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  1. AU="Forster, Benjamin M"
  2. AU="Hewitt, Landyn"
  3. AU="Sanoja, E."
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  5. AU="Launer, Lenore J" AU="Launer, Lenore J"
  6. AU="Tse, Man-Kit"
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  30. AU="Sánchez-Garcia, Joaquín"
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  34. AU="Park, Jung Wan"
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  42. AU="Schmidt, Michael Rahbek"
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  1. Artikel ; Online: A Case Report of Acute Renal Failure as a Result of Light-Chain-Mediated Acute Tubular Interstitial Nephritis in a 30-Year-Old Combat Veteran.

    Forster, Benjamin M / Hinton, Adrian P / Thurlow, John S

    Military medicine

    2017  Band 182, Heft 11, Seite(n) e2099–e2103

    Abstract: We present a 30-year-old combat veteran with an unclear exposure history, with multiple deployments who was later diagnosed with acute renal failure as a result of light-chain deposition disease. Despite a drastic decline in kappa light chains following ... ...

    Abstract We present a 30-year-old combat veteran with an unclear exposure history, with multiple deployments who was later diagnosed with acute renal failure as a result of light-chain deposition disease. Despite a drastic decline in kappa light chains following chemotherapy; his renal function worsened, and he progressed to end-stage renal disease, requiring hemodialysis. Light-chain-mediated acute tubular interstitial nephritis is an uncommon type of monoclonal gammopathy of renal significance presenting with acute renal failure without significant glomerular disease. Our case illustrates that light-chain-mediated acute tubular interstitial nephritis may present clinically like acute interstitial nephritis and that renal biopsy is critical for diagnosis. We also explore possible links between various environmental and occupational exposures that could have precipitated his disease process at such a young age.
    Mesh-Begriff(e) Acute Kidney Injury/etiology ; Adult ; African Americans ; Hepatitis C ; Humans ; Immunoglobulins/deficiency ; Immunologic Deficiency Syndromes/complications ; Kidney/anatomy & histology ; Kidney/injuries ; Male ; Nephritis, Interstitial/complications ; Risk Factors ; United States ; United States Department of Veterans Affairs/organization & administration ; Veterans
    Chemische Substanzen Immunoglobulins
    Sprache Englisch
    Erscheinungsdatum 2017-11-02
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.7205/MILMED-D-17-00164
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Mass Poisoning From Ethylene Glycol at a U.S. Military Base.

    Shah, Nina / Khayat, Maurice / Owshalimpur, David / Banda, Michelle / Munoz, Jesus / White, William C / Forster, Benjamin M / Petteys, Sarah K / Sullivan, Scott B / Watson, Maura / King, Joshua D

    Military medicine

    2022  Band 188, Heft 9-10, Seite(n) e3261–e3264

    Abstract: Ethylene glycol (EG) toxicity is an important cause of toxic alcohol poisoning in the USA with over 5,000 exposures reported annually. While classically characterized by solitary accidental or intentional ingestions, mass toxic alcohol poisoning ... ...

    Abstract Ethylene glycol (EG) toxicity is an important cause of toxic alcohol poisoning in the USA with over 5,000 exposures reported annually. While classically characterized by solitary accidental or intentional ingestions, mass toxic alcohol poisoning outbreaks and more rarely collective consumptions (typically of methanol) have been described. We describe an ethylene glycol poisoning from collective ingestion that involved soldiers presenting at William Beaumont Army Medical Center in El Paso, Texas. Eleven soldiers presented to the emergency department over a 12-h period after ingestion of an unknown substance. The first two patients exhibited severe neurologic symptoms, while the remainder were asymptomatic. As serum EG levels were not immediately available, treatment decisions were based on surrogate laboratory values. Two patients received immediate hemodialysis, and fomepizole (FOM) because of severe acidosis with elevated anion and osmolal gaps. These patients developed acute kidney injury with renal recovery within a 3-week period. Two patients with elevated lactate received bicarbonate-based intravenous (IV) fluids and FOM. Two patients received IV fluids only and required prolonged observation for worsening acidosis and/or acute kidney injury. Five patients with normal laboratory values were treated with IV fluids and observation. All patients received cofactors including thiamine and pyridoxine. All patients survived. The outbreak occurred in the setting of limited dialysis resources, limited FOM availability, and in a resource-limited community. Additional guidelines are needed to determine allocation of limited resources, optimal dialysis and FOM treatment course, and comorbid conditions, which may prolong recovery.
    Mesh-Begriff(e) Humans ; Ethylene Glycol ; Military Facilities ; Renal Dialysis/adverse effects ; Fomepizole ; Acidosis/chemically induced ; Acidosis/epidemiology ; Poisoning/complications ; Poisoning/therapy
    Chemische Substanzen Ethylene Glycol (FC72KVT52F) ; Fomepizole (83LCM6L2BY)
    Sprache Englisch
    Erscheinungsdatum 2022-12-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usac380
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Focal Segmental Glomerulosclerosis, Risk Factors for End Stage Kidney Disease, and Response to Immunosuppression.

    Forster, Benjamin M / Nee, Robert / Little, Dustin J / Greasley, Peter J / Hughes, James B / Gordon, Sarah M / Olson, Stephen W

    Kidney360

    2020  Band 2, Heft 1, Seite(n) 105–113

    Abstract: Background: FSGS is a heterogeneic glomerular disease. Risk factors for kidney disease ESKD and the effect of immunosuppression treatment (IST) has varied in previously published cohorts. These cohorts were limited by relatively small case numbers, ... ...

    Abstract Background: FSGS is a heterogeneic glomerular disease. Risk factors for kidney disease ESKD and the effect of immunosuppression treatment (IST) has varied in previously published cohorts. These cohorts were limited by relatively small case numbers, short follow-up, lack of racial/ethnic diversity, a mix of adult and pediatric patients, lack of renin-angiotensin-aldosterone system (RAAS) inhibition, or lack of subgroup analysis of IST.
    Methods: We compared demographics, clinical characteristics, histopathology, and IST to long-term renal survival in a large, ethnically diverse, adult cohort of 338 patients with biopsy-proven FSGS with long-term follow-up in the era of RAAS inhibition using data from the US Department of Defense health care network.
    Results: Multivariate analysis showed that nephrotic-range proteinuria (NRP), eGFR <60 ml/min per 1.73 m
    Conclusions: Our study suggests that IST should be reserved for patients with FSGS and nephrotic syndrome. It also introduces interstitial inflammation as a potential risk factor for ESKD and does not support the proposed pathogenicity of IgM and complement activation.
    Mesh-Begriff(e) Adult ; Child ; Glomerulosclerosis, Focal Segmental/drug therapy ; Humans ; Immunosuppression Therapy/adverse effects ; Kidney/pathology ; Kidney Failure, Chronic/epidemiology ; Risk Factors ; United States
    Sprache Englisch
    Erscheinungsdatum 2020-12-01
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0006172020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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