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Article ; Online: In the face of the pandemic

Francisco Hidalgo

Alternautas, Vol 8, Iss

The potential of rurality and peasant agriculture

2022 Volume 1

Abstract: At the beginning of July 2020, in Ecuador, as in most of the countries of the region, started loosening emergency lockdown restrictions designed to tackle COVID-19 pandemic. In Ecuador, the governmental discourse drew upon the illustrative figure of ... ...

Abstract	At the beginning of July 2020, in Ecuador, as in most of the countries of the region, started loosening emergency lockdown restrictions designed to tackle COVID-19 pandemic. In Ecuador, the governmental discourse drew upon the illustrative figure of colours in the traffic lights: high-risk zones depicted as red; the colour yellow to denote control over the pandemic and green delineating lower risk zones. Initially, Ecuador was one of the countries with the highest incidence of COVID-19 in Latin America but with the progressive expansion of the pandemic in the region, other countries such as Brazil, Peru and Chile overtook Ecuador in terms of incidences of COVID per 100,000 people, whilst United States became the country where the virus spread the most.
Keywords	Social Sciences ; H
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	University of Warwick
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interlayer angle control of the electronic mini-gaps, band splitting, and hybridization in graphene–WS2 moiré heterostructures

Francisco Hidalgo / Francisco Sánchez-Ochoa / Cecilia Noguez

npj 2D Materials and Applications, Vol 7, Iss 1, Pp 1-

2023 Volume 11

Abstract: Abstract Understanding the electronic properties modulation in graphene/tungsten disulfide (G-WS2) at different interlayer angles is essential for promising building blocks of two-dimensional (2D) heterostructures. G-WS2 heterostructures with four ... ...

Abstract	Abstract Understanding the electronic properties modulation in graphene/tungsten disulfide (G-WS2) at different interlayer angles is essential for promising building blocks of two-dimensional (2D) heterostructures. G-WS2 heterostructures with four different interlayer angles are studied using periodic first-principles calculations and an unfolding method to decipher the supercell crowded-band structure. Electronic mini-gaps of different sizes, band splittings, and band hybridizations are identified because of the interactions between out-of-plane orbitals from both layers. These electronic changes are modulated depending on the interlayer angle in a given energy window and space region. At the same time, the replicas emerging because of the superperiodic potential associated with moiré patterns also modify such electronic alterations, inducing new electronic repulsions or avoided crossings. Therefore, the number of mini-gaps as well as their energy values and positions are intrinsically related to the interlayer angle. Finally, it is anticipated that these results might be essential for designing the electronic properties of 2D heterostructures.
Keywords	Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Chemistry ; QD1-999
Subject code	690
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reformismo social y disputa de hegemonía. Posneoliberalismo y escenarios políticos en Ecuador

Francisco Hidalgo Flor

Ciencia Política, Vol 4, Iss

2009 Volume 8

Abstract: El proceso político y social que se instala en el Ecuador a fines de 2006 constituye una encrucijada para todos los movimientos populares clásicos, porque les plantea varios retos políticos y teóricos, a la vez que también está presente un signo de ... ...

Abstract	El proceso político y social que se instala en el Ecuador a fines de 2006 constituye una encrucijada para todos los movimientos populares clásicos, porque les plantea varios retos políticos y teóricos, a la vez que también está presente un signo de esperanza en el sentido democrático profundo que lo anima. Los viejos caminos recorridos, que permitieron arribar a este punto de quiebre, ya no son suficientemente válidos para los nuevos escenarios que demandan replanteamientos estratégicos en la disputa por la hegemonía en el Ecuador, y un quehacer específico en la coyuntura que se desenvuelve. Los movimientos obrero, indígena, campesino y estudiantil, en gran medida ligados a partidos con tradición de izquierda, fueron decisivos para generar las condiciones de una crisis de hegemonía para el modelo neoliberal, pero no son los que conducen el actual proceso de reformas. La coyuntura que se abre en 2006 toma como lemas: “dejar atrás la larga noche neoliberal”, “acabar con la partidocracia”; y avanzar la “revolución ciudadana”. No es más, ni es menos que eso; es un dato a tener en cuenta para la interpretación política.
Keywords	reformas ; hegemonía ; pos-neoliberalismo ; democracia radical ; socialismo ; Political science ; J ; Political institutions and public administration (General) ; JF20-2112 ; Political science (General) ; JA1-92
Language	English
Publishing date	2009-07-01T00:00:00Z
Publisher	Universidad Nacional de Colombia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reformismo social y disputa de hegemonía. Posneoliberalismo y escenarios políticos en Ecuador

