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  1. Article ; Online: Antimicrobial Resistance Spectrum Conferred by pRErm46 of Emerging Macrolide (Multidrug)-Resistant Rhodococcus equi.

    Erol, Erdal / Scortti, Mariela / Fortner, Jordan / Patel, Mukesh / Vázquez-Boland, José A

    Journal of clinical microbiology

    2021  Volume 59, Issue 10, Page(s) e0114921

    Abstract: Clonal multidrug resistance recently emerged in Rhodococcus equi, complicating the therapeutic management of this difficult-to-treat animal- and human-pathogenic actinomycete. The currently spreading multidrug-resistant (MDR) "2287" clone arose in equine ...

    Abstract Clonal multidrug resistance recently emerged in Rhodococcus equi, complicating the therapeutic management of this difficult-to-treat animal- and human-pathogenic actinomycete. The currently spreading multidrug-resistant (MDR) "2287" clone arose in equine farms upon acquisition, and coselection by mass macrolide-rifampin therapy, of the pRErm46 plasmid carrying the
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial ; Horses ; Humans ; Macrolides/pharmacology ; Microbial Sensitivity Tests ; Rhodococcus ; Rhodococcus equi/genetics
    Chemical Substances Anti-Bacterial Agents ; Macrolides
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.01149-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Antimicrobial susceptibility patterns of Rhodococcus equi from necropsied foals with rhodococcosis.

    Erol, Erdal / Locke, Stephan / Saied, Ahmad / Cruz Penn, Michael Josue / Smith, Jacqueline / Fortner, Jordan / Carter, Craig

    Veterinary microbiology

    2020  Volume 242, Page(s) 108568

    Abstract: Mainstay therapy for rhodococcosis in foals is the combination of rifampicin and a macrolide. While emergence of resistance to rifampicin and macrolides has been reported, studies demonstrating the development of resistance to such drugs is limited in ... ...

    Abstract Mainstay therapy for rhodococcosis in foals is the combination of rifampicin and a macrolide. While emergence of resistance to rifampicin and macrolides has been reported, studies demonstrating the development of resistance to such drugs is limited in necropsied foals with rhodococcosis. In this study, the foal necropsy records between 01/01/2011 and 08/30/2019 were reviewed for culture-positive R. equi with MICs and, whether or not the affected foals received any mainstay dual therapy before their deaths. Resistance to antimicrobials in the R. equi isolates from necropsied foals were then compared between treated foals with dual therapy and untreated foals to determine the association between the administration of antimicrobials and development of the drug resistance. In a total of 256 R. equi isolates from each of the 256 necropsied foals with rhodococcosis, rifampicin, azithromycin, clarithromycin and erythromycin showed high rates of resistance, 22.65 %, 16.01 %, 14.84 % and 15.23 %, respectively. The most active antimicrobials exhibiting MIC
    MeSH term(s) Actinomycetales Infections/drug therapy ; Actinomycetales Infections/microbiology ; Actinomycetales Infections/veterinary ; Animals ; Anti-Bacterial Agents/pharmacology ; Azithromycin/pharmacology ; Clarithromycin/pharmacology ; Drug Resistance, Multiple, Bacterial ; Erythromycin/pharmacology ; Horse Diseases/drug therapy ; Horse Diseases/microbiology ; Horses/microbiology ; Microbial Sensitivity Tests ; Rhodococcus equi/drug effects
    Chemical Substances Anti-Bacterial Agents ; Erythromycin (63937KV33D) ; Azithromycin (83905-01-5) ; Clarithromycin (H1250JIK0A)
    Language English
    Publishing date 2020-01-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2019.108568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genomics accurately predicts antimicrobial resistance in Staphylococcus pseudintermedius collected as part of Vet-LIRN resistance monitoring

