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  1. Book ; Thesis: Das Medial-Shelf-Syndrom

    Fröhlich, Imke

    klinisches Bild und operative Behandlung

    1992  

    Author's details vorgelegt von Imke Fröhlich
    Size [2], 79 S. : Ill.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Marburg, Univ., Diss., 1993
    HBZ-ID HT004491209
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    93 D 1478 order for loan Magazin

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  2. Article ; Online: PROGNOSTIC IMPACT OF LOW ESTROGEN AND PROGESTERONE POSITIVITY IN LUMINAL B (HER2 NEGATIVE) BREAST CANCER.

    Rajc, Jasmina / Fröhlich, Irena / Mrčela, Milanka / Tomaš, Ilijan / Flam, Josipa

    Acta clinica Croatica

    2019  Volume 57, Issue 3, Page(s) 425–433

    Abstract: Luminal B (HER2 negative) subtype is the most diversiform type of breast cancers, with a high Ki-67 proliferation index (>20%) or/and low progesterone (PR; <20%) with various intensity and distribution of hormone receptors. Considerable difference has ... ...

    Abstract - Luminal B (HER2 negative) subtype is the most diversiform type of breast cancers, with a high Ki-67 proliferation index (>20%) or/and low progesterone (PR; <20%) with various intensity and distribution of hormone receptors. Considerable difference has also been noticed in disease outcome, wherefore there is the need for a more detailed classification of this tumor subtype. The clinical and pathologic parameters of 147 luminal B (HER2 negative) breast cancers were examined. The expression of hormone receptors in correlation with other prognostic factors and disease outcome was analyzed by Kaplan-Meier curves and multivariate Cox regression analysis. The Kaplan-Mayer analysis showed that low positivity of estrogen (ER) and PR receptors in tumors was associated with a significantly worse disease outcome (overall survival (ER), p=0.020; disease free survival (ER), p=0.019; overall survival (PR), p=0.026; disease free survival (PR), p=0.038)), unlike Ki-67, which did not show a statistically significant connection (overall survival, p=0.343; disease free survival, p=0.322). The intensity of receptor staining and Ki-67 relative to other histopathologic prognostic factors showed a statistically significant correlation solely with histologic grade of tumor. By using the Cox regression model, PR proved to be an independent prognostic factor for overall survival (p=0.004) and disease free survival (p=0.029). The luminal B (HER2 negative) breast cancer with low expression of hormone receptors, independent of the Ki-67 proliferation index, and in correlation with a higher histologic grade, could be a unique subtype of cancer.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Estrogens/metabolism ; Female ; Humans ; Middle Aged ; Multivariate Analysis ; Outcome Assessment, Health Care/methods ; Outcome Assessment, Health Care/statistics & numerical data ; Predictive Value of Tests ; Progesterone/metabolism ; Prognosis ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Survival Analysis
    Chemical Substances Biomarkers, Tumor ; Estrogens ; Receptors, Estrogen ; Receptors, Progesterone ; Progesterone (4G7DS2Q64Y)
    Language English
    Publishing date 2019-03-27
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1478635-7
    ISSN 1333-9451 ; 0353-9466
    ISSN (online) 1333-9451
    ISSN 0353-9466
    DOI 10.20471/acc.2018.57.03.04
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5057: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Book ; Thesis: Vertragsstrukturen in der Arbeitsverwaltung

    Fröhlich, Ingmar

    (Schriften zum deutschen und europäischen Sozialrecht ; 15)

    2007  

    Author's details Ingmar Fröhlich
    Series title Schriften zum deutschen und europäischen Sozialrecht ; 15
    Keywords Arbeitsverwaltung ; Vertragsrecht ; Deutschland ; Arbeitsverwaltungsrecht
    Language German
    Size 197 S., 21 cm
    Edition 1. Aufl.
    Publisher Nomos
    Publishing place Baden-Baden
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss./2007--Jena, 2006
    Note Literaturverz. S. 185 - 197
    ISBN 3832929649 ; 9783832929640
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Article ; Online: Prognostic role of Nectin-4 expression in luminal B (HER2 negative) breast cancer.

    Rajc, Jasmina / Gugić, Damir / Fröhlich, Irena / Marjanović, Ksenija / Dumenčić, Boris

    Pathology, research and practice

    2017  Volume 213, Issue 9, Page(s) 1102–1108

    Abstract: Nectins are ... ...

    Abstract Nectins are Ca2
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Breast Neoplasms/metabolism ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Cell Adhesion Molecules/analysis ; Cell Adhesion Molecules/biosynthesis ; Female ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Prognosis ; Proportional Hazards Models ; Receptor, ErbB-2 ; Retrospective Studies
    Chemical Substances Biomarkers, Tumor ; Cell Adhesion Molecules ; NECTIN4 protein, human ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2017-07-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 391889-0
    ISSN 1618-0631 ; 0344-0338
    ISSN (online) 1618-0631
    ISSN 0344-0338
    DOI 10.1016/j.prp.2017.07.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud III Zs.20: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: A cone beam CT based 3D-assessment of bony forefoot geometry after modified Lapidus arthrodesis.

