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Article ; Online: Effects of short-wave ultraviolet light, ultrasonic and microwave treatments on banana puree during refrigerated storage

Franco, Rodrigo Rubén / Ojeda, Gonzalo Adrián / Rompato, Karina Mariela / Sgroppo, Sonia Cecilia

Food Science and Technology International. 2023 Jan., v. 29, no. 1 p.50-61

2023

Abstract: Enzymatic browning is a major problem in minimally processed banana puree; it reduces consumer's acceptability and affects nutritional quality. The objective of this work was to evaluate the effects ultrasound (40 kHz/10 min), microwave (800 W/ 25 s) and ...

Abstract	Enzymatic browning is a major problem in minimally processed banana puree; it reduces consumer's acceptability and affects nutritional quality. The objective of this work was to evaluate the effects ultrasound (40 kHz/10 min), microwave (800 W/ 25 s) and UV-C radiation (1.97 kJ/m²) applied to banana puree. Colour parameters (L, a, b*, chroma and hue), browning index (BI), polyphenol oxidase (PPO) and peroxidase (POD) activities, total phenolic compounds (TPC), antioxidant capacity (AOC) and microbiological counts were monitored throughout storage at 4 °C. Ultrasound (US) and microwave (MW) treatments achieved a significant (p < 0.05) reduction in PPO activity and BI; moreover, ultrasound effectively retained phenolic compounds content (75% of initial value). The AOC was in coincidence with TPC values. POD activity was partially inhibited by UV-C while MW and US increase its activity. Although UV-C treatment was not effective to control browning development, it was effective to maintain microbiological stability after 20 days of storage (1.48 ± 0.01 log CFU/g). The evaluated treatments have the advantage of being less aggressive than conventional thermal treatments while maintaining fresh characteristics of the product.
Keywords	antioxidant activity ; bananas ; catechol oxidase ; cold storage ; color ; nutritive value ; peroxidase ; ultrasonics ; ultraviolet radiation ; Food preservation and processing ; emerging technologies ; enzymatic browning ; food color ; antioxidants
Language	English
Dates of publication	2023-01
Size	p. 50-61.
Publishing place	SAGE Publications
Document type	Article ; Online
ZDB-ID	1289316-X
ISSN	1532-1738 ; 1082-0132
ISSN (online)	1532-1738
ISSN	1082-0132
DOI	10.1177/10820132211058444
Database	NAL-Catalogue (AGRICOLA)

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Article: Naturally Derived Phenethyl Isothiocyanate Modulates Induction of Oxidative Stress via Its

Kyriakou, Sotiris / Demosthenous, Nikoletta / Amery, Tom / Stewart, Kyle J / Winyard, Paul G / Franco, Rodrigo / Pappa, Aglaia / Panayiotidis, Mihalis I

Antioxidants (Basel, Switzerland)

2024 Volume 13, Issue 1

Abstract: Phenethyl isothiocyanate (PEITC) is a secondary metabolic product yielded upon the hydrolysis of gluconasturtiin and it is highly accumulated in the flowers of watercress. The aim of the current study was to assess the role of a naturally derived PEITC- ... ...

Abstract	Phenethyl isothiocyanate (PEITC) is a secondary metabolic product yielded upon the hydrolysis of gluconasturtiin and it is highly accumulated in the flowers of watercress. The aim of the current study was to assess the role of a naturally derived PEITC-enriched extract in the induction of oxidative stress and to evaluate its anti-melanoma potency through the regulation of its metabolism with the concurrent production of the
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox13010082
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Article ; Online: Isothiocyanates Potentiate Tazemetostat-Induced Apoptosis by Modulating the Expression of Apoptotic Genes, Members of Polycomb Repressive Complex 2, and Levels of Tri-Methylating Lysine 27 at Histone 3 in Human Malignant Melanoma Cells.

Anestopoulos, Ioannis / Paraskevaidis, Ioannis / Kyriakou, Sotiris / Giova, Lambrini E / Trafalis, Dimitrios T / Botaitis, Sotiris / Franco, Rodrigo / Pappa, Aglaia / Panayiotidis, Mihalis I

International journal of molecular sciences

2024 Volume 25, Issue 5

Abstract: In this study, we utilized an in vitro model consisting of human malignant melanoma as well as non-tumorigenic immortalized keratinocyte cells with the aim of characterizing the therapeutic effectiveness of the clinical epigenetic drug Tazemetostat alone ...