    Tyson, Gregory H / Ceric, Olgica / Guag, Jake / Nemser, Sarah / Borenstein, Stacey / Slavic, Durda / Lippert, Sarah / McDowell, Rebecca / Krishnamurthy, Aparna / Korosec, Shannon / Friday, Cheryl / Pople, Neil / Saab, Matthew E / Fairbrother, Julie-Hélène / Janelle, Isabelle / McMillan, Deanna / Bommineni, Yugendar R / Simon, David / Mohan, Shipra /
    Sanchez, Susan / Phillips, Ashley / Bartlett, Paula / Naikare, Hemant / Watson, Cynthia / Sahin, Orhan / Stinman, Chloe / Wang, Leyi / Maddox, Carol / DeShambo, Vanessa / Hendrix, Kenitra / Lubelski, Debra / Burklund, Amy / Lubbers, Brian / Reed, Debbie / Jenkins, Tracie / Erol, Erdal / Patel, Mukeshbhai / Locke, Stephan / Fortner, Jordan / Peak, Laura / Balasuriya, Udeni / Mani, Rinosh / Kettler, Niesa / Olsen, Karen / Zhang, Shuping / Shen, Zhenyu / Landinez, Martha Pulido / Thornton, Jay Kay / Thachil, Anil / Byrd, Melissa / Jacob, Megan / Krogh, Darlene / Webb, Brett / Schaan, Lynn / Patil, Amar / Dasgupta, Sarmila / Mann, Shannon / Goodman, Laura B / Franklin-Guild, Rebecca June / Anderson, Renee R / Mitchell, Patrick K / Cronk, Brittany D / Aprea, Missy / Cui, Jing / Jurkovic, Dominika / Prarat, Melanie / Zhang, Yan / Shiplett, Katherine / Campos, Dubra Diaz / Rubio, Joany Van Balen / Ramanchandran, Akhilesh / Talent, Scott / Tewari, Deepanker / Thirumalapura, Nagaraja / Kelly, Donna / Barnhart, Denise / Hall, Lacey / Rankin, Shelley / Dietrich, Jaclyn / Cole, Stephen / Scaria, Joy / Antony, Linto / Lawhon, Sara D / Wu, Jing / McCoy, Christine / Dietz, Kelly / Wolking, Rebecca / Alexander, Trevor / Burbick, Claire / Reimschuessel, Renate

    Veterinary microbiology. 2021 Mar., v. 254

    2021  

    Abstract: Whole-genome sequencing (WGS) has changed our understanding of bacterial pathogens, aiding outbreak investigations and advancing our knowledge of their genetic features. However, there has been limited use of genomics to understand antimicrobial ... ...

    Abstract Whole-genome sequencing (WGS) has changed our understanding of bacterial pathogens, aiding outbreak investigations and advancing our knowledge of their genetic features. However, there has been limited use of genomics to understand antimicrobial resistance of veterinary pathogens, which would help identify emerging resistance mechanisms and track their spread. The objectives of this study were to evaluate the correlation between resistance genotypes and phenotypes for Staphylococcus pseudintermedius, a major pathogen of companion animals, by comparing broth microdilution antimicrobial susceptibility testing and WGS. From 2017–2019, we conducted antimicrobial susceptibility testing and WGS on S. pseudintermedius isolates collected from dogs in the United States as a part of the Veterinary Laboratory Investigation and Response Network (Vet-LIRN) antimicrobial resistance monitoring program. Across thirteen antimicrobials in nine classes, resistance genotypes correlated with clinical resistance phenotypes 98.4 % of the time among a collection of 592 isolates. Our findings represent isolates from diverse lineages based on phylogenetic analyses, and these strong correlations are comparable to those from studies of several human pathogens such as Staphylococcus aureus and Salmonella enterica. We uncovered some important findings, including that 32.3 % of isolates had the mecA gene, which correlated with oxacillin resistance 97.0 % of the time. We also identified a novel rpoB mutation likely encoding rifampin resistance. These results show the value in using WGS to assess antimicrobial resistance in veterinary pathogens and to reveal putative new mechanisms of resistance.
    Keywords Salmonella enterica ; Staphylococcus aureus ; Staphylococcus pseudintermedius ; antibiotic resistance ; genes ; genomics ; humans ; microbiology ; minimum inhibitory concentration ; mutation ; oxacillin ; phylogeny ; rifampicin
    Language English
    Dates of publication 2021-03
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-light
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2021.109006
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Genomics accurately predicts antimicrobial resistance in Staphylococcus pseudintermedius collected as part of Vet-LIRN resistance monitoring.

