LIVIVO - Search results -

Search results

Result 1 - 10 of total 498

Search options

Article ; Online: The genetic architecture of dementia with Lewy bodies is shaping up.

Fornage, Myriam

2017 Volume 17, Issue 1, Page(s) 25–26

MeSH term(s)	Dementia ; Humans ; Lewy Bodies ; Lewy Body Disease/genetics ; Parkinson Disease
Language	English
Publishing date	2017-12-16
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	2081241-3
ISSN	1474-4465 ; 1474-4422
ISSN (online)	1474-4465
ISSN	1474-4422
DOI	10.1016/S1474-4422(17)30411-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5955: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Epigenome-wide association study of incident type 2 diabetes in Black and White participants from the Atherosclerosis Risk in Communities Study.

Venkataraghavan, Sowmya / Pankow, James S / Boerwinkle, Eric / Fornage, Myriam / Selvin, Elizabeth / Ray, Debashree

medRxiv : the preprint server for health sciences

2023

Abstract: DNA methylation studies of incident type 2 diabetes in US populations are limited, and to our knowledge none included individuals of African descent living in the US. We performed an epigenome-wide association analysis of blood-based methylation levels ... ...

Abstract	DNA methylation studies of incident type 2 diabetes in US populations are limited, and to our knowledge none included individuals of African descent living in the US. We performed an epigenome-wide association analysis of blood-based methylation levels at CpG sites with incident type 2 diabetes using Cox regression in 2,091 Black and 1,029 White individuals from the Atherosclerosis Risk in Communities study. At an epigenome-wide significance threshold of 10
Language	English
Publishing date	2023-08-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.09.23293896
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: The emerging genetic landscape of cerebral white matter hyperintensities.

Fornage, Myriam / Beecham, Ashley H

Neurology

2019 Volume 92, Issue 8, Page(s) 355–356

MeSH term(s)	Brain ; Genetic Variation ; Humans ; Leukoaraiosis ; White Matter
Language	English
Publishing date	2019-01-18
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000006936
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui II Zs.153: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 18: Show issues
Zs.MO 374: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Imaging Endophenotypes of Stroke as a Target for Genetic Studies.

Jian, Xueqiu / Fornage, Myriam

Stroke

2018 Volume 49, Issue 6, Page(s) 1557–1562

MeSH term(s)	Brain/diagnostic imaging ; Endophenotypes ; Genetic Predisposition to Disease ; Genetic Testing ; Humans ; Stroke/diagnostic imaging ; Stroke/genetics
Language	English
Publishing date	2018-05-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.117.017073
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 448: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Alzheimer's Disease Genetic Risk, Cognition, and Brain Aging in Midlife.

Brenowitz, Willa D / Fornage, Myriam / Launer, Lenore J / Habes, Mohamad / Davatzikos, Christos / Yaffe, Kristine

Annals of neurology

2022 Volume 93, Issue 3, Page(s) 629–634

Abstract: We examined associations of an Alzheimer's disease (AD) Genetic Risk Score (AD-GRS) and midlife cognitive and neuroimaging outcomes in 1,252 middle-aged participants (311 with brain MRI). A higher AD-GRS based on 25 previously identified loci (excluding ... ...

Abstract	We examined associations of an Alzheimer's disease (AD) Genetic Risk Score (AD-GRS) and midlife cognitive and neuroimaging outcomes in 1,252 middle-aged participants (311 with brain MRI). A higher AD-GRS based on 25 previously identified loci (excluding apolipoprotein E [APOE]) was associated with worse Montreal Cognitive Assessment (-0.14 standard deviation [SD] [95% confidence interval {CI}: -0.26, -0.02]), older machine learning predicted brain age (2.35 years[95%CI: 0.01, 4.69]), and white matter hyperintensity volume (0.35 SD [95% CI: 0.00, 0.71]), but not with a composite cognitive outcome, total brain, or hippocampal volume. APOE ε4 allele was not associated with any outcomes. AD risk genes beyond APOE may contribute to subclinical differences in cognition and brain health in midlife. ANN NEUROL 2023;93:629-634.
MeSH term(s)	Middle Aged ; Humans ; Child, Preschool ; Alzheimer Disease/genetics ; Brain ; Aging/genetics ; Cognition ; Apolipoproteins E ; Apolipoprotein E4/genetics
Chemical Substances	Apolipoproteins E ; Apolipoprotein E4
Language	English
Publishing date	2022-12-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80362-5
ISSN	1531-8249 ; 0364-5134
ISSN (online)	1531-8249
ISSN	0364-5134
DOI	10.1002/ana.26569
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1370: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 478: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Identification of novel susceptibility methylation loci for pancreatic cancer in a two-phase epigenome-wide association study.

Wang, Ziqiao / Lu, Yue / Fornage, Myriam / Jiao, Li / Shen, Jianjun / Li, Donghui / Wei, Peng

Epigenetics

2022 Volume 17, Issue 11, Page(s) 1357–1372

Abstract: The role of DNA methylation and its interplay with gene expression in the susceptibility to pancreatic cancer (PanC) remains largely unexplored. To fill in this gap, we conducted an integrative two-phase epigenome-wide association study (EWAS) of PanC ... ...

