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  1. Article ; Online: Modifications in Near Infrared Spectroscopy for Cerebral Monitoring During Carotid Endarterectomy in Asymptomatic and Symptomatic Patients.

    Bissacco, Daniele / Attisani, Luca / Settembrini, Alberto M / Fossati, Alessandro / Carmo, Michele / Dallatana, Raffaello / Settembrini, Piergiorgio G

    Annals of vascular surgery

    2021  Volume 79, Page(s) 239–246

    Abstract: Background: To evaluate trends and differences in Near Infrared Spectroscopy (NIRS) monitoring during carotid endarterectomy (CEA) in patients affected by asymptomatic and symptomatic carotid artery stenosis, to predict postoperative neurological ... ...

    Abstract Background: To evaluate trends and differences in Near Infrared Spectroscopy (NIRS) monitoring during carotid endarterectomy (CEA) in patients affected by asymptomatic and symptomatic carotid artery stenosis, to predict postoperative neurological complications (PNCs).
    Methods: NIRS data of CEAs performed in a University Hospital were retrospectively reviewed. All the interventions were performed under general anesthesia and patients with intraoperative complications were excluded. Mean regional Oxygen Saturation Index (rSO
    Results: Between 2007 and 2015, a total of 399 CEAs were consecutively performed with NIRS monitoring. Three-hundred-seventy-two CEAs in 355 patients were reviewed. Asymptomatic stenoses were 291 (81.9%), eleven (2.9%) PNC were registered (5 in asymptomatic and 6 in symptomatic group). Asymptomatic and symptomatic diseases had different MBv (69.5 ± 7.5 vs. 71.8 ± 6.9, respectively; P = 0.011) and similar rSO
    Conclusions: NIRS as cerebral monitoring during CEA can predict PNCs in asymptomatic stenosis. Asymptomatic and symptomatic groups differ in baseline and intraprocedural cut-off values to detect an augmented PNCs risk.
    MeSH term(s) Aged ; Aged, 80 and over ; Asymptomatic Diseases ; Carotid Stenosis/complications ; Carotid Stenosis/diagnosis ; Carotid Stenosis/physiopathology ; Carotid Stenosis/surgery ; Cerebrovascular Circulation ; Cerebrovascular Disorders/diagnosis ; Cerebrovascular Disorders/etiology ; Cerebrovascular Disorders/physiopathology ; Endarterectomy, Carotid/adverse effects ; Female ; Humans ; Male ; Monitoring, Intraoperative/methods ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Spectroscopy, Near-Infrared ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2021-10-10
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 1027366-9
    ISSN 1615-5947 ; 0890-5096
    ISSN (online) 1615-5947
    ISSN 0890-5096
    DOI 10.1016/j.avsg.2021.06.047
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    Zs.A 2882: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Generics for the Treatment of Hepatitis C in Monoinfected and HIV-coinfected Patients: Pros and Cons.

    Cattaneo, Dario / Fossati, Alessandro / Resnati, Chiara / Galli, Massimo / Gervasoni, Cristina

    AIDS reviews

    2017  Volume 19, Issue 3, Page(s) 167–172

    Abstract: The treatment of hepatitis C virus in monoinfected and HIV-coinfected patients has greatly changed over recent years as a result of the introduction of direct-acting antiviral agents (DAAs), which have revolutionized clinical outcomes and led to ... ...

