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Article ; Online: Fungal Endophytes Enhance Wheat and Tomato Drought Tolerance in Terms of Plant Growth and Biochemical Parameters.

Miranda, Victoria / Silva-Castro, Gloria Andrea / Ruiz-Lozano, Juan Manuel / Fracchia, Sebastian / García-Romera, Inmaculada

Journal of fungi (Basel, Switzerland)

2023 Volume 9, Issue 3

Abstract: Drought is a major threat to plant growth in many parts of the world. During periods of drought, multiple aspects of plant physiology are negatively affected. For instance, water shortages induce osmotic imbalance, inhibit photosynthesis, decrease ... ...

Abstract	Drought is a major threat to plant growth in many parts of the world. During periods of drought, multiple aspects of plant physiology are negatively affected. For instance, water shortages induce osmotic imbalance, inhibit photosynthesis, decrease nutrient uptake, and increases the production of reactive oxygen species (ROS). In this context, it is necessary to develop sustainable strategies for crops that would help mitigate these conditions. In previous studies, endophytic
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof9030384
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Article ; Online: Harnessing the power of electronic health records and open natural language data mining to capture meaningful patient experience during routine clinical care.

Larrow, Danielle R / Kadosh, Orna Katz / Fracchia, Shannon / Radano, Marcella / Hartnick, Christopher J

International journal of pediatric otorhinolaryngology

2023 Volume 173, Page(s) 111698

Abstract: Introduction: Electronic health records (EHR) are a rich data source for both quality improvement and clinical research. Natural language processing can be harnessed to extract data from these previously difficult to access sources.: Objective: The ... ...

Abstract	Introduction: Electronic health records (EHR) are a rich data source for both quality improvement and clinical research. Natural language processing can be harnessed to extract data from these previously difficult to access sources. Objective: The objective of this study was to create and apply a natural language search query to extract EHR data to ask and answer quality improvement questions at a pediatric aerodigestive center. Methods: We developed a combined natural language search query to extract clinically meaningful data along with International Statistical Classification of Diseases (ICD10) and Current Procedural Terminology (CPT) code data. This search query was applied to a single pediatric aerodigestive center to answer key clinical questions asked by families. Data were extracted from EHR data from first clinic visit, operative note, microbiology lab report, and pathology report for all new patients from 2020 to 2021. Included as three queries were: 1) if I bring my child to a pediatric aerodigestive center, how often will my child obtain a medical diagnosis without needing an intervention? 2) if my child has a diagnostic procedure, how often will a diagnosis be made? 3) if a diagnosis is made, can it be addressed during that endoscopic intervention? Results: For the 711 new patients coming to the pediatric aerodigestive center from 2020 to 2021, only 26-32% required an interventional triple endoscopy (rigid/flexible bronchoscopy with esophagoduodenoscopy). Of these triple endoscopies, 75.7% resulted in a positive finding that enabled optimization of that child's care. Of the 221 patients who underwent diagnostic triple endoscopies, 40.7% underwent intervention at the same time for laryngeal cleft (injection or suture, dependent upon age). Conclusion: Here we created an effective model of open language search query to extract meaningful metrics of patient experience from EHR data. This model easily allows the EHR to be harnessed to create retrospective and prospective databases that can be readily queried to answer clinical questions important to patients. Such databases are widely applicable not just to pediatric aerodigestive centers but to any clinical care setting using an EHR.
MeSH term(s)	Child ; Humans ; Electronic Health Records ; Retrospective Studies ; Bronchoscopy ; Data Mining ; Patient Outcome Assessment
Language	English
Publishing date	2023-08-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2023.111698
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Zs.A 1507: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Comorbidity indices disillusion.

Bernardini, Bruno / Fracchia, Stefania

Journal of clinical epidemiology

2016 Volume 71, Page(s) 114–115

MeSH term(s)	Chronic Disease/epidemiology ; Chronic Disease/mortality ; Comorbidity ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Female ; Geriatrics ; Health Status Indicators ; Hospitalization/statistics & numerical data ; Humans ; Male ; Severity of Illness Index
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2015.05.014
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Article ; Online: A multicenter prospective study validated a nomogram to predict individual risk of dependence in ambulation after rehabilitation.

