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  1. AU="Fox, Kevin J"
  2. AU="Nawazish Naqvi"
  3. AU="Marquardt, Viktoria"
  4. AU="Watts, Robyn"
  5. AU="Caballero, Susana J"
  6. AU="van Dijk, J Hessel M"
  7. AU=Della Guardia Lucio
  8. AU="Zhilich V.N."
  9. AU="George, Darren"
  10. AU=Lin Xiukun
  11. AU="Kanwal Gujral"
  12. AU="Christian Young"
  13. AU=Takeuchi Kaoru
  14. AU="Wiślicki, W."
  15. AU="Veiga, Susana"
  16. AU="Reynolds, Matthew W."
  17. AU="Oates, Stephen B"
  18. AU=Okubo K
  19. AU="Behnood, Sanaz"

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  1. Artikel: Measuring real consumption and consumer price index bias under lockdown conditions.

    Diewert, W Erwin / Fox, Kevin J

    The Canadian journal of economics. Revue canadienne d'economique

    2022  Band 55, Heft Suppl 1, Seite(n) 480–502

    Abstract: Millions of goods and services are now unavailable in many countries due to the current coronavirus pandemic, dramatically impacting on the construction of key economic statistics used for informing policy. This situation is unprecedented; hence, methods ...

    Abstract Millions of goods and services are now unavailable in many countries due to the current coronavirus pandemic, dramatically impacting on the construction of key economic statistics used for informing policy. This situation is unprecedented; hence, methods to address it have not previously been developed. Current advice to national statistical offices from the International Monetary Fund, Eurostat and the United Nations is shown to result in downward bias in the consumer price index (CPI) and upward bias in real consumption. We conclude that, to produce a meaningful CPI within the lockdown period, it is necessary to establish a continuous consumer expenditure survey.
    Sprache Englisch
    Erscheinungsdatum 2022-02-08
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 2013251-7
    ISSN 1540-5982 ; 0008-4085
    ISSN (online) 1540-5982
    ISSN 0008-4085
    DOI 10.1111/caje.12545
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Substrate-activated expression of a biosynthetic pathway in Escherichia coli.

    Ni, Cynthia / Fox, Kevin J / Prather, Kristala L J

    Biotechnology journal

    2021  Band 17, Heft 3, Seite(n) e2000433

    Abstract: Microbes can facilitate production of valuable chemicals more sustainably than traditional chemical processes in many cases: they utilize renewable feedstocks, require less energy intensive process conditions, and perform a variety of chemical reactions ... ...

    Abstract Microbes can facilitate production of valuable chemicals more sustainably than traditional chemical processes in many cases: they utilize renewable feedstocks, require less energy intensive process conditions, and perform a variety of chemical reactions using endogenous or heterologous enzymes. In response to the metabolic burden imposed by production pathways, chemical inducers are frequently used to initiate gene expression after the cells have reached sufficient density. While chemically inducible promoters are a common research tool used for pathway expression, they introduce a compound extrinsic to the process along with the associated costs. We developed an expression control system for a biosynthetic pathway for the production of d-glyceric acid that utilizes galacturonate as both the inducer and the substrate, thereby eliminating the need for an extrinsic chemical inducer. Activation of expression in response to the feed is actuated by a galacturonate-responsive transcription factor biosensor. We constructed variants of the galacturonate biosensor with a heterologous transcription factor and cognate hybrid promoter, and selected for the best performer through fluorescence characterization. We showed that native E. coli regulatory systems do not interact with our biosensor and favorable biosensor response exists in the presence and absence of galacturonate consumption. We then employed the control circuit to regulate the expression of the heterologous genes of a biosynthetic pathway for the production d-glyceric acid that was previously developed in our lab. Productivity via substrate-induction with our control circuit was comparable to IPTG-controlled induction and significantly outperformed a constitutive expression control, producing 2.13 ± 0.03 g L
    Mesh-Begriff(e) Biosynthetic Pathways/genetics ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/metabolism ; Metabolic Engineering ; Promoter Regions, Genetic/genetics
    Chemische Substanzen Escherichia coli Proteins
    Sprache Englisch
    Erscheinungsdatum 2021-06-09
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2221885-3
    ISSN 1860-7314 ; 1860-6768
    ISSN (online) 1860-7314
    ISSN 1860-6768
    DOI 10.1002/biot.202000433
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Production of D-Glyceric acid from D-Galacturonate in Escherichia coli

    Fox, Kevin J / Prather, Kristala L. J

    Journal of industrial microbiology & biotechnology. 2020 Dec., v. 47, no. 12

    2020  

    Abstract: A microbial production platform has been developed in Escherichia coli to synthesize D-glyceric acid from D-galacturonate. The expression of uronate dehydrogenase (udh) from Pseudomonas syringae and galactarolactone isomerase (gli) from Agrobacterium ... ...

