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  1. AU="François Lebargy"
  2. AU=Serag Eman AU=Serag Eman
  3. AU="Yang, Guichun"
  4. AU="Amory, Jonathan R"
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  1. Artikel ; Online: Prevalence and Impact of Rheumatologic Pain in Cystic Fibrosis Adult Patients

    Axelle Schmoll / Claire Launois / Jeanne-Marie Perotin / Bruno Ravoninjatovo / Muriel Griffon / Sophie Carré / Pauline Mulette / Julien Ancel / Jean Hagenburg / François Lebargy / Gaëtan Deslée / Jean-Hugues Salmon / Sandra Dury

    Frontiers in Medicine, Vol

    2022  Band 8

    Abstract: BackgroundWith the improvement of cystic fibrosis (CF) patient survival, the prevalence of long-term complications increased, among them rheumatologic disorders.MethodsThe aim of this prospective study was to evaluate the prevalence of spinal and joint ... ...

    Abstract BackgroundWith the improvement of cystic fibrosis (CF) patient survival, the prevalence of long-term complications increased, among them rheumatologic disorders.MethodsThe aim of this prospective study was to evaluate the prevalence of spinal and joint pain, and their impact on disability, anxiety, depression, and quality of life in CF adult patients.ResultsForty-seven patients were analyzed, 72% of men, mean aged 28 years, with a mean body mass index of 22 kg/m2 and a mean FEV1% of 63%. Twenty-two patients (47%) described rheumatologic pain either spinal (n = 15, 32%) and/or joint pain (n = 14, 30%). Patients with spinal and/or joint pain were shorter (p = 0.023), more frequently colonized with Staphylococcus aureus (p < 0.008), had more frequent ΔF508 homozygous mutations (p = 0.014), and a trend for more impairment of the 6-min walking distance (p = 0.050). The presence of rheumatologic pain tended to be associated with disability according to the Health Assessment Questionnaire (HAQ) and anxiety. Compared with patients with no pain patients with both spinal and joint pain exhibited a more pronounced impact on the St George's Respiratory Questionnaire (SGRQ).ConclusionRheumatologic pain is frequent in CF adult patients, and may affect daily living, anxiety and quality of life. Systematic assessment of rheumatologic pain should be included in the management of CF patients.
    Schlagwörter cystic fibrosis ; pain ; joint ; spinal ; rheumatologic ; quality of life ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-02-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells

    Vincent Wellemans / Hassan Ait Benhassou / Eloise Fuselier / Fabienne Bellesort / Sandra Dury / François Lebargy / Valérian Dormoy / Caroline Fichel / Richard Le Naour / Abdelilah S. Gounni / Bouchaib Lamkhioued

    iScience, Vol 24, Iss 12, Pp 103433- (2021)

    2021  

    Abstract: Summary: Respiratory syncytial virus (RSV) infection is the principal cause of severe lower respiratory tract disease and accounts for a significant risk for developing asthma later in life. Clinical studies have shown an increase in airway ... ...

    Abstract Summary: Respiratory syncytial virus (RSV) infection is the principal cause of severe lower respiratory tract disease and accounts for a significant risk for developing asthma later in life. Clinical studies have shown an increase in airway responsiveness and a concomitant Th2 response in the lungs of RSV-infected patients. These indications suggest that RSV may modulate aspects of the immune response to promote virus replication. Here, we show that CCR3 facilitates RSV infection of airway epithelial cells, an effect that was inhibited by eotaxin-1/CCL11 or upon CCR3 gene silencing. Mechanistically, cellular entry of RSV is mediated by binding of the viral G protein to CCR3 and selective chemotaxis of Th2 cells and eosinophils. In vivo, mice lacking CCR3 display a significant reduction in RSV infection, airway inflammation, and mucus production. Overall, RSV G protein-CCR3 interaction may participate in pulmonary infection and inflammation by enhancing eosinophils' recruitment and less potent antiviral Th2 cells.
    Schlagwörter Virology ; Immunology ; Cell biology ; Science ; Q
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2021-12-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Occupational Risk Factors for COPD

    Marie Kraïm-Leleu / Francois-Xavier Lesage / Moustapha Drame / Francois Lebargy / Frédéric Deschamps

    PLoS ONE, Vol 11, Iss 8, p e

    A Case-Control Study.