Abstract	The role of DNA methylation and its interplay with gene expression in the susceptibility to pancreatic cancer (PanC) remains largely unexplored. To fill in this gap, we conducted an integrative two-phase epigenome-wide association study (EWAS) of PanC using genomic DNA from 44 cases and 556 controls (20 local controls and 536 public controls in the Framingham Heart Study) in phase 1 and 23 cases and 22 controls in phase 2. We validated the findings using pre-diagnostic blood samples from 13 cases and 26 controls in the Women's Health Initiative (WHI) Study. We further examined gene expression in peripheral leukocytes of 47 cases and 31 controls involved in the methylation study using RNA sequencing and performed bidirectional Mendelian randomization (MR) analysis using existing single nucleotide polymorphism (SNP) data. In phase 1, we identified 2776 significantly differentially methylated CpG sites (DMPs) and 154 significantly differentially methylated regions (DMRs). In phase 2, we validated six DMPs (in or near
MeSH term(s)	Humans ; Female ; Epigenome ; DNA Methylation ; Genome-Wide Association Study ; DNA ; Pancreatic Neoplasms/genetics ; CpG Islands ; Epigenesis, Genetic
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2022-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1559-2308
ISSN (online)	1559-2308
DOI	10.1080/15592294.2022.2026591
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: White matter hyperintensity genetic risk factor

Yeung, Sunny Hoi-Sang / Lee, Ralph Hon-Sun / Cheng, Gerald Wai-Yeung / Ma, Iris Wai-Ting / Kofler, Julia / Kent, Candice / Ma, Fulin / Herrup, Karl / Fornage, Myriam / Arai, Ken / Tse, Kai-Hei

bioRxiv : the preprint server for biology

2024

Abstract: White matter hyperintensity (WMH) is strongly correlated with age-related dementia and hypertension, but its pathogenesis remains obscure. GWAS identified TRIM47 at 17q25 locus as a top genetic risk factor for WMH formation. TRIM family is a class of E3 ... ...

Abstract	White matter hyperintensity (WMH) is strongly correlated with age-related dementia and hypertension, but its pathogenesis remains obscure. GWAS identified TRIM47 at 17q25 locus as a top genetic risk factor for WMH formation. TRIM family is a class of E3 ubiquitin ligase with pivotal functions in autophagy, which is critical for brain endothelial cell (ECs) remodeling during hypertension. We hypothesize that TRIM47 regulates autophagy and its loss-of-function disturbs cerebrovasculature. Based on transcriptomics and immunohistochemistry, TRIM47 is found selectively expressed by brain ECs in human and mouse, and its transcription is upregulated by artificially-induced autophagy while downregulated in hypertension-like conditions. Using Summary statement: TRIM47, top genetic risk factor for white matter hyperintensity formation, is a negative regulator of autophagy in brain endothelial cells and implicates a novel cellular mechanism for age-related cerebrovascular changes.
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.18.566359
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Genetics of stroke.

Fornage, Myriam

Current atherosclerosis reports

2009 Volume 11, Issue 3, Page(s) 167–174

Abstract: Stroke is the third leading cause of death and the leading cause of severe long-term disability in developed countries. Despite significant progress in understanding the risk factors conferring disease predisposition, the genetic and molecular basis of ... ...

Abstract	Stroke is the third leading cause of death and the leading cause of severe long-term disability in developed countries. Despite significant progress in understanding the risk factors conferring disease predisposition, the genetic and molecular basis of stroke remains poorly understood. Recent advances in the identification and characterization of patterns of DNA sequence variation in human populations hold the promise that stroke genomics will offer significant insights into disease pathophysiology and open new avenues for the development of novel therapeutic modalities. However, beyond single nucleotide polymorphisms, the emergence of additional sources of genomic variability as major factors in disease etiology is likely to transform our DNA-centric approaches toward more integrative and comprehensive strategies. This review provides an overview of the current progress and future prospects of the application of genomic sciences to stroke research.
MeSH term(s)	Developed Countries ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Single Nucleotide ; Risk Factors ; Stroke/genetics ; Stroke/physiopathology
Language	English
Publishing date	2009-04-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057369-8
ISSN	1534-6242 ; 1523-3804
ISSN (online)	1534-6242
ISSN	1523-3804
DOI	10.1007/s11883-009-0027-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5534: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Unsupervised deep representation learning enables phenotype discovery for genetic association studies of brain imaging.

