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Article ; Online: Attractiveness crisis: Caring for those who care.

François, Patrice

Journal of epidemiology and population health

2024 Volume 72, Issue 2, Page(s) 202382

Language	English
Publishing date	2024-04-03
Publishing country	France
Document type	Editorial
ISSN	2950-4333
ISSN (online)	2950-4333
DOI	10.1016/j.jeph.2024.202382
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biology and Regulation of Staphylococcal Biofilm.

François, Patrice / Schrenzel, Jacques / Götz, Friedrich

International journal of molecular sciences

2023 Volume 24, Issue 6

Abstract: Despite continuing progress in medical and surgical procedures, staphylococci remain the major Gram-positive bacterial pathogens that cause a wide spectrum of diseases, especially in patients requiring the utilization of indwelling catheters and ... ...

Abstract	Despite continuing progress in medical and surgical procedures, staphylococci remain the major Gram-positive bacterial pathogens that cause a wide spectrum of diseases, especially in patients requiring the utilization of indwelling catheters and prosthetic devices implanted temporarily or for prolonged periods of time. Within the genus, if
MeSH term(s)	Humans ; Staphylococcus ; Biofilms ; Staphylococcus aureus/physiology ; Staphylococcal Infections/microbiology ; Staphylococcus epidermidis ; Anti-Bacterial Agents/therapeutic use ; Biology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24065218
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Article ; Online: Le chemin de croix du développement professionnel continu (DPC).

François, Patrice

Presse medicale (Paris, France : 1983)

2014 Volume 43, Issue 11, Page(s) 1189–1194

Abstract: Continuing professional development (CPD) is a new approach to continuing medical education and is based on: the assessment of the practitioner needs, pedagogy centered on practices and the consideration of the practitioner social accountability. In ... ...

Title translation	The path to continuing professional development.
Abstract	Continuing professional development (CPD) is a new approach to continuing medical education and is based on: the assessment of the practitioner needs, pedagogy centered on practices and the consideration of the practitioner social accountability. In France, CPD became mandatory for all health professionals in 2009. However, we observe a delay in its implementation, due to several regulatory aspects. The main obstacles are the unique model of CPD for all occupations, the constraint of a single operator and the lack of scale quantifying the professional investment. By correcting these drawbacks, the CPD could really contribute to the continuous improvement of the quality and safety of care.
MeSH term(s)	Education, Medical, Continuing/legislation & jurisprudence ; Education, Medical, Continuing/methods ; France ; Humans ; Patient Safety ; Quality Improvement ; Social Responsibility
Language	French
Publishing date	2014-11
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2014.03.030
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 794: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.87: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Effects of a healthcare students' prevention intervention for school children on their own substance use: a before-after study.

Boussat, Bastien / Gaillet, Mélanie / Fournier, Joey / Guyomard, Alizé / François, Patrice / Shankland, Rebecca

BMC medical education

2023 Volume 23, Issue 1, Page(s) 841

Abstract: Background: Cognitive dissonance theory and research has suggested that engaging in prevention interventions for other students may be a means of reducing one's own problematic behaviors in order to reduce potential cognitive dissonance. This study ... ...

Abstract	Background: Cognitive dissonance theory and research has suggested that engaging in prevention interventions for other students may be a means of reducing one's own problematic behaviors in order to reduce potential cognitive dissonance. This study assessed the effects of a new mandatory prevention intervention program for healthcare students in France. The aim was to measure the effects of engaging in a prevention program in schools on the usual increase in substance use in student populations. Methods: Healthcare students were trained in a French university to develop psychosocial competences as a health promotion means (FEPS training) or more specifically to prevent substance use in teenagers (Unplugged program training). The students (n = 314) who accepted to take part in the study from both groups completed questionnaires before their interventions in schools, and at the end of the year, measuring their representations and behaviors regarding psychoactive substances. Results: The results indicated a significant reduction in alcohol consumption in terms of quantity, but no significant reduction in tobacco and marijuana consumption. Conclusions: This study showed that, contrary to the usual increase in substance use in students as they advance in their year, the students who took part in this study showed reduced self-reported consumption of alcohol after they had performed the prevention intervention in schools regardless of the type of training they had received (general health promotion vs. specific substance use prevention program). Limitations and future perspectives are discussed.
MeSH term(s)	Adolescent ; Humans ; Child ; Controlled Before-After Studies ; Substance-Related Disorders/prevention & control ; Health Promotion/methods ; Students ; Delivery of Health Care
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04813-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Healthcare students' prevention training in a sanitary service: analysis of health education interventions in schools of the Grenoble academy.