Abstract	In this study, we utilized an in vitro model consisting of human malignant melanoma as well as non-tumorigenic immortalized keratinocyte cells with the aim of characterizing the therapeutic effectiveness of the clinical epigenetic drug Tazemetostat alone or in combination with various isothiocyanates. In doing so, we assessed markers of cell viability, apoptotic induction, and expression levels of key proteins capable of mediating the therapeutic response. Our data indicated, for the first time, that Tazemetostat caused a significant decrease in viability levels of malignant melanoma cells in a dose- and time-dependent manner via the induction of apoptosis, while non-malignant keratinocytes were more resistant. Moreover, combinatorial treatment protocols caused a further decrease in cell viability, together with higher apoptotic rates. In addition, a significant reduction in the Polycomb Repressive Complex 2 (PRC2) members [e.g., Enhancer of Zeste Homologue 2 (EZH2), Embryonic Ectoderm Development (EED), and suppressor of zeste 12 (SUZ12)] and tri-methylating lysine 27 at Histone 3 (H3K27me3) protein expression levels was observed, at least partially, under specific combinatorial exposure conditions. Reactivation of major apoptotic gene targets was determined at much higher levels in combinatorial treatment protocols than Tazemetostat alone, known to be involved in the induction of intrinsic and extrinsic apoptosis. Overall, we developed an optimized experimental therapeutic platform aiming to ensure the therapeutic effectiveness of Tazemetostat in malignant melanoma while at the same time minimizing toxicity against neighboring non-tumorigenic keratinocyte cells.
MeSH term(s)	Humans ; Histones/metabolism ; Polycomb Repressive Complex 2/genetics ; Lysine/metabolism ; Melanoma ; Enhancer of Zeste Homolog 2 Protein/genetics ; Apoptosis ; Benzamides ; Biphenyl Compounds ; Morpholines ; Pyridones
Chemical Substances	Histones ; Polycomb Repressive Complex 2 (EC 2.1.1.43) ; Lysine (K3Z4F929H6) ; tazemetostat (Q40W93WPE1) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43) ; Benzamides ; Biphenyl Compounds ; Morpholines ; Pyridones
Language	English
Publishing date	2024-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25052745
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Article ; Online: Redox Biology in Neurological Function, Dysfunction, and Aging.

Franco, Rodrigo / Vargas, Marcelo R

Antioxidants & redox signaling

2018 Volume 28, Issue 18, Page(s) 1583–1586

Abstract: Reduction oxidation (redox) reactions are central to life and when altered, they can promote disease progression. In the brain, redox homeostasis is recognized to be involved in all aspects of central nervous system (CNS) development, function, aging, ... ...

Abstract	Reduction oxidation (redox) reactions are central to life and when altered, they can promote disease progression. In the brain, redox homeostasis is recognized to be involved in all aspects of central nervous system (CNS) development, function, aging, and disease. Recent studies have uncovered the diverse nature by which redox reactions and homeostasis contribute to brain physiology, and when dysregulated to pathological consequences. Redox reactions go beyond what is commonly described as oxidative stress and involve redox mechanisms linked to signaling and metabolism. In contrast to the nonspecific nature of oxidative damage, redox signaling involves specific oxidation/reduction reactions that regulate a myriad of neurological processes such as neurotransmission, homeostasis, and degeneration. This Forum is focused on the role of redox metabolism and signaling in the brain. Six review articles from leading scientists in the field that appraise the role of redox metabolism and signaling in different aspects of brain biology including neurodevelopment, neurotransmission, aging, neuroinflammation, neurodegeneration, and neurotoxicity are included. An original research article exemplifying these concepts uncovers a novel link between oxidative modifications, redox signaling, and neurodegeneration. This Forum highlights the recent advances in the field and we hope it encourages future research aimed to understand the mechanisms by which redox metabolism and signaling regulate CNS physiology and pathophysiology. Antioxid. Redox Signal. 28, 1583-1586.
MeSH term(s)	Aging/metabolism ; Aging/pathology ; Animals ; Central Nervous System/metabolism ; Central Nervous System/pathology ; Central Nervous System/physiopathology ; Humans ; Neurons/metabolism ; Neurons/pathology ; Oxidation-Reduction ; Oxidative Stress ; Signal Transduction
Language	English
Publishing date	2018-04-23
Publishing country	United States
Document type	Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2018.7509
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunosuppression in Kidney Transplantation: State of the Art and Current Protocols.

Bauer, Andrea C / Franco, Rodrigo F / Manfro, Roberto C

Current pharmaceutical design

2020 Volume 26, Issue 28, Page(s) 3440–3450

Abstract: Currently, kidney transplantation is the best treatment option for kidney failure for a majority of eligible patients. It is associated with a better quality of life and reduced mortality as compared to staying on dialysis. Many of the improvements in ... ...