Francisco Hidalgo Flor

Ciencia Política, Vol 4, Iss

2009 Volume 8

Abstract	El proceso político y social que se instala en el Ecuador a fines de 2006 constituye una encrucijada para todos los movimientos populares clásicos, porque les plantea varios retos políticos y teóricos, a la vez que también está presente un signo de esperanza en el sentido democrático profundo que lo anima. Los viejos caminos recorridos, que permitieron arribar a este punto de quiebre, ya no son suficientemente válidos para los nuevos escenarios que demandan replanteamientos estratégicos en la disputa por la hegemonía en el Ecuador, y un quehacer específico en la coyuntura que se desenvuelve. Los movimientos obrero, indígena, campesino y estudiantil, en gran medida ligados a partidos con tradición de izquierda, fueron decisivos para generar las condiciones de una crisis de hegemonía para el modelo neoliberal, pero no son los que conducen el actual proceso de reformas. La coyuntura que se abre en 2006 toma como lemas: “dejar atrás la larga noche neoliberal”, “acabar con la partidocracia”; y avanzar la “revolución ciudadana”. No es más, ni es menos que eso; es un dato a tener en cuenta para la interpretación política.
Keywords	reformas ; hegemonía ; pos-neoliberalismo ; democracia radical ; socialismo ; Political science ; J ; Political institutions and public administration (General) ; JF20-2112 ; Political science (General) ; JA1-92
Language	English
Publishing date	2009-07-01T00:00:00Z
Publisher	Universidad Nacional de Colombia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Inhibidores selectivos de la recaptación de serotonina y riesgo hemorrágico tras ICP. Un estudio con puntuación de propensión

Rafael González-Manzanares / Soledad Ojeda / Francisco Hidalgo / Marina Ruiz-Moreno / Consuelo Fernández-Avilés / Francesco Costa / Guisela Flores-Vergara / Javier Suárez de Lezo / Luz Carmona-Artime / Manuel Pan

REC: Interventional Cardiology, Vol 4, Iss 2, Pp 115-

2022 Volume 122

Abstract: RESUMEN Introducción y objetivos: La cardiopatía isquémica y la enfermedad mental coexisten a menudo. Los inhibidores selectivos de la recaptación de serotonina (ISRS) se utilizan con frecuencia en este contexto, pero se han asociado con un incremento en ...

Abstract	RESUMEN Introducción y objetivos: La cardiopatía isquémica y la enfermedad mental coexisten a menudo. Los inhibidores selectivos de la recaptación de serotonina (ISRS) se utilizan con frecuencia en este contexto, pero se han asociado con un incremento en el riesgo hemorrágico. Los estudios previos han evaluado este fenómeno en pacientes tratados con clopidogrel, con resultados contradictorios. No hay datos sobre el uso de ISRS e inhibidores del P2Y12 potentes o triple terapia antitrombótica. El objetivo de este estudio fue examinar el impacto de los ISRS en los eventos hemorrágicos en pacientes tratados con doble (incluyendo clopidogrel, prasugrel o ticagrelor) o triple terapia antitrombótica tras una intervención coronaria percutánea (ICP). Métodos: Estudio retrospectivo en el que se incluyeron todos los pacientes tratados con ICP en un centro de alto volumen durante 2018. Los pacientes en tratamiento con ISRS fueron emparejados mediante puntaje de propensión con pacientes sin ISRS. El objetivo primario fue el sangrado mayor al año de seguimiento (BARC 3 o 5). Los objetivos secundarios fueron un combinado de sangrado mayor o menor clínicamente relevante (BARC 2, 3 o 5) y un combinado de eventos cardiovasculares adversos mayores. Resultados: De los 1.063 pacientes tratados con ICP durante el periodo del estudio, 1.002 cumplieron los criterios de selección y 139 (13,9%) recibían ISRS. Los pacientes con ISRS tenían un mayor riesgo de sangrado antes del emparejamiento (PRECISE-DAPT: 16 [10-24] frente a 13 [9-21]; p = 0,040). No hubo diferencias en el objetivo primario (2,9% frente a 2,9%; p = 0,991) ni en los objetivos secundarios de sangrado mayor o menor clínicamente relevante (2,9 frente a 7,2%; p = 0,120) y eventos cardiovasculares adversos mayores (7,9 frente a ...
Keywords	Sangrado ; Enfermedad coronaria ; Intervencionismo coronario percutáneo ; Inhibidores selectivos de la recaptación de serotonina ; Terapia antitrombótica ; Internal medicine ; RC31-1245
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: El respeto de los principios laborales y el acceso a la justicia en los procesos de empleo público y seguridad social tramitados ante la jurisdicción contencioso administrativa