Bernardini, Bruno / Baratto, Luigi / Pizzi, Costanza / Biggeri, Annibale / Cerina, Giovanna / Colantonio, Viviana / Corsini, Carla / Ghirmai, Sara / Pagani, Marco / Fracchia, Stefania / Gardella, Marisa / Catelan, Dolores / Malosio, Maria Luisa / Malagamba, Elisa

Journal of clinical epidemiology

2022 Volume 154, Page(s) 97–107

Abstract: Objectives: To develop the Functional Risk Index for Dependence in Ambulation (FRIDA) score, a nomogram to predict individual risk of dependence in ambulation at discharge from postacute rehabilitation and validate its performance temporally and ... ...

Abstract	Objectives: To develop the Functional Risk Index for Dependence in Ambulation (FRIDA) score, a nomogram to predict individual risk of dependence in ambulation at discharge from postacute rehabilitation and validate its performance temporally and spatially. Study design and setting: We analyzed the database of a multicenter prospective observational quality cohort study conducted from January 2012 to March 2016, including data from 8,796 consecutive inpatients who underwent rehabilitation after stroke, hip fracture, lower limb joint replacement, debility, and other neurologic, orthopedic, or miscellaneous conditions. Results: A total of 3,026 patients (34.4%) were discharged dependent in ambulation. In the training set of 5,162 patients (58.7%), Lasso-regression selected advanced age, premorbid disability, and eight indicators of medical and functional adverse syndromes at baseline to establish the FRIDA score. At the temporal validation obtained on an external set of 3,234 patients (41.3%), meta-analyses showed that the FRIDA score had good and homogeneous discrimination (summary area under the curve 0.841, 95% confidence interval = 0.826-0.855, I Conclusion: The FRIDA score is a new clinically useful tool to predict an individual risk for dependence in ambulation at rehabilitation discharge in many different disabilities, and may also reflect well the case-mix composition of the rehabilitation facilities.
MeSH term(s)	Humans ; Nomograms ; Prospective Studies ; Cohort Studies ; Walking ; Hip Fractures
Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2022.10.021
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Article ; Online: Aren't thirty years enough to affirm the full maturity of modern geriatrics?

Fracchia, Stefania / Marchionni, Niccolò / Di Bari, Mauro

The journals of gerontology. Series A, Biological sciences and medical sciences

2015 Volume 70, Issue 2, Page(s) 223–224

MeSH term(s)	Aged ; Evidence-Based Medicine ; Geriatric Assessment ; Geriatrics/trends ; Humans ; Time Factors
Language	English
Publishing date	2015-02
Publishing country	United States
Document type	Editorial
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glu199
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Article ; Online: Signs and symptoms method in neuropsychology: A standardized observational examination of cognitive functions can be effective in detecting mild cognitive impairment.

Trimarchi, Pietro Davide / Sanfilippo, Emma / Gallucci, Alessia / Inglese, Silvia / Tomasini, Emanuele / Fontanella, Anna / Rebecchi, Isabella / Fracchia, Stefania / Parisi, Paola Maria Rita / Tartarone, Federica / Giunco, Fabrizio / Abbate, Carlo

Neuropsychology

2022 Volume 37, Issue 7, Page(s) 846–857

Abstract: Objective: The present study aimed at investigating the sensitivity and specificity of the NeuroPsychological Examination (NPE), a systematic collection of cognitive signs and symptoms based on the observation of the patient's behavior during a clinical ...