Patel, Khush / Xie, Ziqian / Yuan, Hao / Islam, Sheikh Muhammad Saiful / Xie, Yaochen / He, Wei / Zhang, Wanheng / Gottlieb, Assaf / Chen, Han / Giancardo, Luca / Knaack, Alexander / Fletcher, Evan / Fornage, Myriam / Ji, Shuiwang / Zhi, Degui

Communications biology

2024 Volume 7, Issue 1, Page(s) 414

Abstract: Understanding the genetic architecture of brain structure is challenging, partly due to difficulties in designing robust, non-biased descriptors of brain morphology. Until recently, brain measures for genome-wide association studies (GWAS) consisted of ... ...

Abstract	Understanding the genetic architecture of brain structure is challenging, partly due to difficulties in designing robust, non-biased descriptors of brain morphology. Until recently, brain measures for genome-wide association studies (GWAS) consisted of traditionally expert-defined or software-derived image-derived phenotypes (IDPs) that are often based on theoretical preconceptions or computed from limited amounts of data. Here, we present an approach to derive brain imaging phenotypes using unsupervised deep representation learning. We train a 3-D convolutional autoencoder model with reconstruction loss on 6130 UK Biobank (UKBB) participants' T1 or T2-FLAIR (T2) brain MRIs to create a 128-dimensional representation known as Unsupervised Deep learning derived Imaging Phenotypes (UDIPs). GWAS of these UDIPs in held-out UKBB subjects (n = 22,880 discovery and n = 12,359/11,265 replication cohorts for T1/T2) identified 9457 significant SNPs organized into 97 independent genetic loci of which 60 loci were replicated. Twenty-six loci were not reported in earlier T1 and T2 IDP-based UK Biobank GWAS. We developed a perturbation-based decoder interpretation approach to show that these loci are associated with UDIPs mapped to multiple relevant brain regions. Our results established unsupervised deep learning can derive robust, unbiased, heritable, and interpretable brain imaging phenotypes.
MeSH term(s)	Humans ; Genome-Wide Association Study/methods ; Phenotype ; Genetic Loci ; Brain/diagnostic imaging ; Neuroimaging
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-024-06096-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Cerebral Small-Vessel Disease in Individuals with a Family History of Coronary Heart Disease: The Atherosclerosis Risk in Communities Study.

Johansen, Michelle C / Nyquist, Paul / Sullivan, Kevin J / Fornage, Myriam / Gottesman, Rebecca F / Becker, Diane M

Neuroepidemiology

2021 Volume 55, Issue 4, Page(s) 316–322

Abstract: Introduction: The degree to which a family history of coronary heart disease (FHCHD) is associated with silent cerebral small-vessel disease (cSVD) among healthy adults, independent of prevalent CHD and traditional risk factors, is unknown.: Methods: ...

Abstract	Introduction: The degree to which a family history of coronary heart disease (FHCHD) is associated with silent cerebral small-vessel disease (cSVD) among healthy adults, independent of prevalent CHD and traditional risk factors, is unknown. Methods: The Atherosclerosis Risk in Communities (ARIC) study is a community-based cohort study with self-reported family history data and brain magnetic resonance imaging (ages 68-88). The association between markers of cSVD (lacunar infarcts and cerebral microbleeds), or log-transformed white matter hyperintensity (WMH) volume, and FHCHD, or the number of affected relatives was examined using separate adjusted logistic or linear regression models, respectively. Race interaction terms were evaluated. Results: Of 1,639 participants without prevalent CHD (76 ± 5 years, 62% female, 29% black), 686 (42%) had FHCHD. There were higher odds of lacunar infarct (OR 1.40, 95% CI 1.07-1.84) among those with parental FHCHD and higher odds of microhemorrhages (lobar OR 1.86, 95% CI 1.13-3.06; subcortical OR 1.47, 95% CI 1.01-2.15) among those with sibling FHCHD. A greater number of any relative affected was associated with higher odds of lacunar infarct (OR 1.24, 95% CI 1.04-1.47) and lobar microhemorrhages (OR 1.31, 95% CI 1.05-1.64) but not subcortical microhemorrhages (OR 1.09, 95% CI 0.92-1.28). Odds of having a lacunar infarct were higher among blacks (p-interaction 0.04) with paternal FHCHD (OR 2.20, CI 1.35-3.58) than whites with paternal FHCHD (OR 1.17, CI 0.87-1.56). There was no association with WMH. Discussion/conclusion: Markers of cSVD, specifically lacunar infarcts and microhemorrhages, appear to be associated with FHCHD, potentially representing shared mechanisms in different vascular beds, and perhaps a genetic propensity for vascular disease.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Atherosclerosis/diagnostic imaging ; Atherosclerosis/epidemiology ; Atherosclerosis/genetics ; Cerebral Small Vessel Diseases/diagnostic imaging ; Cerebral Small Vessel Diseases/epidemiology ; Cerebral Small Vessel Diseases/genetics ; Cohort Studies ; Coronary Disease/epidemiology ; Coronary Disease/genetics ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Risk Factors ; Stroke, Lacunar
Language	English
Publishing date	2021-06-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603189-4
ISSN	1423-0208 ; 0251-5350
ISSN (online)	1423-0208
ISSN	0251-5350
DOI	10.1159/000516428
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1722: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito