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Article: Periprocedural management of hemostatic alterations in patients with cirrhosis and vascular liver disorders: a step forward of the American Association for the Study of Liver Diseases.

Fortea, José Ignacio / Puente, Ángela / Crespo, Javier / Fábrega, Emilio

2023 Volume 12, Issue 1, Page(s) 105–109

Language	English
Publishing date	2023-01-16
Publishing country	China (Republic : 1949- )
Document type	Editorial ; Comment
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn-22-556
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cirrhosis, a Global and Challenging Disease.

Fortea, José Ignacio / Crespo, Javier / Puente, Ángela

Journal of clinical medicine

2022 Volume 11, Issue 21

Abstract: Cirrhosis is the result of sustained liver damage leading to the diffusion of hepatic fibrosis, wherein the normal hepatic architecture is replaced by abnormally organized nodules separated by fibrous septa that connect the different vascular structures ... ...

Abstract	Cirrhosis is the result of sustained liver damage leading to the diffusion of hepatic fibrosis, wherein the normal hepatic architecture is replaced by abnormally organized nodules separated by fibrous septa that connect the different vascular structures of the hepatic lobule [...].
Language	English
Publishing date	2022-11-02
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11216512
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Article ; Online: A Rare But Recognizable Cholestatic Liver Disease.

Ezcurra, Iranzu / Fortea, José Ignacio / Crespo, Javier

Gastroenterology

2018 Volume 155, Issue 3, Page(s) e17–e19

MeSH term(s)	Adult ; Cholelithiasis/complications ; Cholestasis, Intrahepatic/etiology ; Humans ; Male ; Phospholipids/deficiency ; Syndrome
Chemical Substances	Phospholipids
Language	English
Publishing date	2018-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2018.04.023
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Ui V Zs.44: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Ectopic variceal bleeding secondary to porto-sinusoidal vascular disease.

Antón RodrÍguez, Ángela / Puente Sánchez, Ángela María / Fortea, José Ignacio / Odriozola Herrán, Aitor / Echavarría Rodríguez, Víctor José / Alonso Fernández, Sara / Montano Lumbreras, Elena

Revista espanola de enfermedades digestivas

2023

Abstract: Porto-sinusoidal vascular disease (PSVD) is an uncommon cause of portal hypertension (PHT) characterized by typical manifestations of PHT in the absence of an identifiable cause such as cirrhosis or splenoportal thrombosis (1). There are different ... ...

Abstract	Porto-sinusoidal vascular disease (PSVD) is an uncommon cause of portal hypertension (PHT) characterized by typical manifestations of PHT in the absence of an identifiable cause such as cirrhosis or splenoportal thrombosis (1). There are different etiological factors, including oxaliplatin (2). We present the case of a 67-year-old male with a history of locally advanced rectal cancer in 2007 treated with chemotherapy (capecitabine, folinic acid, 5-fluorouracil and oxaliplatin), radiotherapy and surgery with a definitive colostomy. He was admitted for lower gastrointestinal bleeding from the colostomy with no anemia or hemodynamic repercussion. Colonoscopy was performed and no lesions were found. Abdominal computed tomography (CT) showed peristomal varices with porto-systemic collaterals at that level. There was splenomegaly, no evidence of chronic liver disease and the splenoportal axis was permeable. Laboratory tests showed chronic thrombocytopenia. Laboratory results excluded other causes of liver disease, hepatic elastography showed a value of 7.2 kPa and upper gastrointestinal endoscopy ruled out esophagogastric varices. The catheterisation of hepatic veins demonstrated a hepatic venous pressure gradient of 13.5 mmHg and liver biopsy revealed sinusoidal dilatation with sinusoidal and perivenular fibrosis. Because of the clinical context of the patient with a history of treatment with oxaliplatin, he was diagnosed with peristomal ectopic varices secondary to porto-sinusoidal vascular disease. Due to bleeding recurrence, it was finally decided to place a transjugular intrahepatic portosystemic shunt (TIPS).
Language	English
Publishing date	2023-06-14
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2023.9683/2023
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Article: Risk of Recurrence of Hepatocarcinoma after Liver Transplantation: Performance of Recurrence Predictive Models in a Cohort of Transplant Patients.

Cuadrado, Antonio / Fortea, José Ignacio / Rodríguez-Lope, Carlos / Puente, Ángela / Fernández-Vilchez, Vanesa / Echavarria, Victor Jose / Castillo Suescun, Federico José / Fernández, Roberto / Echeverri, Juan Andrés / Achalandabaso, Mar / Toledo, Enrique / Pellón, Raúl / Rodríguez Sanjuan, Juan Carlos / Crespo, Javier / Fábrega, Emilio

Journal of clinical medicine

2023 Volume 12, Issue 17

Abstract: Liver transplantation (LT) is a curative treatment for early-stage hepatocellular carcinoma (HCC) unsuitable for surgical resection. However, tumor recurrence (TR) rates range from 8% to 20% despite strict selection criteria. The validation of new ... ...

Abstract	Liver transplantation (LT) is a curative treatment for early-stage hepatocellular carcinoma (HCC) unsuitable for surgical resection. However, tumor recurrence (TR) rates range from 8% to 20% despite strict selection criteria. The validation of new prognostic tools, such as pre-MORAL or RETREAT risks, is necessary to improve recurrence prediction. A retrospective study was conducted at Marqués de Valdecilla University Hospital in Cantabria, Spain, between 2010 and 2019 to determine the rate of TR in LT patients and identify associated factors. Patients with liver-kidney transplantation, re-transplantation, HIV infection, survival less than 90 days, or incidental HCC were excluded. Data on demographic, liver disease-related, LT, and tumor-related variables, as well as follow-up records, including TR and death, were collected. TR was analyzed using the Log-Rank test, and a multivariate Cox regression analysis was performed. The study was approved by the IRB of Cantabria. TR occurred in 13.6% of LT patients (95% CI = 7.3-23.9), primarily as extrahepatic recurrence (67%) within the first 5 years (75%). Increased TR was significantly associated with higher Body Mass Index (BMI) (HR = 1.3 [95% CI = 1.1-1.5]), vascular micro-invasion (HR = 8.8 [1.6-48.0]), and medium (HR = 20.4 [3.0-140.4]) and high pre-MORAL risk (HR = 30.2 [1.6-568.6]). TR also showed a significant correlation with increased mortality. Conclusions: LT for HCC results in a 13.6% rate of tumor recurrence. Factors such as BMI, vascular micro-invasion, and medium/high pre-MORAL risk are strongly associated with TR following LT.
Language	English
Publishing date	2023-08-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12175457
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Article ; Online: No evidence of association between inherited thrombophilia and increased risk of liver fibrosis.

Ezcurra, Iranzu / Puente, Ángela / Cuadrado, Antonio / Tamayo, Ibai / Iruzubieta, Paula / Arias-Loste, María Teresa / González, Francisco José / Pellón, Raúl / Sánchez, Sara / Crespo, Juan / Acebo, Mercedes / López-Hoyos, Marcos / Pérez, Rocío / Cuesta, Amalia / Antón, Ángela / Echavarría, Víctor / Fábrega, Emilio / Crespo, Javier / Fortea, Jose Ignacio

United European gastroenterology journal

2023 Volume 11, Issue 10, Page(s) 1010–1020

Abstract: Background: Preliminary evidence suggests that inherited hypercoagulable disorders can lead to an increased risk of significant liver fibrosis.: Objective: We aimed to investigate the prevalence of significant fibrosis in patients with inherited ... ...

