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  1. Article: Serous Borderline Tumor in Transgender Female-to-Male Individuals: A Case Report of Androgen Receptor-Positive Ovarian Cancer.

    Ferreira, Cristina / Fraga, João / Antunes, Célia / Gonçalo, Manuela / Donato, Paulo

    Case reports in radiology

    2021  Volume 2021, Page(s) 8861692

    Abstract: Ovarian cancer is the most fatal gynecologic malignancy. The incidence of ovarian cancer among female-to-male transsexuals receiving treatment with testosterone is unknown, and few cases have been reported in the literature. We report a recent case in ... ...

    Abstract Ovarian cancer is the most fatal gynecologic malignancy. The incidence of ovarian cancer among female-to-male transsexuals receiving treatment with testosterone is unknown, and few cases have been reported in the literature. We report a recent case in our institution, a 23-year-old female-to-male transsexual patient who received testosterone supplementation. The patient underwent a pelvic magnetic resonance imaging to study an ovarian complex cyst that revealed the presence of a bilateral ovarian tumor with imaging features of borderline serous tumor. These masses were surgically removed and the pathology report confirmed the diagnosis associated with noninvasive peritoneal implants and the presence of numerous androgen receptors in the tumor cells. Although there is still insufficient data to validate a direct correlation between hormonotherapy and ovarian cancer in these patients, this case may reinforce previous reports on this association and highlights the relevance of radiological follow-up and bilateral salpingo-oophorectomy as part of gender reassignment surgery.
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627655-0
    ISSN 2090-6870 ; 2090-6862
    ISSN (online) 2090-6870
    ISSN 2090-6862
    DOI 10.1155/2021/8861692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Gal-3 Protein Expression and Localization in Prostate Tumours.

    Lima, Tânia / Macedo-Silva, Catarina / Felizardo, Diana / Fraga, João / Carneiro, Isa / Jerónimo, Carmen / Henrique, Rui / Fardilha, Margarida / Vitorino, Rui

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 3, Page(s) 2729–2742

    Abstract: Gal-3 plays an important role in cell survival, mRNA splicing, and cell-cell and cell-matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. Given the promising ... ...

    Abstract Gal-3 plays an important role in cell survival, mRNA splicing, and cell-cell and cell-matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. Given the promising diagnostic role of Gal-3 in the urine of PCa patients found in our previous study, its concordant gene and protein expression levels, and its involvement in PCa-related biological processes (e.g., morphogenesis of the prostate gland epithelium), we aimed to investigate this protein immunohistochemically in tumour and normal prostate tissues. Gal-3 protein expression was evaluated in 48 tumour prostate tissues, eight normal prostate tissues and 14 adjacent-normal prostate tissues. Decreased Gal-3 staining was detected in tumour tissues compared with normal tissues. Although Gal-3 staining was decreased in tumour tissues with GS 5-8 and pT2 and pT3 stages compared with normal prostate tissue, no correlation was found between Gal-3 expression and PCa progression. In the present study, the pattern of cellular localization differed between groups, as Gal-3 was predominantly excluded from the nucleus in tumour tissues. Furthermore, Gal-3 had no significant effect on survival and relapse in these PCa patients. This work confirms Gal-3 as a promising marker for PCa diagnosis.
    MeSH term(s) Male ; Humans ; Neoplasm Recurrence, Local ; Prostatic Neoplasms/pathology ; Biological Phenomena
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30030206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: Author Correction: An interpretable machine learning system for colorectal cancer diagnosis from pathology slides.

    Neto, Pedro C / Montezuma, Diana / Oliveira, Sara P / Oliveira, Domingos / Fraga, João / Monteiro, Ana / Monteiro, João / Ribeiro, Liliana / Gonçalves, Sofia / Reinhard, Stefan / Zlobec, Inti / Pinto, Isabel M / Cardoso, Jaime S

    NPJ precision oncology

    2024  Volume 8, Issue 1, Page(s) 83

    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Published Erratum
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-024-00581-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: An interpretable machine learning system for colorectal cancer diagnosis from pathology slides.

    Neto, Pedro C / Montezuma, Diana / Oliveira, Sara P / Oliveira, Domingos / Fraga, João / Monteiro, Ana / Monteiro, João / Ribeiro, Liliana / Gonçalves, Sofia / Reinhard, Stefan / Zlobec, Inti / Pinto, Isabel M / Cardoso, Jaime S

    NPJ precision oncology

    2024  Volume 8, Issue 1, Page(s) 56

    Abstract: Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL) system that ... ...

