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  1. Article ; Online: Relationship between Muscle Mass, Bone Density and Vascular Calcifications in Elderly People with SARS-CoV-2 Pneumonia

    Rossella Del Toro / Francesco Palmese / Francesco Feletti / Gianluca Zani / Maria Teresa Minguzzi / Ernesto Maddaloni / Nicola Napoli / Giorgio Bedogni / Marco Domenicali

    Journal of Clinical Medicine, Vol 12, Iss 2372, p

    2023  Volume 2372

    Abstract: Background: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. Methods: In 80 consecutive elderly patients with SARS-CoV-2 infection, we evaluated the ... ...

    Abstract Background: Little is known about the changes in organs and tissues that may make elder patients more vulnerable to acute stressors such as SARS-CoV-2 infection. Methods: In 80 consecutive elderly patients with SARS-CoV-2 infection, we evaluated the association between the descending thoracic aorta calcium score, L1 bone density and T12 skeletal muscle density measured on the same scan by high-resolution computed tomography. Results: At median regression, the ln-transformed DTA calcium score was inversely associated with L1 bone density (−0.02, 95%CI −0.04 to −0.01 ln-Agatston units for an increase of 1 HU) and with T12 muscle density (−0.03, −0.06 to −0.001 ln-Agatston units for an increase of 1 HU). At penalized logistic regression, an increase of 1 ln-Agatston unit of DTA calcium score was associated with an OR of death of 1.480 (1.022 to 2.145), one of 1 HU of bone density with an OR of 0.981 (0.966 to 0.996) and one of 1 HU of muscle density with an OR of 0.973 (0.948 to 0.999). These relationships disappeared after correction for age and age was the stronger predictor of body composition and death. Conclusions: Age has a big effect on the relationship between vascular calcifications, L1 bone density and T12 muscle density and on their relationship with the odds of dying.
    Keywords frailty ; SARS-CoV-2 ; muscle mass ; bone density ; vascular calcifications ; mortality ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Resolution of pulmonary artery thrombosis in patients with moderate COVID-19 disease

    Grazia Zanframundo / Alessandro Graziani / Barbara Caroli / Francesco Palmese / Cristian Bertoldi / Pierluigi Cataleta / Maria Teresa Minguzzi / Ludovico Graziani / Marco Domenicali

    Journal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 4, Pp 470-

    2021  Volume 472

    Abstract: Novel Coronavirus disease (COVID-19) has been widely described as the cause for a proinflammatory and hypercoagulable state. The inflammatory process involving the alveolar vascular endothelium in the respiratory system, is a determining factor for the ... ...

    Abstract Novel Coronavirus disease (COVID-19) has been widely described as the cause for a proinflammatory and hypercoagulable state. The inflammatory process involving the alveolar vascular endothelium in the respiratory system, is a determining factor for the onset of primary Pulmonary Artery Thrombosis (PAT) even in patients with heparin prophylactic treatment. Little is known about the efficacy of the anticoagulant therapy during the course of PAT caused by COVID-19. In this paper we describe the results obtained in patients with moderate COVID-19 disease, previously threated with prophylactic enoxaparin, who then received full Anticoagulant treatment after diagnosis of PAT. After three months Computed Tomography Pulmonary Angiography demonstrated a complete resolution of the vascular obstructive lesions in all patients, while all the coagulation tests were normal.
    Keywords Internal medicine ; RC31-1245
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Resolution of pulmonary artery thrombosis in patients with moderate COVID-19 disease.

    Zanframundo, Grazia / Graziani, Alessandro / Barbara, Caroli / Francesco, Palmese / Teresa, Minguzzi Maria / Cristian, Cataleta / Pierluigi, Graziani / Ludovico, Domenicali

    Journal of community hospital internal medicine perspectives

    2021  Volume 11, Issue 4, Page(s) 470–472

    Abstract: Novel Coronavirus disease (COVID-19) has been widely described as the cause for a proinflammatory and hypercoagulable state. The inflammatory process involving the alveolar vascular endothelium in the respiratory system, is a determining factor for the ... ...

    Abstract Novel Coronavirus disease (COVID-19) has been widely described as the cause for a proinflammatory and hypercoagulable state. The inflammatory process involving the alveolar vascular endothelium in the respiratory system, is a determining factor for the onset of primary Pulmonary Artery Thrombosis (PAT) even in patients with heparin prophylactic treatment. Little is known about the efficacy of the anticoagulant therapy during the course of PAT caused by COVID-19. In this paper we describe the results obtained in patients with moderate COVID-19 disease, previously threated with prophylactic enoxaparin, who then received full Anticoagulant treatment after diagnosis of PAT. After three months Computed Tomography Pulmonary Angiography demonstrated a complete resolution of the vascular obstructive lesions in all patients, while all the coagulation tests were normal.
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2616884-4
    ISSN 2000-9666
    ISSN 2000-9666
    DOI 10.1080/20009666.2021.1921908
    Database MEDical Literature Analysis and Retrieval System OnLINE

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