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  1. Book ; Online: Merchants, Landlords, Magistrates

    Forster, Robert

    The Depont Family in Eighteenth-Century France

    2019  

    Keywords Biography: historical, political & military
    Language 0|e
    Size 1 electronic resource (290 pages)
    Publisher Johns Hopkins University Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021612974
    ISBN 9781421430027 ; 1421430029
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: The House of Saulx-Tavanes

    Forster, Robert

    Versailles and Burgundy, 1700-1830

    2019  

    Keywords European history
    Language 0|e
    Size 1 electronic resource (293 pages)
    Publisher Johns Hopkins University Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021612313
    ISBN 9781421430010 ; 1421430010
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Label-free electrochemical immunosensor for picomolar detection of the cervical cancer biomarker MCM5.

    Barhoum, Ahmed / J Forster, Robert

    Analytica chimica acta

    2022  Volume 1225, Page(s) 340226

    Abstract: An immunosensor for label-free electrochemical detection of MiniChromosome Maintenance Protein 5, MCM5, a protein overexpressed in cervical cancer, based on a gold electrode is reported. The electrode was first modified with a submonolayer (capture layer) ...

    Abstract An immunosensor for label-free electrochemical detection of MiniChromosome Maintenance Protein 5, MCM5, a protein overexpressed in cervical cancer, based on a gold electrode is reported. The electrode was first modified with a submonolayer (capture layer) of 11-mercaptoundecanoic acid (11-MUA) and then activated with N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) to immobilize the capture antibody. The change in electrode surface properties (wettability) during the formation of the 11-MUA layers was determined using the static water contact angle (WCA). The binding of MCM5 antigens to the capture antibody was monitored by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) using 5 mM [Fe(CN)
    MeSH term(s) Biomarkers, Tumor ; Biosensing Techniques/methods ; Cell Cycle Proteins ; Dielectric Spectroscopy/methods ; Electrochemical Techniques ; Electrodes ; Female ; Gold/chemistry ; Humans ; Immunoassay/methods ; Metal Nanoparticles/chemistry ; Uterine Cervical Neoplasms/diagnosis
    Chemical Substances Biomarkers, Tumor ; Cell Cycle Proteins ; MCM5 protein, human ; Gold (7440-57-5)
    Language English
    Publishing date 2022-08-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1483436-4
    ISSN 1873-4324 ; 0003-2670
    ISSN (online) 1873-4324
    ISSN 0003-2670
    DOI 10.1016/j.aca.2022.340226
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Future vehicle energy supply - sustainable design and operation of hybrid hydrogen and electric microgrids

    Forster, Robert / Kaiser, Matthias / Wenninger, Simon

    Applied Energy. 2023 Mar., v. 334 p.120653-

    2023  

    Abstract: To decarbonise road transport, EU policymakers promote battery electric vehicle and fuel cell electric vehicle adaption and advocate the expansion of charging and hydrogen refuelling infrastructure in the Fit-for-55 package. However, infrastructure ... ...

    Abstract To decarbonise road transport, EU policymakers promote battery electric vehicle and fuel cell electric vehicle adaption and advocate the expansion of charging and hydrogen refuelling infrastructure in the Fit-for-55 package. However, infrastructure operators face cost-intensive operations and insufficient low greenhouse gas (GHG) hydrogen availability. Grid-connected hybrid hydrogen refuelling and electric vehicle charging microgrids with on-site hydrogen production, battery and hydrogen energy storages and renewable energy can help to solve these challenges. We investigate the influence of various microgrid design and operation strategies regarding their contribution to profitability and decarbonisation in an optimisation study. Our findings in a real-world case study within Germany indicate that the cost-effectiveness of designing and operating such microgrids does not contribute to the decarbonisation of road transportation under common operation strategies and current demand charge regulations. We advocate revising German demand charge regulations to support sustainable design and operation of future charging and hydrogen refuelling microgrids.
    Keywords batteries ; case studies ; cost effectiveness ; design for environment ; electric vehicles ; energy ; face ; fuel cells ; greenhouse gases ; hydrogen ; hydrogen production ; infrastructure ; profitability ; renewable energy sources ; road transportation ; Germany ; Microgrid ; Hydrogen infrastructure ; Electric vehicle charging ; Hybrid energy storage systems ; Decarbonization
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 2000772-3
    ISSN 0306-2619
    ISSN 0306-2619
    DOI 10.1016/j.apenergy.2023.120653
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Biosensors Designed for Clinical Applications.

