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  1. Article ; Online: Evaluating optimal treatment durations for bloodstream infections: methodological perspectives on the choice of outcomes and sample sizes for non-inferiority design and margins.

    Sadana, Divyajot / Fowler, Robert A

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2021  Volume 28, Issue 4, Page(s) 463–464

    MeSH term(s) Duration of Therapy ; Humans ; Research Design ; Sample Size ; Sepsis/drug therapy
    Language English
    Publishing date 2021-11-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2021.11.020
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    Zs.A 4541: Show issues Location:
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  2. Article ; Online: Understanding Patient- and Hospital-Level Factors Leading to Differences, and Disparities, in Critical Care.

    Nayfeh, Ayah / Fowler, Robert A

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 6, Page(s) 642–644

    MeSH term(s) Critical Care ; Critical Care Outcomes ; Hospitals ; Humans ; Minority Groups
    Language English
    Publishing date 2020-02-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202001-0116ED
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  3. Article ; Online: Redefining Health Care Utilization as a Quality Measure for Goal Concordance at the End of Life.

    Nayfeh, Ayah / Kamra, Maneesha / Fowler, Robert A

    JAMA network open

    2021  Volume 4, Issue 4, Page(s) e213835

    MeSH term(s) Advance Care Planning ; Death ; Goals ; Humans ; Patient Acceptance of Health Care ; Quality Indicators, Health Care
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2021.3835
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  4. Article ; Online: Twenty articles that critical care clinicians should read about COVID-19.

    Tsang, Jennifer L Y / Binnie, Alexandra / Fowler, Robert A

    Intensive care medicine

    2021  Volume 47, Issue 3, Page(s) 337–341

    MeSH term(s) COVID-19/diagnosis ; COVID-19/drug therapy ; COVID-19/psychology ; Critical Care ; Health Personnel/psychology ; Humans ; Occupational Stress ; Respiration, Artificial ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/virology
    Language English
    Publishing date 2021-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-020-06329-3
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  5. Article ; Online: Shortening Antibiotic Treatment Durations for Bacteremia.

    Daneman, Nick / Fowler, Robert A

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2018  Volume 69, Issue 7, Page(s) 1099–1100

    MeSH term(s) Anti-Bacterial Agents ; Bacteremia ; Duration of Therapy ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-12-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciy1057
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    Zs.A 1505: Show issues Location:
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    Zs.MO 480: Show issues

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  6. Article ; Online: How Canada can better embed randomized trials into clinical care.

    Murthy, Srinivas / Fowler, Robert A / Laupacis, Andreas

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 32, Page(s) E928–E929

    MeSH term(s) COVID-19/drug therapy ; Canada ; Dexamethasone/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Randomized Controlled Trials as Topic/economics
    Chemical Substances Glucocorticoids ; Dexamethasone (7S5I7G3JQL)
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country Canada
    Document type Editorial
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.201764
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  7. Article ; Online: [No title information]

    Murthy, Srinivas / Fowler, Robert A / Laupacis, Andreas

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 50, Page(s) E1834–E1835

    Title translation Intégration des essais randomisés dans les soins cliniques : comment le Canada peut faire mieux.
    Language French
    Publishing date 2020-10-27
    Publishing country Canada
    Document type Editorial
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.201764-f
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  8. Article ; Online: Care for Critically Ill Patients With COVID-19.

    Murthy, Srinivas / Gomersall, Charles D / Fowler, Robert A

    JAMA

    2020  Volume 323, Issue 15, Page(s) 1499–1500

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Critical Care/methods ; Critical Care/organization & administration ; Critical Illness/therapy ; Disease Transmission, Infectious/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.3633
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  9. Article ; Online: Critical Illness in Patients With COVID-19: Mounting an Effective Clinical and Research Response.

    Cook, Deborah J / Marshall, John C / Fowler, Robert A

    JAMA

    2020  Volume 323, Issue 16, Page(s) 1559–1560

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Critical Illness ; Humans ; Italy ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.5775
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  10. Article ; Online: Location and outcomes of rehospitalizations after critical illness in a single-payer healthcare system.

    Hill, Andrea D / Scales, Damon C / Fowler, Robert A / Fu, Longdi / Hua, May / Wunsch, Hannah

    Journal of critical care

    2022  Volume 71, Page(s) 154089

    Abstract: Purpose: Unplanned rehospitalization at a hospital other than the initial hospital may contribute to poor outcomes. We examined the location of rehospitalizations and assessed outcomes following critical illness in a single-payer healthcare system.: ... ...

    Abstract Purpose: Unplanned rehospitalization at a hospital other than the initial hospital may contribute to poor outcomes. We examined the location of rehospitalizations and assessed outcomes following critical illness in a single-payer healthcare system.
    Materials and methods: Population-based retrospective cohort study using linked datasets (2012-2017) from Ontario, Canada including adults (≥18 years) with an unplanned rehospitalization within 30-days after an index hospitalization that included an ICU stay with mechanical ventilation. Outcomes were the percentage of 30-day rehospitalizations at non-index hospitals, mortality and costs. We employed logistic regression and generalized linear models to assess associations.
    Results: There were 14,997 (16.4%) 30-day rehospitalizations. Of these 2765 (18.4%) occurred in a non-index hospital. Distance of home residence from the index hospital was the strongest predictor of a non-index rehospitalization (adjusted odds ratio (aOR) 8.40, 95%CI 7.05-10.01, highest vs. lowest distance quintile). Within 30-days of rehospitalization, deaths (aOR 0.91, 95%CI (0.80-1.04)) and total healthcare costs (adjusted relative risk 1.03 (1.00-1.06)), were similar for patients readmitted to the index or a non-index hospital.
    Conclusion: Non-index rehospitalization within 30-days of initial discharge is common following critical illness. These rehospitalizations were not significantly associated with an increased risk of harm or higher costs in a single-payer healthcare system.
    MeSH term(s) Adult ; Critical Illness/therapy ; Delivery of Health Care ; Humans ; Intensive Care Units ; Ontario/epidemiology ; Patient Readmission ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2022.154089
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