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  1. Book: Infirmier comment traiter votre malade

    Fountain, D. / Courtejoie, Jacques

    1993  

    Title translation Primary diagnosis and treatment
    Author's details D. Fountain et J. Courtejoie
    Keywords Diagnosis
    Language French
    Size 670 S. : Ill.
    Publisher Bureau d'Etudes et de Recherches pour la Promotion de la Santé u.a.
    Publishing place Kangu-Mayumbe
    Publishing country XC-ZRCD
    Document type Book
    HBZ-ID HT006831293
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 B 21 order for loan Magazin

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  2. Article: Association Between Neighborhood Socioeconomic Factors and Length of Stay After Surgery for Congenital Heart Disease.

    Lubarsky, Daniel / Van Driest, Sara L / Crum, Kimberly / Fountain, Darlene / Kannankeril, Prince J

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2024  

    Abstract: Objectives: Neighborhood socioeconomic status, as measured by area deprivation index (ADI) is associated with longer length of stay (LOS) after surgery for hypoplastic left heart syndrome. We tested the hypothesis that LOS is associated with ADI in a ... ...

    Abstract Objectives: Neighborhood socioeconomic status, as measured by area deprivation index (ADI) is associated with longer length of stay (LOS) after surgery for hypoplastic left heart syndrome. We tested the hypothesis that LOS is associated with ADI in a large cohort of congenital heart disease (CHD) surgical cases of varying severity and sought to determine which other components of the ADI accounted for any associations.
    Design: Retrospective analysis of a curated dataset. The Brokamp ADI was determined using residential addresses. Overall, ADI and each of its six individual components were dichotomized, and LOS compared between groups above versus below the median for the entire cohort and after stratifying by surgical The Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery (STAT) severity category.
    Setting: Single-center academic pediatric teaching hospital.
    Patients: CHD patients who underwent surgical repair/palliation between September 2007 and August 2022.
    Interventions: None.
    Measurements and main results: A total of 2462 patients (52.7% male) were included. Median age was 254 (interquartile range [IQR] 95-1628) days and median LOS in the hospital was 8 (IQR 5-18) days. We failed to identify an association between Brokamp ADI, above versus below the median for the entire cohort, and LOS; nor in STAT categories 1-4. However, in STAT category 5 (n = 129) those with ADI above the median (more deprived) had a significantly longer LOS (48 [20-88] vs. 36 [18-49] d, p = 0.034). Of the individual components of the ADI, only percent below poverty level and percent vacant houses were associated with LOS in STAT category 5.
    Conclusions: LOS after CHD surgery is associated with Brokamp ADI in STAT category 5 cases, we failed to identify an association in lower-risk cardiac operations.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0000000000003455
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  3. Article ; Online: Getting it right first time: national survey of surgical site infection 2019.

    Gatfield, S A / Atkinson, K V / Fountain, D / Machin, J T / Navaratnam, A V / Hutton, M / Briggs, Twr

    Annals of the Royal College of Surgeons of England

    2022  Volume 105, Issue 6, Page(s) 513–522

    Abstract: Introduction: Surgical site infections (SSIs) are associated with increased morbidity and mortality. Deep SSI, or prosthetic joint infection (PJI), is associated with revision surgery involving longer operative times with higher infection rates, longer ... ...

