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Article ; Online: γ-amino butyric acid (GABA) level as an overall survival risk factor in breast cancer

Anna Brzozowska / Franciszek Burdan / Dariusz Duma / Janusz Solski / Maria Mazurkiewicz

Annals of Agricultural and Environmental Medicine, Vol 24, Iss 3, Pp 435-

2017 Volume 439

Abstract: Introduction The γ-amino butyric acid (GABA) plays important role in the proliferation and migration of cancer cells. The aim of the study was to evaluate the level of GABA in breast cancer, in relation to clinical and epidemiological data. Material and ... ...

Abstract	Introduction The γ-amino butyric acid (GABA) plays important role in the proliferation and migration of cancer cells. The aim of the study was to evaluate the level of GABA in breast cancer, in relation to clinical and epidemiological data. Material and Methods The study was conducted on 89 patients with breast cancer in stage I-II. GABA level was assessed using spectrofluorometric method in tumour homogenates. Immunoexpression of E-cadherin was evaluated histologically on paraffin fixed specimens. Overall and disease-free survival was assessed for a 15-year interval period. Results Median overall survival was significantly longer (127.2 months) in patients with a high level of GABA (>89.3 μg/1), compared with a group with a low level of the amino acid (106.4 months). Disease-free survival was insignificantly different – 99 and 109 months, respectively. A significantly longer overall survival (131.2 months) was seen among patients with a high level of GABA and positive E-cadherin immunoexpression, compared with a group characterized by a low level of GABA and lack of E-cadherin immunorectivity (98.1 months). The co-existence of negative immunoexpression of E-cadherin and low GABA concentration resulted in a six-fold increase in the risk of death (HR=6.03). Conclusions GABA has a significant prognostic value in breast cancer. Co-existence of a low level of GABA and loss of E-cadherin immune-expression seems to be a new, independent, and negative prognostic marker of the neoplasm.
Keywords	breast cancer ; E-cadherin ; GABA/ γ -amino butyric acid/ ; prognostic factors ; prognosis ; Agriculture ; S ; Environmental sciences ; GE1-350
Subject code	610 ; 616
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	Institute of Rural Health
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The effects of caffeine administered at different temperatures on foetal development

Marek Tomaszewski / Franciszek Burdan / Grazyna Olchowik / Monika Tomaszewska

Annals of Agricultural and Environmental Medicine, Vol 23, Iss 1, Pp 148-

2015 Volume 152

Abstract: An easy access to products containing caffeine makes it widely consumed to excess by the general population, including pregnant women. Beverages containing caffeine are consumed at different temperatures (iced, hot, room temperature). Caffeine easily ... ...

Abstract	An easy access to products containing caffeine makes it widely consumed to excess by the general population, including pregnant women. Beverages containing caffeine are consumed at different temperatures (iced, hot, room temperature). Caffeine easily passes through biological membranes, including the blood-brain barrier, the placental barrier, and can also enter the amniotic fluid, breast milk and semen. The aim of this study was to evaluate the relationship between caffeine’s developmental toxicity, and the solution’s temperature (both low and high) administered to pregnant female rats. Fertilized females were randomly divided into two main groups: an experimental (E) and a control group (C). The experimental groups received caffeine (30mg/day) in 10 (E 1 ), 25 (E 2 ) and 45 o C (E 3 ). The females in the control group were given water at the same temperature (C 1 , C 2 and C 3 ). On the day 21 of pregnancy, the pregnant females were killed by decapitation, using a specially prepared laboratory guillotine, after which the mothers’ internal organs were weighed. Additionally, the offspring were examined using standard teratological methods. The study found that caffeine administered to pregnant females at a dose of 30mg/day and at the temperatures of 10°C, 25°C or 45°C did not produce any teratogenic effects. The only sign of its adverse effect was the appearance of developmental abnormalities in the form of haematomas and saturated bleeding in the internal organs. These changes most frequently occurred in foetuses of females which received caffeine at 10°C or 45°C.
Keywords	caffeine ; pregnancy ; developmental anomalies ; Agriculture ; S ; Environmental sciences ; GE1-350
Subject code	630
Language	English
Publishing date	2015-12-01T00:00:00Z
Publisher	Institute of Rural Health
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The influence of caffeine administered at 10°C on bone tissue development

Marek Tomaszewski / Grażyna Olchowik / Monika Tomaszewska / Wojciech Dworzański / Franciszek Burdan

Annals of Agricultural and Environmental Medicine, Vol 23, Iss 2, Pp 319-

2016 Volume 323

Abstract: Introduction and objective Caffeine is a natural methylxanthine widespread throughout the food industry. Many research studies have shown that caffeine readily crosses the placenta causing teratogenic and embryotoxic effects. The objective of this study ... ...

Abstract	Introduction and objective Caffeine is a natural methylxanthine widespread throughout the food industry. Many research studies have shown that caffeine readily crosses the placenta causing teratogenic and embryotoxic effects. The objective of this study was to assess the influence of caffeine, administered at 10°C, on the development of a rat’s bone tissue, with particular reference to elemental bone composition using an X-ray microprobe. Material and Methods The research was conducted on white rats of the Wistar strain. The fertilized females were divided into two groups: an Experimental Group (Group E) and a Control Group (Group C). The females in Group E were given caffeine orally (at 10°C) in 30 mg/day doses from the 8 th – 21 st day of pregnancy. The females in Group C were given water at the same temperature. The foetuses were used to assess the growth and mineralization of the skeleton. Qualitative analysis of the morphology and mineralization of bones was conducted using the alcian-alizarin method. For calcium and potassium analysis, an X-ray microprobe was used. Results By staining the skeleton using the alcian-alizarin method, changes in 47 Group E foetuses were observed. The frequency of the development variants in the Group E rats was statistically higher, compared with Group C. Conclusions On the basis of these results, it can be concluded that caffeine in high doses disturbs the development of bone tissue. An additional factor which enhances the adverse effects of this substance on bone tissue is the temperature of the administered solution (10°C). In the Experimental Group, a significant decrease in the calcium level, as well as an increase in the potassium level, was observed. The X-ray microprobe can be a perfect complement to the methods which enable determination of the mineralization of osseous tissue.
Keywords	caffeine ; bone tissue ; bone development ; rat ; X-ray microprobe ; temperature 10°C ; Agriculture ; S ; Environmental sciences ; GE1-350
Subject code	630
Language	English
Publishing date	2016-06-01T00:00:00Z
Publisher	Institute of Rural Health
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration Use of X-ray microprobe to diagnose bone tissue demineralization after caffeine administration

Marek Tomaszewski / Grazyna Olchowik / Monika Tomaszewska / Franciszek Burdan

Folia Histochemica et Cytobiologica, Vol 50, Iss 3, Pp 436-

2012 Volume 443

Abstract: Caffeine is a methylxanthine which permeates the placenta. In studies on animals, it has been shown to produce teratogenic and embryotoxic effects in large doses. The objective of this study was to assess the influence of caffeine on the development of ... ...

Abstract	Caffeine is a methylxanthine which permeates the placenta. In studies on animals, it has been shown to produce teratogenic and embryotoxic effects in large doses. The objective of this study was to assess the influence of caffeine on the development of bone tissue, with particular reference to elemental bone composition using an X-ray microprobe. The research was conducted on rats. The fertilized females were randomly divided into an experimental and a control group. The experimental group was given caffeine orally in 30 mg/day doses from the 8th to the 21st day of pregnancy, while the control group was given water. The fetuses were used to assess the growth and mineralization of the skeleton. On the basis of double dyeing, a qualitative analysis of the bone morphology and mineralization was conducted. For calcium and potassium analysis, an X-ray microprobe was used. In 67 fetuses from the experimental group, changes in skeleton staining with the alcian-alizarin method were noticed. The frequency of the development of variants in the experimental group was statistically higher. In the experimental group, a significant decrease in the calcium level, as well as an increase in the potassium level, was observed. The X-ray microprobe’s undoubted advantage is that is offers a quick qualitative and quantitative analysis of the elemental composition of the examined samples. Employing this new technique may furnish us with new capabilities when investigating the essence of the pathology process. Caffeine is a methylxanthine which permeates the placenta. In studies on animals, it has been shown to produce teratogenic and embryotoxic effects in large doses. The objective of this study was to assess the influence of caffeine on the development of bone tissue, with particular reference to elemental bone composition using an X-ray microprobe. The research was conducted on rats. The fertilized females were randomly divided into an experimental and a control group. The experimental group was given caffeine orally in 30 mg/day doses from the 8th to the 21st day of pregnancy, while the control group was given water. The fetuses were used to assess the growth and mineralization of the skeleton. On the basis of double dyeing, a qualitative analysis of the bone morphology and mineralization was conducted. For calcium and potassium analysis, an X-ray microprobe was used. In 67 fetuses from the experimental group, changes in skeleton staining with the alcian-alizarin method were noticed. The frequency of the development of variants in the experimental group was statistically higher. In the experimental group, a significant decrease in the calcium level, as well as an increase in the potassium level, was observed. The X-ray microprobe’s undoubted advantage is that is offers a quick qualitative and quantitative analysis of the elemental composition of the examined samples. Employing this new technique may furnish us with new capabilities when investigating the essence of the pathology process.
Keywords	Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	630
Language	English
Publishing date	2012-10-01T00:00:00Z
Publisher	Via Medica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Primary and secondary prevention of breast cancer

