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Article ; Online: Large animal ventilator-integrated volumetric capnography generates clinically acceptable values of physiologic dead space in anesthetized healthy adult horses.

Frampton, Alycia / Floriano, Dario / Simpson, Keith / Hopster, Klaus

2023 Volume 85, Issue 1

Abstract: Objective: To evaluate the agreement between the Tafonius large animal ventilator-integrated volumetric capnography (vCap) software and the Respironics NICO noninvasive cardiac output monitor reference system.: Animals: Data were collected from 56 ... ...

Abstract	Objective: To evaluate the agreement between the Tafonius large animal ventilator-integrated volumetric capnography (vCap) software and the Respironics NICO noninvasive cardiac output monitor reference system. Animals: Data were collected from 56 healthy adult horses undergoing general anesthesia. Methods: Animals were placed under general anesthesia and connected to the Tafonius large animal ventilator circle system. A flow partitioning device with CO2 and flow sensors was utilized to couple the endotracheal tube to the NICO monitor. Tafonius CO2 and flow sensors are incorporated into the Y-piece of the breathing circuit. Arterial blood samples were collected to determine the partial pressure of arterial carbon dioxide (PaCO2) immediately before data collection. The PaCO2 was input into the Tafonius and NICO monitor, and dead space ventilation (%Vd), end-tidal CO2 partial pressure (ETco2), mixed-expired CO2 partial pressure (Peco2), and expired tidal volume (Vt) were calculated over a single breath. Multiple measurements were completed for each patient, with a total of 200 paired data points collected for analysis. Data were assessed for normality, and Bland-Altman analysis was performed. Bias and 95% limits of agreement were calculated. Results: The limits of agreement for %Vd of the ventilator-derived measurements fell within ± 10% of the NICO monitor reference method. Clinical relevance: Our results indicate that, when compared to the NICO monitor method, the Tafonius-integrated vCap software provides clinically acceptable values of Peco2, Vt, and %Vd in healthy adult horses.
MeSH term(s)	Horses ; Animals ; Capnography/veterinary ; Capnography/methods ; Carbon Dioxide ; Respiratory Dead Space/physiology ; Tidal Volume ; Respiration, Artificial/veterinary ; Ventilators, Mechanical
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.23.05.0107
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Conference proceedings ; Online: Runoff dynamics along hillslopes with groundwater springs in a mountainous sub-arctic catchment

Frampton, A. / Fischer, B. / Clemenzi, I. / Scaini, A. / Hamm, A.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

2023

Abstract: Mountainous sub-arctic catchments typically consist of various landscape elements such as glaciers, steep topography, fractured rock outcrops and talus covered slopes, patches of permafrost, vegetated and non-vegetated shallow soils, wetlands, and lakes ... ...

Abstract	Mountainous sub-arctic catchments typically consist of various landscape elements such as glaciers, steep topography, fractured rock outcrops and talus covered slopes, patches of permafrost, vegetated and non-vegetated shallow soils, wetlands, and lakes which are connected by surface and subsurface flows to stream networks. Hydrological flows are strongly influenced by snow and glacier melt that affects seasonal and annual runoff variability, both locally and downstream. This leads to great variability in flow to receiving hydrological systems, which makes it difficult to accurately quantify and predict water resources in downstream regions. Transport of waterborne substances such as solutes and nutrients are also extremely difficult to quantify due to this notable variability, and predictive capabilities are further hampered by still unknown effects of climate warming, which is expected to cause a change from glacial meltwater-dominated runoff to hillslope runoff. In this contribution, we present results from recent field tracer experiments along hillslopes associated with groundwater springs in the sub-arctic periglacial catchment of Tarfala, located in northern Sweden. We obtain breakthrough curves for different wet and dry antecedent moisture conditions based on seasonal variability. This is combined with rainfall-runoff recession analysis as well as physics-based numerical modelling to study and interpret the flow paths through the hillslope and its runoff-generating processes and the relative magnitudes of surface to shallow to deep subsurface runoff. Furthermore, we highlight how these model-based simulations can be used to study long-term changes of permafrost degradation and water and heat fluxes in mountainous sub-arctic catchments subject to climate change.
Subject code	550 ; 551
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Continentality determines warming or cooling impact of heavy rainfall events on permafrost.