    Scheele, Christian B / Christel, Simon T / Fröhlich, Imke / Mehlhorn, Alexander / Walther, Markus / Hörterer, Hubert / Harrasser, Norbert / Kinast, Christian

    Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons

    2019  Volume 26, Issue 8, Page(s) 883–889

    Abstract: Background: Modified Lapidus arthrodesis (MLA) is a well-established treatment modality for hallux valgus deformities (HVD) associated with instability of the first ray. Although the three-dimensional (3D) nature of HVD has long been recognized, ... ...

    Abstract Background: Modified Lapidus arthrodesis (MLA) is a well-established treatment modality for hallux valgus deformities (HVD) associated with instability of the first ray. Although the three-dimensional (3D) nature of HVD has long been recognized, diagnostics still focus on plain radiographs. The objective of this study was to validate 3D Cone Beam CT (CBCT) in the perioperative assessment of HVD with focus on the alignment of the forefoot.
    Methods: In a prospective clinical study, MLA was performed on 30 patients (25 females, 5 males; mean age: 63.2 years). Pre- and postoperatively standard radiographs and CBCT with full weight-bearing were acquired. For the CBCT based assessment, reproducible criteria have been defined, measured, and correlated with established radiological indicators.
    Results: Evaluation of standard radiographic parameters (hallux-valgus angle [HVA], intermetatarsal angle 1-2 [IMA 1-2], distal metatarsal articular angle [DMAA], tibial sesamoid position [TSP]) showed significant improvement postoperatively. Comparison of measurements obtained from plain radiographs and CBCT were significantly correlated between both measuring techniques, indicating high reliability. Pronation of the first metatarsal and the sesamoids were significantly reduced by the procedure. Due to this repositioning effect, the second metatarsal head was elevated by 3.1mm, and the lateral sesamoid was lowered by 3.8mm. However, there was no correlation between the amount of pronation and conventional radiographic measures.
    Conclusions: Compared to plain radiographs, CBCT allows a more detailed view of the forefoot alignment in the coronal plain after MLA. MLA was able to recenter the sesamoids under der first metatarsal head and conversely led to elevation of the second metatarsal head.
    MeSH term(s) Adult ; Arthrodesis ; Cone-Beam Computed Tomography ; Female ; Forefoot, Human/diagnostic imaging ; Hallux Valgus/diagnostic imaging ; Hallux Valgus/surgery ; Humans ; Imaging, Three-Dimensional ; Male ; Middle Aged ; Pronation ; Prospective Studies ; Reproducibility of Results ; Weight-Bearing
    Language English
    Publishing date 2019-12-05
    Publishing country France
    Document type Journal Article
    ZDB-ID 1424533-4
    ISSN 1460-9584 ; 1268-7731
    ISSN (online) 1460-9584
    ISSN 1268-7731
    DOI 10.1016/j.fas.2019.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4246: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book ; Thesis: Die Schnittanatomie am Kopf des Hundes, mit besonderer Berücksichtigung des Zentralnervensystems

    Fröhlich, Iris

    2002  

    Author's details vorgelegt von Iris Fröhlich
    Language German
    Size 131 Bl, zahlr. Ill., graph. Darst
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Wien, 2002
    Database Special collection on veterinary medicine and general parasitology

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  7. Article ; Conference proceedings: Myocardial meta-iodobenzylguanidin SPECT: a useful clinical tool?

    Froehlich, I / Pilloy, W / Vaillant, M / Diederich, N

    Aktuelle Neurologie

    2008  

    Abstract: Purpose: To evaluate the diagnostic usefulness of myocardial Metaiodbenzylguanidin SPECT (MIBG-SPECT) in patients with different parkinsonian syndromes (PS).: Background: The cardiac uptake of MIBG-SPECT is reduced in idiopathic Parkinson's disease ( ... ...