    Abstract The treatment of hepatitis C virus in monoinfected and HIV-coinfected patients has greatly changed over recent years as a result of the introduction of direct-acting antiviral agents (DAAs), which have revolutionized clinical outcomes and led to sustained virological response rates above 90-95%. The discovery of new molecules and the subsequent competition between pharmaceutical companies, together with the negotiated price policies pursued by many national health systems, have led to a gradual reduction in the cost of DAAs, and expand their use to an increasing number of patients, including those with mild liver damage. However, the cost of branded DAAs is still too high for many developing countries, and many patients are still left without therapy. In this context, the availability of generic DAAs certainly provides a major opportunity for further cost savings in industrialized countries and will ensure broader access to treatment elsewhere. However, their more widespread use must not lead to a reduction in pharmaceutical quality because this could result in serious clinical consequences, including high rat failures, and selection of drug resistance. It is therefore essential that all generic formulations of DAAs are pre-qualified by the World Health Organization, and that real-life studies are carried out to verify their pharmacokinetic bioequivalence (ideally in patients, and not just in healthy volunteers) and clinical effectiveness. In this regard, lessons from expanding access programs in the HIV field would be very helpful.
    Language English
    Publishing date 2017-10
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2086783-9
    ISSN 1698-6997 ; 1139-6121
    ISSN (online) 1698-6997
    ISSN 1139-6121
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    Zs.A 5711: Show issues Location:
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  3. Article ; Online: The relevance of drug-drug interactions in clinical practice: the case of concomitant boosted protease inhibitors plus alpha-1 blocker administration.

    Gervasoni, Cristina / Resnati, Chiara / Formenti, Tiziana / Fossati, Alessandro / Minisci, Davide / Meraviglia, Paola / Cattaneo, Dario

    Antiviral therapy

    2018  Volume 23, Issue 5, Page(s) 467–469

    MeSH term(s) Adrenergic alpha-1 Receptor Antagonists/administration & dosage ; Aged ; Atazanavir Sulfate/administration & dosage ; Cobicistat/administration & dosage ; Darunavir/administration & dosage ; Drug Interactions ; HIV Infections/drug therapy ; HIV Infections/virology ; HIV Protease Inhibitors/administration & dosage ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Ritonavir/administration & dosage
    Chemical Substances Adrenergic alpha-1 Receptor Antagonists ; HIV Protease Inhibitors ; Atazanavir Sulfate (4MT4VIE29P) ; Cobicistat (LW2E03M5PG) ; Ritonavir (O3J8G9O825) ; Darunavir (YO603Y8113)
    Language English
    Publishing date 2018-04-02
    Publishing country England
    Document type Letter ; Observational Study
    ZDB-ID 1339842-8
    ISSN 2040-2058 ; 1359-6535
    ISSN (online) 2040-2058
    ISSN 1359-6535
    DOI 10.3851/IMP3214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4877: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 174: Show issues

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  4. Article: Major cardiovascular events in patients with Coronavirus Disease 2019: experience of a cardiovascular Department of Northern Italy

    Bellosta, Raffaello Pegorer Matteo Alberto Bettari Luca Luzzani Luca Attisani Luca Fossati Alessandro Consoli Letizia Maffeo Diego Cuccia Claudio Terragnoli Paolo Bush Ruth L. / Piffaretti, Gabriele

    Thrombosis Research

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #912639
    Database COVID19

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  5. Article ; Online: Acute limb ischemia in patients with COVID-19 pneumonia.

    Bellosta, Raffaello / Luzzani, Luca / Natalini, Giuseppe / Pegorer, Matteo Alberto / Attisani, Luca / Cossu, Luisa Giuseppina / Ferrandina, Camillo / Fossati, Alessandro / Conti, Elena / Bush, Ruth L / Piffaretti, Gabriele

    Journal of vascular surgery

    2020  Volume 72, Issue 6, Page(s) 1864–1872

    Abstract: Objective: The aim of our study was to determine the incidence, characteristics, and clinical outcomes of patients with the novel coronavirus (COVID-19) infection who had presented with and been treated for acute limb ischemia (ALI) during the 2020 ... ...