    Abstract Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL) system that learns from weak labels, a sampling strategy that reduces the number of training samples by a factor of six without compromising performance, an approach to leverage a small subset of fully annotated samples, and a prototype with explainable predictions, active learning features and parallelisation. Noting some problems in the literature, this study is conducted with one of the largest WSI colorectal samples dataset with approximately 10,500 WSIs. Of these samples, 900 are testing samples. Furthermore, the robustness of the proposed method is assessed with two additional external datasets (TCGA and PAIP) and a dataset of samples collected directly from the proposed prototype. Our proposed method predicts, for the patch-based tiles, a class based on the severity of the dysplasia and uses that information to classify the whole slide. It is trained with an interpretable mixed-supervision scheme to leverage the domain knowledge introduced by pathologists through spatial annotations. The mixed-supervision scheme allowed for an intelligent sampling strategy effectively evaluated in several different scenarios without compromising the performance. On the internal dataset, the method shows an accuracy of 93.44% and a sensitivity between positive (low-grade and high-grade dysplasia) and non-neoplastic samples of 0.996. On the external test samples varied with TCGA being the most challenging dataset with an overall accuracy of 84.91% and a sensitivity of 0.996.
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-024-00539-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Digital Pathology Implementation in Private Practice: Specific Challenges and Opportunities.

    Montezuma, Diana / Monteiro, Ana / Fraga, João / Ribeiro, Liliana / Gonçalves, Sofia / Tavares, André / Monteiro, João / Macedo-Pinto, Isabel

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 2

    Abstract: Digital pathology (DP) is being deployed in many pathology laboratories, but most reported experiences refer to public health facilities. In this paper, we report our experience in DP transition at a high-volume private laboratory, addressing the main ... ...

    Abstract Digital pathology (DP) is being deployed in many pathology laboratories, but most reported experiences refer to public health facilities. In this paper, we report our experience in DP transition at a high-volume private laboratory, addressing the main challenges in DP implementation in a private practice setting and how to overcome these issues. We started our implementation in 2020 and we are currently scanning 100% of our histology cases. Pre-existing sample tracking infrastructure facilitated this process. We are currently using two high-capacity scanners (Aperio GT450DX) to digitize all histology slides at 40×. Aperio eSlide Manager WebViewer viewing software is bidirectionally linked with the laboratory information system. Scanning error rate, during the test phase, was 2.1% (errors detected by the scanners) and 3.5% (manual quality control). Pre-scanning phase optimizations and vendor feedback and collaboration were crucial to improve WSI quality and are ongoing processes. Regarding pathologists' validation, we followed the Royal College of Pathologists recommendations for DP implementation (adapted to our practice). Although private sector implementation of DP is not without its challenges, it will ultimately benefit from DP safety and quality-associated features. Furthermore, DP deployment lays the foundation for artificial intelligence tools integration, which will ultimately contribute to improving patient care.
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12020529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: iMIL4PATH: A Semi-Supervised Interpretable Approach for Colorectal Whole-Slide Images.

    Neto, Pedro C / Oliveira, Sara P / Montezuma, Diana / Fraga, João / Monteiro, Ana / Ribeiro, Liliana / Gonçalves, Sofia / Pinto, Isabel M / Cardoso, Jaime S

    Cancers

    2022  Volume 14, Issue 10

    Abstract: Colorectal cancer (CRC) diagnosis is based on samples obtained from biopsies, assessed in pathology laboratories. Due to population growth and ageing, as well as better screening programs, the CRC incidence rate has been increasing, leading to a higher ... ...

    Abstract Colorectal cancer (CRC) diagnosis is based on samples obtained from biopsies, assessed in pathology laboratories. Due to population growth and ageing, as well as better screening programs, the CRC incidence rate has been increasing, leading to a higher workload for pathologists. In this sense, the application of AI for automatic CRC diagnosis, particularly on whole-slide images (WSI), is of utmost relevance, in order to assist professionals in case triage and case review. In this work, we propose an interpretable semi-supervised approach to detect lesions in colorectal biopsies with high sensitivity, based on multiple-instance learning and feature aggregation methods. The model was developed on an extended version of the recent, publicly available CRC dataset (the CRC+ dataset with 4433 WSI), using 3424 slides for training and 1009 slides for evaluation. The proposed method attained 90.19% classification ACC, 98.8% sensitivity, 85.7% specificity, and a quadratic weighted kappa of 0.888 at slide-based evaluation. Its generalisation capabilities are also studied on two publicly available external datasets.
    Language English
    Publishing date 2022-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14102489
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  7. Article: Neuroendocrine Carcinoma and Intracystic Papillary Neoplasm: A Rare Association in the Gallbladder.

    Fraga, João / Caetano Oliveira, Rui / Alexandrino, Henrique / Cipriano, Maria Augusta

    GE Portuguese journal of gastroenterology

    2019  Volume 26, Issue 5, Page(s) 356–361

    Abstract: Neuroendocrine carcinoma of the gallbladder is a very rare neoplasia comprising only 0.2% of all the gastrointestinal neuroendocrine tumors. We present the case of an 85-year-old male with nonspecific gastrointestinal symptoms, progressive weight loss, ... ...

