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  1. Article ; Online: Cellular and molecular imaging of the arteries in the age of precision medicine.

    Forsythe, R O / Newby, D E

    The British journal of surgery

    2018  Volume 105, Issue 4, Page(s) 311–312

    MeSH term(s) Arteries/diagnostic imaging ; Humans ; Magnetic Resonance Angiography/methods ; Molecular Imaging/methods ; Positron Emission Tomography Computed Tomography/methods ; Precision Medicine/methods ; Vascular Diseases/diagnostic imaging
    Language English
    Publishing date 2018-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1002/bjs.10841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Management of peripheral arterial disease and the diabetic foot.

    Forsythe, R O / Hinchliffe, R J

    The Journal of cardiovascular surgery

    2014  Volume 55, Issue 2 Suppl 1, Page(s) 195–206

    Abstract: The management of peripheral arterial disease (PAD) in patients with diabetic foot ulceration (DFU) is complex and there is a lack of robust evidence to guide definitive treatment strategies. Due to the distinct differences in etiology, disease ... ...

    Abstract The management of peripheral arterial disease (PAD) in patients with diabetic foot ulceration (DFU) is complex and there is a lack of robust evidence to guide definitive treatment strategies. Due to the distinct differences in etiology, disease distribution and treatment outcomes patients with diabetes, PAD and foot ulceration should be considered separately from those without diabetes. There is no randomized trial data to compare angioplasty and surgical bypass for revascularization in patients with DFU and PAD and the decision of whether, and how, to revascularize should be taken by experienced surgeons, in a multidisciplinary setting. Revascularization is only part of a treatment regimen which includes aggressive management of infection, neuropathy, foot deformity and cardiovascular risk. The burden and challenge of DFU in the context of PAD is continuing to increase and new research studies should be targeted specifically towards this ever-expanding group of patients.
    MeSH term(s) Diabetic Foot/diagnosis ; Diabetic Foot/epidemiology ; Diabetic Foot/therapy ; Endovascular Procedures/adverse effects ; Humans ; Patient Selection ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/epidemiology ; Peripheral Arterial Disease/therapy ; Risk Assessment ; Risk Factors ; Treatment Outcome ; Vascular Surgical Procedures/adverse effects
    Language English
    Publishing date 2014-04
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 80143-4
    ISSN 1827-191X ; 0021-9509
    ISSN (online) 1827-191X
    ISSN 0021-9509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Peripheral arterial disease and revascularization of the diabetic foot.

    Forsythe, R O / Brownrigg, J / Hinchliffe, R J

    Diabetes, obesity & metabolism

    2015  Volume 17, Issue 5, Page(s) 435–444

    Abstract: Diabetes is a complex disease with many serious potential sequelae, including large vessel arterial disease and microvascular dysfunction. Peripheral arterial disease is a common large vessel complication of diabetes, implicated in the development of ... ...

    Abstract Diabetes is a complex disease with many serious potential sequelae, including large vessel arterial disease and microvascular dysfunction. Peripheral arterial disease is a common large vessel complication of diabetes, implicated in the development of tissue loss in up to half of patients with diabetic foot ulceration. In addition to peripheral arterial disease, functional changes in the microcirculation also contribute to the development of a diabetic foot ulcer, along with other factors such as infection, oedema and abnormal biomechanical loading. Peripheral arterial disease typically affects the distal vessels, resulting in multi-level occlusions and diffuse disease, which often necessitates challenging distal revascularisation surgery or angioplasty in order to improve blood flow. However, technically successful revascularisation does not always result in wound healing. The confounding effects of microvascular dysfunction must be recognised--treatment of a patient with a diabetic foot ulcer and peripheral arterial disease should address this complex interplay of pathophysiological changes. In the case of non-revascularisable peripheral arterial disease or poor response to conventional treatment, alternative approaches such as cell-based treatment, hyperbaric oxygen therapy and the use of vasodilators may appear attractive, however more robust evidence is required to justify these novel approaches.
    MeSH term(s) Diabetic Foot/complications ; Diabetic Foot/physiopathology ; Diabetic Foot/surgery ; Foot/blood supply ; Humans ; Microcirculation ; Peripheral Arterial Disease/etiology ; Peripheral Arterial Disease/therapy ; Vascular Calcification/etiology ; Vascular Calcification/therapy
    Language English
    Publishing date 2015-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.12422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5442: Show issues Location:
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  4. Article ; Online: Synthesis and summary of patient-reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery.