Hamm, Alexandra / Magnússon, Rúna Í / Khattak, Ahmad Jan / Frampton, Andrew

Nature communications

2023 Volume 14, Issue 1, Page(s) 3578

Abstract: Permafrost thaw can cause an intensification of climate change through the release of carbon as greenhouse gases. While the effect of air temperature on permafrost thaw is well quantified, the effect of rainfall is highly variable and not well understood. ...

Abstract	Permafrost thaw can cause an intensification of climate change through the release of carbon as greenhouse gases. While the effect of air temperature on permafrost thaw is well quantified, the effect of rainfall is highly variable and not well understood. Here, we provide a literature review of studies reporting on effects of rainfall on ground temperatures in permafrost environments and use a numerical model to explore the underlying physical mechanisms under different climatic conditions. Both the evaluated body of literature and the model simulations indicate that continental climates are likely to show a warming of the subsoil and hence increased end of season active layer thickness, while maritime climates tend to respond with a slight cooling effect. This suggests that dry regions with warm summers are prone to more rapid permafrost degradation under increased occurrences of heavy rainfall events in the future, which can potentially accelerate the permafrost carbon feedback.
MeSH term(s)	Permafrost ; Cold Temperature ; Climate Change ; Greenhouse Gases ; Carbon/analysis ; Soil
Chemical Substances	Greenhouse Gases ; Carbon (7440-44-0) ; Soil
Language	English
Publishing date	2023-06-16
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-39325-4
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Article: Advective Transport in Discrete Fracture Networks With Connected and Disconnected Textures Representing Internal Aperture Variability

Frampton, A. / Hyman, J. D. / Zou, L.

Water resources research. 2019 July, v. 55, no. 7

2019

Abstract: Flow and transport in three‐dimensional discrete fracture networks with internal variability in aperture and permeability are investigated using a numerical model. The analysis is conducted for three different texture types representing internal ... ...

Abstract	Flow and transport in three‐dimensional discrete fracture networks with internal variability in aperture and permeability are investigated using a numerical model. The analysis is conducted for three different texture types representing internal variability considering various correlation lengths and for an increase in domain size corresponding to an increase in network complexity. Internal variability in discrete fracture networks generally increases median travel times and delays arrival of bulk mass transport when compared against reference cases without texture, corresponding to smooth fractures. In particular, internal variability textures with weak connectivity increase travel times nonlinearly with domain size increase, further delaying bulk mass arrival. Textures with strong connectivity can however decrease median travel times, accelerating bulk mass arrival, but only for limited ranges of correlation length and domain size. As domain size increases, travel times of textures with strong connectivity converge toward travel times obtained for classical multivariant Gaussian textures. Thus, accounting for internal fracture variability is potentially significant for improving conservative estimates of bulk mass arrival, flow channeling, and advective and reactive transport in large‐scale discrete fracture networks. Further, early mass arrival can arrive significantly earlier for textures with strong connectivity and classical Gaussian textures corresponding to intermediate connectivity but are only slightly affected by textures with weak connectivity. Thus, accounting for internal variability in fractures is also important for accurate estimates of early solute mass arrival. The overall impact on predictive transport modeling will depend on the extent of, or lack of, internal fracture connectivity structure in real‐world fractured rocks.
Keywords	mass transfer ; mathematical models ; permeability ; research ; solutes ; texture ; water
Language	English
Dates of publication	2019-07
Size	p. 5487-5501.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	5564-5
ISSN	1944-7973 ; 0043-1397
ISSN (online)	1944-7973
ISSN	0043-1397
DOI	10.1029/2018WR024322
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Current postoperative nutritional practice after pancreatoduodenectomy in the UK: national survey and snapshot audit.

