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  1. Article ; Online: Methanocaldococcus lauensis

    L'Haridon, Stéphane / Goulaouic, Steven / St John, Emily / Fouteau, Stephanie / Reysenbach, Anna-Louise

    International journal of systematic and evolutionary microbiology

    2023  Volume 73, Issue 1

    MeSH term(s) Hydrothermal Vents ; Methanocaldococcus/genetics ; RNA, Ribosomal, 16S/genetics ; Fatty Acids/chemistry ; Phylogeny ; Sequence Analysis, DNA ; DNA, Bacterial/genetics ; Base Composition ; Bacterial Typing Techniques ; Archaea ; Euryarchaeota ; Seawater
    Chemical Substances RNA, Ribosomal, 16S ; Fatty Acids ; DNA, Bacterial
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2002336-4
    ISSN 1466-5034 ; 1466-5026
    ISSN (online) 1466-5034
    ISSN 1466-5026
    DOI 10.1099/ijsem.0.005646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 409: Show issues Location:
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  2. Article ; Online: Bioplastic degradation and assimilation processes by a novel bacterium isolated from the marine plastisphere.

    Barbe, Valérie / Jacquin, Justine / Bouzon, Madeleine / Wolinski, Adèle / Derippe, Gabrielle / Cheng, Jingguang / Cruaud, Corinne / Roche, David / Fouteau, Stéphanie / Petit, Jean-Louis / Conan, Pascal / Pujo-Pay, Mireille / Bruzaud, Stéphane / Ghiglione, Jean-François

    Journal of hazardous materials

    2024  Volume 466, Page(s) 133573

    Abstract: Biosourced and biodegradable plastics offer a promising solution to reduce environmental impacts of plastics for specific applications. Here, we report a novel bacterium named Alteromonas plasticoclasticus MED1 isolated from the marine plastisphere that ... ...

    Abstract Biosourced and biodegradable plastics offer a promising solution to reduce environmental impacts of plastics for specific applications. Here, we report a novel bacterium named Alteromonas plasticoclasticus MED1 isolated from the marine plastisphere that forms biofilms on foils of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). Experiments of degradation halo, plastic matrix weight loss, bacterial oxygen consumption and heterotrophic biosynthetic activity showed that the bacterial isolate MED1 is able to degrade PHBV and to use it as carbon and energy source. The likely entire metabolic pathway specifically expressed by this bacterium grown on PHBV matrices was shown by further genomic and transcriptomic analysis. In addition to a gene coding for a probable secreted depolymerase, a gene cluster was located that encodes characteristic enzymes involved in the complete depolymerization of PHBV, the transport of oligomers, and in the conversion of the monomers into intermediates of central carbon metabolism. The transcriptomic experiments showed the activation of the glyoxylate shunt during PHBV degradation, setting the isocitrate dehydrogenase activity as regulated branching point of the carbon flow entering the tricarboxylic acid cycle. Our study also shows the potential of exploring the natural plastisphere to discover new bacteria with promising metabolic capabilities.
    MeSH term(s) Polyesters ; Bacteria/genetics ; Bacteria/metabolism ; Hydroxybutyrates ; Biopolymers ; Carbon/metabolism
    Chemical Substances Polyesters ; Hydroxybutyrates ; Biopolymers ; Carbon (7440-44-0)
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.133573
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  3. Article ; Online: Characterization of a novel β-alanine biosynthetic pathway consisting of promiscuous metabolic enzymes.

    Perchat, Nadia / Dubois, Christelle / Mor-Gautier, Rémi / Duquesne, Sophie / Lechaplais, Christophe / Roche, David / Fouteau, Stéphanie / Darii, Ekaterina / Perret, Alain

    The Journal of biological chemistry

    2022  Volume 298, Issue 7, Page(s) 102067

    Abstract: Bacteria adapt to utilize the nutrients available in their environment through a sophisticated metabolic system composed of highly specialized enzymes. Although these enzymes can metabolize molecules other than those for which they evolved, their ... ...