Agnieszka Kolak / Marzena Kamińska / Katarzyna Sygit / Agnieszka Budny / Dariusz Surdyka / Bożena Kukiełka-Budny / Franciszek Burdan

Annals of Agricultural and Environmental Medicine, Vol 24, Iss 4, Pp 549-

2017 Volume 553

Abstract: Introduction Breast cancer is the most common cancer among women and is the second cancer frequently occurring worldwide of newly-diagnosed cancers. There is much evidence showing the influence of life style and environmental factors on the development ... ...

Abstract	Introduction Breast cancer is the most common cancer among women and is the second cancer frequently occurring worldwide of newly-diagnosed cancers. There is much evidence showing the influence of life style and environmental factors on the development of mammary gland cancer (high-fat diet, alcohol consumption, lack of physical exercise), the elimination of which (primary prevention) may contribute to a decrease in morbidity and mortality. Secondary prevention, comprising diagnostic tests (e.g. mammography, ultrasonography, magnetic resonance imaging, breast self-examination, as well as modern and more precise imaging methods) help the early detection of tumours or lesions predisposing to tumours. Objective The aim of this study paper is to review current knowledge and reports regarding primary and secondary prevention of breast cancer. State of knowledge It is estimated that nearly 70% of malign tumours are caused by environmental factors, whereas in breast cancer this percentage reaches 90–95%. There are national programmes established in many countries to fight cancer, where both types of prevention are stressed as serving to decrease morbidity and mortality due to cancers. Conclusions Cancer prevention is currently playing a key role in the fight against the disease. Behaviour modification, as well as greater awareness among women regarding breast cancer, may significantly contribute towards reducing the incidence of this cancer. Another important aspect is the number of women undergoing diagnostic tests, which still remains at an unsatisfactory level.
Keywords	breast cancer ; primary and secondary prevention ; risk factors ; life style ; mammography ; modern diagnostics methods ; Agriculture ; S ; Environmental sciences ; GE1-350
Subject code	610
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Institute of Rural Health
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of caffeine administered at 45 °C on bone tissue development

Marek Tomaszewski / Grażyna Olchowik / Monika Tomaszewska / Wojciech Dworzański / Anna Pańczuk / Franciszek Burdan

Annals of Agricultural and Environmental Medicine, Vol 21, Iss 876253, Pp 804-

2014 Volume 809

Abstract: b]introduction and objective[/b]. Caffeine is one of the world’s most commonly ingested alkaloids which easily permeates the placenta. The teratogenic and embryotoxic influence of large doses of caffeine has been established in many experimental studies ...