    McNair, A G K / Whistance, R N / Forsythe, R O / Rees, J / Jones, J E / Pullyblank, A M / Avery, K N L / Brookes, S T / Thomas, M G / Sylvester, P A / Russell, A / Oliver, A / Morton, D / Kennedy, R / Jayne, D G / Huxtable, R / Hackett, R / Dutton, S J / Coleman, M G /
    Card, M / Brown, J / Blazeby, J M

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2015  Volume 17, Issue 11, Page(s) O217–29

    Abstract: Aim: Patient-reported outcome (PRO) measures (PROMs) are standard measures in the assessment of colorectal cancer (CRC) treatment, but the range and complexity of available PROMs may be hindering the synthesis of evidence. This systematic review aimed ... ...

    Abstract Aim: Patient-reported outcome (PRO) measures (PROMs) are standard measures in the assessment of colorectal cancer (CRC) treatment, but the range and complexity of available PROMs may be hindering the synthesis of evidence. This systematic review aimed to: (i) summarize PROMs in studies of CRC surgery and (ii) categorize PRO content to inform the future development of an agreed minimum 'core' outcome set to be measured in all trials.
    Method: All PROMs were identified from a systematic review of prospective CRC surgical studies. The type and frequency of PROMs in each study were summarized, and the number of items documented. All items were extracted and independently categorized by content by two researchers into 'health domains', and discrepancies were discussed with a patient and expert. Domain popularity and the distribution of items were summarized.
    Results: Fifty-eight different PROMs were identified from the 104 included studies. There were 23 generic, four cancer-specific, 11 disease-specific and 16 symptom-specific questionnaires, and three ad hoc measures. The most frequently used PROM was the EORTC QLQ-C30 (50 studies), and most PROMs (n = 40, 69%) were used in only one study. Detailed examination of the 50 available measures identified 917 items, which were categorized into 51 domains. The domains comprising the most items were 'anxiety' (n = 85, 9.2%), 'fatigue' (n = 67, 7.3%) and 'physical function' (n = 63, 6.9%). No domains were included in all PROMs.
    Conclusion: There is major heterogeneity of PRO measurement and a wide variation in content assessed in the PROMs available for CRC. A core outcome set will improve PRO outcome measurement and reporting in CRC trials.
    MeSH term(s) Colorectal Neoplasms/surgery ; Colorectal Surgery/methods ; Humans ; Patient Outcome Assessment ; Self Report ; Surveys and Questionnaires
    Language English
    Publishing date 2015-06-10
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.13021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5799: Show issues Location:
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  5. Article ; Online: A systematic review of outcome reporting in colorectal cancer surgery.

    Whistance, R N / Forsythe, R O / McNair, A G K / Brookes, S T / Avery, K N L / Pullyblank, A M / Sylvester, P A / Jayne, D G / Jones, J E / Brown, J / Coleman, M G / Dutton, S J / Hackett, R / Huxtable, R / Kennedy, R H / Morton, D / Oliver, A / Russell, A / Thomas, M G /
    Blazeby, J M

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2013  Volume 15, Issue 10, Page(s) e548–60

    Abstract: Aim: Evaluation of surgery for colorectal cancer (CRC) is necessary to inform clinical decision-making and healthcare policy. The standards of outcome reporting after CRC surgery have not previously been considered.: Method: Systematic literature ... ...

