Article ; Online: High connectivity between reduced cortical thickness and disrupted white matter tracts in long-standing type 1 diabetes.
2010 Volume 60, Issue 1, Page(s) 315–319
Abstract: Objective: Previous studies have observed disruptions in brain white and gray matter structure in individuals with type 1 diabetes, and these structural differences have been associated with neurocognitive testing deficiencies. This study investigated ... ...
Abstract | Objective: Previous studies have observed disruptions in brain white and gray matter structure in individuals with type 1 diabetes, and these structural differences have been associated with neurocognitive testing deficiencies. This study investigated the relationship between cerebral cortical thickness reductions and white matter microstructural integrity loss in a group of patients with type 1 diabetes and in healthy control subjects using diffusion tensor imaging (DTI). Research design and methods: Twenty-five subjects with type 1 diabetes for at least 15 years and 25 age- and sex-matched control subjects underwent structural T1 and proton-density and DTI on a 3.0 Tesla scanner. Fractional anisotropy measurements were made on major cerebral white matter tracts, and DTI tractography was performed to identify cortical regions with high connectivity to these tracts. Results: Posterior white matter tracts with reduced fractional anisotropy (optic radiations, posterior corona radiata, and the splenium region of the corpus callosum) were found to have high connectivity with a number of posterior cortical regions, including the cuneus, precuneus, fusiform, and posterior parietal cortical regions. A significant reduction in cortical thickness in the diabetic group was observed in the regions with high connectivity to the optic radiations and posterior corona radiata tracts (P < 0.05). Conclusions: The direct relationship between white and gray matter structural pathology has not been previously demonstrated in subjects with long-standing type 1 diabetes. The relationship between posterior white matter microstructural integrity disruption and lower cortical thickness demonstrated using a novel DTI connectivity technique suggests a common or interrelated pathophysiological mechanism in type 1 diabetes. |
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MeSH term(s) | Adult ; Cerebral Cortex/anatomy & histology ; Cerebral Cortex/pathology ; Cognition Disorders/etiology ; Cognition Disorders/pathology ; Corpus Callosum/anatomy & histology ; Corpus Callosum/pathology ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/pathology ; Diabetes Mellitus, Type 1/psychology ; Diffusion Tensor Imaging/methods ; Female ; Humans ; Male ; Middle Aged ; Nerve Fibers/pathology |
Language | English |
Publishing date | 2010-10-27 |
Publishing country | United States |
Document type | Journal Article ; Research Support, N.I.H., Extramural |
ZDB-ID | 80085-5 |
ISSN | 1939-327X ; 0012-1797 |
ISSN (online) | 1939-327X |
ISSN | 0012-1797 |
DOI | 10.2337/db10-0598 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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