    Abstract Bacteria adapt to utilize the nutrients available in their environment through a sophisticated metabolic system composed of highly specialized enzymes. Although these enzymes can metabolize molecules other than those for which they evolved, their efficiency toward promiscuous substrates is considered too low to be of physiological relevance. Herein, we investigated the possibility that these promiscuous enzymes are actually efficient enough at metabolizing secondary substrates to modify the phenotype of the cell. For example, in the bacterium Acinetobacter baylyi ADP1 (ADP1), panD (coding for l-aspartate decarboxylase) encodes the only protein known to catalyze the synthesis of β-alanine, an obligate intermediate in CoA synthesis. However, we show that the ADP1 ΔpanD mutant could also form this molecule through an unknown metabolic pathway arising from promiscuous enzymes and grow as efficiently as the wildtype strain. Using metabolomic analyses, we identified 1,3-diaminopropane and 3-aminopropanal as intermediates in this novel pathway. We also conducted activity screening and enzyme kinetics to elucidate candidate enzymes involved in this pathway, including 2,4-diaminobutyrate aminotransferase (Dat) and 2,4-diaminobutyrate decarboxylase (Ddc) and validated this pathway in vivo by analyzing the phenotype of mutant bacterial strains. Finally, we experimentally demonstrate that this novel metabolic route is not restricted to ADP1. We propose that the occurrence of conserved genes in hundreds of genomes across many phyla suggests that this previously undescribed pathway is widespread in prokaryotes.
    MeSH term(s) Acinetobacter/genetics ; Acinetobacter/metabolism ; Biosynthetic Pathways ; Escherichia coli/metabolism ; Metabolic Networks and Pathways ; Transaminases/genetics ; Transaminases/metabolism ; beta-Alanine/metabolism
    Chemical Substances beta-Alanine (11P2JDE17B) ; Transaminases (EC 2.6.1.-)
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.102067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: A Methylotrophic Bacterium Growing with the Antidiabetic Drug Metformin as Its Sole Carbon, Nitrogen and Energy Source.

    Chaignaud, Pauline / Gruffaz, Christelle / Borreca, Adrien / Fouteau, Stéphanie / Kuhn, Lauriane / Masbou, Jérémy / Rouy, Zoé / Hammann, Philippe / Imfeld, Gwenaël / Roche, David / Vuilleumier, Stéphane

    Microorganisms

    2022  Volume 10, Issue 11

    Abstract: Metformin is one of the most prescribed antidiabetic agents worldwide and is also considered for other therapeutic applications including cancer and endocrine disorders. It is largely unmetabolized by human enzymes and its presence in the environment has ...

    Abstract Metformin is one of the most prescribed antidiabetic agents worldwide and is also considered for other therapeutic applications including cancer and endocrine disorders. It is largely unmetabolized by human enzymes and its presence in the environment has raised concern, with reported toxic effects on aquatic life and potentially also on humans. We report on the isolation and characterisation of strain MD1, an aerobic methylotrophic bacterium growing with metformin as its sole carbon, nitrogen and energy source. Strain MD1 degrades metformin into dimethylamine used for growth, and guanylurea as a side-product. Sequence analysis of its fully assembled genome showed its affiliation to
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10112302
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  5. Article ; Online: Complete Genome Sequence of

    Fouteau, Stéphanie / Bui Van, Vuong / Rouy, Zoé / Beraud, Mélanie / Cruaud, Corinne / Cayol, Jean-Luc / Chifflet, Sandrine / Chu Van, Thuoc / Pham The, Thu / Vallenet, David / Oliveira, Pedro H / Mari, Xavier / Pradel, Nathalie

    Microbiology resource announcements

    2022  Volume 11, Issue 7, Page(s) e0013222

    Abstract: We report the complete genome sequence ... ...

    Abstract We report the complete genome sequence of
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00132-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparative genomic analysis of obligately piezophilic

    Zhang, Wei-Jia / Zhang, Chan / Zhou, Siyu / Li, Xue-Gong / Mangenot, Sophie / Fouteau, Stéphanie / Guerin, Thomas / Qi, Xiao-Qing / Yang, Jian / Bartlett, Douglas H / Wu, Long-Fei

    Microbial genomics

    2021  Volume 7, Issue 7

    Abstract: Hadal trenches are the deepest but underexplored ecosystems on the Earth. Inhabiting the trench bottom is a group of micro-organisms termed obligate piezophiles that grow exclusively under high hydrostatic pressures (HHP). To reveal the genetic and ... ...

    Abstract Hadal trenches are the deepest but underexplored ecosystems on the Earth. Inhabiting the trench bottom is a group of micro-organisms termed obligate piezophiles that grow exclusively under high hydrostatic pressures (HHP). To reveal the genetic and physiological characteristics of their peculiar lifestyles and microbial adaptation to extreme high pressures, we sequenced the complete genome of the obligately piezophilic bacterium
    MeSH term(s) Acclimatization/genetics ; Choline/metabolism ; Ecosystem ; Energy Metabolism/genetics ; Fermentation/genetics ; Fermentation/physiology ; Genome, Bacterial/genetics ; Hydrostatic Pressure ; Moritella/genetics ; Moritella/physiology ; Oceans and Seas ; Water Microbiology ; Whole Genome Sequencing
    Chemical Substances Choline (N91BDP6H0X)
    Language English
    Publishing date 2021-07-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction to: Adaptation in toxic environments: comparative genomics of loci carrying antibiotic resistance genes derived from acid mine drainage waters.

    Arsène-Ploetze, Florence / Chiboub, Olfa / Lièvremont, Didier / Farasin, Julien / Freel, Kelle C / Fouteau, Stephanie / Barbe, Valérie

    Environmental science and pollution research international

    2018  Volume 25, Issue 2, Page(s) 1484–1485

    Abstract: The original version of this article unfortunately contains a mistake. ...