    Abstract A microbial production platform has been developed in Escherichia coli to synthesize D-glyceric acid from D-galacturonate. The expression of uronate dehydrogenase (udh) from Pseudomonas syringae and galactarolactone isomerase (gli) from Agrobacterium fabrum, along with the inactivation of garK, encoding for glycerate kinase, enables D-glyceric acid accumulation by utilizing the endogenous expression of galactarate dehydratase (garD), 5-keto-4-deoxy-D-glucarate aldolase (garL), and 2-hydroxy-3-oxopropionate reductase (garR). Optimization of carbon flux through the elimination of competing metabolic pathways led to the development of a ΔgarKΔhyiΔglxKΔuxaC mutant strain that produced 4.8 g/l of D-glyceric acid from D-galacturonate, with an 83% molar yield. Cultivation in a minimal medium produced similar yields and demonstrated that galactose or glycerol serve as possible carbon co-feeds for industrial production. This novel platform represents an alternative for the production of D-glyceric acid, an industrially relevant chemical, that addresses current challenges in using acetic acid bacteria for its synthesis: increasing yield, enantio-purity and biological stability.
    Schlagwörter Agrobacterium ; Escherichia coli ; Pseudomonas syringae ; acetic acid ; biotechnology ; carbon ; fructose-bisphosphate aldolase ; galactose ; glycerol ; industrial microbiology ; isomerases ; mutants ; oxidoreductases
    Sprache Englisch
    Erscheinungsverlauf 2020-12
    Umfang p. 1075-1081.
    Erscheinungsort Springer International Publishing
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 1482484-X
    ISSN 1476-5535 ; 1367-5435
    ISSN (online) 1476-5535
    ISSN 1367-5435
    DOI 10.1007/s10295-020-02323-2
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: Production of D-Glyceric acid from D-Galacturonate in Escherichia coli.

    Fox, Kevin J / Prather, Kristala L J

    Journal of industrial microbiology & biotechnology

    2020  Band 47, Heft 12, Seite(n) 1075–1081

    Abstract: A microbial production platform has been developed in Escherichia coli to synthesize D-glyceric acid from D-galacturonate. The expression of uronate dehydrogenase (udh) from Pseudomonas syringae and galactarolactone isomerase (gli) from Agrobacterium ... ...

    Abstract A microbial production platform has been developed in Escherichia coli to synthesize D-glyceric acid from D-galacturonate. The expression of uronate dehydrogenase (udh) from Pseudomonas syringae and galactarolactone isomerase (gli) from Agrobacterium fabrum, along with the inactivation of garK, encoding for glycerate kinase, enables D-glyceric acid accumulation by utilizing the endogenous expression of galactarate dehydratase (garD), 5-keto-4-deoxy-D-glucarate aldolase (garL), and 2-hydroxy-3-oxopropionate reductase (garR). Optimization of carbon flux through the elimination of competing metabolic pathways led to the development of a ΔgarKΔhyiΔglxKΔuxaC mutant strain that produced 4.8 g/l of D-glyceric acid from D-galacturonate, with an 83% molar yield. Cultivation in a minimal medium produced similar yields and demonstrated that galactose or glycerol serve as possible carbon co-feeds for industrial production. This novel platform represents an alternative for the production of D-glyceric acid, an industrially relevant chemical, that addresses current challenges in using acetic acid bacteria for its synthesis: increasing yield, enantio-purity and biological stability.
    Mesh-Begriff(e) Agrobacterium ; Agrobacterium tumefaciens ; Alcohol Oxidoreductases ; Aldehyde Oxidoreductases ; Aldehyde-Lyases/metabolism ; Escherichia coli/metabolism ; Glyceric Acids ; Metabolic Networks and Pathways ; Phosphotransferases (Alcohol Group Acceptor)
    Chemische Substanzen Glyceric Acids ; glyceric acid (70KH64UX7G) ; Alcohol Oxidoreductases (EC 1.1.-) ; uronate dehydrogenase (EC 1.1.1.203) ; 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) ; Aldehyde Oxidoreductases (EC 1.2.-) ; Phosphotransferases (Alcohol Group Acceptor) (EC 2.7.1.-) ; glycerate kinase (EC 2.7.1.31) ; Aldehyde-Lyases (EC 4.1.2.-)
    Sprache Englisch
    Erscheinungsdatum 2020-10-14
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1482484-X
    ISSN 1476-5535 ; 1367-5435
    ISSN (online) 1476-5535
    ISSN 1367-5435
    DOI 10.1007/s10295-020-02323-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: R&D, innovation and productivity