    Tyson, Gregory H / Ceric, Olgica / Guag, Jake / Nemser, Sarah / Borenstein, Stacey / Slavic, Durda / Lippert, Sarah / McDowell, Rebecca / Krishnamurthy, Aparna / Korosec, Shannon / Friday, Cheryl / Pople, Neil / Saab, Matthew E / Fairbrother, Julie-Hélène / Janelle, Isabelle / McMillan, Deanna / Bommineni, Yugendar R / Simon, David / Mohan, Shipra /
    Sanchez, Susan / Phillips, Ashley / Bartlett, Paula / Naikare, Hemant / Watson, Cynthia / Sahin, Orhan / Stinman, Chloe / Wang, Leyi / Maddox, Carol / DeShambo, Vanessa / Hendrix, Kenitra / Lubelski, Debra / Burklund, Amy / Lubbers, Brian / Reed, Debbie / Jenkins, Tracie / Erol, Erdal / Patel, Mukeshbhai / Locke, Stephan / Fortner, Jordan / Peak, Laura / Balasuriya, Udeni / Mani, Rinosh / Kettler, Niesa / Olsen, Karen / Zhang, Shuping / Shen, Zhenyu / Landinez, Martha Pulido / Thornton, Jay Kay / Thachil, Anil / Byrd, Melissa / Jacob, Megan / Krogh, Darlene / Webb, Brett / Schaan, Lynn / Patil, Amar / Dasgupta, Sarmila / Mann, Shannon / Goodman, Laura B / Franklin-Guild, Rebecca June / Anderson, Renee R / Mitchell, Patrick K / Cronk, Brittany D / Aprea, Missy / Cui, Jing / Jurkovic, Dominika / Prarat, Melanie / Zhang, Yan / Shiplett, Katherine / Campos, Dubra Diaz / Rubio, Joany Van Balen / Ramanchandran, Akhilesh / Talent, Scott / Tewari, Deepanker / Thirumalapura, Nagaraja / Kelly, Donna / Barnhart, Denise / Hall, Lacey / Rankin, Shelley / Dietrich, Jaclyn / Cole, Stephen / Scaria, Joy / Antony, Linto / Lawhon, Sara D / Wu, Jing / McCoy, Christine / Dietz, Kelly / Wolking, Rebecca / Alexander, Trevor / Burbick, Claire / Reimschuessel, Renate

    Veterinary microbiology

    2021  Volume 254, Page(s) 109006

    Abstract: Whole-genome sequencing (WGS) has changed our understanding of bacterial pathogens, aiding outbreak investigations and advancing our knowledge of their genetic features. However, there has been limited use of genomics to understand antimicrobial ... ...

    Abstract Whole-genome sequencing (WGS) has changed our understanding of bacterial pathogens, aiding outbreak investigations and advancing our knowledge of their genetic features. However, there has been limited use of genomics to understand antimicrobial resistance of veterinary pathogens, which would help identify emerging resistance mechanisms and track their spread. The objectives of this study were to evaluate the correlation between resistance genotypes and phenotypes for Staphylococcus pseudintermedius, a major pathogen of companion animals, by comparing broth microdilution antimicrobial susceptibility testing and WGS. From 2017-2019, we conducted antimicrobial susceptibility testing and WGS on S. pseudintermedius isolates collected from dogs in the United States as a part of the Veterinary Laboratory Investigation and Response Network (Vet-LIRN) antimicrobial resistance monitoring program. Across thirteen antimicrobials in nine classes, resistance genotypes correlated with clinical resistance phenotypes 98.4 % of the time among a collection of 592 isolates. Our findings represent isolates from diverse lineages based on phylogenetic analyses, and these strong correlations are comparable to those from studies of several human pathogens such as Staphylococcus aureus and Salmonella enterica. We uncovered some important findings, including that 32.3 % of isolates had the mecA gene, which correlated with oxacillin resistance 97.0 % of the time. We also identified a novel rpoB mutation likely encoding rifampin resistance. These results show the value in using WGS to assess antimicrobial resistance in veterinary pathogens and to reveal putative new mechanisms of resistance.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Canada ; Dog Diseases/microbiology ; Dogs/microbiology ; Drug Resistance, Bacterial/genetics ; Epidemiological Monitoring/veterinary ; Genomics/methods ; Genomics/standards ; Genotype ; Microbial Sensitivity Tests ; Phenotype ; Phylogeny ; Reproducibility of Results ; Staphylococcal Infections/microbiology ; Staphylococcal Infections/veterinary ; Staphylococcus/drug effects ; Staphylococcus/genetics ; Staphylococcus/isolation & purification ; United States ; Whole Genome Sequencing
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; MecA protein, Staphylococcus pseudintermedius
    Language English
    Publishing date 2021-02-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2021.109006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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