Francisco Hidalgo Rueda / Irving Vargas Rodríguez

Revista Espiga, Vol 14, Iss 30, Pp 65-

2015 Volume 74

Abstract: En este artículo se exponen y analizan las implicaciones que ha tenido la declaratoria de inconstitucionalidad del artículo 3.a) del Código Procesal Contencioso Administrativo (Ley Nº 8508 del 28 de abril del 2006, vigente a partir del 1 de enero del ... ...

Abstract	En este artículo se exponen y analizan las implicaciones que ha tenido la declaratoria de inconstitucionalidad del artículo 3.a) del Código Procesal Contencioso Administrativo (Ley Nº 8508 del 28 de abril del 2006, vigente a partir del 1 de enero del 2008, Gaceta N° 120 del 22 de junio del 2006), así como del numeral 402.d) del Código de Trabajo (Ley Nº 2 del 27 de agosto de 1943), mediante los votos de la Sala Constitucional números 9928, de las 15:00 horas del 9 de junio, 11034 de las 14:51 horas, del 23 de junio y 17900, de las 15:00 horas del 27 de octubre, todos del 2010.
Keywords	Empleo público ; acceso a la justicia ; principios laborales ; jurisdicción contenciosoadministrativo ; Social Sciences ; H
Language	Spanish
Publishing date	2015-09-01T00:00:00Z
Publisher	Universidad Estatal a Distancia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Selective serotonin reuptake inhibitors and bleeding risk after PCI. A propensity score matching study

REC: Interventional Cardiology (English Ed.), Vol 4, Iss 2, Pp 115-

2022 Volume 122

Abstract: ABSTRACT Introduction and objectives: Coronary artery disease and mental health disorders are often coexistent. Selective serotonin reuptake inhibitors (SSRIs) are often used in this context but have been associated with an increased risk of bleeding due ...

Abstract	ABSTRACT Introduction and objectives: Coronary artery disease and mental health disorders are often coexistent. Selective serotonin reuptake inhibitors (SSRIs) are often used in this context but have been associated with an increased risk of bleeding due to platelet dysfunction. Previous studies have assessed this risk in patients treated with clopidogrel-based dual antiplatelet therapy (DAPT) with contradictory results. However, there is no data regarding the use of SSRIs and potent P2Y12 inhibitors or triple antithrombotic therapy after percutaneous coronary intervention (PCI). The purpose of this study was to assess the impact of SSRIs on bleeding outcomes after PCI in patients treated with clopidogrel, prasugrel or ticagrelor-based DAPT or triple antithrombotic therapy. Methods: Retrospective study including all patients undergoing PCI at a high-volume center during 2018. Patients on SSRIs were propensity-score-matched on a 1:1 ratio with patients naive to SSRIs adjusting for the baseline differences. The primary endpoint was major bleeding (BARC type 3 or 5 bleeding) at the 1-year follow-up. Secondary endpoints were a composite of major/non-major clinically relevant bleeding (BARC type 2, 3 or 5 bleeding), and a composite of major adverse cardiovascular events. Results: Out of a total of 1063 patients treated with PCI during the study period, 1002 met the selection criteria, and 139 (13.9%) were on SSRIs. The latter had a higher bleeding risk before matching [PRECISE-DAPT, 16 [10-24] vs 13 [9-21]; P = .040]. No differences were reported in major bleeding (2.9% vs 2.9%, P = .991), major/non-major clinically relevant bleeding (2.9% vs 7.2%, P = .120) or in major adverse cardiovascular events (7.9% vs 7.9%, P = .979) in patients treated with SSRIs. Conclusions: The use of SSRIs was frequent in patients treated with PCI, and although it was a marker of a higher bleeding risk at baseline, this was not associated with an additional ...
Keywords	Bleeding ; Coronary artery disease ; Percutaneous coronary intervention ; Selective serotonin reuptake inhibitors ; Antithrombotic therapy ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: COVID-19