Abstract	Currently, kidney transplantation is the best treatment option for kidney failure for a majority of eligible patients. It is associated with a better quality of life and reduced mortality as compared to staying on dialysis. Many of the improvements in kidney transplant outcomes, observed in recent decades, are due to more efficient immunosuppression strategies. Therefore, developing expertise in the management of immunosuppressive drugs is key to the success of kidney transplantation. In this review, the historical aspects of organ transplant immunosuppression are briefly addressed and the basis of the allograft immune response to contextualize the main topic is provided, which is a deeper view of the immunosuppressive agents, including their known mechanisms of action, pharmacokinetics, interactions, toxicities, and clinical use. The most commonly used immunosuppressive protocols employed based on patients' and donors' characteristics are also presented here.
MeSH term(s)	Calcineurin Inhibitors ; Graft Rejection/drug therapy ; Graft Rejection/prevention & control ; Humans ; Immunosuppression ; Immunosuppressive Agents ; Kidney Transplantation ; Quality of Life
Chemical Substances	Calcineurin Inhibitors ; Immunosuppressive Agents
Language	English
Publishing date	2020-05-21
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612826666200521142448
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of short-wave ultraviolet light, ultrasonic and microwave treatments on banana puree during refrigerated storage.

Franco, Rodrigo Rubén / Ojeda, Gonzalo Adrián / Rompato, Karina Mariela / Sgroppo, Sonia Cecilia

Food science and technology international = Ciencia y tecnologia de los alimentos internacional

2021 Volume 29, Issue 1, Page(s) 50–61

Abstract	Enzymatic browning is a major problem in minimally processed banana puree; it reduces consumer's acceptability and affects nutritional quality. The objective of this work was to evaluate the effects ultrasound (40 kHz/10 min), microwave (800 W/ 25 s) and UV-C radiation (1.97 kJ/m
MeSH term(s)	Musa ; Microwaves ; Ultraviolet Rays ; Ultrasonics ; Catechol Oxidase ; Antioxidants ; Phenols/analysis
Chemical Substances	Catechol Oxidase (EC 1.10.3.1) ; Antioxidants ; Phenols
Language	English
Publishing date	2021-11-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1289316-X
ISSN	1532-1738 ; 1082-0132
ISSN (online)	1532-1738
ISSN	1082-0132
DOI	10.1177/10820132211058444
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Assessment of Methodological Pipelines for the Determination of Isothiocyanates Derived from Natural Sources.

Kyriakou, Sotiris / Trafalis, Dimitrios T / Deligiorgi, Maria V / Franco, Rodrigo / Pappa, Aglaia / Panayiotidis, Mihalis I

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 4

Abstract: Isothiocyanates are biologically active secondary metabolites liberated via enzymatic hydrolysis of their sulfur enriched precursors, glucosinolates, upon tissue plant disruption. The importance of this class of compounds lies in their capacity to induce ...

Abstract	Isothiocyanates are biologically active secondary metabolites liberated via enzymatic hydrolysis of their sulfur enriched precursors, glucosinolates, upon tissue plant disruption. The importance of this class of compounds lies in their capacity to induce anti-cancer, anti-microbial, anti-inflammatory, neuroprotective, and other bioactive properties. As such, their isolation from natural sources is of utmost importance. In this review article, an extensive examination of the various parameters (hydrolysis, extraction, and quantification) affecting the isolation of isothiocyanates from naturally-derived sources is presented. Overall, the effective isolation/extraction and quantification of isothiocyanate is strongly associated with their chemical and physicochemical properties, such as polarity-solubility as well as thermal and acidic stability. Furthermore, the successful activation of myrosinase appears to be a major factor affecting the conversion of glucosinolates into active isothiocyanates.
Language	English
Publishing date	2022-03-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11040642
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Article ; Online: Effectiveness of Web-Based Personalized Nutrition Advice for Adults Using the eNutri Web App: Evidence From the EatWellUK Randomized Controlled Trial.

Zenun Franco, Rodrigo / Fallaize, Rosalind / Weech, Michelle / Hwang, Faustina / Lovegrove, Julie A

Journal of medical Internet research

2022 Volume 24, Issue 4, Page(s) e29088

Abstract: Background: Evidence suggests that eating behaviors and adherence to dietary guidelines can be improved using nutrition-related apps. Apps delivering personalized nutrition (PN) advice to users can provide individual support at scale with relatively low ...