    2016  Band 0158719

    Abstract: The aim of this research was to examine the occupational risk factors for Chronic Obstructive Pulmonary Diseases (COPD) in a range of occupations.Eleven occupations involving different types of exposure were observed in this multicenter case-control ... ...

    Abstract The aim of this research was to examine the occupational risk factors for Chronic Obstructive Pulmonary Diseases (COPD) in a range of occupations.Eleven occupations involving different types of exposure were observed in this multicenter case-control study. Controls and cases were matched for sex, age and smoking. Multiple logistic regression analyses were used to estimate odds ratios (ORs).A total of 1,519 participants were initially recruited between September 2004 and September 2012. After matching, 547 pairs were obtained. The mean age was 56.3 +/- 10.4 years. Smelter workers were the only ones with an increased risk of COPD in this study (OR = 7.6, p < 0.0001, 95% CI [4.5, 12.9]). Physical activity was protective (OR = 0.7), while living in the city was a risk (OR = 1.6). The main used metals were cast iron, aluminum and alloys. Molds and cores were mainly made from sand and synthetic resins. Machine maintenance (65.2%), molding (49.6%), finishing (41.1%) and casting (41.0%) were the most common activities. Almost all workers (95.1%) cleaned the floors and machines with a brush or compressed air.This study demonstrates the importance of occupational factors in the genesis of COPD, especially among smelter workers. As with the fight against smoking-related disease, the removal or substitution of recognized hazardous agents is the best way of preventing the onset of COPD. This is why it is essential to continue research on its occupational risk factors.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2016-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Improvement of dyspnea after bariatric surgery is associated with increased Expiratory Reserve Volume

    Louis Boissière / Jeanne-Marie Perotin-Collard / Eric Bertin / Isabelle Gaubil / Ana Diaz Cives / Coralie Barbe / Sandra Dury / Julie Nardi / François Lebargy / Gaëtan Deslée / Claire Launois

    PLoS ONE, Vol 12, Iss 9, p e

    A prospective follow-up study of 45 patients.

    2017  Band 0185058

    Abstract: To assess the effects of bariatric surgery in patients with obesity on dyspnea and to analyze the relationships between improvement of dyspnea after bariatric surgery and changes in pulmonary function, especially Expiratory Reserve Volume (ERV) which is ... ...

    Abstract To assess the effects of bariatric surgery in patients with obesity on dyspnea and to analyze the relationships between improvement of dyspnea after bariatric surgery and changes in pulmonary function, especially Expiratory Reserve Volume (ERV) which is the lung volume abnormality most frequently associated with obesity.Forty-five patients (5 males/40 females, mean Body Mass Index = 46.2 ± 6.8 kg/m2) were evaluated before and 6 to 12 months after bariatric surgery. Dyspnea was assessed by the modified Medical Research Council (mMRC) scale. Pulmonary function tests, arterial blood gases and six-minute walk test were performed. Laboratory parameters including C-Reactive Protein (CRP) were analyzed.Ninety percent of patients were dyspneic before surgery (mMRC scale ≥ 1) versus 59% after surgery (p<0.001). Mean mMRC score improved after bariatric surgery (1.5 ± 0.9 vs 0.7 ± 0.7, p<0.0001). Among patients with dyspnea before surgery (n = 38), a more marked increase in ERV after surgery was observed in patients with improvement of dyspnea compared to patients with no improvement of dyspnea (+0.17 ± 0.32 L vs +0.49 ± 0.35 L, p = 0.01). Multivariate analysis including age, variation of BMI, variation of CRP, variation of Total Lung Capacity and variation of ERV demonstraded that ERV was the only variable associated with improvement of the mMRc score after bariatric surgery (p = 0.04).Weight loss associated with bariatric surgery improves dyspnea in daily living. This improvement could be partly related to increased ERV.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2017-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Increased iron sequestration in alveolar macrophages in chronic obstructive pulmonary disease.