    Abstract The original version of this article unfortunately contains a mistake.
    Language English
    Publishing date 2018
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-017-0803-7
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  8. Article ; Online: Transformation of the recalcitrant pesticide chlordecone by Desulfovibrio sp.86 with a switch from ring-opening dechlorination to reductive sulfidation activity.

    Della-Negra, Oriane / Chaussonnerie, Sébastien / Fonknechten, Nuria / Barbance, Agnès / Muselet, Delphine / Martin, Déborah E / Fouteau, Stéphanie / Fischer, Cécile / Saaidi, Pierre-Loïc / Le Paslier, Denis

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 13545

    Abstract: The insecticide chlordecone has been used in the French West Indies for decades, resulting in long term pollution, human health problems and social crisis. In addition to bacterial consortia and Citrobacter sp.86 previously described to transform ... ...

    Abstract The insecticide chlordecone has been used in the French West Indies for decades, resulting in long term pollution, human health problems and social crisis. In addition to bacterial consortia and Citrobacter sp.86 previously described to transform chlordecone into three families of transformation products (A: hydrochlordecones, B: polychloroindenes and C: polychloroindenecarboxylic acids), another bacterium Desulfovibrio sp.86, showing the same abilities has been isolated and its genome was sequenced. Ring-opening dechlorination, leading to A, B and C families, was observed as previously described. Changing operating conditions in the presence of chlordecone gave rise to the formation of an unknown sulfur-containing transformation product instead of the aforementioned ones. Its structural elucidation enabled to conclude to a thiol derivative, which corresponds to an undocumented bacterial reductive sulfidation. Microbial experiments pointed out that the chlordecone thiol derivative was observed in anaerobiosis, and required the presence of an electron acceptor containing sulfur or hydrogen sulfide, in a confined atmosphere. It seems that this new reaction is also active on hydrochlordecones, as the 10-monohydrochlordecone A1 was transformed the same way. Moreover, the chlordecone thiol derivative called F1 was detected in several chlordecone contaminated mangrove bed sediments from Martinique Island, highlighting the environmental relevance of these results.
    Language English
    Publishing date 2020-08-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-70124-9
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  9. Article: Genome Sequence of Piezophilic Bacterium

    Fouteau, Stéphanie / Guerin, Thomas / Magdelenat, Ghislaine / Roumagnac, Marie / Bartoli, Manon / Ollivier, Bernard / Dolla, Alain / Barbe, Valérie / Pradel, Nathalie

    Genome announcements

    2017  Volume 5, Issue 44

    Abstract: ... ...

    Abstract Piezophilic
    Language English
    Publishing date 2017-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.01181-17
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  10. Article ; Online: Adaptation in toxic environments: comparative genomics of loci carrying antibiotic resistance genes derived from acid mine drainage waters.

    Arsène-Ploetze, Florence / Chiboub, Olfa / Lièvremont, Didier / Farasin, Julien / Freel, Kelle C / Fouteau, Stephanie / Barbe, Valérie

    Environmental science and pollution research international

    2017  Volume 25, Issue 2, Page(s) 1470–1483

    Abstract: Several studies have suggested the existence of a close relationship between antibiotic-resistant phenotypes and resistance to other toxic compounds such as heavy metals, which involve co-resistance or cross-resistance mechanisms. A metagenomic library ... ...

    Abstract Several studies have suggested the existence of a close relationship between antibiotic-resistant phenotypes and resistance to other toxic compounds such as heavy metals, which involve co-resistance or cross-resistance mechanisms. A metagenomic library was previously constructed in Escherichia coli with DNA extracted from the bacterial community inhabiting an acid mine drainage (AMD) site highly contaminated with heavy metals. Here, we conducted a search for genes involved in antibiotic resistance using this previously constructed library. In particular, resistance to antibiotics was observed among five clones carrying four different loci originating from CARN5 and CARN2, two genomes reconstructed from the metagenomic data. Among the three CARN2 loci, two carry genes homologous to those previously proposed to be involved in antibiotic resistance. The third CARN2 locus carries a gene encoding a membrane transporter with an unknown function and was found to confer bacterial resistance to rifampicin, gentamycin, and kanamycin. The genome of Thiomonas delicata DSM 16361 and Thiomonas sp. X19 were sequenced in this study. Homologs of genes carried on these three CARN2 loci were found in these genomes, two of these loci were found in genomic islands. Together, these findings confirm that AMD environments contaminated with several toxic metals also constitute habitats for bacteria that function as reservoirs for antibiotic resistance genes.
    MeSH term(s) Acids/pharmacology ; Adaptation, Biological/genetics ; Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/genetics ; Databases, Genetic ; Drug Resistance, Microbial/drug effects ; Drug Resistance, Microbial/genetics ; Genomics ; Metals, Heavy/pharmacology ; Mining ; Waste Water/microbiology
    Chemical Substances Acids ; Anti-Bacterial Agents ; Metals, Heavy ; Waste Water
    Language English
    Publishing date 2017-10-31
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-017-0535-8
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