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  1. Book ; Audio / Video ; Conference proceedings: 2nd International Congress on Neurobiology, Psychopharmacology & Treatment Guidance

    Fountoulakis, Konstantinos N.

    Thessaloniki (Greece), November 24 - 27, 2011 ; selected papers

    2012  

    Event/congress International Congress on Neurobiology, Psychopharmacology & Treatment Guidance (2, 2011, Thessaloniki)
    Author's details ed. Konstantinos N. Fountoulakis
    Subject code a616 ; c21
    Language English
    Size VII, 170 S. : Ill., graph. Darst. ; 1 CD-ROM, 12 cm
    Publisher Medimond
    Publishing place Bologna
    Publishing country Italy
    Document type Book ; Audio / Video ; Conference proceedings
    HBZ-ID HT017335164
    ISBN 978-88-7587-641-8 ; 88-7587-641-X
    Database Catalogue ZB MED Medicine, Health

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    2012 MO 489 order for loan Magazin

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  2. Article ; Online: Neither serotonin disorder is at the core of depression nor dopamine at the core of schizophrenia; still these are biologically based mental disorders.

    Fountoulakis, Konstantinos N / Tsapakis, Eva Maria

    Molecular psychiatry

    2024  

    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Letter
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-024-02458-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Should denialism of mental illness and its treatment be included among conspiracy theories?

    Fountoulakis, Konstantinos N

    European archives of psychiatry and clinical neuroscience

    2021  Volume 271, Issue 4, Page(s) 591–593

    MeSH term(s) Denial, Psychological ; Humans ; Mental Disorders/psychology ; Mental Disorders/therapy
    Language English
    Publishing date 2021-05-03
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-021-01272-w
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  4. Article ; Online: Being strictly scientific is the only way forward for psychiatry.

    Fountoulakis, Konstantinos N

    Acta psychiatrica Scandinavica

    2021  Volume 143, Issue 3, Page(s) 187–188

    MeSH term(s) Humans ; Mental Disorders/therapy ; Psychiatry
    Language English
    Publishing date 2021-04-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 103-x
    ISSN 1600-0447 ; 0001-690X
    ISSN (online) 1600-0447
    ISSN 0001-690X
    DOI 10.1111/acps.13284
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  5. Article ; Online: Culturally sanctioned "scientific pluralism" opens the backdoor for the supernatural in Psychiatry.

    Fountoulakis, Konstantinos N

    Acta psychiatrica Scandinavica

    2021  Volume 145, Issue 1, Page(s) 109–110

    MeSH term(s) Cultural Diversity ; Humans ; Psychiatry
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 103-x
    ISSN 1600-0447 ; 0001-690X
    ISSN (online) 1600-0447
    ISSN 0001-690X
    DOI 10.1111/acps.13382
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  6. Article ; Online: Pharmacodynamic properties of lumateperone and its efficacy in acute bipolar depression: a mechanistic hypothesis based on data.

    Fountoulakis, Konstantinos N / Tohen, Mauricio / Zarate, Carlos A

    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

    2024  Volume 81, Page(s) 1–9

    Abstract: The treatment of bipolar depression is one of the most challenging needs in contemporary psychiatry. Currently, only quetiapine, olanzapine-fluoxetine combination, lurasidone, cariprazine, and recently lumateperone have been FDA-approved to treat this ... ...

    Abstract The treatment of bipolar depression is one of the most challenging needs in contemporary psychiatry. Currently, only quetiapine, olanzapine-fluoxetine combination, lurasidone, cariprazine, and recently lumateperone have been FDA-approved to treat this condition. The neurobiology of bipolar depression and the possible mechanistic targets of bipolar antidepressant therapy remain elusive. The current study investigated whether the pharmacodynamic properties of lumateperone fit into a previously developed model which was the first to be derived based on the strict combination of clinical and preclinical data. The authors performed a systematic review of the literature to identify the pharmacodynamic properties of lumateperone. The original model suggests that a constellation of effects on different receptors is necessary, but refinements, including the present study, suggest that the inhibition of the serotonin reuptake at the first level, the 5HT-2A blockade at the second level, and the norepinephrine alpha-1 receptors blockade at a third level in combination with D1 blockade contribute to the antidepressant effect in acute bipolar depression. The D2 blockade acts as a protective mechanism and reduces the risk of switching to mania/hypomania.
    MeSH term(s) Humans ; Bipolar Disorder/drug therapy ; Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; Lurasidone Hydrochloride/pharmacology ; Lurasidone Hydrochloride/therapeutic use ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Heterocyclic Compounds, 4 or More Rings
    Chemical Substances lumateperone (70BSQ12069) ; Antipsychotic Agents ; Lurasidone Hydrochloride (O0P4I5851I) ; Antidepressive Agents ; Heterocyclic Compounds, 4 or More Rings
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 1082947-7
    ISSN 1873-7862 ; 0924-977X
    ISSN (online) 1873-7862
    ISSN 0924-977X
    DOI 10.1016/j.euroneuro.2024.01.002
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  7. Article ; Online: Brain Volume Changes Under Treatment With Antipsychotics.

    Fountoulakis, Konstantinos N

    JAMA psychiatry

    2020  Volume 77, Issue 8, Page(s) 876–877

    MeSH term(s) Antipsychotic Agents/adverse effects ; Brain/diagnostic imaging ; Depressive Disorder, Major/drug therapy ; Humans ; Neuroimaging
    Chemical Substances Antipsychotic Agents
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2020.1358
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  8. Article: Neurocognitive impairment and evidence-based treatment options in Bipolar disorder.