    Quentin Philippot / Gaëtan Deslée / Tracy L Adair-Kirk / Jason C Woods / Derek Byers / Susan Conradi / Sandra Dury / Jeanne Marie Perotin / François Lebargy / Christelle Cassan / Richard Le Naour / Michael J Holtzman / Richard A Pierce

    PLoS ONE, Vol 9, Iss 5, p e

    2014  Band 96285

    Abstract: Free iron in lung can cause the generation of reactive oxygen species, an important factor in chronic obstructive pulmonary disease (COPD) pathogenesis. Iron accumulation has been implicated in oxidative stress in other diseases, such as Alzheimer's and ... ...

    Abstract Free iron in lung can cause the generation of reactive oxygen species, an important factor in chronic obstructive pulmonary disease (COPD) pathogenesis. Iron accumulation has been implicated in oxidative stress in other diseases, such as Alzheimer's and Parkinson's diseases, but little is known about iron accumulation in COPD. We sought to determine if iron content and the expression of iron transport and/or storage genes in lung differ between controls and COPD subjects, and whether changes in these correlate with airway obstruction. Explanted lung tissue was obtained from transplant donors, GOLD 2-3 COPD subjects, and GOLD 4 lung transplant recipients, and bronchoalveolar lavage (BAL) cells were obtained from non-smokers, healthy smokers, and GOLD 1-3 COPD subjects. Iron-positive cells were quantified histologically, and the expression of iron uptake (transferrin and transferrin receptor), storage (ferritin) and export (ferroportin) genes was examined by real-time RT-PCR assay. Percentage of iron-positive cells and expression levels of iron metabolism genes were examined for correlations with airflow limitation indices (forced expiratory volume in the first second (FEV1) and the ratio between FEV1 and forced vital capacity (FEV1/FVC)). The alveolar macrophage was identified as the predominant iron-positive cell type in lung tissues. Furthermore, the quantity of iron deposit and the percentage of iron positive macrophages were increased with COPD and emphysema severity. The mRNA expression of iron uptake and storage genes transferrin and ferritin were significantly increased in GOLD 4 COPD lungs compared to donors (6.9 and 3.22 fold increase, respectively). In BAL cells, the mRNA expression of transferrin, transferrin receptor and ferritin correlated with airway obstruction. These results support activation of an iron sequestration mechanism by alveolar macrophages in COPD, which we postulate is a protective mechanism against iron induced oxidative stress.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2014-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Diagnosis and management of idiopathic pulmonary fibrosis

    Bruno Crestani / Dominique Valeyre / Benoit Wallaert / Jacques Cadranel / Jean-Charles Dalphin / Philippe Delaval / Dominique Israel-Biet / Romain Kessler / Martine Reynaud-Gaubert / Bernard Aguilaniu / Benoit Bouquillon / Philippe Carré / Claire Danel / Jean-Baptiste Faivre / Gilbert Ferretti / Nicolas Just / Serge Kouzan / François Lebargy / Sylvain Marchand-Adam /
    Bruno Philippe / Grégoire Prévot / Bruno Stach / Françoise Thivolet-Béjui / Jean-François Cordier

    European Respiratory Review, Vol 23, Iss 132, Pp 193-

    French practical guidelines

    2014  Band 214

    Abstract: Idiopathic pulmonary fibrosis (IPF) is the most frequent chronic idiopathic interstitial pneumonia in adults. The management of rare diseases in France has been organised by a national plan for rare diseases, which endorsed a network of expert centres ... ...