    Abstract Introduction: Surgical site infections (SSIs) are associated with increased morbidity and mortality. Deep SSI, or prosthetic joint infection (PJI), is associated with revision surgery involving longer operative times with higher infection rates, longer length of stay (LoS) and high costs in addition to the catastrophic effect on the patient. The surveillance of SSI is important for patient decision making, identification of outliers for support and maximising focussed improvement. This paper reports the findings of the second Getting it Right First Time (GIRFT) national SSI survey for orthopaedic and spinal surgery.
    Methods: Data were submitted prospectively by 67 orthopaedic units and 22 spinal units between 1 May 2019 and 31 October 2019. For a patient to be included, they had to present with SSI within the study period and within 1 year of the index procedure.
    Results: A total of 309 SSIs were reported from primary and revision, total hip, knee, shoulder, elbow and ankle replacements, and 58 SSIs were reported from lumbar spine single level discectomy or decompression, lumbar spine single-level instrumented posterior fusion, posterior cervical spine decompression and instrumented fusion and posterior correction of adolescent idiopathic scoliosis. SSIs rates have remained low compared with the 2017 survey. There were variations in SSI rates by procedure, with primary shoulder replacement reporting the lowest (0.4%) and revision shoulder replacement the highest (2.5%) rates.
    Conclusions: The authors recommend that the elective surgical restart following the COVID-19 pandemic provides a unique opportunity for all units to implement a full SSI prevention bundle to minimise the risk of infection and improve patient outcomes.
    MeSH term(s) Humans ; Adolescent ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology ; Pandemics ; COVID-19/epidemiology ; Neurosurgical Procedures ; Morbidity ; Retrospective Studies ; Spinal Fusion/methods
    Language English
    Publishing date 2022-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 80044-2
    ISSN 1478-7083 ; 0035-8843
    ISSN (online) 1478-7083
    ISSN 0035-8843
    DOI 10.1308/rcsann.2022.0083
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  4. Article ; Online: Performance of the Enhanced Liver Fibrosis Score, Comparison with Vibration-controlled Transient Elastography Data, and Development of a Simple Algorithm to Predict Significant Liver Fibrosis in a Community-based Liver Service: A Retrospective Evaluation.

    Reinson, Tina / Patel, Janisha / Mathews, Mead / Fountain, Derek / Buchanan, Ryan M / Byrne, Christopher D

    Journal of clinical and translational hepatology

    2023  Volume 11, Issue 4, Page(s) 800–808

    Abstract: Background and aims: Liver fibrosis is a key risk factor for cirrhosis, hepatocellular carcinoma and end stage liver failure. The National Institute for Health and Care Excellence guidelines for assessment for advanced (≥F3) liver fibrosis in people ... ...

    Abstract Background and aims: Liver fibrosis is a key risk factor for cirrhosis, hepatocellular carcinoma and end stage liver failure. The National Institute for Health and Care Excellence guidelines for assessment for advanced (≥F3) liver fibrosis in people with nonalcoholic fatty liver disease recommend the use of enhanced liver fibrosis (ELF) test, followed by vibration-controlled transient elastography (VCTE). Performance of ELF at predicting significant (≥F2) fibrosis in real-world practice is uncertain. To assess the accuracy of ELF using VCTE; investigate the optimum ELF cutoff value to identify ≥F2 and ≥F3; and develop a simple algorithm, with and without ELF score, for detecting ≥F2.
    Methods: Retrospective evaluation of patients referred to a Community Liver Service for VCTE, Jan-Dec 2020. Assessment included: body mass index (BMI), diabetes status, alanine aminotransferase (ALT) levels, ELF score and biopsy-validated fibrosis stages according to VCTE.
    Results: Data from 273 patients were available.
    Conclusions: Optimal ELF cutoff for ≥F2 is 9.85 and 9.95 for ≥F3. ALT, BMI, and HbA1c (ALBA algorithm) can stratify patients at risk of ≥F2. ELF performance is improved by adding ALBA.
    Language English
    Publishing date 2023-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2022.00335
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  5. Article: Lettuce seed germination and cytokinins: their entry and formation.

    Black, M / Bewley, J D / Fountain, D

    Planta

    2014  Volume 117, Issue 2, Page(s) 145–152

    Abstract: Cytokinins overcome the inhibitory effect of abscisic acid on the germination of isolated embryos of Grand Rapids lettuce. We have used this fact to assess the content of cytokinins in embryos removed from intact seeds which have been supplied with these ...

    Abstract Cytokinins overcome the inhibitory effect of abscisic acid on the germination of isolated embryos of Grand Rapids lettuce. We have used this fact to assess the content of cytokinins in embryos removed from intact seeds which have been supplied with these growth substances i.e. to determine hormonal uptake. The method has also been used to examine the hypothesis that phytochrome and gibberellin lead to increases in active cytokinin levels in seeds. Appreciable amounts of cytokinins enter intact seeds yet seem unable to promote germination. On the other hand, little or no cytokinin-like activity seems to result from light or gibberellin treatments. We conclude that there are unresolved difficulties inherent in the "cytokinin hypothesis" of phytochrome and gibberellin action.
    Language English
    Publishing date 2014-01-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208909-9
    ISSN 1432-2048 ; 0032-0935 ; 1866-2749
    ISSN (online) 1432-2048
    ISSN 0032-0935 ; 1866-2749
    DOI 10.1007/BF00390796
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  6. Article: Additive Manufacturing: The Next Generation of Scapholunate Ligament Reconstruction.

