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  1. Article ; Online: Emergency Liver Retransplantation With Marginal Donors.

    Cuevas López, María Josefa / Bellido, Carmen Bernal / Franco, Carmen Cepeda / Artacho, Gonzalo Suárez / Gómez, Luis Miguel Marín / Martínez, José María Álamo / Ruiz, Francisco Javier Padillo / Bravo, Miguel Ángel Gómez

    Transplantation proceedings

    2023  Volume 55, Issue 10, Page(s) 2282–2284

    Abstract: Background: The goal of the present study is to determine if using marginal donors negatively impacts the outcomes of emergency liver retransplantation.: Methods: A retrospective case-control study was performed, including all emergency liver ... ...

    Abstract Background: The goal of the present study is to determine if using marginal donors negatively impacts the outcomes of emergency liver retransplantation.
    Methods: A retrospective case-control study was performed, including all emergency liver retransplantations done in our center between 1990 and 2021. Recipients from the control group received the second grafts from "ideal donors", and patients from the case group received them from marginal donors. Analyzed variables included demographics of recipients and donors, complications, and survival rates.
    Results: 38 emergency retransplantations were performed. 23 recipients were included in the control group, and the remaining 15 were in the case group. The second donors from the case group were significantly older (mean age 58 vs 71 years old, P < 0.0001). On the contrary, there were no differences between groups regarding the mean age of recipients, comorbidities, Model for End-Stage Liver Disease scores, or causes of retransplantation (the most common was hepatic artery thrombosis). No differences were found in early perioperative death rates (control group 26.1% vs case group 20%, P =1) and, although the case group seemed to have slightly poorer outcomes in long-term survival (control group 70%, 61%, and 55% vs case group 73%, 59%, and 39%, respectively, at 1, 5, and 10 years), the differences were not statistically significant (log-rank = 0.808).
    Conclusions: The use of marginal donors for emergency liver retransplantation was proved safe in our study, as there were no differences in complications or in short- or mid-term survival rates.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Reoperation ; Retrospective Studies ; Case-Control Studies ; Liver Transplantation/adverse effects ; End Stage Liver Disease/surgery ; Treatment Outcome ; Severity of Illness Index ; Tissue Donors ; Graft Survival
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comment on "Improvement in Liver Transplant Outcomes From Older Donors: A US National Analysis": Annals of Surgery, Published Online July, 2019.

    Miranda, Pablo Beltran / Franco, Carmen Cepeda / Martinez, Jose María Álamo / Ruiz, Francisco Javier Padillo / Bravo, Miguel Ángel Gómez

    Annals of surgery

    2019  Volume 274, Issue 6, Page(s) e667–e668

    MeSH term(s) Humans ; Liver Transplantation ; Tissue Donors ; Tissue and Organ Procurement
    Language English
    Publishing date 2019-12-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000003695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Liver Resuscitation With Hypothermic Oxygenated Perfusion After Donation in Asystolic Type Iii With Regional Perfusion in Normothermia: A Case Report About First Experience in Spain.

    Pueyo-Périz, Eva María / Marín Gómez, Luis Miguel / Suárez Artacho, Gonzalo / Franco, Carmen Cepeda / María Álamo Martínez, José / Bellido, Carmen Bernal / Gómez Bravo, Miguel Ángel

    Transplantation proceedings

    2022  

    Abstract: Background: Extended criteria donor livers are increasingly being accepted for transplant in an attempt to bridge the gap between the number of patients on the waiting list and the number of available donor livers. Our objective was to describe our ... ...

    Abstract Background: Extended criteria donor livers are increasingly being accepted for transplant in an attempt to bridge the gap between the number of patients on the waiting list and the number of available donor livers. Our objective was to describe our first case of hepatic resuscitation by means of an ex situ perfusion machine in hypothermia with oxygen insufflation of a liver graft extracted from a donor in type 3 asystole after regional perfusion in normothermia.
    Methods: A 53-year-old woman with disabling polycystic liver disease was included on the liver transplant waiting list. Donation was offered in type 3 asystole with regional perfusion in normothermia. Given that it was an elderly donor with a low-weight graft, hepatic resuscitation was decided by means of an ex situ perfusion machine in hypothermia with oxygen insufflation.
    Results: After performing the bench work, the injector is selectively cannulated via the portal to connect it to the hypothermic perfusion machine. The average temperature of the perfusate (3 L modified Belzer) was 10°C for 120 minutes at 250 mL/min. The implant was completed without the need for transfusion of blood products, postreperfusion Sd, or vasoactive support. Peak of GOT/GPT was 803/276 at 24 hours posttransplant.
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2022.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Management of Large, Spontaneous Portosystemic Shunts in Liver Transplantation: Case Report and Review of Literature.