Abstract	Background: Preliminary evidence suggests that inherited hypercoagulable disorders can lead to an increased risk of significant liver fibrosis. Objective: We aimed to investigate the prevalence of significant fibrosis in patients with inherited thrombophilia, assessed by using liver stiffness (LS), and to compare this prevalence to that found in a large population-based cohort from the same region. Methods: This was a single-center, cross-sectional study. A complete laboratory analysis for liver disease, LS by transient elastography and an abdominal ultrasound were performed in patients with inherited thrombophilia diagnosed between May 2013-February 2017. These patients were propensity score matched (ratio 1:4) with a population-based cohort from the same region (PREVHEP-ETHON study; NCT02749864; N = 5988). Results: Of 241 patients with inherited thrombophilia, eight patients (3.3%) had significant fibrosis (LS ≥8 kPa). All of them had risk factors for liver disease and met diagnostic criteria for different liver diseases. After matching 221 patients with thrombophilia with 884 patients of the PREVHEP-ETHON cohort, the prevalence of significant fibrosis was similar between both cohorts (1.8% vs. 3.6%, p = 0.488). Multivariate analysis showed that age and liver disease risk factors, but not belonging to the thrombophilia cohort, were associated with the presence of significant fibrosis. The magnitude of the increased risk of significant fibrosis in patients with risk factors for liver disease was also similar in both cohorts. Conclusions: Our findings do not provide evidence supporting an association between inherited thrombophilia and an increased risk of significant liver fibrosis, independent of the presence of liver-related causes of fibrosis.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Liver Cirrhosis/diagnosis ; Liver Diseases/complications ; Thrombophilia/complications ; Thrombophilia/epidemiology ; Thrombophilia/genetics
Language	English
Publishing date	2023-11-28
Publishing country	England
Document type	Clinical Study ; Journal Article
ZDB-ID	2728585-6
ISSN	2050-6414 ; 2050-6406
ISSN (online)	2050-6414
ISSN	2050-6406
DOI	10.1002/ueg2.12500
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Article: Portal Vein Thrombosis in the Setting of Cirrhosis: A Comprehensive Review.

Odriozola, Aitor / Puente, Ángela / Cuadrado, Antonio / Rivas, Coral / Anton, Ángela / González, Francisco José / Pellón, Raúl / Fábrega, Emilio / Crespo, Javier / Fortea, José Ignacio

Journal of clinical medicine

2022 Volume 11, Issue 21

Abstract: Portal vein thrombosis constitutes the most common thrombotic event in patients with cirrhosis, with increased rates in the setting of advanced liver disease. Despite being a well-known complication of cirrhosis, the contribution of portal vein ... ...

Abstract	Portal vein thrombosis constitutes the most common thrombotic event in patients with cirrhosis, with increased rates in the setting of advanced liver disease. Despite being a well-known complication of cirrhosis, the contribution of portal vein thrombosis to hepatic decompensation and overall mortality is still a matter of debate. The incorporation of direct oral anticoagulants and new radiological techniques for portal vein recanalization have expanded our therapeutic arsenal. However, the lack of large prospective observational studies and randomized trials explain the heterogenous diagnostic and therapeutic recommendations of current guidelines. This article seeks to make a comprehensive review of the pathophysiology, clinical features, diagnosis, and treatment of portal vein thrombosis in patients with cirrhosis.
Language	English
Publishing date	2022-10-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11216435
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Article ; Online: SARS-CoV-2 and Liver Transplant: How Has It Behaved in This Sixth Wave?

Odriozola, Aitor / San Segundo, David / Cuadrado, Antonio / Hernáez, Tania / Escrich, Víctor / Fortea, José Ignacio / Martínez, Ángela / Puente, Ángela / Lapeña, Berta / Del Barrio, María / López-Hoyos, Marcos / Crespo, Javier / Fábrega, Emilio

Transplantation

2022 Volume 106, Issue 7, Page(s) 1445–1449

Abstract: Background: Since the declaration of a new variant of concern (VOC), Omicron, by the World Health Organization in November 2021, a quick spread has been documented worldwide, being the main VOC in the sixth wave in Spain. The Omicron variant has more ... ...