    Rush, Matthew N / Salas, Christina / Mottishaw, Lorraine / Fountain, Damian / Mercer, Deana

    Journal of wrist surgery

    2021  Volume 10, Issue 6, Page(s) 492–501

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2678060-4
    ISSN 2163-3924 ; 2163-3916
    ISSN (online) 2163-3924
    ISSN 2163-3916
    DOI 10.1055/s-0041-1729993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Quality of life in patients with gastroenteropancreatic tumours: A systematic literature review.

    Watson, Catherine / Tallentire, Craig William / Ramage, John K / Srirajaskanthan, Rajaventhan / Leeuwenkamp, Oscar R / Fountain, Donna

    World journal of gastroenterology

    2020  Volume 26, Issue 25, Page(s) 3686–3711

    Abstract: Background: Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are slow-growing cancers that arise from diffuse endocrine cells in the gastrointestinal tract (GI-NETs) or the pancreas (P-NETs). They are relatively uncommon, accounting for 2% of ... ...

    Abstract Background: Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) are slow-growing cancers that arise from diffuse endocrine cells in the gastrointestinal tract (GI-NETs) or the pancreas (P-NETs). They are relatively uncommon, accounting for 2% of all gastrointestinal malignancies. The usual treatment options in advanced GEP-NET patients with metastatic disease include chemotherapy, biological therapies, and peptide receptor radionuclide therapy. Understanding the impact of treatment on GEP-NET patients is paramount given the nature of the disease. Health-related quality of life (HRQoL) is increasingly important as a concept reflecting the patients' perspective in conjunction with the disease presentation, severity and treatment.
    Aim: To conduct a systematic literature review to identify literature reporting HRQoL data in patients with GEP-NETs between January 1985 and November 2019.
    Methods: The PRISMA guiding principles were applied. MEDLINE, Embase and the Cochrane library were searched. Data extracted from the publications included type of study, patient population data (mid-gut/hind-gut/GI-NET/P-NET), sample size, intervention/comparators, HRQoL instruments, average and data spread of overall and sub-scores, and follow-up time for data collection.
    Results: Forty-three publications met the inclusion criteria. The heterogeneous nature of the different study populations was evident; the percentage of female participants ranged between 30%-60%, whilst average age ranged from 53.8 to 67.0 years. Eight studies investigated GI-NET patients only, six studies focused exclusively on P-NET patients and the remaining studies involved both patient populations or did not report the location of the primary tumour. The most commonly used instrument was the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (
    Conclusion: HRQoL instruments offer a means to monitor patients' general disease condition, disease progression and their physical and mental well-being. Instruments including the commonly used European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30 and GINET21 lack, however, validation and a defined minimal clinical important difference specifically for GI-NET and P-NET patients.
    MeSH term(s) Aged ; Female ; Humans ; Intestinal Neoplasms/therapy ; Middle Aged ; Neuroendocrine Tumors/therapy ; Pancreatic Neoplasms/therapy ; Quality of Life ; Stomach Neoplasms/therapy
    Language English
    Publishing date 2020-08-02
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v26.i25.3686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  8. Article: A distinction between the actions of abscisic acid, gibberellic acid and cytokinins in light-sensitive lettuce seed.

    Bewley, J D / Fountain, D W

    Planta

    2014  Volume 102, Issue 4, Page(s) 368–371

    Abstract: Using isolated lettuce seed embryos it can be shown that the inhibitory effect of abscisic acid upon germination is reversed solely by cytokinin. In the intact seed, however, gibberellic acid is also required for this reversal to be manifested in ... ...

    Abstract Using isolated lettuce seed embryos it can be shown that the inhibitory effect of abscisic acid upon germination is reversed solely by cytokinin. In the intact seed, however, gibberellic acid is also required for this reversal to be manifested in germination.
    Language English
    Publishing date 2014-02-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208909-9
    ISSN 1432-2048 ; 0032-0935 ; 1866-2749
    ISSN (online) 1432-2048
    ISSN 0032-0935 ; 1866-2749
    DOI 10.1007/BF00386622
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  9. Article ; Online: Chlorhexidine dressings could reduce external ventricular drain infections: results from a systematic review and meta-analysis.