Kuenemann, Marie / Gaillet, Mélanie / Shankland, Rebecca / Fournier, Joey / Boussat, Bastien / François, Patrice

BMC medical education

2023 Volume 23, Issue 1, Page(s) 302

Abstract: Background: The sanitary service is a mandatory prevention training programme for all French healthcare students. Students receive training and then have to design and carry out a prevention intervention with various populations. The aim of this study ... ...

Abstract	Background: The sanitary service is a mandatory prevention training programme for all French healthcare students. Students receive training and then have to design and carry out a prevention intervention with various populations. The aim of this study was to analyse the type of health education interventions carried out in schools by healthcare students from one university in order to describe the topics covered and the methods used. Method: The 2021-2022 sanitary service of University Grenoble Alpes involved students in maieutic, medicine, nursing, pharmacy and physiotherapy. The study focused on students who intervened in school contexts. The intervention reports written by the students were read doubly by independent evaluators. Information of interest was collected in a standardised form. Results: Out of the 752 students involved in the prevention training program, 616 (82%) were assigned to 86 schools, mostly primary schools (58%), and wrote 123 reports on their interventions. Each school hosted a median of 6 students from 3 different fields of study. The interventions involved 6853 pupils aged between 3 and 18 years. The students delivered a median of 5 health prevention sessions to each pupil group and spent a median of 25 h (IQR: 19-32) working on the intervention. The themes most frequently addressed were screen use (48%), nutrition (36%), sleep (25%), harassment (20%) and personal hygiene (15%). All students used interactive teaching methods such as workshops, group games or debates that was addressed to pupils' psychosocial (mainly cognitive and social) competences. The themes and tools used differed according to the pupils' grade levels. Conclusion: This study showed the feasibility of conducting health education and prevention activities in schools by healthcare students from five professional fields who had received appropriate training. The students were involved and creative, and they were focused on developing pupils' psychosocial competences.
MeSH term(s)	Humans ; Child, Preschool ; Child ; Adolescent ; Health Education/methods ; Schools ; Students ; Universities ; Delivery of Health Care
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-023-04235-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Extent of Low-density Lipoprotein Cholesterol Reduction and All-cause and Cardiovascular Mortality Benefit: A Systematic Review and Meta-analysis.

Ennezat, Pierre Vladimir / Guerbaai, Raphaëlle-Ashley / Maréchaux, Sylvestre / Le Jemtel, Thierry H / François, Patrice

Journal of cardiovascular pharmacology

2023 Volume 81, Issue 1, Page(s) 35–44

Abstract: Abstract: Lipid-modifying agents steadily lower low-density lipoprotein cholesterol (LDL-C) levels with the aim of reducing mortality. A systematic review and meta-analysis were conducted to determine whether all-cause or cardiovascular (CV) mortality ... ...