Abstract	Objective: The present study aimed at investigating the sensitivity and specificity of the NeuroPsychological Examination (NPE), a systematic collection of cognitive signs and symptoms based on the observation of the patient's behavior during a clinical interview, in detecting Mild Cognitive Impairment (MCI). Method: 475 participants, 208 suffering from MCI, 188 suffering from dementia and 79 subjective cognitive decline (SCD), have been assessed using NPE for the presence of signs and symptoms of cognitive impairment. Receiver operating characteristic (ROC) curve analysis and the Youden's test were used to determine the more appropriate cutoff points for the number of neuropsychological signs at the NPE that enabled to discriminate SCD from MCI, SCD from dementia and MCI from dementia. A sensitivity and specificity analysis and comparisons among the three groups were conducted. Results: The mean number of signs at the NPE were 1.73 for SCD, 7.98 for MCI and 12.82 for dementia. Pairwise comparisons among the three group of participants showed significant differences (SCD vs. MCI, Conclusions: A signs and symptoms approach could be a useful tool for clinical neuropsychologists working in the field of MCI and dementia assessment. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
MeSH term(s)	Humans ; Neuropsychology ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Cognition ; Sensitivity and Specificity ; Neuropsychological Tests ; Dementia/diagnosis ; Dementia/psychology
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042412-x
ISSN	1931-1559 ; 0894-4105
ISSN (online)	1931-1559
ISSN	0894-4105
DOI	10.1037/neu0000871
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Zs.A 3002: Show issues

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Article: L'importanza strategica della risorsa acqua e la tutela dal rischio.

Gilli, G / Fracchia, S

Annali di igiene : medicina preventiva e di comunita

2003 Volume 15, Issue 4 Suppl 1, Page(s) 11–14

Abstract: Water quality and its availability is a current and urgent issue. In fact, water is a unique natural resource, but its availability is limited. The paper presents data on its availability and usage. Its quality is of particular concern for safeguarding ... ...

Title translation	Strategic significance of water sources and risk management.
Abstract	Water quality and its availability is a current and urgent issue. In fact, water is a unique natural resource, but its availability is limited. The paper presents data on its availability and usage. Its quality is of particular concern for safeguarding public health.
MeSH term(s)	Italy ; Risk Management ; Water Supply/standards
Language	Italian
Publishing date	2003-07
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	1018045-x
ISSN	1120-9135 ; 0029-6287
ISSN	1120-9135 ; 0029-6287
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Zs.A 2845: Show issues

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Article: ROS-Scavenging Enzymes as an Antioxidant Response to High Concentration of Anthracene in the Liverwort

Spinedi, Nahuel / Storb, Romina / Aranda, Elisabet / Romani, Facundo / Svriz, Maya / Varela, Santiago A / Moreno, Javier E / Fracchia, Sebastian / Cabrera, Juan / Batista-García, Ramón Alberto / Ponce de León, Inés / Scervino, J Martín

Plants (Basel, Switzerland)

2021 Volume 10, Issue 7

Abstract: Marchantia ... ...

Abstract	Marchantia polymorpha
Language	English
Publishing date	2021-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants10071478
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Article ; Online: Diencephalic versus Hippocampal Amnesia in Alzheimer's Disease: The Possible Confabulation-Misidentification Phenotype.

Abbate, Carlo / Trimarchi, Pietro D / Fumagalli, Giorgio G / Gallucci, Alessia / Tomasini, Emanuele / Fracchia, Stefania / Rebecchi, Isabella / Morello, Elisabetta / Fontanella, Anna / Parisi, Paola M R / Tartarone, Federica / Giunco, Fabrizio / Ciccone, Simona / Nicolini, Paola / Lucchi, Tiziano / Arosio, Beatrice / Inglese, Silvia / Rossi, Paolo D

Journal of Alzheimer's disease : JAD

2022 Volume 91, Issue 1, Page(s) 363–388

Abstract: Background: Alzheimer's disease (AD) is clinically heterogeneous, including the classical-amnesic (CA-) phenotype and some variants.: Objective: We aim to describe a further presentation we (re)named confabulation-misidentification (CM-) phenotype.!## ...

