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Article ; Online: Determination of Binding Strengths of Host-Guest Complexes in Deep Eutectic Solvents Using Spin Probe Methodology.

Cantelli, Andrea / Franchi, Paola / Mezzina, Elisabetta / Lucarini, Marco

Chemphyschem : a European journal of chemical physics and physical chemistry

2021 Volume 22, Issue 6, Page(s) 517–521

Abstract: Electron paramagnetic resonance (EPR) and spin probe methodologies have been employed to study the complexation properties of cyclodextrins (CDs) and cucurbit[n]urils (CB[n]s) in the deep eutectic solvent (DES) choline chloride-urea. In the presence of γ- ...

Abstract	Electron paramagnetic resonance (EPR) and spin probe methodologies have been employed to study the complexation properties of cyclodextrins (CDs) and cucurbit[n]urils (CB[n]s) in the deep eutectic solvent (DES) choline chloride-urea. In the presence of γ-CD an affinity constant very similar to that measured in water was measured in DES with benzyl-tert-butyl nitroxide (BTBN). With β-CD, complexation of BTBN is significantly depressed, although still maintained. Complexation of TEMPO radical probe by CB[7] or CB[8] was instead almost entirely cancelled in DES. In addition, this methodology enabled for the first time to measure the single rate constants for the association and dissociation processes with CDs in DES.
Language	English
Publishing date	2021-02-11
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2025223-7
ISSN	1439-7641 ; 1439-4235
ISSN (online)	1439-7641
ISSN	1439-4235
DOI	10.1002/cphc.202001007
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Article ; Online: EPR Sensing of a Cation Species by Aza-Crown Ethers Incorporating a Persistent Nitroxidic Radical Unit.

Poderi, Cecilia / Neira, Iago / Franchi, Paola / Mezzina, Elisabetta / Baù, Ilario / Neviani, Paolo / Lucarini, Marco

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 29, Issue 55, Page(s) e202301508

Abstract: New nitroxides based on aza-crown ethers were prepared and employed as selective sensors for the detection of inorganic and organic cations by EPR analysis of the corresponding host-guest complexes. The nitroxide unit behaves as a sensitive probe for a ... ...

Abstract	New nitroxides based on aza-crown ethers were prepared and employed as selective sensors for the detection of inorganic and organic cations by EPR analysis of the corresponding host-guest complexes. The nitroxide unit behaves as a sensitive probe for a number of alkali and alkaline earth metal cations affording EPR spectra differing in the value of nitrogen hyperfine constants and in the appearance of splitted signals due to the non-zero nuclear spin of some metal cation upon complexation. Owing to the remarkable EPR spectral differences between the host and the corresponding cation complex the new macrocycles are likely to act as multitasking tools to recognize several cationic species. EPR behaviour of the larger nitroxide azacrown 1⋅ when acting as a wheel in a radical synthetic bistable [2]rotaxane containing both secondary dialkylammonium and 1,2-bis(pyridinium) molecular stations, was also investigated. Reversible movements of the macrocycle between the two recognition sites in the rotaxane were promptly revealed by EPR, which shows significant changes either in nitrogen coupling constant values (a
Language	English
Publishing date	2023-08-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202301508
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Article ; Online: A 343 Italian cohort of patients analysed with array-comparative genomic hybridization: unsolved problems and genetic counselling difficulties.

Palka Bayard de Volo, C / Alfonsi, M / Morizio, E / Guaciali-Franchi, P / Mohn, A / Chiarelli, F

Journal of intellectual disability research : JIDR

2021 Volume 65, Issue 9, Page(s) 863–869

Abstract: Background: The recent introduction of microarrays for genetic analyses has allowed higher etiological diagnostic rates in patient with intellectual disability (ID), autism spectrum disorders (ASD), epilepsy and multiple congenital anomalies (MCA), ... ...