    Abstract Neuroendocrine carcinoma of the gallbladder is a very rare neoplasia comprising only 0.2% of all the gastrointestinal neuroendocrine tumors. We present the case of an 85-year-old male with nonspecific gastrointestinal symptoms, progressive weight loss, and deterioration in the preceding 15 days. Imaging study showed a 5-cm polypoid mass localized at the gallbladder fundus, leading to a radical cholecystectomy. Pathology revealed the known lobulated polypoid lesion, on cut section, constituted by friable tissue without evident infiltration of the gallbladder wall and a contiguous friable, brown, flat lesion. Histological evaluation displayed a small cell neuroendocrine carcinoma, consisting of intermediate and small cells, rounded or spindle, with extensive areas of necrosis, with positivity for neuroendocrine immunomarkers, associated with intracystic papillary neoplasm with high and low dysplasia. This is an uncommon association with few cases presented in the literature.
    Language English
    Publishing date 2019-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2835774-7
    ISSN 2387-1954 ; 2341-4545
    ISSN (online) 2387-1954
    ISSN 2341-4545
    DOI 10.1159/000495523
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Hepatic Myxoid Leiomyoma: A Very Rare Tumor.

    Fraga, João / Caetano Oliveira, Rui / Terracciano, Luigi / Silva, Mário Rui / Cipriano, Maria Augusta

    GE Portuguese journal of gastroenterology

    2019  Volume 27, Issue 5, Page(s) 352–355

    Abstract: Introduction: Mesenchymal tumors of the liver are rare, and in this group, myxoid leiomyomas are even rarer. So far, only 2 cases have been reported in the literature.: Case presentation: We aim to report the case of a 16-year-old female with a large ...

    Abstract Introduction: Mesenchymal tumors of the liver are rare, and in this group, myxoid leiomyomas are even rarer. So far, only 2 cases have been reported in the literature.
    Case presentation: We aim to report the case of a 16-year-old female with a large lesion on the right hepatic lobe, grossly composed of gelatinous and heterogeneous tissue.
    Discussion: Histological evaluation revealed a benign mesenchymal neoplasm with expansive growth, paucicellular, with monotonous and dispersed spindle and ovoid cells, positive for α-smooth actin and h-caldesmon, without atypia or mitoses, consistent with the diagnosis of primary myxoid leiomyoma.
    Language English
    Publishing date 2019-12-18
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2835774-7
    ISSN 2387-1954 ; 2341-4545
    ISSN (online) 2387-1954
    ISSN 2341-4545
    DOI 10.1159/000504762
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  9. Article: Integrated water resouce management as a development driver – Prospecting a sanitation improvement cycle for the greater Rio de Janeiro using the city blueprint approach

    Okumura, Celí Kiyomi / Locke, Micaela / Fraga, João Paulo Rebechi / Beleño de Oliveira, Antonio Krishnamurti / Veról, Aline Pires / Canedo de Magalhães, Paulo / Miguez, Marcelo Gomes

    Journal of cleaner production. 2021 Sept. 15, v. 315

    2021  

    Abstract: Fast urban growth and climate change have intensified water-related challenges, especially in large cities considering their scale and complexity. The purpose of this work is to pose the key role of Integrated Water Resource Management for a city's ... ...

    Abstract Fast urban growth and climate change have intensified water-related challenges, especially in large cities considering their scale and complexity. The purpose of this work is to pose the key role of Integrated Water Resource Management for a city's sustainable development, aiming to improve social, economic, and environmental conditions. To reach this goal, the Greater Rio de Janeiro (GRJ), in Brazil, will be used as an exploratory case study to support the discussion about proposing a cause-consequence framework. The GRJ has 13.1 million inhabitants and suffers from uneven distribution of goods, services, and infrastructure throughout its territory. The method includes 1. Apply the City Blueprint Approach (CBA) to assess the current IWRM of the GRJ; 2. Compare the results with the sanitation main findings identified in the Strategic Integrated Urban Development Plan (PEDUI) of the GRJ; 3. Given the similarity of the CBA outcomes and the PEDUI sanitation diagnosis, the City Blueprint Framework is subsequently applied to assess the behavior of GRJ in 2040. By comparing the current and future GRJ's IWRM status, a cause-consequence framework is built, highlighting the potentials and opportunities of a sanitation improvement cycle that intends to balance social inequalities towards a better quality of life in developing cities.
    Keywords case studies ; climate change ; infrastructure ; quality of life ; sanitation ; sustainable development ; urbanization ; water management ; Brazil
    Language English
    Dates of publication 2021-0915
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0959-6526
    DOI 10.1016/j.jclepro.2021.128054
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Large Pedunculated Lipoma of the Colon: Endoscopic Resection Using "Loop-and-Let-Go" Technique.

    Gravito-Soares, Elisa / Gravito-Soares, Marta / Fraga, João / Figueiredo, Pedro

    GE Portuguese journal of gastroenterology

    2017  Volume 25, Issue 5, Page(s) 268–270

    Language English
    Publishing date 2017-12-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2835774-7
    ISSN 2387-1954 ; 2341-4545
    ISSN (online) 2387-1954
    ISSN 2341-4545
    DOI 10.1159/000485350
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