    Abstract Aim: Evaluation of surgery for colorectal cancer (CRC) is necessary to inform clinical decision-making and healthcare policy. The standards of outcome reporting after CRC surgery have not previously been considered.
    Method: Systematic literature searches identified randomized and nonrandomized prospective studies reporting clinical outcomes of CRC surgery. Outcomes were listed verbatim, categorized into broad groups (outcome domains) and examined for a definition (an appropriate textual explanation or a supporting citation). Outcome reporting was considered inconsistent if results of the outcome specified in the methods were not reported. Outcome reporting was compared between randomized and nonrandomized studies.
    Results: Of 5644 abstracts, 194 articles (34 randomized and 160 nonrandomized studies) were included reporting 766 different clinical outcomes, categorized into seven domains. A mean of 14 ± 8 individual outcomes were reported per study. 'Anastomotic leak', 'overall survival' and 'wound infection' were the three most frequently reported outcomes in 72, 60 and 44 (37.1%, 30.9% and 22.7%) studies, respectively, and no single outcome was reported in every publication. Outcome definitions were significantly more often provided in randomized studies than in nonrandomized studies (19.0% vs 14.9%, P = 0.015). One-hundred and twenty-seven (65.5%) papers reported results of all outcomes specified in the methods (randomized studies, n = 21, 61.5%; nonrandomized studies, n = 106, 66.2%; P = 0.617).
    Conclusion: Outcome reporting in CRC surgery lacks consistency and method. Improved standards of outcome measurement are recommended to permit data synthesis and transparent cross-study comparisons.
    MeSH term(s) Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Humans ; Neoplasm Recurrence, Local ; Neoplasm, Residual ; Outcome and Process Assessment, Health Care ; Postoperative Complications ; Research Report/standards
    Language English
    Publishing date 2013-08-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.12378
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    Zs.A 5799: Show issues Location:
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  6. Article ; Online: The safety profile of anti-tumour necrosis factor therapy in inflammatory bowel disease in clinical practice: analysis of 620 patient-years follow-up.

    Lees, C W / Ali, A I / Thompson, A I / Ho, G-T / Forsythe, R O / Marquez, L / Cochrane, C J / Aitken, S / Fennell, J / Rogers, P / Shand, A G / Penman, I D / Palmer, K R / Wilson, D C / Arnott, I D R / Satsangi, J

    Alimentary pharmacology & therapeutics

    2009  Volume 29, Issue 3, Page(s) 286–297

    Abstract: Background: Anti-TNF agents are now widely used in Crohn's disease (CD), and in ulcerative colitis (UC).: Aim: To review the safety profile of anti-TNF agents in all patients treated with infliximab in Edinburgh from 1999 to 2007.: Methods: ... ...

    Abstract Background: Anti-TNF agents are now widely used in Crohn's disease (CD), and in ulcerative colitis (UC).
    Aim: To review the safety profile of anti-TNF agents in all patients treated with infliximab in Edinburgh from 1999 to 2007.
    Methods: Complete data were available on 202/207 patients comprising 157 CD, 42 UC and three coeliac disease. Median follow-up was 2.4 years (1.0-4.9) with a total of 620 patient-years follow-up. About 19.1% of CD patients were subsequently treated with adalimumab.
    Results: Seven deaths (3.3%) occurred in follow-up; only one death was <1 year post-infliximab (at day 72, from lung cancer). A total of six malignancies (three haematological, three bronchogenic) and six cases of suspected demyelination (three with confirmed neurological disease) were reported. In the 90 days following infliximab, 95 adverse events (36 serious) occurred in 58/202 (28.7%) patients. In all, 42/202 (20.8%) had an infectious event (22 serious) and 27/202 (13.4%) of patients had an infusion reaction: 19 acute (four serious) and eight delayed (three serious).
    Conclusions: Serious infections, malignancies and neurological disease complicate anti-TNF use in clinical practice. Although evidence for causality is unclear, potential mechanisms and predisposing factors need to be explored. In individual patients, the risk/benefit analysis needs to be carefully assessed and discussed prior to commencement of therapy.
    MeSH term(s) Adalimumab ; Adolescent ; Adult ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/adverse effects ; Antibodies, Monoclonal, Humanized ; Autoimmune Diseases/chemically induced ; Autoimmune Diseases/mortality ; Drug Monitoring ; Female ; Follow-Up Studies ; Gastrointestinal Agents/administration & dosage ; Gastrointestinal Agents/adverse effects ; Humans ; Infections/chemically induced ; Infections/mortality ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/mortality ; Infliximab ; Male ; Neoplasms/chemically induced ; Neoplasms/mortality ; Retrospective Studies ; Serum Sickness/chemically induced ; Serum Sickness/mortality ; Young Adult
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Gastrointestinal Agents ; Infliximab (B72HH48FLU) ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2009-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/j.1365-2036.2008.03882.x
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