Abstract	Background: The recent introduction of microarrays for genetic analyses has allowed higher etiological diagnostic rates in patient with intellectual disability (ID), autism spectrum disorders (ASD), epilepsy and multiple congenital anomalies (MCA), because of its resolution. This approach still results of high complexity and some limitations have been reported. In fact, it discloses several variants of unknown significance (VOUS) or incidental findings. In all cases, a massive amount of data is generated, because of this, the analysis and the interpretation is very difficult and often without a definitive conclusion. Method: We analysed an Italian cohort of 343 patients with ID, MCA and ASD by array-comparative genomic hybridization. The purpose of this work was to consider the proportion of the chromosomal abnormalities in such cohort and to assess the distribution of the different type of the chromosomal abnormalities concerning their pathogenic significance, their origin and their correlation to these clinical phenotypes. Results: Array-comparative genomic hybridization analysis revealed 76 positive results. Abnormalities were detected in 27.8% of patients with ID, 11.1% with ASD, 10.7% with epilepsy and 19.4% with multiple congenital anomalies. The anomalies were classified in three major groups: group 1 (27 patients) with pathogenic alterations (P group); group 2 (34 patients) with VOUS potentially pathogenic (PP group); and group 3 (13 patients) with VOUS potentially benign (PB group). As expected, comparing the diagnostic groups, we observed a greater number of deletions in the P group and that all the abnormalities of the PB group were inherited. Conclusions: Our retrospective study resulted in confirming the high detection rate of microarrays. CNV classification remains a complex procedure. The difficulty in CNV classification points out the importance of the patient selection, helping the interpretation of the molecular cytogenetic results.
MeSH term(s)	Chromosome Aberrations ; Comparative Genomic Hybridization ; Genetic Counseling ; Humans ; Intellectual Disability/epidemiology ; Intellectual Disability/genetics ; Retrospective Studies
Language	English
Publishing date	2021-08-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1103832-9
ISSN	1365-2788 ; 0964-2633
ISSN (online)	1365-2788
ISSN	0964-2633
DOI	10.1111/jir.12867
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Article: First case of two supernumerary markers derived from chromosome 5 and chromosome 8.

Giansante, Roberta / Palka Bayard De Volo, Chiara / Alfonsi, Melissa / Morizio, Elisena / Guanciali Franchi, Paolo

Molecular cytogenetics

2022 Volume 15, Issue 1, Page(s) 26

Abstract: Background: Small supernumerary marker chromosomes (sSMC) are additional centric chromosome fragments too small to be identified by banding cytogenetics alone. A sSMC can originate from any chromosome and it is estimated that 70% of sSMC are de novo, ... ...

Abstract	Background: Small supernumerary marker chromosomes (sSMC) are additional centric chromosome fragments too small to be identified by banding cytogenetics alone. A sSMC can originate from any chromosome and it is estimated that 70% of sSMC are de novo, while 30% are inherited. Cases of sSMC derived from chromosome 5 (sSMC5) are rare, accounting for1.4% of all reported sSMC cases. In these patients, the most common reported features are macrocephaly, dysmorphic facial features, heart defects, growth retardation, hypotonia, and intellectual disability. Also sSMC derived from chromosome 8 are very rare and the phenotype of patients with sSMC8 is very variable. Common clinical features of the patients include developmental delay, mental retardation, intellectual disability, hypotonia, hypospadias, attention deficit hyperactivity disorders (ADHD), skeletal anomalies, dysmorphic facial features, and renal dysplasia. To the best of our knowledge, in literature there are no cases with coexistence of sSMC5 and sSMC8, so we reviewed the literature to compare cases with SMC5 and those with SMC8 separately. This study is aimed to highlight the unique findings of a patient with the coexistence of sSMC5 and sSMC8. Case presentation: We describe a female patient with two supernumerary markers derived from chromosome 5 (SMC5) and chromosome 8 (SMC8). The patient was born prematurely at 30 weeks with respiratory distress and bronchodysplasia. On physical examination she presented dysmorphic features, respiratory issues, congenital heart defect, developmental delay, and intellectual disability. The G-banded chromosome analysis on cultured lymphocytes revealed in all the analyzed cells a female karyotype with the presence of two supernumerary chromosomal markers and the array-CGH highlighted the region and the size of these two duplications. We also used the fluorescent in situ hybridization analysis (FISH) using painting of chromosomes 5 and 8 to confirm the origin of the two sSMC. So, the karyotype of the patient was: 48, XX, +mar1, +mar2. Conclusions: This is the first case with two markers: one from chromosome 5 and one from chromosome 8. Based on the data reported, we can affirm that the phenotype of our patient is probably caused mainly by the presence of the sSMC.
Language	English
Publishing date	2022-06-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2420849-8
ISSN	1755-8166
ISSN	1755-8166
DOI	10.1186/s13039-022-00601-5
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Article ; Online: "Reversible cytotoxic lesion of the corpus callosum following SARS-CoV-2 mRNA vaccine administration: a finding to be aware of".