Abstract	Background: Evidence suggests that eating behaviors and adherence to dietary guidelines can be improved using nutrition-related apps. Apps delivering personalized nutrition (PN) advice to users can provide individual support at scale with relatively low cost. Objective: This study aims to investigate the effectiveness of a mobile web app (eNutri) that delivers automated PN advice for improving diet quality, relative to general population food-based dietary guidelines. Methods: Nondiseased UK adults (aged >18 years) were randomized to PN advice or control advice (population-based healthy eating guidelines) in a 12-week controlled, parallel, single-blinded dietary intervention, which was delivered on the web. Dietary intake was assessed using the eNutri Food Frequency Questionnaire (FFQ). An 11-item US modified Alternative Healthy Eating Index (m-AHEI), which aligned with UK dietary and nutritional recommendations, was used to derive the automated PN advice. The primary outcome was a change in diet quality (m-AHEI) at 12 weeks. Participant surveys evaluated the PN report (week 12) and longer-term impact of the PN advice (mean 5.9, SD 0.65 months, after completion of the study). Results: Following the baseline FFQ, 210 participants completed at least 1 additional FFQ, and 23 outliers were excluded for unfeasible dietary intakes. The mean interval between FFQs was 10.8 weeks. A total of 96 participants were included in the PN group (mean age 43.5, SD 15.9 years; mean BMI 24.8, SD 4.4 kg/m Conclusions: These findings suggest that the eNutri app is an effective web-based tool for the automated delivery of PN advice. Furthermore, eNutri was demonstrated to improve short-term diet quality and increase engagement in healthy eating behaviors in UK adults, as compared with population-based healthy eating guidelines. This work represents an important landmark in the field of automatically delivered web-based personalized dietary interventions. Trial registration: ClinicalTrials.gov NCT03250858; https://clinicaltrials.gov/ct2/show/NCT03250858.
MeSH term(s)	Adult ; Diet ; Diet, Healthy ; Humans ; Internet ; Mobile Applications ; Nutritional Status
Language	English
Publishing date	2022-04-25
Publishing country	Canada
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1439-4456
ISSN (online)	1438-8871
ISSN	1439-4456
DOI	10.2196/29088
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Article: Chemical Characterization and Biological Evaluation of

Kyriakou, Sotiris / Tragkola, Venetia / Paraskevaidis, Ioannis / Plioukas, Mihalis / Trafalis, Dimitrios T / Franco, Rodrigo / Pappa, Aglaia / Panayiotidis, Mihalis I

Plants (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Malignant melanoma is an aggressive type of skin cancer characterised by high metastatic capacity and mortality rate. On the other hand, ...

Abstract	Malignant melanoma is an aggressive type of skin cancer characterised by high metastatic capacity and mortality rate. On the other hand,
Language	English
Publishing date	2023-04-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12081590
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Article ; Online: Redox Regulation and Metabolic Dependency of Zika Virus Replication: Inhibition by Nrf2-Antioxidant Response and NAD(H) Antimetabolites.

Sahoo, Bikash R / Crook, Alexandra A / Pattnaik, Aryamav / Torres-Gerena, Alondra D / Khalimonchuk, Oleh / Powers, Robert / Franco, Rodrigo / Pattnaik, Asit K

Journal of virology

2023 Volume 97, Issue 2, Page(s) e0136322

Abstract: Viral infections alter host cell metabolism and homeostasis; however, the mechanisms that regulate these processes have only begun to be elucidated. We report here that Zika virus (ZIKV) infection activates the antioxidant nuclear factor erythroid 2- ... ...

Abstract	Viral infections alter host cell metabolism and homeostasis; however, the mechanisms that regulate these processes have only begun to be elucidated. We report here that Zika virus (ZIKV) infection activates the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf2), which precedes oxidative stress. Downregulation of Nrf2 or inhibition of glutathione (GSH) synthesis resulted in significantly increased viral replication. Interestingly, 6-amino-nicotinamide (6-AN), a nicotinamide analog commonly used as an inhibitor of the pentose phosphate pathway (PPP), decreased viral replication by over 1,000-fold. This inhibition was neither recapitulated by the knockdown of PPP enzymes, glucose 6-phosphate dehydrogenase (G6PD), or 6-phosphogluconate dehydrogenase (6PGD), nor prevented by supplementation with ribose 5-phosphate. Instead, our metabolomics and metabolic phenotype studies support a mechanism in which 6-AN depletes cells of NAD(H) and impairs NAD(H)-dependent glycolytic steps resulting in inhibition of viral replication. The inhibitory effect of 6-AN was rescued with precursors of the salvage pathway but not with those of other NAD
MeSH term(s)	Humans ; Antioxidants/metabolism ; Antioxidants/therapeutic use ; NAD/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidation-Reduction ; Viral Proteins/metabolism ; Virus Replication/physiology ; Zika Virus/physiology ; Zika Virus Infection/drug therapy ; Zika Virus Infection/prevention & control ; Zika Virus Infection/virology ; Oxidoreductases/genetics ; Gene Knockdown Techniques ; Cells, Cultured ; Host Microbial Interactions/physiology
Chemical Substances	Antioxidants ; NAD (0U46U6E8UK) ; NF-E2-Related Factor 2 ; Viral Proteins ; Oxidoreductases (EC 1.-)
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01363-22
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