    Rusling, James F / Forster, Robert J

    Biomedicines

    2021  Volume 9, Issue 7

    Abstract: Emerging and validated biomarkers promise to revolutionize clinical practice, shifting the emphasis away from the management of chronic disease towards prevention, early diagnosis and early intervention. The challenge of detecting these low abundance ... ...

    Abstract Emerging and validated biomarkers promise to revolutionize clinical practice, shifting the emphasis away from the management of chronic disease towards prevention, early diagnosis and early intervention. The challenge of detecting these low abundance protein and nucleic acid biomarkers within the clinical context demands the development of highly sensitive, even single molecule, assays that are also capable of selectively measuring a small number of defined analytes in complex samples such as whole blood, interstitial fluid, saliva or urine. Success relies on significant innovations in nanomaterials, bioreceptor engineering, transduction strategies and microfluidics. Primarily using examples from our work, this article discusses some recent advance in the selective and sensitive detection of disease biomarkers, highlights key innovations in sensor materials and identifies issues and challenges that need to be carefully considered especially for researchers entering the field.
    Language English
    Publishing date 2021-06-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9070702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Apple Watch spO

    Schröder, Christina / Förster, Robert / Zwahlen, Daniel R / Windisch, Paul

    NPJ digital medicine

    2023  Volume 6, Issue 1, Page(s) 63

    Abstract: It is unclear how frequently the Apple Watch produces ... ...

    Abstract It is unclear how frequently the Apple Watch produces spO
    Language English
    Publishing date 2023-04-08
    Publishing country England
    Document type Journal Article
    ISSN 2398-6352
    ISSN (online) 2398-6352
    DOI 10.1038/s41746-023-00814-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Accuracy of the Apple Watch Oxygen Saturation Measurement in Adults: A Systematic Review.

    Windisch, Paul / Schröder, Christina / Förster, Robert / Cihoric, Nikola / Zwahlen, Daniel R

    Cureus

    2023  Volume 15, Issue 2, Page(s) e35355

    Abstract: The purpose of this review is to summarize the research on the accuracy of oxygen saturation ( ... ...

    Abstract The purpose of this review is to summarize the research on the accuracy of oxygen saturation (spO
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.35355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Converting between the International Prostate Symptom Score (IPSS) and the Expanded Prostate Cancer Index Composite (EPIC) urinary subscales: modeling and external validation.

    Windisch, Paul / Becker, Ivo / Tang, Hongjian / Schröder, Christina / Buchali, André / Aebersold, Daniel M / Zwahlen, Daniel R / Förster, Robert / Shelan, Mohamed

    BMC urology

    2024  Volume 24, Issue 1, Page(s) 28

    Abstract: Background: Prostate-related quality of life can be assessed with a variety of different questionnaires. The 50-item Expanded Prostate Cancer Index Composite (EPIC) and the International Prostate Symptom Score (IPSS) are two widely used options. The ... ...

    Abstract Background: Prostate-related quality of life can be assessed with a variety of different questionnaires. The 50-item Expanded Prostate Cancer Index Composite (EPIC) and the International Prostate Symptom Score (IPSS) are two widely used options. The goal of this study was, therefore, to develop and validate a model that is able to convert between the EPIC and the IPSS to enable comparisons across different studies.
    Methods: Three hundred forty-seven consecutive patients who had previously received radiotherapy and surgery for prostate cancer at two institutions in Switzerland and Germany were contacted via mail and instructed to complete both questionnaires. The Swiss cohort was used to train and internally validate different machine learning models using fourfold cross-validation. The German cohort was used for external validation.
    Results: Converting between the EPIC Urinary Irritative/Obstructive subscale and the IPSS using linear regressions resulted in mean absolute errors (MAEs) of 3.88 and 6.12, which is below the respective previously published minimal important differences (MIDs) of 5.2 and 10 points. Converting between the EPIC Urinary Summary and the IPSS was less accurate with MAEs of 5.13 and 10.45, similar to the MIDs. More complex model architectures did not result in improved performance in this study. The study was limited to the German versions of the respective questionnaires.
    Conclusions: Linear regressions can be used to convert between the IPSS and the EPIC Urinary subscales. While the equations obtained in this study can be used to compare results across clinical trials, they should not be used to inform clinical decision-making in individual patients.
    Trial registration: This study was retrospectively registered on clinicaltrials.gov on January 14th, 2022, under the registration number NCT05192876.
    MeSH term(s) Male ; Humans ; Prostate ; Quality of Life ; Surveys and Questionnaires ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/radiotherapy ; Germany
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059857-9
    ISSN 1471-2490 ; 1471-2490
    ISSN (online) 1471-2490
    ISSN 1471-2490
    DOI 10.1186/s12894-024-01421-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Lignocelluloytic activities and composition of bacterial community in the camel rumen.