    Miranda, Pablo Beltran / Artacho, Gonzalo Suarez / Bellido, Carmen Bernal / Marín Gómez, Luis Miguel / Franco, Carmen Cepeda / Álamo Martinez, Jose María / Padillo Ruiz, Francisco Javier / Gómez Bravo, Miguel Ángel

    Transplantation proceedings

    2020  Volume 52, Issue 2, Page(s) 566–568

    Abstract: Background: The presence of collateral circulation in liver cirrhosis patients with portal hypertension is quite frequent due to re-permeabilization of closed embryonic channels. In some cases, these shunts could measure over 1 cm wide, therefore, ... ...

    Abstract Background: The presence of collateral circulation in liver cirrhosis patients with portal hypertension is quite frequent due to re-permeabilization of closed embryonic channels. In some cases, these shunts could measure over 1 cm wide, therefore, containing a significative blood flow. Its management during liver transplantation could be challenging due to possible complications resulting from either ligation of the shunts or from ignoring them. We present the case of a patient with recurrent hepatic encephalopathy (HE) and a large spontaneous portosystemic shunt (SPSS) who submitted to liver transplant and review the literature identifying options, complications, and outcomes with the aim of facilitating decision making.
    Material and methods: A 68-year-old, Spanish man diagnosed with liver cirrhosis with portal hypertension and recurrent episodes of HE is proposed for LT. The patient's Child-Pugh score was A6-B7, and the Model for End-stage Liver Disease score was 12. Preoperatively, a computed tomography scan showed a large SPSS running to the inferior cava vein. During the surgery, a small-sized portal vein and a large shunt measuring almost 3 cm wide were identified. After reperfusion, portal vein flow was 1000 to 1100 mL/min. Owing to the previous HE and the risk of low portal flow, the shunt was closed increasing the portal flow to 1800 mL/min. The patient was discharged without any complications.
    Conclusions: The presence of large SPSSs are frequent during LT. Decision making intraoperatively can be challenging due to possible complications derived from ligation of the SPSS or from ignoring it. Either preoperative assessment of a further HE risk or portal vein flow measurement after reperfusion are essential to achieve a correct resolution.
    MeSH term(s) Aged ; Collateral Circulation ; Hepatic Encephalopathy/complications ; Hepatic Encephalopathy/surgery ; Humans ; Hypertension, Portal/complications ; Hypertension, Portal/surgery ; Intraoperative Complications/etiology ; Intraoperative Complications/surgery ; Ligation/adverse effects ; Ligation/methods ; Liver Cirrhosis/complications ; Liver Cirrhosis/surgery ; Liver Transplantation/adverse effects ; Liver Transplantation/methods ; Male ; Portal Vein/abnormalities ; Portal Vein/diagnostic imaging ; Portal Vein/surgery ; Recurrence ; Tomography, X-Ray Computed ; Vascular Malformations/complications ; Vascular Malformations/surgery ; Vena Cava, Inferior/diagnostic imaging
    Language English
    Publishing date 2020-02-10
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2019.11.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Results of Early Liver Retransplantation.

    López, María Josefa Cuevas / Franco, Carmen Cepeda / Artacho, Gonzalo Suárez / Gómez, Luis Miguel Marín / Bellido, Carmen Bernal / Martínez, José María Álamo / Ruiz, Francisco Javier Padillo / Bravo, Miguel Ángel Gómez

    Transplantation proceedings

    2020  Volume 52, Issue 5, Page(s) 1486–1488

    Abstract: Background: Liver retransplantation can be classified as urgent (when performed in the first week after the transplantation) or elective, which may be considered as early (first month post-transplantation) or late (after the first month). The time in ... ...