Halle-Smith, James M / Pathak, Samir / Frampton, Adam / Pandanaboyana, Sanjay / Sutcliffe, Robert P / Davidson, Brian R / Smith, Andrew M / Roberts, Keith J

BJS open

2024 Volume 8, Issue 2

MeSH term(s)	Humans ; Pancreaticoduodenectomy ; Practice Patterns, Physicians' ; Medical Audit ; United Kingdom
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Journal Article
ISSN	2474-9842
ISSN (online)	2474-9842
DOI	10.1093/bjsopen/zrae021
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Article ; Online: The role of intraoperative pancreatoscopy in the surgical management of intraductal papillary mucinous neoplasms of the pancreas: a systematic scoping review.

Ciprani, Debora / Frampton, Adam / Amar, Hoda / Oppong, Kofi / Pandanaboyana, Sanjay / Aroori, Somaiah

Surgical endoscopy

2023 Volume 37, Issue 12, Page(s) 9043–9051

Abstract: Background: The type and the extent of surgery is still debatable for intraductal papillary mucinous neoplasm (IPMN). Intraoperative pancreatoscopy (IOP) allows the visualization of the main pancreatic duct (MPD) in its entire length and could help ... ...

Abstract	Background: The type and the extent of surgery is still debatable for intraductal papillary mucinous neoplasm (IPMN). Intraoperative pancreatoscopy (IOP) allows the visualization of the main pancreatic duct (MPD) in its entire length and could help determine the extent of MPD involvement and the type and extent of pancreatic resection. However, current guidelines do not advise its routine use as there is a lack of evidence supporting its safety and feasibility. The present study aims to perform a scoping review of published evidence on the safety and feasibility of IOP in IPMN surgical management. Methods: We systematically searched PubMed, Cochrane, Medline and EMbase to identify studies reporting the use of IOP in IPMN surgical management. The research was completed in June 2023. Data extracted included patient selection criteria, demographics, safety of the procedure, intraoperative findings, impact on surgical strategy, histology results and postoperative outcomes. Results: Four retrospective and one prospective study were included in this scoping review. A total of 142 patients had IOP. The selection criteria for inclusion were heterogenous, with one out of five studies including branch duct (BD), main duct (MD) and mixed type IPMN. Indications for IOP and surgical resection were only reported in two studies. A median of seven outcomes (range 5-8) was described, including the type of surgical resection, additional lesions and change of surgical plan, and complications after IOP. IOP showed additional lesions in 48 patients (34%) and a change of surgical plan in 48(34%). No IOP-related complications were reported. Conclusions: This scoping review suggests IOP is safe and identifies additional lesions impacting the surgical strategy for IPMN. However, the included studies were small and heterogeneous regarding IPMN definition and indications for surgery and IOP. There is a need for a large multi-centre prospective study to determine the role of IOP and its impact on surgical strategy for IPMN.
MeSH term(s)	Humans ; Pancreatic Intraductal Neoplasms/surgery ; Retrospective Studies ; Prospective Studies ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/pathology ; Pancreas/pathology ; Carcinoma, Pancreatic Ductal/surgery ; Carcinoma, Pancreatic Ductal/pathology
Language	English
Publishing date	2023-10-31
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-023-10518-8
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Article ; Online: Reporting of gunshot wounds by doctors in emergency departments: a duty or a right? Some legal and ethical issues surrounding breaking patient confidentiality.

Frampton, A

Emergency medicine journal : EMJ

2005 Volume 22, Issue 2, Page(s) 84–86

Abstract: Recent guidelines have been produced advising doctors working in emergency departments that they should report all gunshot injuries to the police (albeit with consent in all but very limited circumstances). This article will discuss some of the legal and ...