    Fountoulakis, Konstantinos N

    Annals of general psychiatry

    2020  Volume 19, Page(s) 54

    Abstract: Background: The current paper briefly summarizes the literature on the neurocognitive deficit and its treatment in BD patients.: Methods: The material was chosen on the basis of previous systematic reviews the author has taken part in.: Results: ... ...

    Abstract Background: The current paper briefly summarizes the literature on the neurocognitive deficit and its treatment in BD patients.
    Methods: The material was chosen on the basis of previous systematic reviews the author has taken part in.
    Results: The data so far suggest that the deficit is qualitatively similar but quantitatively milder in comparison to schizophrenia, it is present already since the first episode, is weakly related to mood symptoms and somewhat stronger to psychotic symptoms, it probably determines much of the disability and treatment is problematic. This deficit is also present during periods of euthymia. The possible adverse effect of psychotropic medication is rather small if any at all and is confounded by the specific clinical symptoms, for which medication is used for their treatment. This is especially true concerning antipsychotics and psychotic symptoms. The origin and the etiopathogenesis of the core neurocognitive impairment remain elusive. The presence of a neurodegenerative and of a neurodevelopmental component has both data in favor and against and they are both the focus of debate.
    Conclusions: Treatment of the neurocognitive deficit and restoration of functioning is problematic. The data are limited and treatment options are few and with a weak overall effect. Pharmacological treatments, ECT and rTMS present some hard data, while the literature is inconclusive concerning psychotherapeutic interventions.
    Language English
    Publishing date 2020-09-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2090401-0
    ISSN 1744-859X ; 1475-2832
    ISSN 1744-859X ; 1475-2832
    DOI 10.1186/s12991-020-00304-4
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  9. Article ; Online: Climate rather than economic variables might have caused increase in US homicide but not suicide rates during the Great Depression.

    Fountoulakis, Konstantinos N / Fountoulakis, Nikolaos K

    Psychiatry research

    2022  Volume 309, Page(s) 114378

    Abstract: Background: It is widely believed that during the Great Depression (1929-1933) there was a rise in suicidal rates which was causally related to the increase in unemployment. There are no studies on the effect the Great Depression had on homicidal rates ... ...

    Abstract Background: It is widely believed that during the Great Depression (1929-1933) there was a rise in suicidal rates which was causally related to the increase in unemployment. There are no studies on the effect the Great Depression had on homicidal rates METHODS: The data concerning suicide, homicide, economic and climatic variables for the years 1900-1940 for the whole of the US were gathered from the US Center for Disease Control, the Maddison Project, the National Bureau of Economic Research and the National Climatic Data Center. Time Series Analysis was performed.
    Results: The results are inconclusive on the role of economic factors but preclude any role of climate on suicidal rates during the years 1900-1940 in the US. Suicidal rates might have a 24-years periodicity, however much longer time series are needed to confirm this. On the contrary they strongly suggest an effect of higher temperatures on homicidal rates after 1922.
    Conclusions: The results of the current study suggest a direct and clear effect of climate (higher temperatures) on the increasing homicidal rates in the US after 1922 but failed to establish a causal relationship between suicide rates and economic or climate variables. These should be considered together with increasing concerns on the possible effect of climate change on mental health.
    MeSH term(s) Depression ; Homicide/psychology ; Humans ; Suicidal Ideation ; Suicide/psychology ; Unemployment/psychology
    Language English
    Publishing date 2022-01-15
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2021.114378
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  10. Article ; Online: The effect of first- and second-generation antipsychotics on brain morphology in schizophrenia: A systematic review of longitudinal magnetic resonance studies with a randomized allocation to treatment arms.

    Fountoulakis, Konstantinos N / Stahl, Stephen M

    Journal of psychopharmacology (Oxford, England)

    2022  Volume 36, Issue 4, Page(s) 428–438

    Abstract: Schizophrenia manifests as loss of brain volume in specific areas in a progressive nature and an important question concerns whether long-term treatment with medications contributes to this. The aim of the current PRISMA systematic review was to search ... ...

    Abstract Schizophrenia manifests as loss of brain volume in specific areas in a progressive nature and an important question concerns whether long-term treatment with medications contributes to this. The aim of the current PRISMA systematic review was to search for prospective studies involving randomization to treatment. PROSPERO ID: CRD42020197874. The MEDLINE/PUBMED was searched and it returned 2638 articles; 3 were fulfilling the inclusion criteria. A fourth was published later; they included 359 subjects, of whom 86 were healthy controls, while the rest were first-episode patients, with 91 under olanzapine, 93 under haloperidol, 48 under risperidone, 5 under paliperidone, 6 under ziprasidone, and 30 under placebo. Probably one-third of patients were suffering from a psychotic disorder other than schizophrenia. The consideration of their results suggested that there is no significant difference between these medications concerning their effects on brain structure and also in comparison to healthy subjects. There does not seem to be any strong support to the opinion that medications that treat psychosis cause loss of brain volume in patients with schizophrenia. On the contrary, the data might imply the possible presence of a protective effect for D2, 5-HT2, and NE alpha-2 antagonists (previously called SGAs). However, the literature is limited and focused research in large study samples is essential to clarify the issue, since important numerical differences do exist. The possibility of the results and their heterogeneity to be artifacts secondary to a modification of magnetic resonance imaging (MRI) signal by antipsychotics should not be easily rejected until relevant data are available.
    MeSH term(s) Antipsychotic Agents ; Benzodiazepines/adverse effects ; Brain/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Prospective Studies ; Schizophrenia/chemically induced ; Schizophrenia/drug therapy
    Chemical Substances Antipsychotic Agents ; Benzodiazepines (12794-10-4)
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 639313-5
    ISSN 1461-7285 ; 0269-8811
    ISSN (online) 1461-7285
    ISSN 0269-8811
    DOI 10.1177/02698811221087645
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