Abstract	[b]introduction and objective[/b]. Caffeine is one of the world’s most commonly ingested alkaloids which easily permeates the placenta. The teratogenic and embryotoxic influence of large doses of caffeine has been established in many experimental studies on animals. The objective of this work was to assess the influence of caffeine, administered at 45 °C, on the development of the bone tissue of rats, with particular reference to elemental bone composition using an X-ray microprobe. [b]materials and methods[/b]. The research was conducted on white rats of the Wistar strain. The fertilized females were divided into two groups: an Experimental Group (Group E) and a Control Group (Group C). The females in Group E were given caffeine orally (at 45 °C) in 30 mg/day doses from the 8 [sup]th [/sup] to the 21 [sup]st[/sup] day of pregnancy. The females in Group C were given water at the same temperature. The fetuses were used to assess the growth and mineralization of the skeleton. A qualitative analysis of the morphology and mineralization of bones was conducted using the alcian-alizarin method. For calcium and potassium analysis, an X-ray microprobe was used. [b]results.[/b] By staining the skeleton using the alcian-alizarin method, changes in 52 of Group E fetuses were observed. The frequency of the development variants in the Group E rats was statistically higher, compared with Group C. [b]conclusions[/b]. Receiving caffeine at a higher temperature may result in different pharmacodynamics and significantly change tolerance to it. In Group E, a significant decrease in the calcium level, as well as an increase in the potassium level, was observed. The X-ray microprobe can be a perfect complement to the methods which enable determination of the mineralization of osseous tissue.
Keywords	temperature 45 °C;X-ray microprobe;Rat;bone tissue;Caffeine ; Agriculture ; S ; Environmental sciences ; GE1-350
Subject code	630
Language	English
Publishing date	2014-11-01T00:00:00Z
Publisher	Institute of Rural Health
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hipercysteinaemia and stroke Hipercysteinemia a udar mózgu

Grzegorz Opielak / Wojciech Dworzañski / Franciszek Burdan / £ukasz Szeszko / Jakub Piotrkowicz / Mykola Tsyganok

Polish Journal of Cardiology, Vol 14, Iss 4, Pp 287-

2012 Volume 291

Abstract: Strokes are considered as the third, as for the frequency, cause of death and the most frequent cause of loss of the ability to lead active life, and, in many cases, of permanent disability in population of adults. The epidemiological research points at ... ...

Abstract	Strokes are considered as the third, as for the frequency, cause of death and the most frequent cause of loss of the ability to lead active life, and, in many cases, of permanent disability in population of adults. The epidemiological research points at large differences in the incidence and mortality due to stroke in various countries. In Poland, mortality ratio due to stroke is one of the highest in Europe and, in comparison to the situation in highly industrialized countries in the last 10 years, continues on the same high level. In Poland mortality related to stroke reaches about 60%, while in Western Europe and in the United States 30%. The percentage of disabilities after stroke in Poland is also relatively high, up to 70% as compared to 50% in Western Europe. According to the Helsingborg Declaration (1995), which specifies current procedures for stroke, the principles of stroke prevention are of great significance. This refers to the primary prevention based on the attempt to eliminate modifiable risk factors, and the secondary prevention based on preventing vascular incidents in persons who experienced stroke or who experienced ischaemic episodes (transient ischemic attack TIA). In the etiopathogenesis of the ischemic stroke, the significance of atherosclerosis, heart diseases, arterial hypertension, lipid disorders, smoking, alcoholism, haematological disorders, genetic factors and other risk factors is emphasized. However, it is known that in spite of performing many types of additional examination, the etiology of 30-50 % of strokes remains unexplained.
Keywords	Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	590
Language	Polish
Publishing date	2012-01-01T00:00:00Z
Publisher	Cornetis sp. z o.o.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Redox Imbalance and the Reduction of Contractile Protein Content in Rat Hearts Administered with L-Thyroxine and Doxorubicin

Agnieszka Korga / Jaroslaw Dudka / Franciszek Burdan / Justyna Sliwinska / Slawomir Mandziuk / Katarzyna Dawidek-Pietryka

Oxidative Medicine and Cellular Longevity, Vol

2012 Volume 2012

Keywords	Cytology ; QH573-671 ; Biology (General) ; QH301-705.5 ; Science ; Q
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	Hindawi Publishing Corporation
Document type	Article ; Online
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Article ; Online: Place of residence does not significantly influence radiological morphology of cervical cancer

Franciszek Burdan / Agnieszka Mocarska / Robert Klepacz / Jerzy Walocha / Tomasz Kubiatowski / Dariusz Surdyka / Dariusz Kieszko / Krzysztof Patyra / Iwonna Żelzowska-Cieślińska / Elżbieta Starosławska

Annals of Agricultural and Environmental Medicine, Vol 24, Iss 3, Pp 527-

2017 Volume 531

Abstract: Introduction and objective Cervical squamous cell carcinoma is one of the most common malignancies of women. Its incidence and morphology was analyzed based on the magnetic resonance (MR) data among rural and urban residents. Material and Methods The ... ...

