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  1. Article ; Online: Reply to "Therapeutic drug monitoring of inhaled corticosteroids in exhaled breath for adherence assessment".

    Fowler, Stephen J

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 12, Page(s) 4507–4508

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Drug Monitoring ; Exhalation ; Humans
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.09.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Can FeNO help guide first-line treatment in suspected asthma?

    Fowler, Stephen J

    Respirology (Carlton, Vic.)

    2021  Volume 26, Issue 7, Page(s) 632–633

    MeSH term(s) Asthma/diagnosis ; Asthma/drug therapy ; Breath Tests ; Exhalation ; Humans
    Language English
    Publishing date 2021-05-26
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.14092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Breath analysis for label-free characterisation of airways disease.

    Fowler, Stephen J

    The European respiratory journal

    2018  Volume 51, Issue 1

    MeSH term(s) Airway Obstruction ; Breath Tests ; Humans ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2018-01-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02586-2017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Protocol for a scoping review to map health outcomes in individuals with inducible laryngeal obstruction.

    Ludlow, Siobhan / Holmes, Leanne-Jo / Simpson, Lauren / Fowler, Stephen J / Byrne-Davis, Lucie

    International journal of language & communication disorders

    2024  

    Abstract: Background: Inducible laryngeal obstruction causes narrowing of the laryngeal aperture in response to external triggers. Outcomes are measured in inducible laryngeal obstruction to monitor changes in health status over time.: Methods: This study is a ...

    Abstract Background: Inducible laryngeal obstruction causes narrowing of the laryngeal aperture in response to external triggers. Outcomes are measured in inducible laryngeal obstruction to monitor changes in health status over time.
    Methods: This study is a scoping review based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. The review will be guided by the following research question: 'What health outcomes are measured in studies including people with inducible laryngeal obstruction?' The research question was validated using the Population-Concept-Context framework according to the methodology for Joanna Briggs Institution Scoping Reviews. Relevant peer-reviewed studies and grey literature conducted over the last 40 years will be identified from electronic databases including AMED, CINAHL, Embase, EMCARE, MEDLINE, OVID, PubMed and PsycINFO. The search strings 'inducible laryngeal obstruction', 'ILO', 'vocal cord dysfunction', 'VCD', 'paradoxical vocal fold motion', 'PVFM', 'outcome', 'measure', 'measurement instrument', 'assessment', 'scale', 'questionnaire' will be combined using Boolean logic. An independent reviewer will conduct title screening; two independent reviewers will conduct abstract and full article screening, followed by data extraction by two reviewers. Analyses will be conducted appropriate to the findings.
    Discussion: The review will document evidence of health outcomes measured in inducible laryngeal obstruction, identifying measurement characteristics and potential utility. Collating studies may identify gaps in coverage, the need for novel tools, and for standardisation for clinical and research purposes.
    What this paper adds: What is already known on the subject Inducible laryngeal obstruction causes narrowing of the laryngeal aperture in response to external triggers. Outcomes are measured in inducible laryngeal obstruction to monitor changes in health status over time. Currently, there are no standardised outcome measures for measuring the effects of interventions in inducible laryngeal obstruction (ILO). What this paper adds to existing knowledge Assessment of health can be measured in a variety of ways. Physiological, radiological and biochemical measurements of impairment are more common historically but there are a lot of outcomes of other factors now including subjective measures of functional status and health-related quality of life, with data collected directly from patients. This study will allow us to scope the literature to see the health outcomes being measured in ILO to attempt to standardise and develop future health outcomes. What are the potential or actual clinical implications of this work? The review will document evidence of health outcomes measured in inducible laryngeal obstruction, identifying measurement characteristics and potential utility. Collating studies may identify gaps in coverage, the need for novel tools and for standardisation for clinical and research purposes.
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415919-3
    ISSN 1460-6984 ; 1368-2822
    ISSN (online) 1460-6984
    ISSN 1368-2822
    DOI 10.1111/1460-6984.13007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Molecular phenotyping approaches for the detection and monitoring of carbapenem-resistant Enterobacteriaceae by mass spectrometry.

