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  1. Article ; Online: Methodological progress note: Utilizing inpatient data sources to minimize common biases when emulating target trials.

    Colacci, Michael / Fralick, Michael

    Journal of hospital medicine

    2023  Volume 18, Issue 11, Page(s) 1017–1020

    MeSH term(s) Humans ; Information Sources ; Inpatients ; Bias
    Language English
    Publishing date 2023-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2233783-0
    ISSN 1553-5606 ; 1553-5592
    ISSN (online) 1553-5606
    ISSN 1553-5592
    DOI 10.1002/jhm.13171
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  2. Article ; Online: [No title information]

    Sarma, Shohinee / Tran, Susan / Fralick, Michael

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2024  Volume 196, Issue 10, Page(s) E355–E356

    Title translation Nouveaux traitements contre l’obésité.
    MeSH term(s) Humans ; Obesity
    Language French
    Publishing date 2024-03-17
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.230820-f
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  3. Article ; Online: The Basics of Machine Learning.

    Fralick, Michael / Campbell, Kieran R

    NEJM evidence

    2022  Volume 1, Issue 5, Page(s) EVIDe2200062

    Abstract: The Basics of Machine LearningWhen a person is pregnant, a key question is how to establish the "date" of the pregnancy. Classically, the date was based on the last menstrual period (LMP). For the past 3 decades or more, in high-resource countries, this ... ...

    Abstract The Basics of Machine LearningWhen a person is pregnant, a key question is how to establish the "date" of the pregnancy. Classically, the date was based on the last menstrual period (LMP). For the past 3 decades or more, in high-resource countries, this has been done using "hospital-grade" ultrasound machines, with testing performed by trained sonographers. In many parts of the world, neither the machines nor the trained sonographers are accessible. In an article published in
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Editorial
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDe2200062
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  4. Article ; Online: Pharmacologic Thromboprophylaxis for Patients Admitted to General Medicine - Is It Necessary?

    Fralick, Michael / Sholzberg, Michelle

    NEJM evidence

    2022  Volume 1, Issue 6, Page(s) EVIDtt2200085

    Abstract: Necessity of Pharmacologic ThromboprophylaxisIt is a busy night on call, with 15 new admissions to general internal medicine. The senior resident checks over the admission orders, including low-molecular-weight heparin for venous thromboembolism ... ...

    Abstract Necessity of Pharmacologic ThromboprophylaxisIt is a busy night on call, with 15 new admissions to general internal medicine. The senior resident checks over the admission orders, including low-molecular-weight heparin for venous thromboembolism prophylaxis. The resident wonders: Does everyone admitted to general medicine really require pharmacologic thromboprophylaxis?
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Journal Article
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDtt2200085
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  5. Article ; Online: Novel obesity treatments.

    Sarma, Shohinee / Tran, Susan / Fralick, Michael

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2023  Volume 195, Issue 45, Page(s) E1546–E1547

    MeSH term(s) Humans ; Obesity/therapy
    Language English
    Publishing date 2023-08-07
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.230820
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  6. Article ; Online: Response: Sodium-Glucose Cotransporter-2 Inhibitors and Risk of Diabetic Ketoacidosis Among Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis.

    Colacci, Michael / Fralick, Michael

    Canadian journal of diabetes

    2021  Volume 46, Issue 2, Page(s) 110

    MeSH term(s) Adult ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetic Ketoacidosis/chemically induced ; Diabetic Ketoacidosis/epidemiology ; Glucose ; Humans ; Sodium ; Sodium-Glucose Transporter 2 Inhibitors/adverse effects
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-10-22
    Publishing country Canada
    Document type Letter ; Comment
    ISSN 2352-3840
    ISSN (online) 2352-3840
    DOI 10.1016/j.jcjd.2021.10.003
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  7. Article ; Online: The discovery of insulin in Toronto: beginning a 100 year journey of research and clinical achievement.

    Fralick, Michael / Zinman, Bernard

    Diabetologia

    2021  Volume 64, Issue 5, Page(s) 947–953

    Abstract: There has been a great deal of controversy regarding priority of discovery of insulin. Indeed, many scientists made important and, in some cases, seminal contributions to identifying the endocrine role of the pancreas and the potential for pancreatic ... ...

    Abstract There has been a great deal of controversy regarding priority of discovery of insulin. Indeed, many scientists made important and, in some cases, seminal contributions to identifying the endocrine role of the pancreas and the potential for pancreatic extracts to have a glucose-lowering effect. The purpose of this article is to describe the early experiences with respect to research leading to the discovery of insulin in Toronto (ON, Canada). The experiments conducted at the University of Toronto resulted in the first demonstration that a pancreatic extract could be prepared that would consistently lower glucose, reverse ketosis and arrest the catabolic effects of type 1 diabetes. The remarkably rapid commercial production of insulin soon followed. The Toronto story begins on 17 May 1921, when Frederick Banting and Charles Best began their summer research project in the laboratory of John James Rickard Macleod, and we are now celebrating the 100th anniversary of this landmark achievement. The article herein outlines the steps leading up to the discovery of insulin and provides an overview of some of the key developments in insulin therapy over the past 100 years.
    MeSH term(s) Biomedical Research/history ; Biomedical Research/trends ; Canada ; Drug Discovery/history ; Endocrinology/history ; Endocrinology/trends ; History, 20th Century ; History, 21st Century ; Humans ; Insulin/history ; Insulin/isolation & purification ; Insulin/therapeutic use
    Chemical Substances Insulin
    Language English
    Publishing date 2021-01-25
    Publishing country Germany
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-020-05371-6
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  8. Article ; Online: Correction to: The discovery of insulin in Toronto: beginning a 100 year journey of research and clinical achievement.

    Fralick, Michael / Zinman, Bernard

    Diabetologia

    2021  Volume 64, Issue 6, Page(s) 1454

    Language English
    Publishing date 2021-03-30
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-021-05445-z
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  9. Article ; Online: Thyrotoxic Periodic Paralysis.

    Fralick, Michael / Sarma, Shohinee

    The New England journal of medicine

    2021  Volume 384, Issue 19, Page(s) e71

    MeSH term(s) Adult ; Graves Disease/complications ; Graves Disease/diagnosis ; Graves Disease/drug therapy ; Humans ; Hypokalemia/complications ; Male ; Muscle Weakness/etiology ; Paralysis/etiology ; Phosphates/therapeutic use ; Potassium/therapeutic use
    Chemical Substances Phosphates ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2021-05-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm2030770
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  10. Article ; Online: Randomized controlled trials of switching to a new medication vs continuing a chronic medication may underestimate the risk of adverse events in those continuing because of asymmetric depletion of susceptibles.

    Colacci, Michael / Raissi, Afsaneh / Ray, Prachi / Sholzberg, Michelle / Rothman, Kenneth J / Fralick, Michael

    Journal of clinical epidemiology

    2024  , Page(s) 111336

    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Letter
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2024.111336
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