Abstract	Abstract: Lipid-modifying agents steadily lower low-density lipoprotein cholesterol (LDL-C) levels with the aim of reducing mortality. A systematic review and meta-analysis were conducted to determine whether all-cause or cardiovascular (CV) mortality effect size for lipid-lowering therapy varied according to the magnitude of LDL-C reduction. Electronic databases were searched, including PubMed and ClinicalTrials.gov , from inception to December 31, 2019. Eligible studies included randomized controlled trials that compared lipid-modifying agents (statins, ezetimibe, and PCSK-9 inhibitors) versus placebo, standard or usual care or intensive versus less-intensive LDL-C-lowering therapy in adults, with or without known history of CV disease with a follow-up of at least 52 weeks. All-cause and CV mortality as primary end points, myocardial infarction, stroke, and non-CV death as secondary end points. Absolute risk differences [ARD (ARDs) expressed as incident events per 1000 person-years], number needed to treat (NNT), and rate ratios (RR) were assessed. Sixty randomized controlled trials totaling 323,950 participants were included. Compared with placebo, usual care or less-intensive therapy, active or more potent lipid-lowering therapy reduced the risk of all-cause death [ARD -1.33 (-1.89 to -0.76); NNT 754 (529-1309); RR 0.92 (0.89-0.96)]. Intensive LDL-C percent lowering was not associated with further reductions in all-cause mortality [ARD -0.27 (-1.24 to 0.71); RR 1.00 (0.94-1.06)]. Intensive LDL-C percent lowering did not further reduce CV mortality [ARD -0.28 (-0.83 to 0.38); RR 1.02 (0.94-1.09)]. Our findings indicate that risk reduction varies across subgroups and that overall NNTs are high. Identifying patient subgroups who benefit the most from LDL-C levels reduction is clinically relevant and necessary.
MeSH term(s)	Humans ; Anticholesteremic Agents/adverse effects ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Ezetimibe/therapeutic use ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/drug therapy ; Myocardial Infarction/drug therapy ; Randomized Controlled Trials as Topic
Chemical Substances	Anticholesteremic Agents ; Cholesterol, LDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Ezetimibe (EOR26LQQ24)
Language	English
Publishing date	2023-01-01
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001345
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1471: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Two-Component Systems of

Bleul, Lisa / Francois, Patrice / Wolz, Christiane

Genes

2021 Volume 13, Issue 1

Abstract: Staphylococcus ... ...

Abstract	Staphylococcus aureus
MeSH term(s)	Animals ; Bacterial Proteins/genetics ; Gene Expression Regulation, Bacterial/genetics ; Humans ; Signal Transduction/genetics ; Staphylococcus aureus/genetics
Chemical Substances	Bacterial Proteins
Language	English
Publishing date	2021-12-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes13010034
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Co-Carriage of Metal and Antibiotic Resistance Genes in Sewage Associated Staphylococci.

Amirsoleimani, Atena / Brion, Gail / Francois, Patrice

Genes

2021 Volume 12, Issue 10

Abstract: Controlling spread of resistance genes from wastewater to aquatic systems requires more knowledge on how resistance genes are acquired and transmitted. Whole genomic sequences from sewage-associated staphylococcus isolates ( ... ...

Abstract	Controlling spread of resistance genes from wastewater to aquatic systems requires more knowledge on how resistance genes are acquired and transmitted. Whole genomic sequences from sewage-associated staphylococcus isolates (20
MeSH term(s)	Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Bacterial Proteins/genetics ; Drug Resistance, Bacterial/genetics ; Gene Transfer, Horizontal/genetics ; Genome, Bacterial/genetics ; Humans ; Membrane Proteins/genetics ; Metals/adverse effects ; Metals/therapeutic use ; Plasmids/genetics ; Sewage/microbiology ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/genetics ; Staphylococcal Infections/microbiology ; Staphylococcus/drug effects ; Staphylococcus/genetics ; Staphylococcus aureus/genetics ; Staphylococcus aureus/pathogenicity ; Whole Genome Sequencing
Chemical Substances	Anti-Bacterial Agents ; Bacterial Proteins ; Membrane Proteins ; Metals ; Sewage ; cadD protein, Staphylococcus aureus
Language	English
Publishing date	2021-09-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12101473
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Insights of undergraduate health sciences students about a French interprofessional training initiative.