    Abstract Objective: The aim of our study was to determine the incidence, characteristics, and clinical outcomes of patients with the novel coronavirus (COVID-19) infection who had presented with and been treated for acute limb ischemia (ALI) during the 2020 coronavirus pandemic.
    Methods: We performed a single-center, observational cohort study. The data from all patients who had tested positive for COVID-19 and had presented with ALI requiring urgent operative treatment were collected in a prospectively maintained database. For the present series, successful revascularization of the treated arterial segment was defined as the absence of early (<30 days) re-occlusion or major amputation or death within 24 hours. The primary outcomes were successful revascularization, early (≤30 days) and late (≥30 days) survival, postoperative (≤30 days) complications, and limb salvage.
    Results: We evaluated the data from 20 patients with ALI who were positive for COVID-19. For the period from January to March, the incidence rate of patients presenting with ALI in 2020 was significantly greater than that for the same months in 2019 (23 of 141 [16.3%] vs 3 of 163 [1.8%];
    Conclusions: In our preliminary experience, the incidence of ALI has significantly increased during the COVID-19 pandemic in the Italian Lombardy region. Successful revascularization was lower than expected, which we believed was due to a virus-related hypercoagulable state. The use of prolonged systemic heparin might improve surgical treatment efficacy, limb salvage, and overall survival.
    MeSH term(s) Acute Disease ; Aged ; Aged, 80 and over ; Amputation ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/therapy ; Databases, Factual ; Female ; Humans ; Incidence ; Ischemia/diagnostic imaging ; Ischemia/mortality ; Ischemia/surgery ; Italy/epidemiology ; Limb Salvage ; Male ; Middle Aged ; Peripheral Arterial Disease/diagnostic imaging ; Peripheral Arterial Disease/mortality ; Peripheral Arterial Disease/surgery ; Risk Factors ; Time Factors ; Treatment Outcome ; Vascular Surgical Procedures/adverse effects ; Vascular Surgical Procedures/mortality
    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2020.04.483
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    Zs.A 1933: Show issues Location:
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  6. Article ; Online: Major cardiovascular events in patients with Coronavirus Disease 2019: Experience of a cardiovascular department of Northern Italy.

    Bellosta, Raffaello / Pegorer, Matteo Alberto / Bettari, Luca / Luzzani, Luca / Attisani, Luca / Fossati, Alessandro / Consoli, Letizia / Maffeo, Diego / Cuccia, Claudio / Terragnoli, Paolo / Bush, Ruth L / Piffaretti, Gabriele

    Thrombosis research

    2020  Volume 197, Page(s) 202–204

    MeSH term(s) Anticoagulants ; COVID-19 ; Cardiovascular Diseases/epidemiology ; Humans ; Italy/epidemiology ; SARS-CoV-2
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2020-11-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.10.038
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    Zs.A 863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Immunogenicity and clinical efficacy of anti-SARS-CoV-2 vaccination in patients with hematological malignancies: Results of a prospective cohort study of 365 patients.

    Salvini, Marco / Damonte, Camilla / Mortara, Lorenzo / Maggi, Fabrizio / Bruno, Antonino / Pellegrini, Giacomo / Mora, Barbara / Brociner, Marco / Ingrassia, Alessia / Mattarucchi, Roberta / Bianchi, Benedetta / Sirocchi, Davide / Agnoli, Stefania / Rumi, Elisa / Merli, Michele / Fossati, Alessandro / Bassi, Susanna / Bombelli, Raffaella / Gallazzi, Matteo /
    Borsani, Oscar / Baj, Andreina / Franchi, Matteo / Grossi, Paolo A / Passamonti, Francesco

    American journal of hematology

    2022  Volume 97, Issue 8, Page(s) E321–E324

    MeSH term(s) Antibodies, Viral ; COVID-19/prevention & control ; Hematologic Neoplasms/therapy ; Humans ; Prospective Studies ; Treatment Outcome ; Vaccination
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26629
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    Zs.A 1251: Show issues Location:
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  8. Article ; Online: Major cardiovascular events in patients with Coronavirus Disease 2019: experience of a cardiovascular Department of Northern Italy

    Bellosta, Raffaello / Pegorer, Matteo Alberto / Bettari, Luca / Luzzani, Luca / Attisani, Luca / Fossati, Alessandro / Consoli, Letizia / Maffeo, Diego / Cuccia, Claudio / Terragnoli, Paolo / Bush, Ruth L. / Piffaretti, Gabriele

    Thromb Res

    Abstract: Although small with short-term data, our series reports a translational experience of a cardiovascular department facing MACE in COVID-19 patients being acute arterial events the new insight into this COVID-19 pandemic. • COVID-19 infection may trigger ...