Raquel Ferrandis / Juan V. Llau / Manuel Quintana / Pilar Sierra / Francisco Hidalgo / Concepción Cassinello / Aurelio Gómez-Luque

Critical Care, Vol 24, Iss 1, Pp 1-

opening a new paradigm in thromboprophylaxis for critically ill patients?

2020 Volume 3

Keywords	Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; covid19
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Parenteral Cu Supplementation of Late-Gestating and Lactating Iberian Red Deer Hinds Fed a Balanced Diet Reduces Somatic Cell Count and Modifies Mineral Profile of Milk

Martina Pérez Serrano / Andrés José García / Tomás Landete-Castillejos / Jamil Cappelli / José Ángel Gómez / Francisco Hidalgo / Laureano Gallego

Animals, Vol 10, Iss 1, p

2020 Volume 83

Abstract: This study describes the effects that Cu supplementation of late-gestating and lactating females (hinds) of Iberian red deer fed a balanced diet have on milk production, composition, and somatic cell count (SCC). Experimental hinds ( n = 9) were ... ...

Abstract	This study describes the effects that Cu supplementation of late-gestating and lactating females (hinds) of Iberian red deer fed a balanced diet have on milk production, composition, and somatic cell count (SCC). Experimental hinds ( n = 9) were subcutaneously injected every 42 days with Cu (0.83 mg Cu/kg body weight) from day 202 of gestation until the end of lactation (week 18). Control hinds ( n = 8) were injected with a physiological saline solution with the same volume and at the same frequency as the experimental group. Copper supplementation decreased the SCC from 1.64 to 1.36 log 10/mL ( p = 0.003) and modified the milk mineral profile. In particular, milk from hinds supplemented with Cu had more Ca ( p = 0.02), Mg ( p = 0.06), and K ( p = 0.03) than milk from control hinds. However, Cu supplementation did not influence the Cu content of milk. Therefore, it can be concluded that Cu supplementation of hinds fed a balanced diet from late-gestation to the end of lactation could be a good strategy to reduce SCC and modify the mineral profile of milk increasing its Ca content.
Keywords	cu supply ; iberian hinds ; lactation stage ; milk nutrient ; milk production ; offspring growth ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	630
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model

Antonio Ginés García-Saura / Rubén Zapata-Pérez / José Francisco Hidalgo / Álvaro Sánchez-Ferrer

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 12

Abstract: Abstract Poly-ADP-ribose polymerases (PARPs) are involved in the regulation of important cellular processes, such as DNA repair, aging and apoptosis, among others. They have been considered as promising therapeutic targets, since human cancer cells ... ...

Abstract	Abstract Poly-ADP-ribose polymerases (PARPs) are involved in the regulation of important cellular processes, such as DNA repair, aging and apoptosis, among others. They have been considered as promising therapeutic targets, since human cancer cells carrying BRCA1 and BRCA2 mutations are highly sensitive to human PARP-1 inhibitors. Although extensive work has been carried out with the latter enzyme, little is known on bacterial PARPs, of which only one has been demonstrated to be active. To extend this limited knowledge, we demonstrate that the Gram-positive bacterium Clostridioides difficile CD160 PARP is a highly active enzyme with a high production yield. Its phylogenetic analysis also pointed to a singular domain organization in contrast to other clostridiales, which could be due to the long-term divergence of C. difficile CD160. Surprisingly, its PARP becomes the first enzyme to be characterized from this strain, which has a genotype never before described based on its sequenced genome. Finally, the inhibition study carried out after a high-throughput in silico screening and an in vitro testing with hPARP1 and bacterial PARPs identified a different inhibitory profile, a new highly inhibitory compound never before described for hPARP1, and a specificity of bacterial PARPs for a compound that mimics NAD+ (EB-47).
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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