    Elnasri, Amani / Fox, Kevin J

    Han'guk-kaebal-yŏn'gu : kyegan Vol. 37, No. 1 , p. 73-96

    the role of public support

    2015  Band 37, Heft 1, Seite(n) 73–96

    Verfasserangabe by Amani Elnasri; Kevin J. Fox
    Schlagwörter Research and Development ; Productivity ; Innovation ; Intangible assets ; Public funding
    Sprache Englisch
    Umfang graph. Darst.
    Erscheinungsort Sŏul
    Dokumenttyp Artikel
    ZDB-ID 2665499-4
    ISSN 1738-656X
    Datenquelle ECONomics Information System

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  6. Buch ; Online: The allocation and valuation of time

    Diewert, Walter E / Fox, Kevin J / Schreyer, Paul

    (Discussion paper / Vancouver School of Economics, University of British Columbia ; 17, 04)

    2017  

    Verfasserangabe W. Erwin Diewert, Kevin J. Fox and Paul Schreyer
    Serientitel Discussion paper / Vancouver School of Economics, University of British Columbia ; 17, 04
    Sprache Englisch
    Umfang 1 Online-Ressource (circa 30 Seiten)
    Verlag University of British Columbia
    Erscheinungsort Vancouver, Canada
    Dokumenttyp Buch ; Online
    Datenquelle ECONomics Information System

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  7. Buch ; Online: Substitution bias in multilateral methods for CPI construction using scanner data

    Diewert, Walter E / Fox, Kevin J

    (Discussion paper / Vancouver School of Economics, University of British Columbia ; 17, 02)

    2017  

    Verfasserangabe W. Erwin Diewert and Kevin J. Fox
    Serientitel Discussion paper / Vancouver School of Economics, University of British Columbia ; 17, 02
    Sprache Englisch
    Umfang 1 Online-Ressource (circa
    Verlag University of British Columbia
    Erscheinungsort Vancouver, Canada
    Dokumenttyp Buch ; Online
    Datenquelle ECONomics Information System

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  8. Buch ; Online: The digital economy, new products and consumer welfare

    Diewert, Walter E / Fox, Kevin J / Schreyer, Paul

    (Discussion paper / Vancouver School of Economics, University of British Columbia ; 17, 09)

    2017  

    Verfasserangabe Erwin Diewert, Kevin J. Fox and Paul Schreyer
    Serientitel Discussion paper / Vancouver School of Economics, University of British Columbia ; 17, 09
    Sprache Englisch
    Umfang 1 Online-Ressource (circa 23 Seiten)
    Verlag University of British Columbia
    Erscheinungsort Vancouver, Canada
    Dokumenttyp Buch ; Online
    Datenquelle ECONomics Information System

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  9. Buch ; Online: The difference approach to productivity measurement and exact indicators

    Diewert, Walter E / Fox, Kevin J

    (Discussion paper / Vancouver School of Economics, University of British Columbia ; 17, 08)

    2017  

    Verfasserangabe Erwin Diewert and Kevin J. Fox
    Serientitel Discussion paper / Vancouver School of Economics, University of British Columbia ; 17, 08
    Sprache Englisch
    Umfang 1 Online-Ressource (circa 28 Seiten)
    Verlag University of British Columbia
    Erscheinungsort Vancouver, Canada
    Dokumenttyp Buch ; Online
    Datenquelle ECONomics Information System

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  10. Buch ; Online: The impact of quarantine policies on the quality of imports

    Bunting, Daniel / Fox, Kevin J

    (Australian School of Business working paper ; 2014,01)

    2014  

    Verfasserangabe by Daniel Bunting and Kevin J. Fox
    Serientitel Australian School of Business working paper ; 2014,01
    Sprache Englisch
    Umfang Online-Ressource (27 S.)
    Verlag School of Economics, the Univ. of New South Wales
    Erscheinungsort Kensington, NSW
    Dokumenttyp Buch ; Online
    Datenquelle ECONomics Information System

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