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  1. AU="Francesco Lazzerini"
  2. AU="Alain Putot"
  3. AU="Moustakim, Hamza"
  4. AU="Lavoie, Julie"
  5. AU="Wahlen, Bianca M"
  6. AU="Iqra Rasheed, -"
  7. AU="Rincon-Arevalo, Hector"
  8. AU="Kirsch, L"
  9. AU="Yurong Qiao"
  10. AU="Shapera, Shane"
  11. AU="O'Connor, Richard J"
  12. AU="Li, Zhixing"
  13. AU="Fender, Christian"
  14. AU="Frangou, Nikoletta"
  15. AU="Chan, Curtis"
  16. AU="Yang, Shilun"
  17. AU="Viswanathan, Thiruselvam"
  18. AU="Rexach, Irene"
  19. AU="CUI Yongchun"

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  1. Artikel ; Online: Does the Remote Microphone Still Outperform the Pre-Processing Algorithms? A Group Study in Adult Nucleus Recipients

    Francesco Lazzerini / Luca Baldassari / Adriana Angileri / Luca Bruschini / Stefano Berrettini / Francesca Forli

    Journal of Otorhinolaryngology, Hearing and Balance Medicine, Vol 4, Iss 2, p

    2023  Band 9

    Abstract: Despite the evolution of hearing aids and cochlear implants, noisy environments are reportedly still an important hurdle for persons with hearing loss, especially in the process of speech recognition. The development of pre-processing algorithms and the ... ...

    Abstract Despite the evolution of hearing aids and cochlear implants, noisy environments are reportedly still an important hurdle for persons with hearing loss, especially in the process of speech recognition. The development of pre-processing algorithms and the pairing with a wireless device can bring relief to this situation, but it is still under scrutiny whether one or the other is more effective. The purpose of this study was to compare the benefits of speech recognition in a noisy environment by recipients of cochlear implants when using the pre-processing automatic algorithms or when using a wireless microphone. Twenty-nine participants were selected, aged 14 to 83, suffering from sensorineural hearing loss and recipients of cochlear implants for at least 6 months. The proprietary Cochlear Limited SCAN technology uses pre-processing algorithms to attenuate various noises; the wireless device MiniMic2 uses a 2.4 GHz connection to facilitate communications between the recipient and the signal source. Participants were asked to repeat 20 sentences randomly generated by the adaptive Italian Matrix Sentence Test, first while using the SCAN technology and then with the wireless MiniMic2. Both signal and noise were administered through a single loudspeaker set 1 m away from the subject. Significantly better results in speech recognition of noise were achieved with the wireless MiniMic2 when compared to the SCAN technology.
    Schlagwörter cochlear implant ; remote microphone ; wireless ; pre-processing ; algorithm ; Internal medicine ; RC31-1245
    Thema/Rubrik (Code) 600
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: The Role of the Functional Head Impulse Test with and without Optokinetic Stimuli in Vestibular Migraine and Acute Unilateral Vestibulopathy

    Augusto Pietro Casani / Francesco Lazzerini / Ottavia Marconi / Nicola Vernassa

    Journal of Clinical Medicine, Vol 10, Iss 3787, p

    Discovering a Dynamic Visual Dependence

    2021  Band 3787

    Abstract: 1) Background: Visually induced vertigo (i.e., vertigo provoked by moving visual scenes) can be considered a noticeable feature of vestibular migraines (VM) and can be present in patients suffering from acute unilateral vestibulopathy (AUV). ... ...

    Abstract (1) Background: Visually induced vertigo (i.e., vertigo provoked by moving visual scenes) can be considered a noticeable feature of vestibular migraines (VM) and can be present in patients suffering from acute unilateral vestibulopathy (AUV). Hypersensitivity to moving or conflicting visual stimulation is named visual dependence. (2) Methods: Visuo-vestibular interactions were analyzed via the functional Head Impulse Test (fHIT) with and without optokinetic stimulation (o-fHIT) in 25 patients with VM, in 20 subjects affected by AUV, and in 20 healthy subjects. We calculated the percentage of correct answers () without and with the addition of the optokinetic background (OB). (3) In VM groups, the on the fHIT was 92.07% without OB and 73.66% with OB. A significant difference was found between on the deficit side and that on the normal side in AUV, both without OB and with OB. (4) Conclusions: The fHIT results in terms of with and without OB could be useful to identify the presence of a dynamic visual dependence, especially in patients suffering from VM. The difference in with and without OB could provide instrumental support to help correctly identify subjects suffering from VM. We propose the use of the fHIT in clinical practice whenever there is a need to highlight a condition of dynamic visual dependence.
    Schlagwörter vestibular migraine ; acute unilateral vestibulopathy ; vertigo ; visual dependence ; visuo-vestibular interactions ; functional head impulse test ; Medicine ; R
    Thema/Rubrik (Code) 150
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Lichen planus of the external auditory canal

    Francesco Lazzerini / Luca Bruschini / Stefano Berrettini / Andrea De Vito / Francesca Forli

    Clinical Case Reports, Vol 8, Iss 10, Pp 2017-

    Treatment options and review of literature

    2020  Band 2020

    Abstract: Abstract Medical topic therapies can relieve symptoms associated with lichen planus of external auditory canal. Further, bone‐anchored hearing devices represent an optimal solution for hearing restoration in otic lichen planus. ...