    Abstract • Although small with short-term data, our series reports a translational experience of a cardiovascular department facing MACE in COVID-19 patients being acute arterial events the new insight into this COVID-19 pandemic. • COVID-19 infection may trigger a hypercoagulable status leading to challenging MACE and is associated with high mortality rate. • COVID-19 patient with MACE should be treated with both ventilator support, extensive operative cardiac and peripheral revascularization, and the adjunct of heparin which provides better survival chance independently of the infection-related drug treatment.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/j.thromres.2020.10.038
    Database COVID19

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  9. Article: Acute limb ischemia in patients with COVID-19 pneumonia

    Bellosta, Raffaello / Luzzani, Luca / Natalini, Giuseppe / Pegorer, Matteo Alberto / Attisani, Luca / Cossu, Luisa Giuseppina / Ferrandina, Camillo / Fossati, Alessandro / Conti, Elena / Bush, Ruth L / Piffaretti, Gabriele

    J. vasc. surg

    Abstract: OBJECTIVE: The aim of our study was to determine the incidence, characteristics, and clinical outcomes of patients with the novel coronavirus (COVID-19) infection who had presented with and been treated for acute limb ischemia (ALI) during the 2020 ... ...

    Abstract OBJECTIVE: The aim of our study was to determine the incidence, characteristics, and clinical outcomes of patients with the novel coronavirus (COVID-19) infection who had presented with and been treated for acute limb ischemia (ALI) during the 2020 coronavirus pandemic. METHODS: We performed a single-center, observational cohort study. The data from all patients who had tested positive for COVID-19 and had presented with ALI requiring urgent operative treatment were collected in a prospectively maintained database. For the present series, successful revascularization of the treated arterial segment was defined as the absence of early (<30 days) re-occlusion or major amputation or death within 24 hours. The primary outcomes were successful revascularization, early (≤30 days) and late (≥30 days) survival, postoperative (≤30 days) complications, and limb salvage. RESULTS: We evaluated the data from 20 patients with ALI who were positive for COVID-19. For the period from January to March, the incidence rate of patients presenting with ALI in 2020 was significantly greater than that for the same months in 2019 (23 of 141 [16.3%] vs 3 of 163 [1.8%]; P < .001)]. Of the 20 included patients, 18 were men (90%) and two were women (10%). Their mean age was 75 ± 9 years (range, 62-95 years). All 20 patients already had a diagnosis of COVID-19 pneumonia. Operative treatment was performed in 17 patients (85%). Revascularization was successful in 12 of the 17 (70.6%). Although successful revascularization was not significantly associated with the postoperative use of intravenous heparin (64.7% vs 83.3%; P = .622), no patient who had received intravenous heparin required reintervention. Of the 20 patients, eight (40%) had died in the hospital. The patients who had died were significantly older (81 ± 10 years vs 71 ± 5 years; P = .008). The use of continuous postoperative systemic heparin infusion was significantly associated with survival (0% vs 57.1%; P = .042). CONCLUSIONS: In our preliminary experience, the incidence of ALI has significantly increased during the COVID-19 pandemic in the Italian Lombardy region. Successful revascularization was lower than expected, which we believed was due to a virus-related hypercoagulable state. The use of prolonged systemic heparin might improve surgical treatment efficacy, limb salvage, and overall survival.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #133630
    Database COVID19

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  10. Article ; Online: Acute limb ischemia in patients with COVID-19 pneumonia

    Bellosta, Raffaello / Luzzani, Luca / Natalini, Giuseppe / Pegorer, Matteo Alberto / Attisani, Luca / Cossu, Luisa Giuseppina / Ferrandina, Camillo / Fossati, Alessandro / Conti, Elena / Bush, Ruth L. / Piffaretti, Gabriele

    Journal of Vascular Surgery ; ISSN 0741-5214

    2020  

    Keywords Surgery ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.jvs.2020.04.483
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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