    Dixon, Breanna / Ahmed, Waqar M / Felton, Tim / Fowler, Stephen J

    Journal of mass spectrometry and advances in the clinical lab

    2022  Volume 26, Page(s) 9–19

    Abstract: Antimicrobial resistance is increasing in prevalence and there is a clear need for the development of rapid detection methods in clinical diagnostics. This review explores -omics studies utilising mass spectrometry to investigate the molecular phenotype ... ...

    Abstract Antimicrobial resistance is increasing in prevalence and there is a clear need for the development of rapid detection methods in clinical diagnostics. This review explores -omics studies utilising mass spectrometry to investigate the molecular phenotype associated with carbapenem resistance. Whilst the specific mechanisms of carbapenem resistance are well characterised, the resistant phenotype is poorly understood. Understanding how the acquisition of resistance affects cellular physiology and cell metabolism through molecular phenotyping is a necessary step towards detecting resistance by diagnostic means. In addition, this article examines the potential of mass spectrometry for the identification of resistance biomarkers through molecular profiling of bacteria. Developments in mass spectrometry platforms are expanding the biomarker-based diagnostic landscape. Targeted measures, such as high-resolution mass spectrometry coupled with chromatographic separation show considerable promise for the identification of molecular signatures and the development of a rapid diagnostic assay for the detection of carbapenem resistance.
    Language English
    Publishing date 2022-09-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2667-145X
    ISSN (online) 2667-145X
    DOI 10.1016/j.jmsacl.2022.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Volatilomes of human infection.

    Fitzgerald, Shane / Holland, Linda / Ahmed, Waqar / Piechulla, Birgit / Fowler, Stephen J / Morrin, Aoife

    Analytical and bioanalytical chemistry

    2023  Volume 416, Issue 1, Page(s) 37–53

    Abstract: The human volatilome comprises a vast mixture of volatile emissions produced by the human body and its microbiomes. Following infection, the human volatilome undergoes significant shifts, and presents a unique medium for non-invasive biomarker discovery. ...

    Abstract The human volatilome comprises a vast mixture of volatile emissions produced by the human body and its microbiomes. Following infection, the human volatilome undergoes significant shifts, and presents a unique medium for non-invasive biomarker discovery. In this review, we examine how the onset of infection impacts the production of volatile metabolites that reflects dysbiosis by pathogenic microbes. We describe key analytical workflows applied across both microbial and clinical volatilomics and emphasize the value in linking microbial studies to clinical investigations to robustly elucidate the metabolic species and pathways leading to the observed volatile signatures. We review the current state of the art across microbial and clinical volatilomics, outlining common objectives and successes of microbial-clinical volatilomic workflows. Finally, we propose key challenges, as well as our perspectives on emerging opportunities for developing clinically useful and targeted workflows that could significantly enhance and expedite current practices in infection diagnosis and monitoring.
    MeSH term(s) Humans ; Gas Chromatography-Mass Spectrometry ; Volatile Organic Compounds/analysis
    Chemical Substances Volatile Organic Compounds
    Language English
    Publishing date 2023-10-16
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-023-04986-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Multidisciplinary management of inducible laryngeal obstruction and breathing pattern disorder.

    Ludlow, Siobhan / Daly, Rachel / Elsey, Lynn / Hope, Helen / Sheehan, Reyenna / Fowler, Stephen J

    Breathe (Sheffield, England)

    2023  Volume 19, Issue 3, Page(s) 230088

    Abstract: We provide an overview of the assessment and management of inducible laryngeal obstruction and breathing pattern disorder. We highlight the multidisciplinary team members involved and their essential roles within a complex breathlessness service. We ... ...