Gaillet, Mélanie / François, Patrice / Fond, Guillaume / Shankland, Rebecca / Novais, Maria de Fatima / Provost, Julien / Herr, Marie / Boyer, Laurent / Boussat, Bastien

BMC medical education

2024 Volume 24, Issue 1, Page(s) 220

Abstract: Background: Incorporating interprofessional collaboration within healthcare is critical to delivery of patient-centered care. Interprofessional Education (IPE) programs are key to promoting such collaboration. The 'Public Health Service' (PHS) in France ...

Abstract	Background: Incorporating interprofessional collaboration within healthcare is critical to delivery of patient-centered care. Interprofessional Education (IPE) programs are key to promoting such collaboration. The 'Public Health Service' (PHS) in France is a mandatory IPE initiative that embodies this collaborative spirit, bringing together students from varied health undergraduate training programs-nursing, physiotherapy, pharmacy, midwifery, and medicine- in a common training program focused on primary prevention. The aim of the study was to assess the experience and attitudes of students in the five health training programs regarding the interest of IPEs in the PHS. Methods: A cross-sectional survey was administered to 823 students from the 2022-2023 cohort at a French university. The questionnaire was designed with 12 Likert-scale questions specifically created to evaluate the students' experiences, knowledge, and attitudes focused on IPE during the practical seminars, school interventions, and the overall PHS. Additionally, an open-ended question was utilized to gather qualitative data. Statistical analyses assessed satisfaction levels across undergraduate training programs, while thematic analysis was applied to the qualitative responses. Results: Within the surveyed cohort, 344 students responded to the survey. The findings showed that students were satisfied with the interprofessional collaboration, both in practical teaching sessions (75% satisfaction) and in primary prevention projects conducted in schools (70% satisfaction), despite their having faced challenges with coordination. Pharmacy students, in particular, highlighted the need for adjustments in program scheduling. The qualitative feedback underscored the positive value of IPE, notwithstanding the organizational difficulties stemming from different academic timetables. Conclusion: The student feedback indicated a high level of satisfaction with the interprofessional work carried out in both the practical teaching and the primary prevention projects. To further enhance the educational impact and address the scheduling complexities, it is recommended that program refinements be made based on student feedback and pedagogical best practices.
MeSH term(s)	Humans ; Interprofessional Relations ; Cross-Sectional Studies ; Students ; Curriculum ; Delivery of Health Care
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-024-05212-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Co-Carriage of Metal and Antibiotic Resistance Genes in Sewage Associated Staphylococci

Amirsoleimani, Atena / Brion, Gail / Francois, Patrice

Genes. 2021 Sept. 23, v. 12, no. 10

2021

Abstract	Controlling spread of resistance genes from wastewater to aquatic systems requires more knowledge on how resistance genes are acquired and transmitted. Whole genomic sequences from sewage-associated staphylococcus isolates (20 S. aureus, 2 Staphylococcus warneri, and 2 Staphylococcus delphini) were analyzed for the presence of antibiotic resistance genes (ARGs) and metal resistance genes (MRGs). Plasmid sequences were identified in each isolate to investigate co-carriage of ARGs and MRGs within. BLASTN analysis showed that 67% of the isolates carried more than one ARG. The carriage of multiple plasmids was observed more in CC5 than CC8 S. aureus strains. Plasmid exchange was observed in all staphylococcus species except the two S. delphini isolates that carried multiple MRGs, no ARGs, and no plasmids. 85% of S. aureus isolates carried the blaZ gene, 76% co-carried blaZ with cadD and cadX, with 62% of these isolates carrying blaZ, cadD, and cadX on the same plasmid. The co-carriage of ARGs and MRGs in S. warneri isolates, and carriage of MRGs in S. delphini, without plasmids suggests non-conjugative transmission routes for gene acquisition. More studies are required that focus on the transduction and transformation routes of transmission to prevent interspecies exchange of ARGs and MRGs in sewage-associated systems.
Keywords	Staphylococcus delphini ; Staphylococcus warneri ; antibiotic resistance ; genomics ; metal tolerance ; plasmids ; sewage ; wastewater
Language	English
Dates of publication	2021-0923
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12101473
Database	NAL-Catalogue (AGRICOLA)

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