    Abstract Idiopathic pulmonary fibrosis (IPF) is the most frequent chronic idiopathic interstitial pneumonia in adults. The management of rare diseases in France has been organised by a national plan for rare diseases, which endorsed a network of expert centres for rare diseases throughout France. This article is an overview of the executive summary of the French guidelines for the management of IPF, an initiative that emanated from the French National Reference Centre and the Network of Regional Competence Centres for Rare Lung Diseases. This review aims at providing pulmonologists with a document that: 1) combines the current available evidence; 2) reviews practical modalities of diagnosis and management of IPF; and 3) is adapted to everyday medical practice. The French practical guidelines result from the combined efforts of a coordination committee, a writing committee and a multidisciplinary review panel, following recommendations from the Haute Autorité de Santé. All recommendations included in this article received at least 90% agreement by the reviewing panel. Herein, we summarise the main conclusions and practical recommendations of the French guidelines.
    Schlagwörter Diseases of the respiratory system ; RC705-779 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Thema/Rubrik (Code) 028
    Sprache Englisch
    Erscheinungsdatum 2014-06-01T00:00:00Z
    Verlag European Respiratory Society
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Long-term safety of pirfenidone

    Vincent Cottin / Dirk Koschel / Andreas Günther / Carlo Albera / Arata Azuma / C. Magnus Sköld / Sara Tomassetti / Philip Hormel / John L. Stauffer / Indiana Strombom / Klaus-Uwe Kirchgaessler / Toby M. Maher / PASSPORT study group / Peter Cerkl / Holger Flick / Christian Geltner / Judith Löffler-Ragg / Michael Studnicka / Elisabeth Bendstrup /
    Helle Dall Madsen / Saher B. Shaker / Maritta Kilpelainen / Marjukka Myllaerniemi / Minna Purokivi / Seppo Saarelainen / Emmanuel Bergot / Philippe Bonniaud / Raphael Borie / Pascal Chanez / Francis Couturaud / Claire Dromer / Frederic Gagnadoux / Anne-Sophie Gamez / Anne Gondouin / Dominique Israel-Biet / Stephane Jouneau / Romain Kessler / Francois Lebargy / Sylvain Marchand-Adam / Borsi Melloni / Jean-Marc Naccache / Christophe Pison / Gregoire Prevot / Martine Reynaud-Gaubert / Abdellatif Tazi / Dominique Valeyre / Benoit Wallaert / Jost Achenbach / Stefan Andreas

    ERJ Open Research, Vol 4, Iss

    results of the prospective, observational PASSPORT study

    2018  Band 4

    Abstract: Real-world studies include a broader patient population for a longer duration than randomised controlled trials (RCTs) and can provide relevant insights for clinical practice. PASSPORT was a multicentre, prospective, post-authorisation study of patients ... ...

    Abstract Real-world studies include a broader patient population for a longer duration than randomised controlled trials (RCTs) and can provide relevant insights for clinical practice. PASSPORT was a multicentre, prospective, post-authorisation study of patients who were newly prescribed pirfenidone and followed for 2 years after initiating treatment. Physicians collected data on adverse drug reactions (ADRs), serious ADRs (SADRs) and ADRs of special interest (ADRSI) at baseline and then every 3 months. Post hoc stepwise logistic regression models were used to identify baseline characteristics associated with discontinuing treatment due to an ADR. Patients (n=1009, 99.7% with idiopathic pulmonary fibrosis) had a median pirfenidone exposure of 442.0 days. Overall, 741 (73.4%) patients experienced ADRs, most commonly nausea (20.6%) and fatigue (18.5%). ADRs led to treatment discontinuation in 290 (28.7%) patients after a median of 99.5 days. Overall, 55 (5.5%) patients experienced SADRs, with a fatal outcome in six patients. ADRSI were reported in 693 patients, most commonly gastrointestinal symptoms (38.3%) and photosensitivity reactions/skin rashes (29.0%). Older age and female sex were associated with early treatment discontinuation due to an ADR. Findings were consistent with the known safety profile of pirfenidone, based on RCT data and other post-marketing experience, with no new safety signals observed.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2018-10-01T00:00:00Z
    Verlag European Respiratory Society
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