    Abstract Abstract Medical topic therapies can relieve symptoms associated with lichen planus of external auditory canal. Further, bone‐anchored hearing devices represent an optimal solution for hearing restoration in otic lichen planus.
    Schlagwörter bone‐anchored hearing device ; dermatology ; ear ; external auditory canal stenosis ; lichen planus ; nose and throat ; Medicine ; R ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Titanium Biohybrid Middle Ear Prostheses

    Mario Mosconi / Elena Carlotto / Laura Caliogna / Micaela Berni / Giulia Gastaldi / Michele Conti / Alice Maria Brancato / Valentina Bina / Domenico Minervini / Stefano Malpede / Anna Chiara Stellato / Francesco Lazzerini / Luca Bruschini / Marco Benazzo / Pietro Canzi

    Journal of Functional Biomaterials, Vol 14, Iss 12, p

    A Preliminary In Vitro Study

    2023  Band 561

    Abstract: Ossiculoplasty is a surgical operation performed to restore auditory transmission through the reconstruction of the ossicular chain using prosthetics. Tissue bioengineering has assumed a pivotal role in implementing alternatives to conventional ossicular ...

    Abstract Ossiculoplasty is a surgical operation performed to restore auditory transmission through the reconstruction of the ossicular chain using prosthetics. Tissue bioengineering has assumed a pivotal role in implementing alternatives to conventional ossicular middle ear replacement prostheses, to overcome extrusion while preserving acoustic properties. This in vitro study aims to explore, for the first time in current literature, the feasibility of a biohybrid middle ear prosthesis, composed of titanium surrounded by a bone extracellular matrix as bio-coating. We have hereby studied the adhesion and proliferation of human adipose-derived mesenchymal stem cells (hASC) on titanium scaffolds in vitro . Moreover, we identified the osteogenic differentiation of hASC using an immunofluorescence assay to analyze osteoblasts’ gene expression profiles (Alp, Runx2, Col1a1, Osx, and Bglap), and we counted the presence of collagen as a marker of hASC’s ability to secrete an extracellular matrix. We utilized scanning electron microscopy to evaluate the presence of an extracellular matrix on the scaffolds. Our preliminary data demonstrated the titanium’s ability to support human adipose-derived mesenchymal stem cell colonization, proliferation, and osteoblastic differentiation, in order to obtain a biohybrid device. Our experience seems encouraging; thus, we advocate for further in vivo research to corroborate our results regarding bone transplantation.
    Schlagwörter middle ear ; ossicular replacement prosthesis ; titanium ; bone transplantation ; tissue engineering ; hearing loss ; Biotechnology ; TP248.13-248.65 ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Effects of a short period of postural training on postural stability and vestibulospinal reflexes.

    Claudia Grasso / Massimo Barresi / Maria Paola Tramonti Fantozzi / Francesco Lazzerini / Luca Bruschini / Stefano Berrettini / Paolo Andre / Cristina Dolciotti / Vincenzo De Cicco / Davide De Cicco / Paola d'Ascanio / Paolo Orsini / Francesco Montanari / Ugo Faraguna / Diego Manzoni

    PLoS ONE, Vol 18, Iss 6, p e

    2023  Band 0287123

    Abstract: The effects of postural training on postural stability and vestibulospinal reflexes (VSRs) were investigated in normal subjects. A period (23 minutes) of repeated episodes (n = 10, 50 seconds) of unipedal stance elicited a progressive reduction of the ... ...

    Abstract The effects of postural training on postural stability and vestibulospinal reflexes (VSRs) were investigated in normal subjects. A period (23 minutes) of repeated episodes (n = 10, 50 seconds) of unipedal stance elicited a progressive reduction of the area covered by centre of pressure (CoP) displacement, of average CoP displacement along the X and Y axes and of CoP velocity observed in this challenging postural task. All these changes were correlated to each other with the only exception of those in X and Y CoP displacement. Moreover, they were larger in the subjects showing higher initial instability in unipedal stance, suggesting that they were triggered by the modulation of sensory afferents signalling body sway. No changes in bipedal stance occurred soon and 1 hour after this period of postural training, while a reduction of CoP displacement was apparent after 24 hours, possibly due to a beneficial effect of overnight sleep on postural learning. The same period of postural training also reduced the CoP displacement elicited by electrical vestibular stimulation (EVS) along the X axis up to 24 hours following the training end. No significant changes in postural parameters of bipedal stance and VSRs could be observed in control experiments where subjects were tested at identical time points without performing the postural training. Therefore, postural training led to a stricter control of CoP displacement, possibly acting through the cerebellum by enhancing feedforward mechanisms of postural stability and by depressing the VSR, the most important reflex mechanism involved in balance maintenance under challenging conditions.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 796
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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