Procaccini, Luca / Mincuzzi, Erica / Bernardini, Antonio / Franchi, Paola / Voicu, Ioan P / Caulo, Massimo

The neuroradiology journal

2022 Volume 35, Issue 6, Page(s) 758–762

Abstract: Cytotoxic lesions of the corpus callosum (CLOCCs) are a clinical-radiological spectrum of disorders secondary to several etiopathogeneses. Cytotoxic lesions of the corpus callosum are typically associated with mild clinical symptoms including fever, ... ...

Abstract	Cytotoxic lesions of the corpus callosum (CLOCCs) are a clinical-radiological spectrum of disorders secondary to several etiopathogeneses. Cytotoxic lesions of the corpus callosum are typically associated with mild clinical symptoms including fever, headache, confusion, and altered mental status. We present a case of a 51-year-old Caucasian woman who developed a reversible lesion of the splenium of the corpus callosum associated with small round-shaped white matter hyperintensities after the first dose of SARS-CoV-2 mRNA vaccine. Magnetic resonance imaging is fundamental for diagnosis and no treatment is generally required.
MeSH term(s)	Female ; Humans ; Middle Aged ; Corpus Callosum/diagnostic imaging ; Corpus Callosum/pathology ; COVID-19 Vaccines/adverse effects ; SARS-CoV-2 ; COVID-19/prevention & control ; Magnetic Resonance Imaging ; mRNA Vaccines
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-04-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/19714009221096825
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Article: Effects of unburned tobacco smoke on inflammatory and oxidative mediators in the rat prefrontal cortex.

Vivarelli, Fabio / Morosini, Camilla / Rullo, Laura / Losapio, Loredana Maria / Lacorte, Antonio / Sangiorgi, Stefano / Ghini, Severino / Fagiolino, Ivan / Franchi, Paola / Lucarini, Marco / Candeletti, Sanzio / Canistro, Donatella / Romualdi, Patrizia / Paolini, Moreno

Frontiers in pharmacology

2024 Volume 15, Page(s) 1328917

Abstract: Although the Food and Drug Administration has authorized the marketing of "heat-not-burn" (HnB) electronic cigarettes as a modified risk tobacco product (MRTP), toxicological effects of HnB smoke exposure on the brain are still unexplored. Here, ... ...

Abstract	Although the Food and Drug Administration has authorized the marketing of "heat-not-burn" (HnB) electronic cigarettes as a modified risk tobacco product (MRTP), toxicological effects of HnB smoke exposure on the brain are still unexplored. Here, paramagnetic resonance of the prefrontal cortex (PFC) of HnB-exposed rats shows a dramatic increase in reactive radical species (RRS) yield coupled with an inflammatory response mediated by NF-κB-target genes including TNF-α, IL-1β, and IL-6 and the downregulation of peroxisome proliferator-activated receptor (PPAR) alpha and gamma expression. The PFC shows higher levels of 8-hydroxyguanosine, a marker of DNA oxidative damage, along with the activation of antioxidant machinery and DNA repair systems, including xeroderma pigmentosum group C (XPC) protein complex and 8-oxoguanine DNA glycosylase 1. HnB also induces the expression of drug-metabolizing enzymes such as CYP1A1, CYP2A6, CYP2B6, and CYP2E, particularly involved in the biotransformation of nicotine and several carcinogenic agents such as aldehydes and polycyclic aromatic hydrocarbons here recorded in the HnB stick smoke. Taken together, these effects, from disruption of redox homeostasis, inflammation, PPAR manipulation along with enhanced bioactivation of neurotoxicants, and upregulation of cMYC protooncogene to impairment of primary cellular defense mechanisms, suggest a possible increased risk of brain cancer. Although the HnB device reduces the emission of tobacco toxicants, our findings indicate that its consumption may carry a risk of potential adverse health effects, especially in non-smokers so far. Further studies are needed to fully understand the long-term effects of these devices.
Language	English
Publishing date	2024-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2024.1328917
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Article: Spin-labelled mechanically interlocked molecules as models for the interpretation of biradical EPR spectra.

