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  1. Article ; Online: High mobility group box 1, ATP, lipid mediators, and tissue factor are elevated in COVID-19 patients: HMGB1 as a biomarker of worst prognosis.

    Vicentino, Amanda Roberta Revoredo / Fraga-Junior, Vanderlei da Silva / Palazzo, Matheus / Tasmo, Natalia Recardo Amorim / Rodrigues, Danielle A S / Barroso, Shana Priscila Coutinho / Ferreira, Sâmila Natiane / Neves-Borges, Anna Cristina / Allonso, Diego / Fantappié, Marcelo Rosado / Scharfstein, Julio / Oliveira, Ana Carolina / Vianna-Jorge, Rosane / Vale, André Macedo / Coutinho-Silva, Robson / Savio, Luiz Eduardo Baggio / Canetti, Claudio / Benjamim, Claudia Farias

    Clinical and translational science

    2023  Volume 16, Issue 4, Page(s) 631–646

    Abstract: The severe acute respiratory syndrome coronavirus 2, the agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, has spread worldwide since it was first identified in November 2019 in Wuhan, China. Since then, progress in pathogenesis linked ... ...

    Abstract The severe acute respiratory syndrome coronavirus 2, the agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, has spread worldwide since it was first identified in November 2019 in Wuhan, China. Since then, progress in pathogenesis linked severity of this systemic disease to the hyperactivation of network of cytokine-driven pro-inflammatory cascades. Here, we aimed to identify molecular biomarkers of disease severity by measuring the serum levels of inflammatory mediators in a Brazilian cohort of patients with COVID-19 and healthy controls (HCs). Critically ill patients in the intensive care unit were defined as such by dependence on oxygen supplementation (93% intubated and 7% face mask), and computed tomography profiles showing ground-glass opacity pneumonia associated to and high levels of D-dimer. Our panel of mediators included HMGB1, ATP, tissue factor, PGE
    MeSH term(s) Humans ; Thromboplastin ; COVID-19/diagnosis ; HMGB1 Protein ; Biomarkers ; Prognosis ; Lipids ; Adenosine Triphosphate
    Chemical Substances Thromboplastin (9035-58-9) ; HMGB1 Protein ; Biomarkers ; Lipids ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2433157-0
    ISSN 1752-8062 ; 1752-8054
    ISSN (online) 1752-8062
    ISSN 1752-8054
    DOI 10.1111/cts.13475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y

    Borges, Paula Alvarenga / Waclawiak, Ingrid / Georgii, Janaína Lima / Fraga-Junior, Vanderlei da Silva / Barros, Janaína Figueiredo / Lemos, Felipe Simões / Russo-Abrahão, Thaís / Saraiva, Elvira Maria / Takiya, Christina M / Coutinho-Silva, Robson / Penido, Carmen / Mermelstein, Claudia / Meyer-Fernandes, José Roberto / Canto, Fábio B / Neves, Josiane Sabbadini / Melo, Paulo A / Canetti, Claudio / Benjamim, Claudia Farias

    Frontiers in immunology

    2021  Volume 12, Page(s) 651740

    Abstract: Chronic wounds are a public health problem worldwide, especially those related to diabetes. Besides being an enormous burden to patients, it challenges wound care professionals and causes a great financial cost to health system. Considering the absence ... ...

    Abstract Chronic wounds are a public health problem worldwide, especially those related to diabetes. Besides being an enormous burden to patients, it challenges wound care professionals and causes a great financial cost to health system. Considering the absence of effective treatments for chronic wounds, our aim was to better understand the pathophysiology of tissue repair in diabetes in order to find alternative strategies to accelerate wound healing. Nucleotides have been described as extracellular signaling molecules in different inflammatory processes, including tissue repair. Adenosine-5'-diphosphate (ADP) plays important roles in vascular and cellular response and is immediately released after tissue injury, mainly from platelets. However, despite the well described effect on platelet aggregation during inflammation and injury, little is known about the role of ADP on the multiple steps of tissue repair, particularly in skin wounds. Therefore, we used the full-thickness excisional wound model to evaluate the effect of local ADP application in wounds of diabetic mice. ADP accelerated cutaneous wound healing, improved new tissue formation, and increased both collagen deposition and transforming growth factor-β (TGF-β) production in the wound. These effects were mediated by P2Y
    MeSH term(s) Adenosine Diphosphate/pharmacology ; Adenosine Diphosphate/therapeutic use ; Administration, Cutaneous ; Alloxan/administration & dosage ; Alloxan/toxicity ; Animals ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Experimental/complications ; Humans ; Male ; Mice ; Purinergic P2Y Receptor Agonists/pharmacology ; Purinergic P2Y Receptor Agonists/therapeutic use ; Receptors, Purinergic P2Y12/metabolism ; Skin/drug effects ; Skin/injuries ; Skin/pathology ; Wound Healing/drug effects
    Chemical Substances P2ry12 protein, mouse ; Purinergic P2Y Receptor Agonists ; Receptors, Purinergic P2Y12 ; Adenosine Diphosphate (61D2G4IYVH) ; Alloxan (6SW5YHA5NG)
    Language English
    Publishing date 2021-03-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.651740
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: HMGB1 correlates with severity and death of COVID-19 patients

    Vicentino, Amanda Roberta Revoredo / Fraga Junior, Vanderlei da Silva / Palazzo, Matheus / Tasmo, Natalia Recardo Amorim / Rodrigues, Danielle A. S. / Barroso, Shana Priscila Coutinho / Ferreira, Samila Natiane / Borges, Anna Cristina Neves / Allonso, Diego / Fantappie, Marcelo Rosado / Scharfstein, Julio / Oliveira, Ana Carolina / Vianna-Jorge, Rosane / Vale, André Macedo / Coutinho-Silva, Robson / Savio, Luiz Eduardo Baggio / Canetti, Claudio / Benjamim, Claudia Farias

    medRxiv

    Abstract: SARS-CoV-2, the causative agent of the ongoing COVID-19, has spread worldwide since it was first identified in November 2019 in Wuhan. Since then, it was already demonstrated an exuberant inflammation, cytokine storm, endothelium dysfunction, platelets ... ...

    Abstract SARS-CoV-2, the causative agent of the ongoing COVID-19, has spread worldwide since it was first identified in November 2019 in Wuhan. Since then, it was already demonstrated an exuberant inflammation, cytokine storm, endothelium dysfunction, platelets hyperactivation and aggregation, following T cell exhaustion leading to severe multi-organ damage and death of COVID-19 patients. Here, we sought to identify molecular biomarkers of disease severity in a Brazilian cohort of COVID-19 patients by measuring the serum levels of endogenous danger signals. Our data revealed that ICU patients that are critically ill, at the early hyperinflammatory phase of COVID-19 (around 12-25 days after hospital admission) display higher serum levels of the classical alarmin HMGB1. Serum levels of HMGB1 were positively correlated with cys-leukotrienes, D-dimer, AST, and ALT. Notably, we verified that HMGB1 levels above 125.4 ng/mL is the cut off that distinguishes the patients that are at higher risk of death. Serum levels of extracellular ATP, PGE<2, LTB4, cys-LTs, and tissue factor were also elevated in the serum of ICU patients. In conclusion, we propose that serum levels of HMGB1 serve as prognostic biomarker of risk of death in patients suffering from severe COVID-19.
    Keywords covid19
    Language English
    Publishing date 2022-05-31
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.05.26.22275611
    Database COVID19

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