrogen receptors ; estrogens ; glutamic acid ; glutamine ; hypoxia-inducible factor 1 ; mitochondria ; neoplasm progression ; ornithine ; oxidoreductases ; proline ; proline dipeptidase ; reactive oxygen species ; transcription (genetics)
    Language English
    Dates of publication 2021-1210
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10121314
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Recombinant Prolidase Activates EGFR-Dependent Cell Growth in an Experimental Model of Inflammation in HaCaT Keratinocytes. Implication for Wound Healing.

    Nizioł, Magdalena / Ościłowska, Ilona / Baszanowska, Weronika / Pałka, Jerzy / Besio, Roberta / Forlino, Antonella / Miltyk, Wojciech

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 876348

    Abstract: This study was conducted to investigate the proliferative capacity of recombinant human prolidase (rhPEPD) in a human model of inflammation induced by IL- ... ...

    Abstract This study was conducted to investigate the proliferative capacity of recombinant human prolidase (rhPEPD) in a human model of inflammation induced by IL-1
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.876348
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  8. Article: Compression Fractures and Partial Phenotype Rescue With a Low Phosphorus Diet in the

    Cotti, Silvia / Huysseune, Ann / Larionova, Daria / Koppe, Wolfgang / Forlino, Antonella / Witten, Paul Eckhard

    Frontiers in endocrinology

    2022  Volume 13, Page(s) 851879

    Abstract: Osteogenesis imperfecta (OI) is a group of heritable disorders affecting bone and other connective tissues. Dominant OI forms are mainly caused by mutations in collagen type I. Patients suffer from skeletal deformities, fractures of long bones and ... ...

    Abstract Osteogenesis imperfecta (OI) is a group of heritable disorders affecting bone and other connective tissues. Dominant OI forms are mainly caused by mutations in collagen type I. Patients suffer from skeletal deformities, fractures of long bones and vertebral compression fractures from early childhood onward. Altered collagen structure and excess mineralisation are the main causes for the bone phenotype. The
    MeSH term(s) Animals ; Collagen ; Diet ; Disease Models, Animal ; Fractures, Compression ; Humans ; Musculoskeletal Abnormalities ; Osteogenesis Imperfecta/genetics ; Osteogenesis Imperfecta/pathology ; Phenotype ; Phosphorus ; Spinal Fractures ; Zebrafish
    Chemical Substances Phosphorus (27YLU75U4W) ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2022.851879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Highly Efficient Expression System of Recombinant Human Prolidase and the Effect of N-Terminal His-Tag on the Enzyme Activity.

    Czyrko-Horczak, Justyna / Nizioł, Magdalena / Forlino, Antonella / Besio, Roberta / Miltyk, Wojciech

    Cells

    2022  Volume 11, Issue 20

    Abstract: Prolidase is an enzyme hydrolyzing dipeptides containing proline or hydroxyprolineat the C-terminus and plays an important role in collagen turnover. Human prolidase is active as a dimer with the C-terminal domain containing two ... ...

    Abstract Prolidase is an enzyme hydrolyzing dipeptides containing proline or hydroxyprolineat the C-terminus and plays an important role in collagen turnover. Human prolidase is active as a dimer with the C-terminal domain containing two Mn
    MeSH term(s) Humans ; Collagen ; Proline ; Dipeptides ; ErbB Receptors
    Chemical Substances proline dipeptidase (EC 3.4.13.9) ; Collagen (9007-34-5) ; Proline (9DLQ4CIU6V) ; Dipeptides ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11203284
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  10. Article ; Online: Steady-State and Pulse-Chase Analyses of Fibrillar Collagen.

    Forlino, Antonella / Tonelli, Francesca / Besio, Roberta

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1952, Page(s) 45–53

    Abstract: Steady-state and pulse-chase collagen analyses are powerful approaches to investigate in vitro the structure of collagen and its kinetic of secretion, respectively. The electrophoretic analysis of ... ...

    Abstract Steady-state and pulse-chase collagen analyses are powerful approaches to investigate in vitro the structure of collagen and its kinetic of secretion, respectively. The electrophoretic analysis of purified
    MeSH term(s) Animals ; Electrophoresis, Polyacrylamide Gel/methods ; Fibrillar Collagens/chemistry ; Fibroblasts/chemistry ; Humans ; Proline/analysis ; Protein Processing, Post-Translational ; Tritium/analysis ; Urea/chemistry
    Chemical Substances Fibrillar Collagens ; Tritium (10028-17-8) ; Urea (8W8T17847W) ; Proline (9DLQ4CIU6V)
    Language English
    Publishing date 2019-03-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9133-4_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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