    Abstract We provide an overview of the assessment and management of inducible laryngeal obstruction and breathing pattern disorder. We highlight the multidisciplinary team members involved and their essential roles within a complex breathlessness service. We discuss treatments initiated by physiotherapy and speech and language therapy, the importance of joint working, and discuss the high incidence of comorbidities and the association with other respiratory disorders.
    Educational aims: Inducible laryngeal obstruction and breathing pattern disorder are common causes of breathlessness.Inducible laryngeal obstruction is an inappropriate, transient, reversible narrowing of the laryngeal area that causes breathlessness and laryngeal symptoms.Breathing pattern disorder is an alteration in the normal biomechanical patterns of breathing that results in intermittent or chronic symptoms, which may be respiratory and/or non-respiratory.People with inducible laryngeal obstruction or breathing pattern disorder often have other comorbidities that will also need addressing.Multidisciplinary assessment and treatment is essential for comprehensive workup and holistic care.Timely assessment and diagnosis can prevent unnecessary medication use and hospital admissions and facilitate effective management of the condition using reassurance, advice, education, breathing retraining and vocal exercises.
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0088-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Clinical Characteristics and Impact of Inducible Laryngeal Obstruction in the UK National Registry.

    Haines, Jemma / Simpson, Andrew J / Slinger, Claire / Selby, Julia / Pargeter, Nicola / Fowler, Stephen J / Hull, James H

    The journal of allergy and clinical immunology. In practice

    2024  

    Abstract: Background: Inducible laryngeal obstruction (ILO) describes inappropriate laryngeal closure during respiration, with airflow obstruction occurring at the glottic and/or supraglottic level, leading to breathlessness.: Objective: There is a paucity of ... ...

    Abstract Background: Inducible laryngeal obstruction (ILO) describes inappropriate laryngeal closure during respiration, with airflow obstruction occurring at the glottic and/or supraglottic level, leading to breathlessness.
    Objective: There is a paucity of data describing the demographics and impact of ILO. We aimed to report the clinical and demographic features of ILO in individuals entered prospectively in the UK national ILO registry.
    Methods: Data were entered into a Web-based registry from participants with endoscopically confirmed ILO who were attending four established UK-wide specialist ILO centers between March 2017 and November 2019. All patients provided written informed consent.
    Results: Data from 137 individuals were included. Most (87%) had inspiratory ILO and required provocation during endoscopy to induce symptoms. There was a female predominance (80%), mean age 47 years (SD, 15 years). The most common comorbidities included asthma (68%) and reflux (57%). Health care use was high: 88% had attended emergency health care with symptoms at least once in the previous 12 months and nearly half had been admitted to the hospital. A fifth had required admission to critical care owing to ILO symptoms. Patient morbidity was substantial; 64% reported impaired functional capacity (≥3 on the Medical Research Council Dyspnoea Scale) and a third stated that symptoms affected working capability.
    Conclusion: We describe the first multicenter prospective characterization of individuals with endoscopically diagnosed ILO. Analysis of our multicenter data set identified ILO as associated with a high burden of morbidity and health care use, comparable to severe asthma. These data will support the development of health care resources in the future and guide research priorities.
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2024.01.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Differentiating Throat Symptoms in Inducible Laryngeal Obstruction From Anaphylaxis-Information for Patients and Health Care Professionals.

    Tidmarsh, Bethany / Marinho, Susana / Haines, Jemma / Fowler, Stephen J

    The journal of allergy and clinical immunology. In practice

    2022  Volume 10, Issue 2, Page(s) 645–646

    MeSH term(s) Airway Obstruction/diagnosis ; Anaphylaxis/diagnosis ; Health Personnel ; Humans ; Laryngeal Diseases/diagnosis ; Pharynx
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Breath biomarkers in asthma: we're getting answers, but what are the important questions?

    Fowler, Stephen J / Sterk, Peter J

    The European respiratory journal

    2019  Volume 54, Issue 3

    MeSH term(s) Asthma ; Biomarkers ; Exhalation ; Humans ; Respiratory System ; Volatile Organic Compounds
    Chemical Substances Biomarkers ; Volatile Organic Compounds
    Language English
    Publishing date 2019-09-29
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01411-2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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