    Event/congress Jahrestagung der Deutschen Gesellschaft für Neurologie (DGN), Hamburg, 2008
    Abstract Purpose: To evaluate the diagnostic usefulness of myocardial Metaiodbenzylguanidin SPECT (MIBG-SPECT) in patients with different parkinsonian syndromes (PS).
    Background: The cardiac uptake of MIBG-SPECT is reduced in idiopathic Parkinson's disease (IPD), Lewy Body dementia (LBD) and idiopathic REM sleep behaviour disorder (iRBD). It is normal in PS related to tauopathies and in other dementia disorders.
    Methods: The concordance of MIBG diagnosis (MD) and clinical diagnosis (CD) was evaluated in different clinical set-ups. CD was based on established guidelines and reassessed at the last follow up visit. MD was based on the delayed heart/mediastinum (HM) ratio. Based on literature a unique cut off of 1.6 was chosen, with values below considered to be abnormal. The following clinical set-ups were retrospectively analyzed. Set-up A: differentiation between IPD and other PS or essential tremor. Set-up B: differentiation between LBD and other dementia disorders. Set-up C: prognostic evaluation of iRBD. We analyzed 50 consecutive patients: 24 men and 26 women; mean age 65; range 38–87. All patients were maintained on their antiparkinsonian or antihypertensive medications. The follow-up period after the SPECT exam was 2.72 years (range: 0.16–13)
    Results: In set-up A 38 patients were analyzed; in set-up B 9 patients and in set-up C 2 patients. In set-up A diagnostic concordance was 64%. MIBG-SPECT suggested IPD in further 26% of patients, not confirmed by clinical follow-ups. In set-up 2 the concordance rate was 88%. In set-up 3, MIBG suggested possible progression to PD/LBD in both patients included.
    Conclusion: In clinical set-ups, myocardiac MIBG-scintigraphy is of moderate diagnostic accuracy. False positive diagnostic results are possibly due to not yet recognized age-related, but PS-independent postsynaptic noradrenergic degeneration or reduced uptake caused by antihypertensive co-medications. Further investigations should include larger cohorts of presumably healthy elderly subjects and separately address the individual impact of currently used antihypertensive co-medications sustained and complete withdrawal of these medications, as presently suggested, is risky and thus hard to realize in ambulatory patients.
    Language English
    Publishing date 2008-09-02
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 124980-0
    ISSN 1438-9428 ; 0302-4350 ; 1431-4886
    ISSN (online) 1438-9428
    ISSN 0302-4350 ; 1431-4886
    DOI 10.1055/s-0028-1086801
    Database Thieme publisher's database

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    Zs.A 970: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 141: Show issues

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  8. Book ; Thesis: 'Time and times and half a time'

    Fröhlich, Ida

    historical consciousness in the Jewish literature of the Persian and Hellenistic eras

    (Journal for the study of the pseudepigrapha : Supplement series ; 19)

    1996  

    Abstract: The aims of this significant study are to present pictures of the past as it manifested itself in Jewish literary works written in the Persian and Hellenistic periods, and to reveal the origin of materials and methods used in them in order to construct ... ...

    Author's details Ida Fröhlich
    Series title Journal for the study of the pseudepigrapha : Supplement series ; 19
    Abstract The aims of this significant study are to present pictures of the past as it manifested itself in Jewish literary works written in the Persian and Hellenistic periods, and to reveal the origin of materials and methods used in them in order to construct historical traditions. The works investigated are literary works of three types: pseudohistorical narratives (i.e. historical legends), visions and their interpretations, and 'rewritten Bibles' (i.e. works retelling the historical tradition of the Bible, with alterations in order to create a new structure of history).
    Language English
    Size 248 S, 24 cm
    Publisher Sheffield Acad. Press
    Publishing place Sheffield
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Leningrad/St Petersburg, 1984
    ISBN 1850755663 ; 9781850755661
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Myocardial MIBG scintigraphy: a useful clinical tool? : A retrospective study in 50 parkinsonian patients.

    Fröhlich, Ines / Pilloy, Wilfried / Vaillant, Michel / Diederich, Nico J

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2010  Volume 31, Issue 3, Page(s) 403–406

    Abstract: Meta-iodbenzylguanidine scintigraphy (MIBG scintigraphy) shows reduced uptake in idiopathic Parkinson's disease (IPD), idiopathic REM sleep behavior disorder (IRBD) and Lewy body dementia (LBD), but not in other parkinsonian or dementia syndromes. We ... ...

    Abstract Meta-iodbenzylguanidine scintigraphy (MIBG scintigraphy) shows reduced uptake in idiopathic Parkinson's disease (IPD), idiopathic REM sleep behavior disorder (IRBD) and Lewy body dementia (LBD), but not in other parkinsonian or dementia syndromes. We retrospectively reevaluated 50 patients. Concordance rate between last clinical diagnosis and scintigraphy diagnosis was only given in two-thirds of the patients. Confounding factors were: decreasing heart/mediastinum ratio (HMR) with progressive age, higher HMR in women and possibly interference with antihypertensive medication. Standardization of the methods and precise clinical guidelines are warranted for better clinical use.
    MeSH term(s) 3-Iodobenzylguanidine ; Adult ; Aged ; Aged, 80 and over ; Aging ; Antihypertensive Agents/adverse effects ; Antihypertensive Agents/therapeutic use ; Diagnosis, Differential ; Female ; Heart/physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Perfusion Imaging/methods ; Parkinsonian Disorders/diagnostic imaging ; Parkinsonian Disorders/physiopathology ; Predictive Value of Tests ; Radiopharmaceuticals ; Retrospective Studies ; Sensitivity and Specificity ; Sex Characteristics
    Chemical Substances Antihypertensive Agents ; Radiopharmaceuticals ; 3-Iodobenzylguanidine (35MRW7B4AD)
    Language English
    Publishing date 2010-02-13
    Publishing country Italy
    Document type Comparative Study ; Evaluation Study ; Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-010-0218-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Book ; Thesis: Das Medial-Shelf-Syndrom

    Fröhlich, Imke

    klinisches Bild und operative Behandlung

    1992  

    Language Undetermined
    Size [2], 79 S, graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @Marburg, Univ., Diss. : 1993
    Database Former special subject collection: coastal and deep sea fishing

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