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  1. Article ; Online: American Society of Hematology 2020 Podcast Collection: FL and DLBCL.

    Fox, Christopher Paul / Osborne, Wendy

    Advances in therapy

    2021  Volume 38, Issue Suppl 1, Page(s) 8–15

    MeSH term(s) Hematology ; Humans ; Lymphoma, Large B-Cell, Diffuse ; Retrospective Studies ; United States
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-021-01679-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2101: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Rare central nervous system lymphomas.

    Kaji, Furqaan Ahmed / Martinez-Calle, Nicolás / Sovani, Vishakha / Fox, Christopher Paul

    British journal of haematology

    2022  Volume 197, Issue 6, Page(s) 662–678

    Abstract: Central nervous system (CNS) lymphomas are rare malignancies characterised by lymphoid infiltration into the brain, spinal cord, cranial nerves, meninges and/or eyes in the presence or absence of previous or concurrent systemic disease. Most CNS ... ...

    Abstract Central nervous system (CNS) lymphomas are rare malignancies characterised by lymphoid infiltration into the brain, spinal cord, cranial nerves, meninges and/or eyes in the presence or absence of previous or concurrent systemic disease. Most CNS lymphomas are of the diffuse large B-cell lymphoma (DLBCL) subtype for which treatment strategies, particularly the use of high-dose methotrexate-based protocols and consolidation with autologous stem cell transplantation, are well established. Other histopathological subtypes of CNS lymphoma are comparatively less common with published data on these rare lymphomas dominated by smaller case series and retrospective reports. Consequently, there exists little clinical consensus on the optimal methods to diagnose and manage these clinically and biologically heterogeneous CNS lymphomas. In this review article, we focus on rarer CNS lymphomas, summarising the available clinical data on incidence, context, diagnostic features, reported management strategies, and clinical outcomes.
    MeSH term(s) Central Nervous System Neoplasms/drug therapy ; Central Nervous System Neoplasms/therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/therapy ; Lymphoma, Non-Hodgkin/epidemiology ; Meninges ; Retrospective Studies ; Transplantation, Autologous
    Language English
    Publishing date 2022-03-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.182: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Herpes Simplex Necrotic Lymphadenitis Masquerading as Richter's Transformation in Treatment-Naive Patients With Chronic Lymphocytic Leukemia.

    Hodgson, Yan Amber / Jones, Stephen Gareth / Knight, Helen / Sovani, Vishakha / Fox, Christopher Paul

    Journal of hematology

    2019  Volume 8, Issue 2, Page(s) 79–82

    Abstract: Richter's transformation from chronic lymphocytic leukemia (CLL) to aggressive lymphoma is a relatively rare event with well-characterised clinical and radiological features, and can typically be distinguished from infectious complications of CLL. ... ...

    Abstract Richter's transformation from chronic lymphocytic leukemia (CLL) to aggressive lymphoma is a relatively rare event with well-characterised clinical and radiological features, and can typically be distinguished from infectious complications of CLL. Opportunistic infections in CLL happen predominantly in the context of immunosuppressive therapy and/or relapsed/refractory disease. Herpes simplex viral (HSV) lymphadenitis is a rare phenomenon in treatment-naive CLL patients with only six cases reported in the English-language literature. Its diagnosis is challenging; its management and the outcome of the subsequent treatment for CLL are not well documented. We report three cases of rapidly progressive lymphadenopathy occurring in the context of previously untreated CLL, clinically and radiologically mimicking Richter's transformation, but histologically confirmed as necrotic HSV lymphadenitis. We describe the presentation, diagnosis and management of all three cases, including for the first time the positron emission tomography-computed tomography (PET-CT) appearance of this condition, as well as how we later on delivered CLL-directed immunochemotherapy safely and successfully without recrudescence of HSV-related disease. Our cases underscore the importance of obtaining biopsy in all cases of rapidly progressive or disconcordant lymphadenopathy in CLL patients, or in those with highly
    Language English
    Publishing date 2019-06-30
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2662519-2
    ISSN 1927-1220 ; 1927-1212
    ISSN (online) 1927-1220
    ISSN 1927-1212
    DOI 10.14740/jh517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Allogeneic hematopoietic cell transplantation for patients with TP53 mutant or deleted chronic lymphocytic leukemia: Results of a prospective observational study

    Schetelig, Johannes / Middeke, Jan Moritz / Fox, Christopher Paul / Kröger, Nicolaus / Dreger, Peter

    http://lobid.org/resources/99370676016606441#!, 56(3):692-695

    2020  

    Abstract: Schwannomas are tumors of the peripheral nervous system, consisting of different cell types. These include tumorigenic Schwann cells, axons, macrophages, T cells, fibroblasts, blood vessels, and an extracellular matrix. All cell types involved constitute ...

    Abstract Schwannomas are tumors of the peripheral nervous system, consisting of different cell types. These include tumorigenic Schwann cells, axons, macrophages, T cells, fibroblasts, blood vessels, and an extracellular matrix. All cell types involved constitute an intricate 'tumor microenvironment' and play relevant roles in the development and progression of schwannomas. Although Nf2 tumor suppressor gene-deficient Schwann cells are the primary tumorigenic element and principle focus of current research efforts, evidence is accumulating regarding the contributory roles of other cell types in schwannoma pathology. In this review, we aim to provide an overview of intra- and intercellular mechanisms contributing to schwannoma formation. 'Genes load the gun, environment pulls the trigger.' -George A. Bray.
    Keywords Correspondence ; Chronic lymphocytic leukaemia ; Hematopoietic Stem Cell Transplantation [MeSH] ; Humans [MeSH] ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics [MeSH] ; Leukemia, Lymphocytic, Chronic, B-Cell/therapy [MeSH] ; Stem-cell therapies ; Prospective Studies [MeSH] ; Transplantation, Homologous [MeSH] ; Tumor Suppressor Protein p53/genetics [MeSH]
    Language English
    Document type Article
    Database Repository for Life Sciences

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