    Rabee, Alaa Emara / Forster, Robert / Sabra, Ebrahim A

    AIMS microbiology

    2021  Volume 7, Issue 3, Page(s) 354–367

    Abstract: The camel is well-adapted to utilize the poor-quality forages in the harsh desert conditions as the camel rumen sustains fibrolytic microorganisms, mainly bacteria that are capable of breaking down the lignocellulosic biomass efficiently. Exploring the ... ...

    Abstract The camel is well-adapted to utilize the poor-quality forages in the harsh desert conditions as the camel rumen sustains fibrolytic microorganisms, mainly bacteria that are capable of breaking down the lignocellulosic biomass efficiently. Exploring the composition of the bacterial community in the rumen of the camel and quantifying their cellulolytic and xylanolytic activities could lead to understanding and improving fiber fermentation and discovering novel sources of cellulases and xylanases. In this study, Illumina MiSeq sequencing of the V4 region on 16S rRNA was applied to identify the bacterial and archaeal communities in the rumen of three camels fed wheat straw and broom corn. Furthermore, rumen samples were inoculated into bacterial media enriched with xylan and different cellulose sources, including filter paper (FP), wheat straw (WS), and alfalfa hay (AH) to assess the ability of rumen bacteria to produce endo-cellulase and endo-xylanase at different fermentation intervals. The results revealed that the phylum Bacteroidetes dominated the bacterial community and
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Journal Article
    ISSN 2471-1888
    ISSN (online) 2471-1888
    DOI 10.3934/microbiol.2021022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: HER2 Low Expression in Primary Male Breast Cancer.

    Nobbe, Katleen / Erices-Leclercq, Melanie / Foerster, Frank / Förster, Robert / Baldus, Stephan E / Rudlowski, Christian / Schröder, Lars / Lubig, Sabine

    Breast cancer (Dove Medical Press)

    2024  Volume 16, Page(s) 141–148

    Abstract: Purpose: The introduction of HER2-targeting antibody drug conjugates (ADCs) offers new treatment options for female breast cancer patients (FBC) expressing low levels of HER2 (HER2 low). No evidence was found that HER2 low describes a new FBC subtype. ... ...

    Abstract Purpose: The introduction of HER2-targeting antibody drug conjugates (ADCs) offers new treatment options for female breast cancer patients (FBC) expressing low levels of HER2 (HER2 low). No evidence was found that HER2 low describes a new FBC subtype. There is a lack of studies determining the impact of HER2 low in male breast cancer (MBC). In this study, we evaluate the prevalence of HER2 low in primary MBC and correlate the results with patient characteristics.
    Patients and methods: In this study, histological specimens were obtained from 120 male patients diagnosed and treated for primary invasive breast cancer from 1995 to 2022 at Breast Cancer Units in Bergisch Gladbach, Chemnitz, and Zwickau, Germany. HER2 immunostaining and in situ hybridization were performed by central pathology and evaluated based on the ASCO/CAP guidelines. The correlation of expression of HER2 low with tumor biological characteristics and patient outcomes was investigated.
    Results: Out of all cases, four patients (3.3%) showed HER2 positivity (3+), 39 (32.5%) patients were classified as HER2 low, 7 (5.8%) were HER2 2+ (no amplification), 32 (26.7%) were HER2 1+, and 77 (64.2%) were classified as HER2 zero. Out of 77 HER2 zero cases, 47 tumors (61.0%) showed incomplete staining, with <10% of tumor cells classified as HER2 ultralow. No statistical correlation between HER2 low and tumor biological characteristics and patients' survival was found.
    Conclusion: Our findings show a notable, albeit lower, prevalence of HER2 low expression in primary MBC. However, tumors expressing HER2 low do not show specific tumor biological features to define a new breast cancer subtype in MBC. Our results suggest that a significant number of MBC patients could benefit from ADCs, as shown in FBC. Further studies are required to better understand HER2 low breast cancer, both generally and in MBC.
    Language English
    Publishing date 2024-03-28
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2520722-2
    ISSN 1179-1314
    ISSN 1179-1314
    DOI 10.2147/BCTT.S450682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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