Abstract	Recent guidelines have been produced advising doctors working in emergency departments that they should report all gunshot injuries to the police (albeit with consent in all but very limited circumstances). This article will discuss some of the legal and ethical issues that surround breaking patient confidentiality in relation to gunshot wounds and other potentially dangerous patients; and looks at some cases from the UK and the USA where such issues have been ruled on. Finally, the issue of whether physicians do, or should, have a duty to warn when they feel that their patient may be dangerous will be discussed.
MeSH term(s)	Confidentiality/ethics ; Confidentiality/legislation & jurisprudence ; Disclosure/ethics ; Disclosure/legislation & jurisprudence ; Emergency Service, Hospital/ethics ; Emergency Service, Hospital/legislation & jurisprudence ; Humans ; Social Responsibility ; United Kingdom ; Wounds, Gunshot/therapy
Language	English
Publishing date	2005-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emj.2004.016733
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Article ; Online: Contaminated area instability along Ångermanälven River, northern Sweden.

Ströberg, A / Ebert, K / Jarsjö, J / Frampton, A

Environmental monitoring and assessment

2017 Volume 189, Issue 3, Page(s) 118

Abstract: Industrially utilized river basins are frequently exposed to contaminants originating from polluting activities. However, the physical instability and probability of mass movement mobilization of contaminated soil into rivers have only received little ... ...

Abstract	Industrially utilized river basins are frequently exposed to contaminants originating from polluting activities. However, the physical instability and probability of mass movement mobilization of contaminated soil into rivers have only received little attention. In this study, we present a GIS-based method to produce a regional overview of where and how contaminated areas are potentially exposed to slope instability. A landslide susceptibility-index was used to study the degree and distribution of overlap between contaminated sites and unstable ground. A contaminated area instability hazard classification was produced integrating slope instability and contamination risk classification. Our results indicate that mass movement can be tied mainly to a slope gradient ≥16°, a proximity to the river that is <500 m, a distance of <500 m from roads, concave surface curvature, and sand- and silt soils. Forty-six (22%) of all considered contaminated sites are located within areas with a non-negligible slope instability, of which a majority, 30 sites (14%) are situated on ground with a low or moderate instability. Three sites with a class 2 contamination risk (the 2nd highest class) are located on ground with a very high slope instability.
MeSH term(s)	Environmental Monitoring/methods ; Environmental Pollution/analysis ; Landslides ; Rivers ; Soil ; Soil Pollutants/analysis ; Sweden
Chemical Substances	Soil ; Soil Pollutants
Language	English
Publishing date	2017-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-017-5839-0
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Article ; Online: Continentality determines warming or cooling impact of heavy rainfall events on permafrost

Hamm, Alexandra / Magnússon, Rúna / Khattak, Ahmad Jan / Frampton, Andrew

Nature Communications

2023 Volume 14, Issue 1

Abstract	Permafrost thaw can cause an intensification of climate change through the release of carbon as greenhouse gases. While the effect of air temperature on permafrost thaw is well quantified, the effect of rainfall is highly variable and not well understood. Here, we provide a literature review of studies reporting on effects of rainfall on ground temperatures in permafrost environments and use a numerical model to explore the underlying physical mechanisms under different climatic conditions. Both the evaluated body of literature and the model simulations indicate that continental climates are likely to show a warming of the subsoil and hence increased end of season active layer thickness, while maritime climates tend to respond with a slight cooling effect. This suggests that dry regions with warm summers are prone to more rapid permafrost degradation under increased occurrences of heavy rainfall events in the future, which can potentially accelerate the permafrost carbon feedback.
Keywords	Life Science
Subject code	550
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	2553671-0
ISSN	2041-1723
ISSN	2041-1723
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Youth Mental Health Services: Promoting Wellness or Treating Mental Illness?

Malla, Ashok / Frampton, Alyssa / Mansouri, Bilal Issaoui

Canadian journal of psychiatry. Revue canadienne de psychiatrie

2020 Volume 65, Issue 8, Page(s) 531–535

MeSH term(s)	Adolescent ; Humans ; Mental Disorders/therapy ; Mental Health ; Mental Health Services/organization & administration
Language	English
Publishing date	2020-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	304227-3
ISSN	1497-0015 ; 0008-4824 ; 0706-7437
ISSN (online)	1497-0015
ISSN	0008-4824 ; 0706-7437
DOI	10.1177/0706743720920033
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