LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Using Computer Simulation Models of Physiological and Metabolic Processes in Laboratory Animals.

    Foster, David M. / Boston, Ray C.

    ILAR journal

    2001  Volume 38, Issue 2, Page(s) 58–68

    Language English
    Publishing date 2001-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2192062-X
    ISSN 1930-6180 ; 1084-2020
    ISSN (online) 1930-6180
    ISSN 1084-2020
    DOI 10.1093/ilar.38.2.58
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Model-based approaches to biomarker discovery and evaluation: a multidisciplinary integrated review.

    Vicini, Paolo / Gastonguay, Marc R / Foster, David M

    Critical reviews in biomedical engineering

    2003  Volume 30, Issue 4-6, Page(s) 379–418

    Abstract: The most common use of any mathematical or statistical model in physiology, pathophysiology, or therapy evaluation is to organize all relevant components characterizing the system behavior into a rigorously testable framework. This approach is widely ... ...

    Abstract The most common use of any mathematical or statistical model in physiology, pathophysiology, or therapy evaluation is to organize all relevant components characterizing the system behavior into a rigorously testable framework. This approach is widely applied both to the study of complex homeostatic paradigms involving endogenous substances and to the evaluation of the kinetics and dynamics of xenobiotics such as toxicants and drugs. In either case, one seeks a quantitative framework of the system that is consistent with known physiology and pharmacology and is "compatible" (in some meaningful sense) with all available data. The models are then evaluated and subjected to identifiability and validity tests and can then be used to estimate unknown parameters of interest, to make predictions about system behavior, to simulate previously unobserved behavior in response to a putative perturbation, and to aid in further experimental design. In a broader context, however, the focus and ultimate goal of this set of methodologies (whether this is explicitly stated or not) lies in understanding the mechanisms of physiology and pathophysiology and measuring the effect of therapeutic interventions through the accurate quantification of biomarkers of interest. In this review, we attempt to bring together under this comprehensive framework more than four decades of investigation on modeling and simulation in the life sciences (in particular, we will concentrate on the areas of pharmacology, physiology, and bioengineering). We demonstrate that such modeling approaches, when appropriately designed and evaluated, have significant potential and can be used to understand the multiple factors of disease progression and response to therapeutic interventions, the most likely causes of variability in population and individual responses to therapy, and the most appropriate timing of treatment administration. Lastly, they may allow estimation and prediction of significant outcomes in feasibility and clinical studies.
    MeSH term(s) Animals ; Biomarkers ; Biomarkers, Tumor/metabolism ; Computer Simulation ; Disease Progression ; Drug Design ; Drug Evaluation/methods ; Humans ; Kinetics ; Metabolism/drug effects ; Models, Biological ; Pharmacokinetics ; Pharmacology/methods ; Reproducibility of Results ; Research Design ; Sensitivity and Specificity ; Species Specificity
    Chemical Substances Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2003-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 1411103-2
    ISSN 0278-940X
    ISSN 0278-940X
    DOI 10.1615/critrevbiomedeng.v30.i456.60
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1104: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: The Role of zinc in taste and smell

    Henkin, Robert I / Aamodt, Roger L / Agarwal, R.P / Foster, David M

    Clinical, biochemical, and nutritional aspects of trace elements / editor, Ananda S. Prasad.

    1982  

    Abstract: Abstract: Historical and recent studies concerning diminished taste and smell acuity in patients with zinc (Zn) deficiency are reviewed and discussed. Various studies that implicate Zn in losses of taste and smell are examined. Possible mechanisms of the ...

    Abstract Abstract: Historical and recent studies concerning diminished taste and smell acuity in patients with zinc (Zn) deficiency are reviewed and discussed. Various studies that implicate Zn in losses of taste and smell are examined. Possible mechanisms of the role of Zn in the senses of taste and smell are discussed, including the association of Zn in protein synthesis, Zn involvement in rapidly dividing tissues and in the promotion of diffusion of taste stimuli to taste buds, and the possible significance of a Zn-containing protein in human saliva (gustin). It is speculated, despite the paucity of studies on the mechanism of Zn effects on smell acuity, that Zn may play a role at the olfactory receptor in much the same way that it does for taste (i.e., through a role played by a Zn-containing protein). (wz)
    Keywords zinc ; nutrient deficiencies ; smell ; taste sensitivity ; proteins ; mineral metabolism ; nutrient-nutrient interactions
    Language English
    Size p. 161-188., ill., charts.
    Publisher A. R. Liss, c1982.
    Publishing place New York
    Document type Article
    Note Literature review.
    ISBN 0845116053 ; 9780845116050
    Database NAL-Catalogue (AGRICOLA)

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Metabolism of high-density lipoprotein apolipoproteins in Tangier disease

    Schaefer, Ernst J / Blum, Conrad B / Levy, Robert I / Jenkins, Leslie L / Alaupovic, Petar / Foster, David M / Brewer, H. Bryan Jr

    New England journal of medicine Oct 26, 1978. v. 299 (17)

    1978  

    Abstract: Extract: Eleven normal subjects, two obligate heterozygotes, and two homozygotes were studied to define the metabolic defect in Tangier disease. Mean synthesis of apolipoproteins A-I and A-II was 8.24 mg per kilogram per day in the normal group, 7.94 in ... ...

    Abstract Extract: Eleven normal subjects, two obligate heterozygotes, and two homozygotes were studied to define the metabolic defect in Tangier disease. Mean synthesis of apolipoproteins A-I and A-II was 8.24 mg per kilogram per day in the normal group, 7.94 in heterozygotes and 3.86 in homozygotes. The mean plasma-residence time for both apolipoproteins was 5.21 days in the normal subjects, 3.41 days in heterozygotes, and 0.52 days in homozygotes. In normal subjects and heterozygotes the apolipoproteins were catabolized at similar rates, whereas in homozygotes apolipoprotein A-I was catabolized at a much greater fractional rate than apolipoprotein A-II. These findings indicate that the deficiency of these apolipoproteins in Tangier disease is largely due to rapid and altered catabolism.
    Keywords metabolism ; lipoproteins ; lipid metabolism disorders ; hematologic tests
    Language English
    Dates of publication 1978-1026
    Size p. 905-910., ill., charts.
    Document type Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    Database NAL-Catalogue (AGRICOLA)

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 48/58: Show issues
    Z70.00 NE01: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top