Abstract	Background: Since the declaration of a new variant of concern (VOC), Omicron, by the World Health Organization in November 2021, a quick spread has been documented worldwide, being the main VOC in the sixth wave in Spain. The Omicron variant has more transmissibility, lower virulence, and less risk of severe disease than previously described VOC. Here we analyze the current wave of severe acute respiratory syndrome coronavirus 2 infection in liver transplant recipients (LTRs). Methods: A retrospective observational study of 355 LTRs was conducted in La Rioja and Cantabria regions of Spain. Epidemiological and clinical parameters were gathered on the basis of clinical records and telephone interviews. Results: In the current wave of infection, a higher number of LTRs have been found to be infected than the sum of the previous 5 waves (30 versus 16 LTRs). Of the 30 infected LTRs, 29 (96.6%) had received 3 vaccine doses (mRNA based), in a median of 93 d (interquartile range, 86-108) before infection. Eight of 30 LTRs (24.0%) were asymptomatic and 21 LTRs (67.8%) were with mild symptoms with a mean duration of 4.6 d (interquartile range, 2.5-7), whereas in the unvaccinated LTRs, the symptoms were fever, nausea, vomiting, and diarrhea. Moreover, in the sixth wave, intrafamiliar transmission was the main route of infection (17/30; 56.6%), and nosocomial transmission was confirmed in 2 LTRs (6.6%). Conclusions: In our series, increased transmissibility of the Omicron variant was confirmed, including nosocomial infection, with a lower risk of severe disease in LTRs. These findings could be supported by the universal vaccination of LTRs and less virulence of the Omicron variant.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/transmission ; COVID-19 Vaccines/administration & dosage ; Humans ; Liver Transplantation ; SARS-CoV-2 ; Spain/epidemiology ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-04-08
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004157
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: An Elusive Diagnosis in Noncirrhotic Chronic Portal Vein Thrombosis.

Fortea, José Ignacio / Puente, Angela / Cuadrado, Antonio / Del Pozo, Carmen / García, Inés / Pellon, Raul / Cagigal, Maria Luisa / Fábrega, Emilio / Crespo, Javier

The American journal of medicine

2020 Volume 134, Issue 3, Page(s) e199–e200

MeSH term(s)	Aged ; Chronic Disease ; Humans ; Male ; Portal Vein ; Venous Thrombosis/diagnosis
Language	English
Publishing date	2020-09-18
Publishing country	United States
Document type	Case Reports ; Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2020.07.039
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Article: Prevalence of hepatitis C in patients with non-affective psychotic disorders.

Cuadrado, Antonio / Cabezas, Joaquín / Llerena, Susana / Nieves Salceda, Juan Francisco / Fortea, José Ignacio / Crespo-Facorro, Benedicto / Crespo, Javier

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2020 Volume 112, Issue 7, Page(s) 550–554

Abstract: Introduction: the goal of this study was to determine the prevalence of hepatitis C virus (HCV) infection in patients with non-affective psychotic disorders and to compare it with population-based data.: Material and methods: an observational study ... ...

Abstract	Introduction: the goal of this study was to determine the prevalence of hepatitis C virus (HCV) infection in patients with non-affective psychotic disorders and to compare it with population-based data. Material and methods: an observational study was performed that measured anti-HCV antibodies (HCV-RNA in case of seropositivity) in 425 serum samples from patients with non-affective psychosis. Eight patients were positive for anti-HCV (1.9 %) and five had detectable HCV-RNA (1.2 %). The prevalence of viremia was significantly higher than in the general population (OR: 5.4; 95 % CI: 1.9-14.6). Conclusions: patients with non-affective psychotic disorder have a higher prevalence of active infection than that of the general population and should undergo systematic screening.
MeSH term(s)	Hepacivirus/genetics ; Hepatitis C/epidemiology ; Hepatitis C Antibodies ; Humans ; Prevalence ; Psychotic Disorders/epidemiology
Chemical Substances	Hepatitis C Antibodies
Language	English
Publishing date	2020-08-04
Publishing country	Spain
Document type	Journal Article ; Observational Study
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2020.7278/2020
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