Abstract	Introduction and objective Cervical squamous cell carcinoma is one of the most common malignancies of women. Its incidence and morphology was analyzed based on the magnetic resonance (MR) data among rural and urban residents. Material and Methods The study involved 61 Caucasian women (58.26±9.63 years) preliminary diagnosed with a cervical cancer without any previous treatment. Standard MR examination, including diffusion weighted imagining, apparent diffusion coefficient (ADC) value measurement and dynamic contrast enhancement, was performed. Results The rural residents (n=22) were insignificantly older. Their first and last menstruation were observed later and number of pregnancy was higher than in urban women (n=39). However, the incidence of miscarriage was insignificantly rarer. All the tumour linear diameters as well as its volume were insignificantly higher in rural women. The ADC value of the cervical tumor was insignificantly lower, while ADC of lymphatic nodules was higher in rural women. Insignificant changes in tumour grade between both examined groups were found in histological, clinical and radiological examinations. Place of residence did not influence any clinical symptoms nor tumour volume and its ADC. Colporrhoea and colpodynia were insignificantly more often observed in urban women, while parametrium, urinary bladder and rectal infiltrations were more commonly seen in rural residents. Higher risk of lymphatic spread to the internal iliac and parametral lymphatic nodes was reporte[b]d in the rural community. Conclusions Cervical cancer had similar morphology and growth pattern, regardless of the place of residence. However, a insignificantly larger tumour size among rural residents may suggest a higher incidence of lymphatic spread, probably as a result of less aaccess to modern health care.
Keywords	cervical cancer ; rural-urban differences ; magnetic resonance ; oncology ; Agriculture ; S ; Environmental sciences ; GE1-350
Subject code	610
Language	English
Publishing date	2017-09-01T00:00:00Z
Publisher	Institute of Rural Health
Document type	Article ; Online
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Article ; Online: Unusual interleukin-1 and -6 expression in fetal cartilage is associated with placental abnormalities.

Robert Klepacz / Michal Szumilo / Katarzyna Dyndor / Agnieszka Korobowicz-Markiewicz / Justyna Szumilo / Franciszek Burdan

Folia Histochemica et Cytobiologica, Vol 48, Iss 1, Pp 30-

2010 Volume 36

Abstract: Unusual expression of interleukin-1alpha, -1beta and -6 was previously found in the epiphyseal cartilage of rat fetuses prenatally exposed to various non-steroidal anti-inflammatory drugs (NSAID, i.e., ibuprofen, piroxicam, tolmetin) and selective ... ...

Abstract	Unusual expression of interleukin-1alpha, -1beta and -6 was previously found in the epiphyseal cartilage of rat fetuses prenatally exposed to various non-steroidal anti-inflammatory drugs (NSAID, i.e., ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitor (DFU). The aim of the present study was to evaluate the role of placenta in such phenomenon. Morphology of the organ, thickness of basal and labyrinth layer, immunoexpression of COX isoenzymes were examined, and confronted with maternal biochemical data and fetal developmental parameters. Higher maternal urea level, as well as lower placental weight and labyrinth thickness were found in the group of fetuses who revealed expression of genes coded the selected interleukins, when compared with the xenobiotic-exposed pups without the selected genes expression and untreated control. A significant correlation between placental weight and maternal total protein or urea level was revealed. Histological changes like inflammatory infiltration and calcification were observed sporadically. Location and intensity of COX-1 staining was similar in all cases. However, more intense COX-2 staining for majority of cells of the basal zone and in dispersed giant cells of the labyrinth was found in inflamed organs. It could be concluded that abnormal expression of the selected interleukins is associated with low placental weight and decrease of its thickness, especially labyrinth zone, as well as with high maternal urea level.
Keywords	Biology (General) ; QH301-705.5 ; Science ; Q ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
Subject code	616 ; 610
Language	English
Publishing date	2010-06-01T00:00:00Z
Publisher	Via Medica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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