    Waqar, M / Chari, A / Islim, A I / Davies, B M / Fountain, D M / Larkin, S / Jenkinson, M D / Patel, H C

    The Journal of hospital infection

    2021  Volume 117, Page(s) 37–43

    Abstract: The incidence of external ventricular drain (EVD) infections remains high. Chlorhexidine dressings have demonstrated efficacy in reducing infections associated with indwelling catheters at other body sites, although evidence for their use with EVDs is ... ...

    Abstract The incidence of external ventricular drain (EVD) infections remains high. Chlorhexidine dressings have demonstrated efficacy in reducing infections associated with indwelling catheters at other body sites, although evidence for their use with EVDs is limited. The aim of this systematic review and meta-analysis was to evaluate the efficacy of chlorhexidine dressings in reducing EVD-associated cerebrospinal fluid infection (EVDAI). MEDLINE, EMBASE and the Cochrane library were queried for articles from inception. The primary outcome was the incidence of EVDAI. Secondary outcomes included device safety, microbiological outcomes and shunt-dependency. From 896 unique records, five studies were included of which four presented suitable data for quantitative analysis including three case series and one underpowered randomized controlled trial. There was a high risk of bias in all studies. A total of 880 patients were included with a mean age of 57.7 years (95% confidence interval (CI) 57.4-58.0 years). In primary outcome analysis, the chlorhexidine dressing group had a significantly lower incidence of EVDAI (1.7% vs 7.9%, risk difference (RD) = 0.07, 95% CI 0.00-0.13, P=0.04). In conclusion, chlorhexidine dressings may reduce the incidence of EVDAI but require future study in randomized trials to definitively determine efficacy.
    MeSH term(s) Bandages ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/prevention & control ; Catheters, Indwelling ; Chlorhexidine ; Drainage ; Humans ; Middle Aged
    Chemical Substances Chlorhexidine (R4KO0DY52L)
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2021.06.006
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  10. Article: Additive Manufacturing: The Next Generation of Scapholunate Ligament Reconstruction

    Rush, Matthew N. / Salas, Christina / Mottishaw, Lorraine / Fountain, Damian / Mercer, Deana

    Journal of Wrist Surgery

    2021  Volume 10, Issue 06, Page(s) 492–501

    Abstract: Background: Ligament reconstruction, as a surgical method used to stabilize joints, requires significant strength and tissue anchoring to restore function. Historically, reconstructive materials have been fraught with problems from an inability to ... ...

    Abstract Background: Ligament reconstruction, as a surgical method used to stabilize joints, requires significant strength and tissue anchoring to restore function. Historically, reconstructive materials have been fraught with problems from an inability to withstand normal physiological loads to difficulties in fabricating the complex organization structure of native tissue at the ligament-to-bone interface. In combination, these factors have prevented the successful realization of nonautograft reconstruction.
    Methods: A review of recent improvements in additive manufacturing techniques and biomaterials highlight possible options for ligament replacement.
    Description of Technique: In combination, three dimensional-printing and electrospinning have begun to provide for nonautograft options that can meet the physiological load and architectures of native tissues; however, a combination of manufacturing methods is needed to allow for bone-ligament enthesis. Hybrid biofabrication of bone-ligament tissue scaffolds, through the simultaneous deposition of disparate materials, offer significant advantages over fused manufacturing methods which lack efficient integration between bone and ligament materials.
    Results: In this review, we discuss the important chemical and biological properties of ligament enthesis and describe recent advancements in additive manufacturing to meet mechanical and biological requirements for a successful bone–ligament–bone interface.
    Conclusions: With continued advancement of additive manufacturing technologies and improved biomaterial properties, tissue engineered bone-ligament scaffolds may soon enter the clinical realm.
    Keywords bone–ligament ; interface ; regeneration ; tissue engineering ; additive manufacturing
    Language English
    Publishing date 2021-06-21
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2678060-4
    ISSN 2163-3924 ; 2163-3916 ; 2163-3924
    ISSN (online) 2163-3924
    ISSN 2163-3916 ; 2163-3924
    DOI 10.1055/s-0041-1729993
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