    Abstract Background: Liver retransplantation can be classified as urgent (when performed in the first week after the transplantation) or elective, which may be considered as early (first month post-transplantation) or late (after the first month). The time in which retransplantation takes place is determined by the cause that makes it necessary. The goal of this study is to analyze the causes and results of early retransplantation in our center.
    Methods: A retrospective analysis of liver retransplantations performed within the first month after the original transplantation in our center between 2007 and 2017 was carried out. The variables analyzed were demographic, causes of the first transplant and retransplantation, and the complications and mortality resulting from the latter.
    Results: A total of 698 liver transplants were performed, including 67 patients who required retransplantation (8.9%). Among these, 37 were late elective retransplantations and 30 were early retransplantations. Regarding the latter, the causes that led to the first transplant were hepatocellular carcinoma (46.7%) and noncholestatic cirrhosis (30%). On the other hand, the main precipitants of the retransplantation were hepatic artery thrombosis (60%) and primary graft failure (13.3%). The reoperation rate was 16.7%, and the perioperative mortality rate was 16.7%. The 1-, 2-, and 5-year survival rates were 83.3%, 76.7% and 59.9%, respectively.
    Conclusion: Despite the high perioperative morbidity of liver retransplantation, its results in terms of survival are similar to those of the global series of liver transplantation.
    MeSH term(s) Adult ; Female ; Humans ; Liver Transplantation/mortality ; Male ; Middle Aged ; Postoperative Complications/etiology ; Postoperative Complications/mortality ; Postoperative Complications/surgery ; Reoperation/mortality ; Retrospective Studies ; Survival Rate ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Evaluation Study ; Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2020.02.055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A scoring system for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: a multicenter EUROPEAN validation.

    Manuel-Vázquez, Alba / Balakrishnan, Anita / Agami, Paul / Andersson, Bodil / Berrevoet, Frederik / Besselink, Marc G / Boggi, Ugo / Caputo, Damiano / Carabias, Alberto / Carrion-Alvarez, Lucia / Franco, Carmen Cepeda / Coppola, Alessandro / Dasari, Bobby V M / Diaz-Mercedes, Sherley / Feretis, Michail / Fondevila, Constantino / Fusai, Giuseppe Kito / Garcea, Giuseppe / Gonzabay, Victor /
    Bravo, Miguel Ángel Gómez / Gorris, Myrte / Hendrikx, Bart / Hidalgo-Salinas, Camila / Kadam, Prashant / Karavias, Dimitrios / Kauffmann, Emanuele / Kourdouli, Amar / La Vaccara, Vincenzo / van Laarhoven, Stijn / Leighton, James / Liem, Mike S L / Machairas, Nikolaos / Magouliotis, Dimitris / Mahmoud, Adel / Marino, Marco V / Massani, Marco / Requena, Paola Melgar / Mentor, Keno / Napoli, Niccolò / Nijhuis, Jorieke H T / Nikov, Andrej / Nistri, Cristina / Nunes, Victor / Ruiz, Eduardo Ortiz / Pandanaboyana, Sanjay / Saborido, Baltasar Pérez / Pohnán, Radek / Popa, Mariuca / Pérez, Belinda Sánchez / Bueno, Francisco Sánchez / Serrablo, Alejandro / Serradilla-Martín, Mario / Skipworth, James R A / Soreide, Kjetil / Symeonidis, Dimitris / Zacharoulis, Dimitris / Zelga, Piotr / Aliseda, Daniel / Santiago, María Jesús Castro / Mancilla, Carlos Fernández / Fragua, Raquel Latorre / Hughes, Daniel Llwyd / Llorente, Carmen Payá / Lesurtel, Mickaël / Gallagher, Tom / Ramia, José Manuel

    Langenbeck's archives of surgery

    2022  Volume 407, Issue 8, Page(s) 3447–3455

    Abstract: Purpose: A preoperative estimate of the risk of malignancy for intraductal papillary mucinous neoplasms (IPMN) is important. The present study carries out an external validation of the Shin score in a European multicenter cohort.: Methods: An ... ...

    Abstract Purpose: A preoperative estimate of the risk of malignancy for intraductal papillary mucinous neoplasms (IPMN) is important. The present study carries out an external validation of the Shin score in a European multicenter cohort.
    Methods: An observational multicenter European study from 2010 to 2015. All consecutive patients undergoing surgery for IPMN at 35 hospitals with histological-confirmed IPMN were included.
    Results: A total of 567 patients were included. The score was significantly associated with the presence of malignancy (p < 0.001). In all, 64% of the patients with benign IPMN had a Shin score < 3 and 57% of those with a diagnosis of malignancy had a score ≥ 3. The relative risk (RR) with a Shin score of 3 was 1.37 (95% CI: 1.07-1.77), with a sensitivity of 57.1% and specificity of 64.4%.
    Conclusion: Patients with a Shin score ≤ 1 should undergo surveillance, while patients with a score ≥ 4 should undergo surgery. Treatment of patients with Shin scores of 2 or 3 should be individualized because these scores cannot accurately predict malignancy of IPMNs. This score should not be the only criterion and should be applied in accordance with agreed clinical guidelines.
    Language English
    Publishing date 2022-10-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-022-02687-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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