Abstract	Background: Alzheimer's disease (AD) is clinically heterogeneous, including the classical-amnesic (CA-) phenotype and some variants. Objective: We aim to describe a further presentation we (re)named confabulation-misidentification (CM-) phenotype. Methods: We performed a retrospective longitudinal case-series study of 17 AD outpatients with the possible CM-phenotype (CM-ADs). Then, in a cross-sectional study, we compared the CM-ADs to a sample of 30 AD patients with the CA-phenotype (CA-ADs). The primary outcome was the frequency of cognitive and behavioral features. Data were analyzed as differences in percentage by non-parametric Chi Square and mean differences by parametric T-test. Results: Anterograde amnesia (100%) with early confabulation (88.2%), disorientation (88.2%) and non-infrequently retrograde amnesia (64.7%) associated with reduced insight (88.2%), moderate prefrontal executive impairment (94.1%) and attention deficits (82.3%) dominated the CM-phenotype. Neuropsychiatric features with striking misidentification (52.9%), other less-structured delusions (70.6%), and brief hallucinations (64.7%) were present. Marked behavioral disturbances were present early in some patients and very common at later stages. At the baseline, the CM-ADs showed more confabulation (p < 0.001), temporal disorientation (p < 0.02), misidentification (p = 0.013), other delusions (p = 0.002), and logorrhea (p = 0.004) than the CA-ADs. In addition, more social disinhibition (p = 0.018), reduction of insight (p = 0.029), and hallucination (p = 0.03) persisted at 12 months from baseline. Both the CA- and CM-ADs showed anterior and medial temporal atrophy. Compared to HCs, the CM-ADs showed more right fronto-insular atrophy, while the CA-ADs showed more dorsal parietal, precuneus, and right parietal atrophy. Conclusion: We described an AD phenotype resembling diencephalic rather than hippocampal amnesia and overlapping the past-century description of presbyophrenia.
MeSH term(s)	Humans ; Alzheimer Disease/complications ; Alzheimer Disease/psychology ; Retrospective Studies ; Cross-Sectional Studies ; Amnesia/psychology ; Memory Disorders ; Hippocampus ; Hallucinations ; Confusion ; Neuropsychological Tests
Language	English
Publishing date	2022-11-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-220919
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Zs.A 6084: Show issues

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Article: Dispersal of arbuscular mycorrhizal fungi and dark septate endophytes by Ctenomys cf. knighti (Rodentia) in the northern Monte Desert of Argentina

Fracchia, S / Krapovickas, L / Aranda-Rickert, A / Valentinuzzi, V.S

Journal of arid environments. 2011 Nov., v. 75, issue 11

2011

Abstract: In arid and semi-arid environments, root-associated fungi may play a key role in plant communities (e.g., seedling establishment, nutrient acquisition, plant survival and heat tolerance). Several studies have shown the importance of small mammals as ... ...

Abstract	In arid and semi-arid environments, root-associated fungi may play a key role in plant communities (e.g., seedling establishment, nutrient acquisition, plant survival and heat tolerance). Several studies have shown the importance of small mammals as consumers and dispersal agents of mycorrhizal fungi spores in tropical and temperate ecosystems. However, little is known about the dispersal of infective propagules of endophytic fungi in arid and semi-arid ecosystems. This study analyzed the potential role of the subterranean rodent Ctenomys cf. knighti as a dispersal agent of root-associated fungi. In order to demonstrate this role, we analyzed: (1) the incidence of colonization of arbuscular mycorrhizae and dark septate endophytes on representative plant species of the Monte Desert; (2) the presence of fungal structures of arbuscular mycorrhizae and dark septate endophytes in C. cf. knighti fecal samples; and (3) the infectivity of the fungal propagules contained in the scat and their growth effects on nine native plant species. Data strongly suggest that this South American subterranean rodent may play a key role as a dispersal agent of arbuscular mycorrhizae and dark septate endophytes fungi in the arid environment of the northern Monte Desert of Argentina.
Keywords	Rodentia ; deserts ; ecosystems ; endophytes ; feces ; heat tolerance ; indigenous species ; mycorrhizal fungi ; pathogenicity ; plant communities ; rodents ; seedlings ; small mammals ; spores ; vesicular arbuscular mycorrhizae ; Argentina
Language	English
Dates of publication	2011-11
Size	p. 1016-1023.
Document type	Article
ZDB-ID	428507-4
ISSN	1095-922X ; 0140-1963
ISSN (online)	1095-922X
ISSN	0140-1963
DOI	10.1016/j.jaridenv.2011.04.034
Database	NAL-Catalogue (AGRICOLA)

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