Gualandi, Lorenzo / Franchi, Paola / Mezzina, Elisabetta / Goldup, Stephen M / Lucarini, Marco

Chemical science

2021 Volume 12, Issue 24, Page(s) 8385–8393

Abstract: Biradical spin probes can provide detailed information about the distances between molecules/regions of molecules because the through-space coupling of radical centres, characterised ... ...

Abstract	Biradical spin probes can provide detailed information about the distances between molecules/regions of molecules because the through-space coupling of radical centres, characterised by
Language	English
Publishing date	2021-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d1sc01462e
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Article ; Online: Radiotherapy in combination with nivolumab for relapsed/refractory classical Hodgkin lymphoma: About two cases.

de Forceville, L / Deau-Fischer, B / Franchi, P / Arsène-Henry, A / Cassou Mounat, T / Bouscary, D / Kirova, Y M

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2019 Volume 23, Issue 3, Page(s) 232–239

Abstract: Hodgkin lymphoma is a highly curable malignancy involving lymph nodes and the lymphatic system. Even at late stage disease, about 70% of patients will be cured with standard first line therapy. For patients who experience relapse or refractory classical ... ...

Abstract	Hodgkin lymphoma is a highly curable malignancy involving lymph nodes and the lymphatic system. Even at late stage disease, about 70% of patients will be cured with standard first line therapy. For patients who experience relapse or refractory classical Hodgkin lymphoma, the standard treatment option is high-dose chemotherapy followed by autologous stem cell rescue or transplant. However about 50% of patients will have recurrence after high-dose chemotherapy followed by autologous stem cell rescue or transplantation and have worse prognosis with median overall survival of 32% at 5 years. The anti-PD1 checkpoints inhibitors pembrolizumab and nivolumab have remarkably improved outcomes of patients with relapse of refractory classical Hodgkin lymphoma after high-dose chemotherapy followed by autologous stem cell rescue or transplantation. On the other hand, radiotherapy is an entire component of salvage therapy and its efficacy is now well established in term of local disease control in sites of relapsed or refractory Hodkin lymphoma. Defining the optimal modality and timing of radiotherapy as these new agents arrive is a challenge. An interesting approach is the combination of radiotherapy with checkpoint inhibitor and the possibility of stopping the treatment when complete response is achieved. We add to the literature two new cases of combination of radiotherapy with immunotherapy in patients who relapsed after high-dose chemotherapy followed by autologous stem cell rescue or transplantation and consolidation with brentuximab vedotin, resulting in excellent outcomes.
MeSH term(s)	Adult ; Antineoplastic Agents, Immunological/therapeutic use ; Combined Modality Therapy ; Female ; Hodgkin Disease/drug therapy ; Hodgkin Disease/radiotherapy ; Humans ; Male ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/radiotherapy ; Nivolumab/therapeutic use ; Young Adult
Chemical Substances	Antineoplastic Agents, Immunological ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2019-05-27
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2018.12.005
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Article ; Online: Management of patients with multiple myeloma in the era of COVID-19 pandemic: how hospital at home changes our medical practice.

Fouquet, G / Franchi, P / Mittaine-Marzac, B / Laporte, N / Ihaddadene, H / Decroocq, J / Breal, C / Bouscary, D / Ammar, F / Zogo, A / Burgun, S / Zerbit, J / Willems, L / Deau-Fischer, B / Vignon, M

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

2021 Volume 30, Issue 2, Page(s) 973–975

MeSH term(s)	COVID-19 ; Hospitals ; Humans ; Multiple Myeloma/epidemiology ; Multiple Myeloma/therapy ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-05-31
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1134446-5
ISSN	1433-7339 ; 0941-4355
ISSN (online)	1433-7339
ISSN	0941-4355
DOI	10.1007/s00520-021-06297-4
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Article ; Online: Evolution of radiotherapy techniques for mediastinal Hodgkin lymphoma: a single-center experience.

Loap, Pierre / El Ayachy, Radouane / Beddok, Arnaud / Abbassi, Louisa / Boilève, Alice / Deau Fischer, Bénédicte / Willems, Lise / Franchi, Patricia / Bouscary, Didier / Kirova, Youlia

Mediastinum (Hong Kong, China)

2023 Volume 8, Page(s) 10

Language	English
Publishing date	2023-12-07
Publishing country	China
Document type	Journal Article
ISSN	2522-6711
ISSN (online)	2522-6711
DOI	10.21037/med-23-13
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